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Sökning: WFRF:(Hogan Aileen) > (2013) > Divergent metabolic...

Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity

Murphy, Eileen F. (författare)
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Alimentary Health Ltd., Cork, Ireland
Cotter, Paul D. (författare)
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland
Hogan, Aileen (författare)
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
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O'Sullivan, Orla (författare)
Teagasc Food Research Centre, Fermoy, Ireland
Joyce, Andy (författare)
Alimentary Health Ltd., Cork, Ireland
Fouhy, Fiona (författare)
Teagasc Food Research Centre, Fermoy, Ireland; Department of Microbiology, University College Cork, Cork, Ireland
Clarke, Siobhan F. (författare)
Teagasc Food Research Centre, Fermoy, Ireland; Department of Microbiology, University College Cork, Cork, Ireland
Marques, Tatiana M., 1980- (författare)
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland
O'Toole, Paul W. (författare)
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Microbiology, University College Cork, Cork, Ireland
Stanton, Catherine (författare)
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland
Quigley, Eamonn M. M. (författare)
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Medicine, University College Cork, Cork, Ireland
Daly, Charlie (författare)
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
Ross, Paul R. (författare)
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland
O'Doherty, Robert M. (författare)
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh PA, USA
Shanahan, Fergus (författare)
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Medicine, University College Cork, Cork, Ireland
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Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Alimentary Health Ltd, Cork, Ireland Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland (creator_code:org_t)
2012-02-16
2013
Engelska.
Ingår i: Gut. - : BMJ Publishing Group Ltd. - 0017-5749 .- 1468-3288. ; 62:2, s. 220-226
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • OBJECTIVE: The gut microbiota is an environmental regulator of fat storage and adiposity. Whether the microbiota represents a realistic therapeutic target for improving metabolic health is unclear. This study explored two antimicrobial strategies for their impact on metabolic abnormalities in murine diet-induced obesity: oral vancomycin and a bacteriocin-producing probiotic (Lactobacillus salivarius UCC118 Bac(+)).DESIGN: Male (7-week-old) C57BL/J6 mice (9-10/group) were fed a low-fat (lean) or a high-fat diet for 20 weeks with/without vancomycin by gavage at 2 mg/day, or with L. salivarius UCC118Bac(+) or the bacteriocin-negative derivative L. salivarius UCC118Bac(-) (each at a dose of 1×10(9) cfu/day by gavage). Compositional analysis of the microbiota was by 16S rDNA amplicon pyrosequencing.RESULTS: Analysis of the gut microbiota showed that vancomycin treatment led to significant reductions in the proportions of Firmicutes and Bacteroidetes and a dramatic increase in Proteobacteria, with no change in Actinobacteria. Vancomycin-treated high-fat-fed mice gained less weight over the intervention period despite similar caloric intake, and had lower fasting blood glucose, plasma TNFα and triglyceride levels compared with diet-induced obese controls. The bacteriocin-producing probiotic had no significant impact on the proportions of Firmicutes but resulted in a relative increase in Bacteroidetes and Proteobacteria and a decrease in Actinobacteria compared with the non-bacteriocin-producing control. No improvement in metabolic profiles was observed in probiotic-fed diet-induced obese mice.CONCLUSION: Both vancomycin and the bacteriocin-producing probiotic altered the gut microbiota in diet-induced obese mice, but in distinct ways. Only vancomycin treatment resulted in an improvement in the metabolic abnormalities associated with obesity thereby establishing that while the gut microbiota is a realistic therapeutic target, the specificity of the antimicrobial agent employed is critical.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

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