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The A2b adenosine r...
The A2b adenosine receptor protects against inflammation and excessive vascular adhesion
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- Young, D. (författare)
- Boston University School of Medicine
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- Zhang, Y (författare)
- Boston University School of Medicine
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- Nguyen, H G (författare)
- Boston University School of Medicine
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- Koupenova, M. (författare)
- Boston University School of Medicine
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- Chauhan, A K (författare)
- Boston University School of Medicine
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Mäkitalo, Maria (författare)
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- Jones, M R (författare)
- Boston University School of Medicine
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- Hilaire, C. St (författare)
- Boston University School of Medicine
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- Seldin, D C (författare)
- Boston University School of Medicine
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- Toselli, P (författare)
- Boston University School of Medicine
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- Lamperti, E (författare)
- Boston University School of Medicine
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- Schreiber, B M (författare)
- Boston University School of Medicine
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- Gavras, H (författare)
- Boston University School of Medicine
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- Wagner, D D (författare)
- Boston University School of Medicine
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- Ravid, K (författare)
- Boston University School of Medicine
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(creator_code:org_t)
- 2006
- 2006
- Engelska.
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Ingår i: Journal of Clinical Investigation. - 0021-9738 .- 1558-8238. ; 116:7, s. 1913-1923
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Adenosine has been described as playing a role in the control of inflammation, but it has not been certain which of its receptors mediate this effect. Here, we generated an A2B adenosine receptor-knockout/reporter gene-knock-in (A2BAR-knockout/reporter gene-knock-in) mouse model and showed receptor gene expression in the vasculature and macrophages, the ablation of which causes low-grade inflammation compared with age-, sex-, and strain-matched control mice. Augmentation of proinflammatory cytokines, such as TNF-alpha, and a consequent downregulation of IkappaB-alpha are the underlying mechanisms for an observed upregulation of adhesion molecules in the vasculature of these A2BAR-null mice. Intriguingly, leukocyte adhesion to the vasculature is significantly increased in the A2BAR-knockout mice. Exposure to an endotoxin results in augmented proinflammatory cytokine levels in A2BAR-null mice compared with control mice. Bone marrow transplantations indicated that bone marrow (and to a lesser extent vascular) A2BARs regulate these processes. Hence, we identify the A2BAR as a new critical regulator of inflammation and vascular adhesion primarily via signals from hematopoietic cells to the vasculature, focusing attention on the receptor as a therapeutic target
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Geokemi (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Geochemistry (hsv//eng)
Nyckelord
- Applied Geology
- Tillämpad geologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Young, D.
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Zhang, Y
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Nguyen, H G
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Koupenova, M.
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Chauhan, A K
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Mäkitalo, Maria
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visa fler...
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Jones, M R
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Hilaire, C. St
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Seldin, D C
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Toselli, P
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Lamperti, E
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Schreiber, B M
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Gavras, H
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Wagner, D D
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Ravid, K
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visa färre...
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