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Sökning: WFRF:(Hjelmsø Mathis Hjort) > (2022) > The developing airw...

The developing airway and gut microbiota in early life is influenced by age of older siblings

Christensen, Emil Dalgaard (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark; Department of Food Science, University of Copenhagen, Frederiksberg, Denmark
Hjelmsø, Mathis Hjort (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark
Thorsen, Jonathan (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Shah, Shiraz (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark
Redgwell, Tamsin (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark
Poulsen, Christina Egeø (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark; Department of Food Science, University of Copenhagen, Frederiksberg, Denmark
Trivedi, Urvish (författare)
Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark
Russel, Jakob (författare)
Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark
Gupta, Shashank, 1989- (författare)
Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark
Chawes, Bo L. (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark
Bønnelykke, Klaus (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark
Sørensen, Søren Johannes (författare)
Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark
Rasmussen, Morten Arendt (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark; Department of Food Science, University of Copenhagen, Frederiksberg, Denmark
Bisgaard, Hans (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark
Stokholm, Jakob (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark; Department of Food Science, University of Copenhagen, Frederiksberg, Denmark; Department of Pediatrics, Slagelse Hospital, Slagelse, Denmark
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 (creator_code:org_t)
2022-07-13
2022
Engelska.
Ingår i: Microbiome. - : BioMed Central (BMC). - 2049-2618. ; 10:1
Relaterad länk:
https://doi.org/10.1...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Growing up with siblings has been linked to numerous health outcomes and is also an important determinant for the developing microbiota. Nonetheless, research into the role of having siblings on the developing microbiota has mainly been incidental.Results: Here, we investigate the specific effects of having siblings on the developing airway and gut microbiota using a total of 4497 hypopharyngeal and fecal samples taken from 686 children in the COPSAC2010 cohort, starting at 1 week of age and continuing until 6 years of age. Sibship was evaluated longitudinally and used for stratification. Microbiota composition was assessed using 16S rRNA gene amplicon sequencing of the variable V4 region. We found siblings in the home to be one of the most important determinants of the developing microbiota in both the airway and gut, with significant differences in alpha diversity, beta diversity, and relative abundances of the most abundant taxa, with the specific associations being particularly apparent during the first year of life. The age gap to the closest older sibling was more important than the number of older siblings. The signature of having siblings in the gut microbiota at 1 year was associated with protection against asthma at 6 years of age, while no associations were found for allergy.Conclusions: Having siblings is one of the most important factors influencing a child's developing microbiota, and the specific effects may explain previously established associations between siblings and asthma and infectious diseases. As such, siblings should be considered in all studies involving the developing microbiota, with emphasis on the age gap to the closest older sibling rather than the number of siblings. Video abstract.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

Nyckelord

Cohort study
human microbiota
pediatrics
risk factors
siblings

Publikations- och innehållstyp

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art (ämneskategori)

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