| 1. |
- Liu, D., et al.
(författare)
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Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling
- 2014
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Ingår i: Cell Death and Disease. - : Nature Publishing Group: Open Access Journals - Option B / Nature Publishing Group. - 2041-4889. ; 5:e1251
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Tidskriftsartikel (refereegranskat)abstract
- The present study was designed to investigate the role of endogenous sulfur dioxide (SO2) in vascular smooth muscle cell (VSMC) proliferation, and explore the possible role of cross-talk between cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) and extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) pathways in this action. By cell counting, growth curve depict, flow cytometry and bromodeoxyuridine (BrdU) labeling assays, we found that SO2 inhibited VSMC proliferation by preventing cell cycle progression from G1 to S phase and by reducing DNA synthesis. SO2 synthase aspartate aminotransferase (AAT1 and AAT2) overexpression significantly inhibited serum-induced proliferating cell nuclear antigen (PCNA) protein expression in VSMCs, demonstrated by western blot analysis. Moreover, overexpression of AAT1 or AAT2 markedly reduced incorporation of BrdU in serum-treated VSMCs. By contrast, either AAT1 or AAT2 knockdown significantly exacerbated serum-stimulated VSMC proliferation. Thus, both exogenous-and endogenous-derived SO2 suppressed serum-induced VSMC proliferation. However, annexin V-propidium iodide (PI) staining and cell cycle analysis demonstrated that SO2 did not influence VSMC apoptosis in the serum-induced proliferation model. In a platelet-derived growth factor (PDGF)-BB-stimulated VSMC proliferation model, SO2 dephosphorylated the active sites of Erk1/2, MAPK kinase 1/2 and RAF proto-oncogene serine/threonine-protein kinase (c-Raf) induced by PDGF-BB. However, the inactivation of the three kinases of the Erk/MAPK pathway was not due to the separate interferences on them by SO2 simultaneously, but a consequence of the influence on the upstream activity of the c-Raf molecule. Hence, we examined the cAMP/PKA pathway, which could inhibit Erk/MAPK transduction in VSMCs. The results showed that SO2 could stimulate the cAMP/PKA pathway to block c-Raf activation, whereas the Ser259 site on c-Raf had an important role in SO2-induced suppression of Erk/MAPK pathway. The present study firstly demonstrated that SO2 exerted a negative regulation of VSMC proliferation via suppressing the Erk/MAPK pathway mediated by cAMP/PKA signaling.
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| 2. |
- McClune, Brian L., et al.
(författare)
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Allotransplantation for Patients Age >= 40 Years with Non-Hodgkin Lymphoma : Encouraging Progression-Free Survival
- 2014
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Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 20:7, s. 960-968
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Tidskriftsartikel (refereegranskat)abstract
- Non-Hodgkin lymphoma (NHL) disproportionately affects older patients, who do not often undergo allogeneic hematopoietic cell transplantation (HCT). We analyzed Center for International Blood and Marrow Transplant Research data on 1248 patients age >= 40 years receiving reduced-intensity conditioning (RIC) or nonmyeloablative (NMA) conditioning HCT for aggressive (n = 668) or indolent (n = 580) NHL Aggressive lymphoma was more frequent in the oldest cohort 49% for age 40 to 54 versus 57% for age 55 to 64 versus 67% for age >= 65; P = .0008). Fewer patients aged >= 65 had previous autografting (26% versus 24% versus 9%; P = .002). Rates of relapse, acute and chronic GVHD, and nonrelapse mortality (NRM) at 1 year post-HCT were similar in the 3 age cohorts (22% [95% confidence interval (CI), 19% to 26%] for age 40 to 54, 27% [95% CI, 23% to 31%] for age 55 to 64, and 34% [95% CI, 24% to 44%] for age >= 65. Progression-free survival (PFS) and overall survival (OS) at 3 years was slightly lower in the older cohorts (OS: 54% [95% CI, 50% to 58%] for age 40 to 54; 40% [95% CI, 36% to 44%] for age 55 to 64, and 39% [95% CI, 28% to 50%] for age >= 65; P < .0001). Multivariate analysis revealed no significant effect of age on the incidence of acute or chronic GVHD or relapse. Age >= 55 years, Karnofsky Performance Status <80, and HLA mismatch adversely affected NRM, PFS, and OS. Disease status at HCT, but not histological subtype, was associated with worse NRM, relapse, PFS, and OS. Even for patients age >= 55 years, OS still approached 40% at 3 years, suggesting that HCT affects long-term remission and remains underused in qualified older patients with NHL.
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| 3. |
- Welch, C. C., et al.
(författare)
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Formation of nanoscale structures by inductively coupled plasma etching
- 2012
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Ingår i: International Conference Micro- and Nano-Electronics 2012. - : SPIE - International Society for Optical Engineering. - 9780819494870 ; , s. 870002-
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Konferensbidrag (refereegranskat)abstract
- This paper will review the top down technique of ICP etching for the formation of nanometer scale structures. The increased difficulties of nanoscale etching will be described. However it will be shown and discussed that inductively coupled plasma (ICP) technology is well able to cope with the higher end of the nanoscale: features from 100nm down to about 40nm are relatively easy with current ICP technology. It is the ability of ICP to operate at low pressure yet with high plasma density and low (controllable) DC bias that helps greatly compared to simple reactive ion etching (RIE) and, though continual feature size reduction is increasingly challenging, improvements to ICP technology as well as improvements in masking are enabling sub-10nm features to be reached. Nanoscale ICP etching results will be illustrated in a range of materials and technologies. Techniques to facilitate etching (such as the use of cryogenic temperatures) and techniques to improve the mask performance will be described and illustrated.
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| 4. |
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| 5. |
- Roussos, E., et al.
(författare)
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Energetic electron observations of Rhea's magnetospheric interaction
- 2012
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Ingår i: Icarus. - : Elsevier BV. - 0019-1035 .- 1090-2643. ; 221:1, s. 116-134
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Tidskriftsartikel (refereegranskat)abstract
- Saturn's moon Rhea is thought to be a simple plasma absorber, however, energetic particle observations in its vicinity show a variety of unexpected and complex interaction features that do not conform with our current understanding about plasma absorbing interactions. Energetic electron data are especially interesting, as they contain a series of broad and narrow flux depletions on either side of the moon's wake. The association of these dropouts with absorption by dust and boulders orbiting within Rhea's Hill sphere was suggested but subsequently not confirmed, so in this study we review data from all four Cassini flybys of Rhea to date seeking evidence for alternative processes operating within the moon's interaction region. We focus on energetic electron observations, which we put in context with magnetometer, cold plasma density and energetic ion data. All flybys have unique features, but here we only focus on several structures that are consistently observed. The most interesting common feature is that of narrow dropouts in energetic electron fluxes, visible near the wake flanks. These are typically seen together with narrow flux enhancements inside the wake. A phase-space-density analysis for these structures from the first Rhea flyby (R1) shows that Liouville's theorem holds, suggesting that they may be forming due to rapid transport of energetic electrons from the magnetosphere to the wake, through narrow channels. A series of possibilities are considered to explain this transport process. We examined whether complex energetic electron drifts in the interaction region of a plasma absorbing moon (modeled through a hybrid simulation code) may allow such a transport. With the exception of several features (e.g. broadening of the central wake with increasing electron energy), most of the commonly observed interaction signatures in energetic electrons (including the narrow structures) were not reproduced. Additional dynamical processes, not simulated by the hybrid code, should be considered in order to explain the data. For the small scale features, the possibility that a flute (interchange) instability acts on the electrons is discussed. This instability is probably driven by strong gradients in the plasma pressure and the magnetic field magnitude: magnetometer observations show clearly signatures consistent with the (expected) plasma pressure loss due to ion absorption at Rhea. Another potential driver of the instability could have been gradients in the cold plasma density, which are, however, surprisingly absent from most crossings of Rhea's plasma wake. The lack of a density depletion in Rhea's wake suggests the presence of a local cold plasma source region. Hybrid plasma simulations show that this source cannot be the ionized component of Rhea's weak exosphere. It is probably related to accelerated photoelectrons from the moon's negatively charged surface, indicating that surface charging may play a very important role in shaping Rhea's magnetospheric interaction region. (C) 2012 Elsevier Inc. All rights reserved.
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| 6. |
- Baglioni, M., et al.
(författare)
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Nanostructured fluids from degradable nonionic surfactants for the cleaning of works of art from polymer contaminants
- 2014
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Ingår i: Soft Matter. - : Royal Society of Chemistry (RSC). - 1744-6848 .- 1744-683X. ; 10:35, s. 6798-6809
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Tidskriftsartikel (refereegranskat)abstract
- Nanostructured fluids containing anionic surfactants are among the best performing systems for the cleaning of works of art. Though efficient, their application may result in the formation of a precipitate, due to the combination with divalent cations that might leach out from the artifact. We propose here two new aqueous formulations based on nonionic surfactants, which are non-toxic, readily biodegradable and insensitive to the presence of divalent ions. The cleaning properties of water-nonionic surfactant-2-butanone (MEK) were assessed both on model surfaces and on a XIII century fresco that could not be cleaned using conventional methods. Structural information on nanofluids has been gathered by means of small-angle neutron scattering, dynamic light scattering and nuclear magnetic resonance with diffusion monitoring. Beside the above-mentioned advantages, these formulations turned out to be considerably more efficient in the removal of polymer coatings than those based on anionic surfactants. Our results indicate that the cleaning process most likely consists of two steps: initially, the polymer film is swollen by the MEK dissolved in the continuous domain of the nanofluid; in the second stage, surfactant aggregates come into play by promoting the removal of the polymer film with a detergency-like mechanism. The efficiency can be tuned by the composition and nature of amphiphiles and is promoted by working as close as possible to the cloud point of the formulation, where the second step proceeds at maximum rate.
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| 7. |
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| 8. |
- Berglund, Anders, et al.
(författare)
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Social differences in lung cancer management and survival in South East England : a cohort study
- 2012
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 2:3, s. e001048-
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE:To examine possible social variations in lung cancer survival and assess if any such gradients can be attributed to social differences in comorbidity, stage at diagnosis or treatment.DESIGN:Population-based cohort identified in the Thames Cancer Registry.SETTING:South East England.PARTICIPANTS:15 582 lung cancer patients diagnosed between 2006 and 2008.MAIN OUTCOME MEASURES:Stage at diagnosis, surgery, radiotherapy, chemotherapy and survival.RESULTS:The likelihood of being diagnosed as having early-stage disease did not vary by socioeconomic quintiles (p=0.58). In early-stage non-small-cell lung cancer, the likelihood of undergoing surgery was lowest in the most deprived group. There were no socioeconomic differences in the likelihood of receiving radiotherapy in stage III disease, while in advanced disease and in small-cell lung cancer, receipt of chemotherapy differed over socioeconomic quintiles (p<0.01). In early-stage disease and following adjustment for confounders, the HR between the most deprived and the most affluent group was 1.24 (95% CI 0.98 to 1.56). Corresponding estimates in stage III and advanced disease or small-cell lung cancer were 1.16 (95% CI 1.01 to 1.34) and 1.12 (95% CI 1.05 to 1.20), respectively. In early-stage disease, the crude HR between the most deprived and the most affluent group was approximately 1.4 and constant through follow-up, while in patients with advanced disease or small-cell lung cancer, no difference was detectable after 3 months.CONCLUSION:We observed socioeconomic variations in management and survival in patients diagnosed as having lung cancer in South East England between 2006 and 2008, differences which could not fully be explained by social differences in stage at diagnosis, co-morbidity and treatment. The survival observed in the most affluent group should set the target for what is achievable for all lung cancer patients, managed in the same healthcare system.
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| 9. |
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| 10. |
- Born, D. -P, et al.
(författare)
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Hitze, Kälte und Höhenexposition im Fuβball : Adaptive Mechanismen und Verhaltensstrategien in variierenden Umweltbedingungen
- 2014
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Ingår i: Sportverletzung, Sportschaden. - : Georg Thieme Verlag KG. - 0932-0555 .- 1439-1236. ; 28:1, s. 17-23
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Tidskriftsartikel (refereegranskat)abstract
- Football is played worldwide and players often have to cope with hot and cold temperatures as well as high altitude conditions. The upcoming and past world championships in Brazil, Qatar and South Africa illustrate the necessity for behavioural strategies and adaptation to extreme environmental conditions. When playing football in the heat or cold, special clothing, hydration and nutritional and acclimatisation strategies are vital for high-level performance. When playing at high altitude, the reduced oxygen partial pressure impairs endurance performance and alters the technical and tactical requirements. Special high-altitude adaptation and preparation strategies are essential for football teams based at sea-level in order to perform well and compete successfully. Therefore, the aim of the underlying review is: 1) to highlight the difficulties and needs of football teams competing in extreme environmental conditions, 2) to summarise the thermoregulatory, physiological, neuronal and psychological mechanism, and 3) to provide recommendations for coping with extreme environmental conditions in order to perform at a high level when playing football in the heat, cold and at high altitude.
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| 11. |
- Cheng, Arthur J., et al.
(författare)
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Doublet discharge stimulation increases sarcoplasmic reticulum Ca2+ release and improves performance during fatiguing contractions in mouse muscle fibres
- 2013
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Ingår i: Journal of Physiology. - : Wiley. - 0022-3751 .- 1469-7793. ; 591:15, s. 3739-3748
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Tidskriftsartikel (refereegranskat)abstract
- Double discharges (doublets) of motor neurones at the onset of contractions increase both force and rate of force development during voluntary submaximal contractions. The purpose of this study was to examine the role of doublet discharges on force and myoplasmic free [Ca2+] ([Ca2+](i)) during repeated fatiguing contractions, using a stimulation protocol mimicking the in vivo activation pattern during running. Individual intact fibres from the flexor digitorum brevis muscle of mice were stimulated at 33 degrees C to undergo 150 constant-frequency (five pulses at 70 Hz) or doublet (an initial, extra pulse at 200 Hz) contractions at 300 ms intervals. In the unfatigued state, doublet stimulation resulted in a transient (approximate to 10 ms) approximate doubling of [Ca2+](i), which was accompanied by a greater force-time integral (approximate to 70%) and peak force (approximate to 40%) compared to constant frequency contractions. Moreover, doublets markedly increased force-time integral and peak force during the first 25 contractions of the fatiguing stimulation. In later stages of fatigue, addition of doublets increased force production but the increase in force production corresponded to only a minor portion of the fatigue-induced reduction in force. In conclusion, double discharges at the onset of contractions effectively increase force production, especially in early stages of fatigue. This beneficial effect occurs without additional force loss in later stages of fatigue, indicating that the additional energy cost induced by doublet discharges to skeletal muscle is limited.
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| 12. |
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| 13. |
- Dubois, D. M., et al.
(författare)
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Adaptive and rational anticipations in risk management systems and economy
- 2010
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Ingår i: AIP Conference Proceedings. - Liege : American Institute of Physics (AIP). - 9780735408586 ; , s. 398-407
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Konferensbidrag (refereegranskat)abstract
- The global financial crisis of year 2009 is explained as a result of uncoordinated risk management decisions in business firms and economic organisations. The underlying reason for this can be found in the current financial system. As the financial market has lost much of its direct coupling to the concrete economy it provides misleading information to economic decision makers at all levels. Hence, the financial system has moved from a state of moderate and slow cyclical fluctuations into a state of fast and chaotic ones. Those misleading decisions can further be described, but not explained, by help of adaptive and rational expectations from macroeconomic theory. In this context, AE, the Adaptive Expectations are related to weak passive Exo-anticipation, and RE, the Rational expectations can be related to a strong, active and design oriented anticipation. The shortcomings of conventional cures, which builds on a reactive paradigm, have already been demonstrated in economic literature and are here further underlined by help of Ashby's "Law of Requisite Variety", Weaver's distinction between systems of "Disorganized Complexity" and those of "Organized Complexity", and Klir's "Reconstructability Analysis". Anticipatory decision-making is hence here proposed as a replacement to current expectation based and passive risk management. An anticipatory model of the business cycle is presented for supporting that proposition. The model, which is an extension of the Kaldor-Kalecki model, includes both retardation and anticipation. While cybernetics with the feedback process in control system deals with an explicit goal or purpose given to a system, the anticipatory system discussed here deals with a behaviour for which the future state of the system is built by the system itself, without explicit goal. A system with weak anticipation is based on a predictive model of the system, while a system with strong anticipation builds its own future by itself. Numerical simulations on computer confirm the feasibility of this approach. Hence, functional differential equations with both retardation and anticipation are found to be useful tools for modelling financial systems. © 2010 American Institute of Physics.
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| 14. |
- Dubois, D. M., et al.
(författare)
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Anticipatory mechanisms in evolutionary living systems
- 2010
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Ingår i: CASYS'09. - Liege : American Institute of Physics (AIP). - 9780735408586 ; , s. 324-333
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Konferensbidrag (refereegranskat)abstract
- This paper deals firstly with a revisiting of Darwin's theory of Natural Selection. Darwin in his book never uses the word "evolution", but shows a clear position about mutability of species. Darwin's Natural Selection was mainly inspired by the anticipatory Artificial Selection by humans in domestication, and the Malthus struggle for existence. Darwin showed that the struggle for existence leads to the preservation of the most divergent offspring of any one species. He cited several times the canon of "Natura non facit saltum". He spoke about the origin of life from some one primordial form, into which life was first breathed. Finally, Darwin made anticipation about the future researches in psychology. This paper cites the work of Ernst Mayr who was the first, after 90 years of an intense scientific debate, to present a new and stable Darwinian paradigm as the "Evolutionary Synthesis" in 1942. To explain what is life, the Living Systems Theory (LST) by J. G. Miller is presented. It is showed that the Autopoietic Systems Theory of Varela et al is also a fundamental component of living systems. In agreement with Darwin, the natural selection is a necessary condition for transformation of biological systems, but is not a sufficient condition. Thus, in this paper we conjecture that an anticipatory evolutionary mechanism exists with the genetic code that is a self-replicating and self-modifying anticipatory program. As demonstrated by Nobel laureate McClintock, evolution in genomes is programmed. The word "program" comes from "pro-gram" meaning to write before, by anticipation, and means a plan for the programming of a mechanism, or a sequence of coded instructions that can be inserted into a mechanism, or a sequence of coded instructions, as genes of behavioural responses, that is part of an organism. For example, cell death may be programmed by what is called the apoptosis. This definitively is a great breakthrough in our understanding of biological evolution. Hence, it is possible to formulate a new principle of evolution, i.e. the principle of Double Anticipatory Loop (DAL) of evolution: Biological evolution is driven by interaction between a mindless environment that is passively selecting the fittest inhabitants and purposeful anticipatory living systems, which are actively selecting and creating their own environment. Evolution on the genome level is trigged by environmental stress but guided by an inherent program. © 2010 American Institute of Physics.
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| 15. |
- Engberg, Anna E., et al.
(författare)
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Blood protein-polymer adsorption : Implications for understanding complement-mediated hemoincompatibility
- 2011
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Ingår i: Journal of Biomedical Materials Research - Part A. - : Wiley. - 1549-3296. ; 97A:1, s. 74-84
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to create polymeric materials with known properties to study the preconditions for complement activation. Initially, 22 polymers were screened for complement activating capacity. Based on these results, six polymers (P1-P6) were characterized regarding physico-chemical parameters, for example, composition, surface area, pore size, and protein adsorption from human EDTA-plasma. P2, P4, and reference particles of polystyrene and polyvinyl chloride, were hydrophobic, bound low levels of protein and were poor complement activators. Their accessible surface was limited to protein adsorption in that they had pore diameters smaller than most plasma proteins. P1 and P3 were negatively charged and adsorbed IgG and C1q. A 10-fold difference in complement activation was attributed to the fact that P3 but not P1 bound high amounts of C1-inhibitor. The hydrophobic P5 and P6 were low complement activators. They selectively bound apolipoproteins AI and AIV (and vitronectin), which probably limited the binding of complement activators to the surface. We demonstrate the usefulness of the modus operandi to use a high-throughput procedure to synthesize a great number of novel substances, assay their physico-chemical properties with the aim to study the relationship between the initial protein coat on a surface and subsequent biological events. Data obtained from the six polymers characterized here, suggest that a complement-resistant surface should be hydrophobic, uncharged, and have a small available surface, accomplished by nanostructured topography. Additional attenuation of complement can be achieved by selective enrichment of inert proteins and inhibitors.
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| 16. |
- Gamier, P., et al.
(författare)
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Deriving the characteristics of warm electrons (100-500 eV) in the magnetosphere of Saturn with the Cassini Langmuir probe
- 2014
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Ingår i: Planetary and Space Science. - : Elsevier BV. - 0032-0633 .- 1873-5088. ; 104, s. 173-184
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Tidskriftsartikel (refereegranskat)abstract
- Though Langmuir probes (LP) are designed to investigate cold plasma regions (e.g. ionospheres), a recent analysis revealed a strong sensitivity of the Cassini LP measurements to hundreds of eV electrons. These warm electrons impact the surface of the probe and generate a significant current of secondary electrons, that impacts both the DC level and the slope of the current-voltage curve of the LP (for negative potentials) through energetic contributions that may be modeled with a reasonable precision. We show here how to derive information about the incident warm electrons from the analysis of these energetic contributions, in the regions where the cold plasma component is small with an average temperature in the range similar to [100-500] eV. First, modeling the energetic contributions (based on the incident electron flux given by a single anode of the CAPS spectrometer) allows us to provide information about the pitch angle anisotropies of the incident hundreds of eV electrons. The modeling reveals indeed sometimes a large variability of the estimated maximum secondary electron yield (which is a constant for a surface material) needed to reproduce the observations. Such dispersions give evidence for strong pitch angle anisotropies of the incident electrons, and using a functional form of the pitch angle distribution even allows us to derive the real peak angle of the distribution. Second, rough estimates of the total electron temperature may be derived in the regions where the warm electrons are dominant and thus strongly influence the LP observations, i.e. when the average electron temperature is in the range similar to [100-500] eV. These regions may be identified from the LP observations through large positive values of the current-voltage slope at negative potentials. The estimated temperature may then be used to derive the electron density in the same region, with estimated densities between similar to 0.1 and a few particles/cm(3) (cc). The derived densities are in better agreement with the CAPS measurements than the values derived from the proxy technique (Morooka et al., 2009) based on the floating potential of the LP. Both the electron temperature and the density estimates lie outside the classical capabilities of the LP, which are essentially n(e) > 5 cc and T-e <5 eV at Saturn. This approximate derivation technique may be used in the regions where the cold plasma component is small with an average temperature in the range similar to [100-500] eV, which occurs often in the L range 6.4-9.4 R-S when Cassini is off the equator, but may occur anywhere in the magnetosphere. This technique may be all the more interesting since the CAPS instrument was shut down, and, though it cannot replace the CAPS instrument, the technique can provide useful information about the electron moments, with probably even better estimates than CAPS in some cases (when the plasma is strongly anisotropic). Finally, a simple modeling approach allows us to predict the impact of the energetic contributions on LP measurements in any plasma environment whose characteristics (density, temperature, etc.) are known. LP observations may thus be influenced by warm electrons in several planetary plasma regions in the solar system, and ambient magnetospheric electron density and temperature could be estimated in some of them (e.g. around several galilean satellites) through the use of Langmuir probes.
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| 17. |
- Garnier, P., et al.
(författare)
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Mapping 300 eV electrons at Saturn with the Cassini RPWS Langmuir probe
- 2011
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Ingår i: EPSC-DPS Joint Meeting 2011.
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Konferensbidrag (refereegranskat)abstract
- The Cassini Langmuir probe (onboard RPWS experiment) has provided wealth of information about the kronian cold plasma environment since the Saturn Orbit Insertion in 2004. The usage of the Langmuir probe is based on the fitting of the currentvoltage curve which brings information on several plasma parameters in cold and dense plasma regions. The ion part of the I-V curve may however be influenced by energetic particles hitting the probe, leading to an enhanced ion current measured. We report here the influence of 300 eV electrons on the probe current, with a current belt observed between Dione and Rhea.
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| 18. |
- Garnier, P., et al.
(författare)
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The detection of energetic electrons with the Cassini Langmuir probe at Saturn
- 2012
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 117, s. A10202-
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Tidskriftsartikel (refereegranskat)abstract
- The Cassini Langmuir probe, part of the Radio and Plasma Wave Science (RPWS) instrument, has provided a wealth of information about the cold and dense plasma in the Saturnian system. The analysis of the ion side current (current for negative potentials) measured by the probe from 2005 to 2008 reveals also a strong sensitivity to energetic electrons (250-450 eV). These electrons impact the surface of the probe, and generate a detectable current of secondary electrons. A broad secondary electrons current region is inferred from the observations in the dipole L Shell range of similar to 6-10, with a peak full width at half maximum (FWHM) at L = 6.4-9.4 (near the Dione and Rhea magnetic dipole L Shell values). This magnetospheric flux tube region, which displays a large day/night asymmetry, is related to the similar structure in the energetic electron fluxes as the one measured by the onboard Electron Spectrometer (ELS) of the Cassini Plasma Spectrometer (CAPS). It corresponds spatially to both the outer electron radiation belt observed by the Magnetosphere Imaging Instrument (MIMI) at high energies and to the low-energy peak which has been observed since the Voyager era. Finally, a case study suggests that the mapping of the current measured by the Langmuir probe for negative potentials can allow to identify the plasmapause-like boundary recently identified at Saturn, and thus potentially identify the separation between the closed and open magnetic field lines regions.
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| 19. |
- Garnier, Philippe, et al.
(författare)
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The influence of the secondary electrons induced by energetic electrons impacting the Cassini Langmuir probe at Saturn
- 2013
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Ingår i: Journal of geophysical research Space Physics. - 2169-9402. ; 118:11, s. 7054-7073
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Tidskriftsartikel (refereegranskat)abstract
- The Cassini Langmuir Probe (LP) onboard the Radio and Plasma Wave Science experiment has provided much information about the Saturnian cold plasma environment since the Saturn Orbit Insertion in 2004. A recent analysis revealed that the LP is also sensitive to the energetic electrons (250–450 eV) for negative potentials. These electrons impact the surface of the probe and generate a current of secondary electrons, inducing an energetic contribution to the DC level of the current-voltage (I-V) curve measured by the LP. In this paper, we further investigated this influence of the energetic electrons and (1) showed how the secondary electrons impact not only the DC level but also the slope of the (I-V) curve with unexpected positive values of the slope, (2) explained how the slope of the (I-V) curve can be used to identify where the influence of the energetic electrons is strong, (3) showed that this influence may be interpreted in terms of the critical and anticritical temperatures concept detailed by Lai and Tautz (2008), thus providing the first observational evidence for the existence of the anticritical temperature, (4) derived estimations of the maximum secondary yield value for the LP surface without using laboratory measurements, and (5) showed how to model the energetic contributions to the DC level and slope of the (I-V) curve via several methods (empirically and theoretically). This work will allow, for the whole Cassini mission, to clean the measurements influenced by such electrons. Furthermore, the understanding of this influence may be used for other missions using Langmuir probes, such as the future missions Jupiter Icy Moons Explorer at Jupiter, BepiColombo at Mercury, Rosetta at the comet Churyumov-Gerasimenko, and even the probes onboard spacecrafts in the Earth magnetosphere.
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| 20. |
- Hamadani, Mehdi, et al.
(författare)
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Early Failure of Frontline Rituximab-Containing Chemo-immunotherapy in Diffuse Large B Cell Lymphoma Does Not Predict Futility of Autologous Hematopoietic Cell Transplantation
- 2014
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Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 20:11, s. 1729-1736
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Tidskriftsartikel (refereegranskat)abstract
- The poor prognosis for patients with diffuse large B cell lymphoma (DLBCL) who relapse within 1 year of initial diagnosis after first-line rituximab-based chemo-immunotherapy has created controversy about the role of autologous transplantation (HCT) in this setting. We compared autologous HCT outcomes for chemosensitive DLBCL patients between 2000 and 2011 in 2 cohorts based on time to relapse from diagnosis. The early rituximab failure (ERF) cohort consisted of patients with primary refractory disease or those with first relapse within 1 year of initial diagnosis. The ERF cohort was compared with those relapsing >1 year after initial diagnosis (late rituximab failure [LRF] cohort). ERF and LRF cohorts included 300 and 216 patients, respectively. Nonrelapse mortality (NRM), progression/relapse, progression-free survival (PFS), and overall survival (OS) of ERF versus LRF cohorts at 3 years were 9% (95% confidence interval [CI], 6% to 13%) versus 9% (95% CI, 5% to 13%), 47% (95% CI, 41% to 52%) versus 39% (95% CI, 33% to 46%), 44% (95% CI, 38% to 50%) versus 52% (95% CI, 45% to 59%), and 50% (95% CI, 44% to 56%) versus 67% (95% CI, 60% to 74%), respectively. On multivariate analysis, ERF was not associated with higher NRM (relative risk [RR], 1.31; P = .34). The ERF cohort had a higher risk of treatment failure (progression/relapse or death) (RR, 2.08; P < .001) and overall mortality (RR, 3.75; P < .001) within the first 9 months after autologous HCT. Beyond this period, PFS and OS were not significantly different between the ERF and LRF cohorts. Autologous HCT provides durable disease control to a sizeable subset of DLBCL despite ERF (3-year PFS, 44%) and remains the standard-of-care in chemosensitive DLBCL regardless of the timing of disease relapse.
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| 21. |
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| 22. |
- Holmberg, Anna, 1974, et al.
(författare)
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Does waterborne citalopram affect the aggressive and sexual behaviour of rainbow trout and guppy?
- 2011
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Ingår i: Journal of hazardous materials. - : Elsevier BV. - 1873-3336 .- 0304-3894. ; 187:1-3, s. 596-9
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Tidskriftsartikel (refereegranskat)abstract
- Citalopram is one of several selective serotonin reuptake inhibitors (SSRIs) commonly found in treated sewage effluents. Accordingly, there are concerns about possible adverse effects of SSRIs on aquatic organisms, particularly behavioural effects similar to those associated with SSRI use in humans. Rainbow trout fry and adult male guppies were therefore exposed to waterborne citalopram, ranging from environmentally relevant to high concentrations (1, 10, 100 μg/L) for 3-7 days. Under these experimental conditions citalopram does not appear to cause significant effects on aggression in rainbow trout fry or on sexual behaviour in male guppies. This may be explained by a relatively low uptake of citalopram from water to fish.
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| 23. |
- Holmberg, Lars, et al.
(författare)
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A comparison of prostate cancer survival in England, Norway and Sweden : A population-based study
- 2012
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Ingår i: Cancer Epidemiology. - : Elsevier BV. - 1877-7821 .- 1877-783X. ; 36:1, s. e7-e12
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Tidskriftsartikel (refereegranskat)abstract
- Purpose The objective of the study was to compare patterns of survival 2001-2004 in prostate cancer patients from England, Norway and Sweden in relation to age and period of follow-up. Subjects and methods Excess mortality in men with prostate cancer was estimated using nation-wide cancer register data using a period approach for relative survival. 179,112 men in England, 23,192 in Norway and 59,697 in Sweden were included. Results In all age groups, England had the lowest survival, particularly so among men aged 80+. Overall age-standardised five-year survival was 76.4%, 80.3% and 83.0% for England, Norway and Sweden, respectively. The majority of the excess deaths in England were confined to the first year of follow-up. Conclusion The results indicate that a small but important group of older patients present at a late stage and succumb early to their cancers, possibly in combination with severe comorbidity, and this situation is more common in England than in Norway or Sweden.
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| 24. |
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| 25. |
- Morooka, Michiko W., et al.
(författare)
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Dusty plasma in the vicinity of Enceladus
- 2011
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Ingår i: Journal of Geophysical Research. - : American Geophysical Union (AGU). - 0148-0227 .- 2156-2202. ; 116
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Tidskriftsartikel (refereegranskat)abstract
- We present in situ Cassini Radio Plasma Wave Science observations in the vicinity of Enceladus and in the E ring of Saturn that indicate the presence of dusty plasma. The four flybys of Enceladus in 2008 revealed the following cold plasma characteristics: (1) there is a large plasma density (both ions and electrons) within the Enceladus plume region, (2) no plasma wake effect behind Enceladus was detected, (3) electron densities are generally much lower than the ion densities in the E ring (n(e)/n(i) < 0.5) as well as in the plume (n(e)/n(i) < 0.01), and (4) the average bulk ion drift speed is significantly less than the corotation speed and is instead close to the Keplerian speed. These signatures result from half or more of the electrons being attached to dust grains and by the interaction between the surrounding cold plasma and the predominantly negatively charged submicrometer-sized dust grains. The dust and plasma properties estimated from the observations clearly show that the dust-plasma interaction is collective. This strong dust-plasma coupling appears not only in the Enceladus plume but also in the Enceladus torus, typically from about 20 R(E) (similar to 5000 km) north and about 60 R(E) (similar to 15,000 km) south of Enceladus. We also suggest that the dust-plasma interaction in the E ring is the cause of the planetary spin-modulated dynamics of Saturn's magnetosphere at large.
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| 26. |
- Møller, H, et al.
(författare)
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Completeness of case ascertainment and survival time error in English cancer registries : impact on 1-year survival estimates
- 2011
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 105:1, s. 170-176
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: It has been suggested that cancer registries in England are too dependent on processing of information from death certificates, and consequently that cancer survival statistics reported for England are systematically biased and too low. METHODS: We have linked routine cancer registration records for colorectal, lung, and breast cancer patients with information from the Hospital Episode Statistics (HES) database for the period 2001-2007. Based on record linkage with the HES database, records missing in the cancer register were identified, and dates of diagnosis were revised. The effects of those revisions on the estimated survival time and proportion of patients surviving for 1 year or more were studied. Cases that were absent in the cancer register and present in the HES data with a relevant diagnosis code and a relevant surgery code were used to estimate (a) the completeness of the cancer register. Differences in survival times calculated from the two data sources were used to estimate (b) the possible extent of error in the recorded survival time in the cancer register. Finally, we combined (a) and (b) to estimate (c) the resulting differences in 1-year cumulative survival estimates. RESULTS: Completeness of case ascertainment in English cancer registries is high, around 98-99%. Using HES data added 1.9%, 0.4% and 2.0% to the number of colorectal, lung, and breast cancer registrations, respectively. Around 5-6% of rapidly fatal cancer registrations had survival time extended by more than a month, and almost 3% of rapidly fatal breast cancer records were extended by more than a year. The resulting impact on estimates of 1-year survival was small, amounting to 1.0, 0.8, and 0.4 percentage points for colorectal, lung, and breast cancer, respectively. INTERPRETATION: English cancer registration data cannot be dismissed as unfit for the purpose of cancer survival analysis. However, investigators should retain a critical attitude to data quality and sources of error in international cancer survival studies.
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| 27. |
- Nielsen, J., et al.
(författare)
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Human skeletal muscle glycogen utilization in exhaustive exercise : Role of subcellular localization and fibre type
- 2011
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Ingår i: Journal of Physiology. - : Wiley. - 0022-3751 .- 1469-7793. ; 589:11, s. 2871-2885
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Tidskriftsartikel (refereegranskat)abstract
- Although glycogen is known to be heterogeneously distributed within skeletal muscle cells, there is presently little information available about the role of fibre types, utilization and resynthesis during and after exercise with respect to glycogen localization. Here, we tested the hypothesis that utilization of glycogen with different subcellular localizations during exhaustive arm and leg exercise differs and examined the influence of fibre type and carbohydrate availability on its subsequent resynthesis. When 10 elite endurance athletes (22 ± 1 years, = 68 ± 5 ml kg-1 min-1, mean ± SD) performed one hour of exhaustive arm and leg exercise, transmission electron microscopy revealed more pronounced depletion of intramyofibrillar than of intermyofibrillar and subsarcolemmal glycogen. This phenomenon was the same for type I and II fibres, although at rest prior to exercise, the former contained more intramyofibrillar and subsarcolemmal glycogen than the latter. In highly glycogen-depleted fibres, the remaining small intermyofibrillar and subsarcolemmal glycogen particles were often found to cluster in groupings. In the recovery period, when the athletes received either a carbohydrate-rich meal or only water the impaired resynthesis of glycogen with water alone was associated primarily with intramyofibrillar glycogen. In conclusion, after prolonged high-intensity exercise the depletion of glycogen is dependent on subcellular localization. In addition, the localization of glycogen appears to be influenced by fibre type prior to exercise, as well as carbohydrate availability during the subsequent period of recovery. These findings provide insight into the significance of fibre type-specific compartmentalization of glycogen metabolism in skeletal muscle during exercise and subsequent recovery. © 2011 The Authors. Journal compilation © 2011 The Physiological Society.
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| 28. |
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| 29. |
- Paridaens, Robert J, et al.
(författare)
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Adjuvant! Online estimation of chemotherapy effectiveness when added to ovarian function suppression plus tamoxifen for premenopausal women with estrogen-receptor-positive breast cancer
- 2010
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Ingår i: Breast cancer research and treatment. - : Springer Science and Business Media LLC. - 1573-7217 .- 0167-6806. ; 123:1, s. 303-310
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Tidskriftsartikel (refereegranskat)abstract
- Adjuvant! Online (Adjuvant!) is a user-friendly, web-based tool that provides estimates of adjuvant therapy outcomes for individual patients. While reliable evidence underpins estimates for most patient cohorts, there is a paucity of data on the effect of adding chemotherapy to complete estrogen blockade for premenopausal women with estrogen-receptor positive breast cancer. International Breast Cancer Study Group (IBCSG) Trial 11-93 enrolled 174 premenopausal women with estrogen-receptor positive, node-positive breast cancer. Among these patients, 55% had one positive axillary lymph node and 97% had three or fewer positive nodes. Patients were randomized to receive ovarian function suppression plus 5 years of tamoxifen with or without anthracycline-based chemotherapy. Estimated hazard rates and corresponding 10-year relapse-free survival percentages obtained from Trial 11-93 data were compared with those predicted using Adjuvant!. The 10-year relapse-free survival percentages predicted from Adjuvant! were 64.4% (95% CI, 61.9-67.2%) for endocrine therapy alone and 74.9% (95% CI, 73.1-76.8%) for chemoendocrine therapy. By contrast, these estimates in Trial 11-93 were 76.4% (95% CI, 65.8-84.0%) for endocrine therapy alone and 74.9% (95% CI, 64.5-82.7%) for chemoendocrine therapy. The Adjuvant! estimate for the endocrine-alone control group is lower than that observed in Trial 11-93 (P = 0.03), while the estimates for the two chemoendocrine therapy groups are similar. Adjuvant! appears to underestimate the effectiveness of adjuvant endocrine therapy alone for premenopausal women with endocrine responsive breast cancer, thus overestimating the added benefit, if any, from chemotherapy for this patient population.
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| 30. |
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| 31. |
- Sakai, S., et al.
(författare)
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Dust-plasma interaction through magnetosphere-ionosphere coupling in Saturn’s plasma disk
- 2012
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Ingår i: European Planetary Science Congress 2012, held 23-28 September, 2012 in Madrid, Spain. http://meetings.copernicus.org/epsc2012, id. EPSC2012-433.
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Konferensbidrag (refereegranskat)abstract
- The ion bulk speeds in the equatorial region of Saturn’s inner magnetosphere, according to data from the Langmuir Probe (LP) on board the Cassini spacecraft, are about 60% of the ideal co-rotation speed. These findings suggest that sub-micrometer negatively charged E ring dust contributes to the plasma dynamics in the plasma disk. We calculated the ion speeds by using multicomponent MHD equations, taking into account dust interactions to investigate the effects of ion-dust coulomb collision, mass loading, as well as taking into account magnetosphere-ionosphere coupling to investigate the effect of the magnetospheric electric field. The results show that the ion speeds can be significantly reduced by the electric fields generated by the ion-dust collisions when the dust density is high and the thickness of dust distribution is large. We also show that the ion speeds from our model are consistent with the LP observations when the maximum density of dust is larger than ~10\^5 m\^-3.
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| 32. |
- Sakai, S., et al.
(författare)
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Dust-plasma interaction through magnetosphere-ionosphere coupling in Saturn's plasma disk
- 2013
-
Ingår i: Planetary and Space Science. - : Elsevier BV. - 0032-0633 .- 1873-5088. ; 75:1, s. 11-16
-
Forskningsöversikt (refereegranskat)abstract
- The ion bulk speeds in the equatorial region of Saturn's inner magnetosphere, according to data from the Langmuir Probe (LP) on board the Cassini spacecraft, are about 60% of the ideal co-rotation speed; the ion speeds are between the co-rotation and Keplerian speeds (Holmberg et al.; Ion densities and velocities in the inner plasma torus of Saturn, Planetary and Space Science). These findings suggest that sub-micrometer negatively charged E ring dust contributes to the plasma dynamics in the plasma disk. We calculated the ion speeds by using a multi-species fluid model, taking into account dust interactions to investigate the effects of ion-dust coulomb collision, mass loading, as well as taking into account magnetosphere-ionosphere coupling to investigate the effect of the magnetospheric electric field. The results show that the ion speeds can be significantly reduced by the electric fields generated by the collisions between ions and dusts when the dust density is high and the thickness of dust distribution is large. We also show that the ion speeds from our model are consistent with the LP observations when the maximum density of dust is larger than ∼105 m-3.
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| 33. |
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| 34. |
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| 35. |
- Sperlich, B., et al.
(författare)
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Does upper-body compression improve 3 × 3-min double-poling sprint performance?
- 2014
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Ingår i: International Journal of Sports Physiology and Performance. - 1555-0265 .- 1555-0273. ; 9:1, s. 48-57
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To evaluate whether upper-body compression affects power output and selected metabolic, cardiorespiratory, hemodynamic, and perceptual responses during three 3-min sessions of double-poling (DP) sprint. Method: Ten well-trained male athletes (25 ± 4 y, 180 ± 4 cm, 74.6 ± 3.2 kg) performed such sprints on a DP ski ergometer with and without a long-sleeved compression garment. Result: Mean power output was not affected by such compression (216 ± 25 W in both cases; P = 1.00, effect size [ES] = 0.00), although blood lactate concentration was lowered (P < .05, ES = 0.50-1.02). Blood gases (ES = 0.07-0.50), oxygen uptake (ES = 0.04-0.28), production of carbon dioxide (ES = 0.01-0.46), heart rate (ES = 0.00-0.21), stroke volume (ES = 0.33-0.81), and cardiac output (ES = 0.20-0.91) were also all unaffected by upper-body compression (best P = 1.00). This was also the case for changes in the tissue saturation index (ES = 0.45-1.17) and total blood content of hemoglobin (ES = 0.09-0.85), as well as ratings of perceived exertion (ES = 0.15-0.88; best P = .96). Conclusion: The authors conclude that the performance of well-trained athletes during 3 × 3-min DP sprints will not be enhanced by upper-body compression. © 2014 Human Kinetics, Inc.
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| 36. |
- Uttervall, K., et al.
(författare)
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The Use of Novel Drugs Can Effectively Improve Response, Delay Relapse and Enhance Overall Survival in Multiple Myeloma Patients with Renal Impairment
- 2014
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 9:7
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Tidskriftsartikel (refereegranskat)abstract
- Background: Renal impairment is a common feature in multiple myeloma and is considered a poor prognostic factor. Aim: To determine the impact of novel drugs (i.e. bortezomib, lenalidomide and thalidomide) in the treatment of myeloma patients with renal impairment. The primary endpoint was overall survival and secondary endpoints were time to next treatment and response. Methods: The study population included all patients diagnosed with treatment-demanding multiple myeloma January 2000 to June 2011 at 15 Swedish hospitals. Renal impairment was defined as an estimated glomerular filtration rate under 60 mL/min/1.73 m(2). Result: The study population consisted of 1538 patients, of which 680 had renal impairment at diagnosis. The median overall survival in patients with renal impairment was 33 months, which was significantly shorter than 52 months in patients with normal renal function (P<0.001). Novel agents in first line improved overall survival (median 60 months) in non-high-dose treated patients with renal impairment (n = 143) as compared to those treated with conventional cytotoxic drugs (n = 411) (median 27 months) (P<0.001). In the multivariate analysis up front treatment with bortezomib was an independent factor for better overall survival in non-high-dose treated renally impaired patients. High-dose treated renally impaired patients had significantly better median overall survival than non-high-dose ones (74 versus 26 months) and novel drugs did not significantly improve survival further in these patients. Patients with renal impairment had both a shorter median time to next treatment and a lower response rate than those with normal renal function. However, novel drugs and high dose treatment lead to a significantly longer time to next treatment and the use of novel agents significantly improved the response rate of these patients. Conclusion: High dose treatment and novel drugs, especially bortezomib, can effectively overcome the negative impact of renal impairment in patients with multiple myeloma.
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| 37. |
- Örtenblad, Niels, et al.
(författare)
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Repeated sprint exercise impairs contractile force of isolated single human muscle fibers
- 2013
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Ingår i: Proceedings for the 6<sup>th</sup> International Congress on Science and Skiing. - 9783200034174 ; , s. 93-
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Konferensbidrag (refereegranskat)abstract
- INTRODUCTION: The purpose of the present study was, to examine the effects of repeated sprint skiing on the contractile apparatus of single muscle fibres obtained from a group of elite skiers. We have recently demonstrated that prolonged cycling exercise impairs the contractile apparatus of single muscle fibres, and that this can be restored following recovery. However, little is known about the effect of repeated high intensity exercise on single fibre properties, as i.e. during cross-country (cc) sprint competitions. We hypothesize that repeated high intensity exercise in highly trained subjects will impair the contractile apparatus maximum force output.METHOD: Eleven elite male sprint talented cc skiers (age 24 ± 4 years; VO2max 5.1 ± 0.5 (diagonal skiing, DIA), 4.9 ± 0.5 (double pooling, DP) L·min-1)) volunteered for the study. The skiers performed a simulated intermittent classic sprint roller skiing competition on a treadmill. The sprint exercise included 4 times1300m, with 45 min recovery between sprints. Each sprint consisted of 3 DP sections (1° uphill) and 2 DIA sections (7° uphill). Muscle biopsies were obtained in arm muscle (m. biceps brachii) before and after the sprint exercises. Muscle fibre bundles were cooled and skinned in a glycerinating solution and stored until analyzed. Single muscle fibre segments (n=232) were isolated and attached to a sensitive force recording transducer, and activated by Ca2+ buffered solutions at pH 7.1 to measure mechanically properties (maximum force Po and Po/cross sectional area (CSA)) and fibre typed by the Sr2+ sensitivity (Hvid et al. 2013).RESULTS: Average sprint time was 3min 49s ± 9s, with no difference between sprints. A total of 232 fibres were analysed (150 type I and 82 type II fibres). Type II fibres had a sign. (P<0.05) higher CSA (8103 ± 2334 µm2 (type I) and 8852 ± 2288 µm2 (type II) and Po (0.82 ± 0.43 and 1.24 ± 0.50 mN) than type I fibres. Also type II fibres had a 31% higher Po/CSA (108 ± 55 vs 142 ± 45 kN/m2). Following the intermittent sprint exercise, type II fibres exhibited a sign. (P = 0.01) 20% decrease in Po, with no difference in type I fibres. To test if the decrease in the single fibre Po were associated with oxidative stress we tested if this could be reversed with a strong reducing agent (dithiothreitol, DTT). DTT did not alter Po at pre nor the decrease in type II fibres following sprint exercise.DISCUSSION: By using a translational approach from whole body exercise to single fibre measurements, we here we demonstrate that type II fibres from highly trained cross country skiers, has a 20% decrease in Po following repeated sprint. Thus, part of the experienced fatigue following sprint competitions is due to impairments at the level of the contractile apparatus. Further, we did not find any evidence for oxidative stress as a causative component in the observed decrease in Po.CONCLUSION: Here we demonstrate for the first time, in highly trained sprint skiers, that repeated sprint impairs single fibre maximum force at the level of the contractile apparatus, which may have a significant impact on muscle function and fatigue.REFERENCES: Gejl K, Hvid LG, Ulrik Frandsen U, Jensen K, Sahlin K and Ørtenblad N. Muscle glycogen content modifies SR Ca2+ release rate in elite endurance athletes. Med. Sci. Sports Ex. (2013).
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