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Serglycin Is Involv...
Serglycin Is Involved in Adipose Tissue Inflammation in Obesity
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- Doncheva, Atanaska, I (författare)
- Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Box 1046, N-0317 Oslo, Norway.
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- Norheim, Frode A. (författare)
- Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Box 1046, N-0317 Oslo, Norway.
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- Hjorth, Marit (författare)
- Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Box 1046, N-0317 Oslo, Norway.
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- Grujic, Mirjana (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Paivandy, Aida (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Dankel, Simon N. (författare)
- Univ Bergen, Dept Clin Sci, Mohn Nutr Res Lab, Bergen, Norway.;Haukeland Hosp, Dept Med Biochem & Pharmacol, Hormone Lab, Bergen, Norway.
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- Hertel, Jens Kristoffer (författare)
- Vestfold Hosp Trust, Morbid Obes Ctr, Tonsberg, Norway.
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- Valderhaug, Tone G. (författare)
- Akershus Univ Hosp, Dept Endocrinol, Div Med, Oslo, Norway.
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- Bottcher, Yvonne (författare)
- Univ Oslo, Inst Clin Med, Dept Clin Mol Biol, EpiGen, Oslo, Norway.;Akershus Univ Hosp, Med Div, EpiGen, Nordbyhagen, Norway.
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- Ferno, Johan (författare)
- Univ Bergen, Dept Clin Sci, Mohn Nutr Res Lab, Bergen, Norway.;Haukeland Hosp, Dept Med Biochem & Pharmacol, Hormone Lab, Bergen, Norway.
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- Mellgren, Gunnar (författare)
- Univ Bergen, Dept Clin Sci, Mohn Nutr Res Lab, Bergen, Norway.;Haukeland Hosp, Dept Med Biochem & Pharmacol, Hormone Lab, Bergen, Norway.
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- Dalen, Knut T. (författare)
- Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Box 1046, N-0317 Oslo, Norway.
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- Pejler, Gunnar (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Kolset, Svein O. (författare)
- Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Box 1046, N-0317 Oslo, Norway.
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Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Box 1046, N-0317 Oslo, Norway Institutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)
- 2022-01-01
- 2022
- Engelska.
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Ingår i: Journal of Immunology. - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 208:1, s. 121-132
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- Chronic local inflammation of adipose tissue is an important feature of obesity. Serglycin is a proteoglycan highly expressed by various immune cell types known to infiltrate adipose tissue under obese conditions. To investigate if serglycin expression has an impact on diet-induced adipose tissue inflammation, we subjected Srgn(+/+) and Srgn(-/-) mice (C57BL/6J genetic background) to an 8-wk high-fat and high-sucrose diet. The total body weight was the same in Srgn(+/+) and Srgn(-/-) mice after diet treatment. Expression of white adipose tissue genes linked to inflammatory pathways were lower in Srgn(-/)- mice. We also noted reduced total macrophage abundance, a reduced proportion of proinflammatory M1 macrophages, and reduced formation of crown-like structures in adipose tissue of Srgn(-/-) compared with Srgn(+/+) mice. Further, Srgn(-/-) mice had more medium-sized adipocytes and fewer large adipocytes. Differentiation of preadipocytes into adipocytes (3T3-L1) was accompanied by reduced Srgn mRNA expression. In line with this, analysis of single-cell RNA sequencing data from mouse and human adipose tissue supports that Srgn mRNA is predominantly expressed by various immune cells, with low expression in adipocytes. Srgn mRNA expression was higher in obese compared with lean humans and mice, accompanied by an increased expression of immune cell gene markers. SRGN and inflammatory marker mRNA expression was reduced upon substantial weight loss in patients after bariatric surgery. Taken together, this study introduces a role for serglycin in the regulation of obesity-induced adipose inflammation.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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Doncheva, Atanas ...
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Norheim, Frode A ...
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Hjorth, Marit
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Grujic, Mirjana
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Paivandy, Aida
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Dankel, Simon N.
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visa fler...
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Hertel, Jens Kri ...
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Valderhaug, Tone ...
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Bottcher, Yvonne
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Ferno, Johan
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Mellgren, Gunnar
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Dalen, Knut T.
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Pejler, Gunnar
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Kolset, Svein O.
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