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Träfflista för sökning "WFRF:(Holmen A.) srt2:(1996-1999)"

Sökning: WFRF:(Holmen A.) > (1996-1999)

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  • Andreasson, Joakim, 1973, et al. (författare)
  • The photophysical properties of the adenine chromophore
  • 1999
  • Ingår i: Journal of Physical Chemistry B. ; 103:44, s. 9782-9789
  • Tidskriftsartikel (refereegranskat)abstract
    • The efficient nonradiative deactivation process of the excited adenine chromophore is studied in this paper. By comparing the photophysical properties and temperature dependence of several alkylated adenine derivatives, a mechanism for the thermally activated internal conversion process is suggested, Several alkylamino derivatives of adenine show dual fluorescence, and the solvent dependence of the excited states is investigated. It is concluded that the long wavelength emission originates from a CT state involving the alkylamino group and purine chromophore as donor and acceptor, respectively. The experimental observations are supported by quantum mechanical calculations, and the results are summarized into a model for the photophysical properties of the adenine chromophore. In this model, the two excited states associated with the dual emission from the alkylamino derivatives are populated from a common Franck-Condon state followed by independent decay to the ground state.
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  • Son, G.S., et al. (författare)
  • Binding Mode of Norfloxacin to Calf Thymus DNA
  • 1998
  • Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 1520-5126 .- 0002-7863. ; 120:26, s. 6451-6457
  • Tidskriftsartikel (refereegranskat)abstract
    • Norfloxacin, a quinolone antibacterial reagent, has been studied with respect to its binding to calf thymus DNA using fluorescence and linear dichroism techniques and unwinding of supercoiled DNA. The fluorescence of norfloxacin is strongly quenched in the presence of DNA and using this decrease in a fluorescence titration the equilibrium constant of the complex formation was established to be 2.8 x 10(3) M-1. The electric transition moments of the norfloxacin chromophore have been analyzed using fluorescence anisotropy, magnetic circular dichroism, and linear dichroism in stretched poly(vinyl alcohol) film and INDO/S calculations. These data are then used to interpret flow linear dichroism results for the norfloxacin-DNA complex. The transition moments for the long-wavelength transitions are found to be oriented at about 65.0-85.0 degrees with respect to the DNA helix axis. A near perpendicular orientation of the norfloxacin chromophore plane makes it possible to exclude classical groove or surface binding modes. The possibility of a classical intercalation binding mode also can be ruled out from unwinding experiments. However, it is shown that the molecular plane of norfloxacin is near perpendicular relative to the DNA helix axis with a possibility of a bending of the DNA helix at the binding site.
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  • Resultat 1-9 av 9

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