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1.	Hermanrud, C, et al. (author) Anti-interferon beta antibody titers strongly correlate between two bioassays and in vivo biomarker expression, and indicates that a titer of 150 TRU/mL is a biologically functional cut-point 2014 In: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. - : Mary Ann Liebert Inc. - 1557-7465. ; 34:7, s. 498-504 Journal article (peer-reviewed)
2.	Hermanrud, C, et al. (author) Intradermal Administration of Interferon Beta Induces Dermal Dendritic Cell Activation 2014 In: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. - 0300-9475. ; 79:6, s. 477-478 Conference paper (other academic/artistic)
3.	Link, J, et al. (author) Human leukocyte antigen genes and interferon beta preparations influence risk of developing neutralizing anti-drug antibodies in multiple sclerosis 2014 In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 84:1, s. 109-109 Journal article (peer-reviewed)
4.	Lundstrom, W, et al. (author) Interferon beta treatment of multiple sclerosis increases serum interleukin-7 2014 In: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1477-0970 .- 1352-4585. ; 20:13, s. 1727-1736 Journal article (peer-reviewed)abstract Interleukin-7 (IL-7) is a non-redundant cytokine for T-cell development and survival. The IL-7 signaling pathway has been genetically and functionally associated with several autoimmune diseases including multiple sclerosis (MS). Objective: The objective of this paper is to elucidate the effect of the widely used immunomodulatory MS therapy interferon beta (IFNβ) on IL-7 homeostasis. Methods: Swedish MS patients were screened for IL-7 concentration in serum and blood cell counts. IL-7 receptor alpha chain (IL-7Rα) expression was determined by semi-quantitative real-time polymerase chain reaction (PCR) and flow cytometry. Results: IFNβ treatment led to significantly increased serum IL-7 levels (mean: 17 pg/ml) compared with healthy controls (mean: 7.6 pg/ml) and natalizumab-treated patients (mean: 5.3 pg/ml). In vitro and in vivo, peripheral blood leukocytes showed decreased IL-7Rα expression and IL-7 consumption upon IFNβ exposure, suggesting that their IL-7 responsiveness is impaired during treatment. Conclusions: MS patients undergoing IFNβ treatment have increased serum IL-7 levels and decreased IL-7 consumption. Given IL-7’s important role in T-cell immunity, this relationship may be highly relevant for IFNβ’s treatment efficacy.
5.	Ryner, ML, et al. (author) Human Leucocyte Antigen Genes and Interferon Beta Preparations Influence Risk of Developing Neutralizing Antidrug Antibodies in Multiple Sclerosis 2014 In: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. - 0300-9475. ; 79:6, s. 450-450 Conference paper (other academic/artistic)

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Type of publication: journal article (3); conference paper (2)

Type of content: peer-reviewed (3); other academic/artistic (2)

Author/Editor: Fogdell-Hahn, A (5); Hermanrud, C (5); Hillert, J (3); Ryner, ML (3); Kockum, I. (2); Fink, K (2); show more...; Lima, I (2); Link, J (2); Brynedal, B (2); Olsson, T (1); Wahren-Herlenius, M (1); Sjostrand, M (1); Brauner, S (1); Lundstrom, W (1); Engdahl, E. (1); Karrenbauer, V (1); show less...

University: Karolinska Institutet (5)

Language: English (5)

Year: 2014 (5)Undo refine

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