| 1. |
- Asplund, Monika Stenkvist, et al.
(författare)
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Chemotherapy in severe nasal polyposis - a possible beneficial effect? : A report of three cases
- 2010
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Ingår i: Rhinology. - 0300-0729 .- 1996-8604. ; 48:3, s. 374-376
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Tidskriftsartikel (refereegranskat)abstract
- Background: Nasal polyposis is an inflammatory process of the nasal mucosa. Treatment has changed from surgery to an anti-inflammatory approach, but neither of these treatments addresses the underlying cause. Topical steroids and occasional use of systemic steroids in patients with nasal polyposis can frequently control the polypoid disease. In a few cases, when the disease is more aggressive, the repeated application of systemic steroids together with sinus surgery is required. Material and Methods: We present our experience with one case of rheumatoid arthritis and two cases with malignant diseases, all of which were treated with chemotherapy and were also accompanied by severe nasal polyposis. All of our patients had eosinophilic polypoid disease. Various chemotherapeutic treatment schemes were utilized. Results: During chemotherapy all three patients were markedly improved symptomatically including olfaction along with a significant reduction in their nasal polyposis. Duration of remission lasted for a few months in two cases and for three years, in a third case. Conclusion: This is the first report describing the successful treatment of severe nasal polyposis with chemotherapy. Based on this experience, we suggest a phase II trial with chemotherapy, preferably "low dose" methotrexate, in patients with severe nasal polyposis.
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| 2. |
- Austeng, Dordi, et al.
(författare)
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Incidence of and risk factors for neonatal morbidity after active perinatal care : extremely preterm infants study in Sweden (EXPRESS)
- 2010
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 99:7, s. 978-992
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Tidskriftsartikel (refereegranskat)abstract
- Aims: The aim of this study was to determine the incidence of neonatal morbidity in extremely preterm infants and to identify associated risk factors. Methods: Population based study of infants born before 27 gestational weeks and admitted for neonatal intensive care in Sweden during 2004-2007. Results: Of 638 admitted infants, 141 died. Among these, life support was withdrawn in 55 infants because of anticipation of poor long-term outcome. Of 497 surviving infants, 10% developed severe intraventricular haemorrhage (IVH), 5.7% cystic periventricular leucomalacia (cPVL), 41% septicaemia and 5.8% necrotizing enterocolitis (NEC); 61% had patent ductus arteriosus (PDA) and 34% developed retinopathy of prematurity (ROP) stage >= 3. Eighty-five per cent needed mechanical ventilation and 25% developed severe bronchopulmonary dysplasia (BPD). Forty-seven per cent survived to one year of age without any severe IVH, cPVL, severe ROP, severe BPD or NEC. Tocolysis increased and prolonged mechanical ventilation decreased the chances of survival without these morbidities. Maternal smoking and higher gestational duration were associated with lower risk of severe ROP, whereas PDA and poor growth increased this risk. Conclusion: Half of the infants surviving extremely preterm birth suffered from severe neonatal morbidities. Studies on how to reduce these morbidities and on the long-term health of survivors are warranted.
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| 3. |
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| 4. |
- Davidsson, Åke, 1956-, et al.
(författare)
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Näspolyper och den täppta näsan
- 2014
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Ingår i: Fagbladet Allergi i praksis. - Oslo, Norway : Norges Astma- og Allergiforbund. - 0806-5462. ; :2, s. 16-20
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Tidskriftsartikel (refereegranskat)
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| 5. |
- Ekenbäck, Andreas, et al.
(författare)
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Energetic neutral atoms around HD 209458b : estimations of magnetospheric properties
- 2010
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Ingår i: Astrophysical Journal. - Bristol : Institute of Physics (IOP). - 0004-637X .- 1538-4357. ; 709:2, s. 670-679
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Tidskriftsartikel (refereegranskat)abstract
- HD 209458b is an exoplanet found to transit the disk of its parent star. Observations have shown a broad absorption signature about the Ly alpha stellar line during transit, suggesting the presence of a thick cloud of atomic hydrogen around the "hot Jupiter" HD 209458b. This work expands on an earlier work studying the production of energetic neutral atoms (ENAs) as a result of the interaction between the stellar wind and the exosphere. We present an improved flow model of HD 209458b and use stellar wind values similar to those in our solar system. We find that the ENA production is high enough to explain the observations, and we show that-using expected values for the stellar wind and exosphere-the spatial and velocity distributions of ENAs would give absorption in good agreement with the observations. We also study how the production of ENAs depends on the exospheric parameters and establish an upper limit for the obstacle standoff distance at approximately 4-10 planetary radii. Finally, we compare the results obtained for the obstacle standoff distance with existing exomagnetospheric models and show how the magnetic moment of HD 209458b can be estimated from ENA observations.
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| 6. |
- Fatemi, Shahab, et al.
(författare)
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Effects of protons deflected by lunar crustal magnetic fields on the global lunar plasma environment
- 2014
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Ingår i: Journal of Geophysical Research - Space Physics. - : John Wiley & Sons. - 2169-9380 .- 2169-9402. ; 119:8, s. 6095-6105
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Tidskriftsartikel (refereegranskat)abstract
- Solar wind plasma interaction with lunar crustal magnetic fields is different than that of magnetized bodies like the Earth. Lunar crustal fields are, for typical solar wind conditions, not strong enough to form a (bow)shock upstream but rather deflect and perturb plasma and fields. Here we study the global effects of protons reflected from lunar crustal magnetic fields on the lunar plasma environment when the Moon is in the unperturbed solar wind. We employ a three-dimensional hybrid model of plasma and an observed map of reflected protons from lunar magnetic anomalies over the lunar farside. We observe that magnetic fields and plasma upstream over the lunar crustal fields compress to nearly 120% and 160% of the solar wind, respectively. We find that these disturbances convect downstream in the vicinity of the lunar wake, while their relative magnitudes decrease. In addition, solar wind protons are disturbed and heated at compression regions and their velocity distribution changes from Maxwellian to a non-Maxwellian. Finally, we show that these features persists, independent of the details of the ion reflection by the magnetic fields.
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| 7. |
- Fatemi, Shahab, et al.
(författare)
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The effects of lunar surface plasma absorption and solar wind temperature anisotropies on the solar wind proton velocity space distributions in the low-altitude lunar plasma wake
- 2012
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 117:10
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Tidskriftsartikel (refereegranskat)abstract
- We study the solar wind proton velocity space distribution functions on the lunar nightside at low altitudes (∼100 km) above the lunar surface using a three-dimensional hybrid plasma solver, when the Moon is in the unperturbed solar wind. When the solar wind encounters a passive obstacle, such as the Moon, without any strong magnetic field and no atmosphere, solar wind protons that impact the obstacle's surface are absorbed and removed from the velocity space distribution functions. We show first that a hybrid model of plasma is applicable to study the low-altitude lunar plasma wake by comparing the simulation results with observations. Then we examine the effects of a solar wind bi-Maxwellian velocity space distribution function and the lunar surface plasma absorption on the solar wind protons' velocity space distribution functions and their entry in the direction parallel to the interplanetary magnetic field lines into the low-altitude lunar wake. We present a backward Liouville method for particle-in-cell solvers that improves velocity space resolution. The results show that the lunar surface plasma absorption and anisotropic solar wind velocity space distributions result in substantial changes in the solar wind proton distribution functions in the low-altitude lunar plasma wake, modifying proton number density, velocity, and temperature there. Additionally, a large temperature anisotropy is found at close distances to the Moon on the lunar nightside as a consequence of the lunar surface plasma absorption effect
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| 8. |
- Fatemi, Shahab, et al.
(författare)
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The lunar wake current systems
- 2013
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Ingår i: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 40:1, s. 17-21
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Tidskriftsartikel (refereegranskat)abstract
- We present the lunar wake current systems when the Moon is assumed to be a non-conductive body, absorbing the solar wind plasma. We show that in the transition regions between the plasma void, the expanding rarefaction region, and the interplanetary plasma, there are three main currents flowing around these regions in the lunar wake. The generated currents induce magnetic fields within these regions and perturb the field lines there. We use a three-dimensional, self-consistent hybrid model of plasma (particle ions and fluid electrons) to show the flow of these three currents. First, we identify the different plasma regions, separated by the currents, and then we show how the currents depend on the interplanetary magnetic field direction. Finally, we discuss the current closures in the lunar wake.
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| 9. |
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| 10. |
- Holmström, Mats, et al.
(författare)
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The interaction between the Moon and the solar wind
- 2012
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Ingår i: Earth Planets and Space. - : Springer Science and Business Media LLC. - 1343-8832 .- 1880-5981. ; 64:2, s. 237-245
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Tidskriftsartikel (refereegranskat)abstract
- We study the interaction between the Moon and the solar wind using a three-dimensional hybrid plasma solver. The proton fluxes and electromagnetical fields are presented for typical solar wind conditions with different magnetic field directions. We find two different wake structures for an interplanetary magnetic field that is perpendicular to the solar wind flow, and for one that is parallell to the flow. The wake for intermediate magnetic field directions will be a mix of these two extreme conditions. Several features are consistent with a fluid interaction, e.g., the presence of a rarefaction cone, and an increased magnetic field in the wake. There are however several kinetic features of the interaction. We find kinks in the magnetic field at the wake boundary. There are also density and magnetic field variations in the far wake, maybe from an ion beam instability related to the wake refill. The results are compared to observations by the WIND spacecraft during a wake crossing. The model magnetic field and ion velocities are in agreement with the measurements. The density and the electron temperature in the central wake are not as well captured by the model, probably from the lack of electron physics in the hybrid model.
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| 11. |
- Holmström, Mats
(författare)
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The use of objective measures in selecting patients for septal surgery
- 2010
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Ingår i: Rhinology. - 0300-0729 .- 1996-8604. ; 48:4, s. 387-393
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Forskningsöversikt (refereegranskat)abstract
- To improve results in septal surgery, patient selection is the mainstay of a successful outcome. Patient history is the basis as well as clinical examination but both are subjective and must be considered towards a background with a high frequency of septal deviation in the population and a lack of good correlation between function and status. Rhinomanometry and acoustic rhinometry as well as nasal peak inspiratory flow are tests of different nasal parameters as resistance to breathing, nasal dimensions and flow. This article illuminates the use of these more objective tests in selection of patients for septoplasty. Objective tests have in several studies shown to predict postoperative satisfaction while normal values can be a marker for a poor surgical outcome. Pros and cons with objective tests are discussed and the conclusion is: operate when there is a good correlation between the patient's status, history and the results of rhinometry!
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| 12. |
- Lue, Charles, et al.
(författare)
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Strong influence of lunar crustal fields on the solar wind flow
- 2011
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Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 38:3
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Tidskriftsartikel (refereegranskat)abstract
- We discuss the influence of lunar magnetic anomalies on the solar wind and on the lunar surface, based on maps of solar wind proton fluxes deflected by the magnetic anomalies. The maps are produced using data from the Solar WInd Monitor (SWIM) onboard the Chandrayaan-1 spacecraft. We find a high deflection efficiency (average ∼10%, locally ∼50%) over the large-scale (>1000 km) regions of magnetic anomalies. Deflections are also detected over weak (<3 nT at 30 km altitude) and small-scale (<100 km) magnetic anomalies, which might be explained by charge separation and the resulting electric potential. Strong deflection from a wide area implies that the magnetic anomalies act as a magnetosphere-like obstacle, affecting the upstream solar wind. It also reduces the implantation rate of the solar wind protons to the lunar surface, which may affect space weathering near the magnetic anomalies.
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| 13. |
- Mani, Maria, et al.
(författare)
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Factors Related to Quality of Life and Satisfaction with Nasal Appearance in Patients Treated for Unilateral Cleft Lip and Palate
- 2013
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Ingår i: The Cleft Palate-Craniofacial Journal. - : SAGE Publications. - 1055-6656 .- 1545-1569. ; 50:4, s. 432-439
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To identify factors related to Quality of Life (QoL) and satisfaction with nasal appearance among patients treated for unilateral cleft lip and palate (UCLP).Design: Cross sectional population study with long-term follow-up.Patients/Settings:All patients with UCLP born between 1960-1987, treated at Uppsala University Hospital, were invited (n=109), 86 (79%) participated. Mean follow-up time was 35 years.Main outcome measures:QoL was measured with Short Form-36 (SF-36) and analyzed using mental and physical cluster scores (MCS and PCS). Nasal appearance was self-assessed with "Satisfaction with Appearance" questionnaire and by panel judgment. Multivariate regression analyses explored endogenous factors (age, gender, infancy cleft width, nasal function, nasolabial appearance) and exogenous factors (marital status, number of children, education level, operation method, number of rhinoplasties performed).Results:A larger cleft width in infancy was associated with less satisfaction with nasal appearance as adults. A lower mental health QoL was associated with less satisfaction with nasal appearance. Despite female gender being linked to less satisfaction with nasal appearance, it was associated with higher mental health QoL. Higher resistance during nasal breathing was associated to lower physical health QoL.Conclusions:Gender and infant cleft width may affect QoL and satisfaction with nasal appearance among adults. They are potential predictive factors for satisfaction with nasal appearance and QoL during adulthood. The correlation of nasal function impairment and decreased physical health QoL underlines the importance of treatment of nasal symptoms in these patients.
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| 14. |
- Mani, Maria, et al.
(författare)
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Objective Assessment of Nasal Airway in Unilateral Cleft Lip and Palate : a Long-term Study
- 2010
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Ingår i: The Cleft Palate-Craniofacial Journal. - : SAGE Publications. - 1055-6656 .- 1545-1569. ; 47:3, s. 217-224
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To objectively evaluate the nasal function in adults operated on for unilateral cleft lip and palate with one-stage or two-stage palate closure. DESIGN: The population consists of all unilateral cleft lip and palate patients born from 1960 to 1987 and treated at the Cleft Lip and Palate Center, Uppsala University Hospital, Sweden. The patients were treated according to the same protocol except for palate closure, which was performed in one stage until 1977 and in two stages thereafter. Eighty-three patients participated. Mean follow-up time after primary surgery was 32 years. An age-matched control group underwent the same examinations. MAIN OUTCOME MEASURES: Nasal minimum cross-sectional area (cm(2)) and volume (cm(3)) were assessed (acoustic rhinometry). Airflow resistance (Pa s/cm(3)) (rhinomanometry), peak inspiratory flow (L/min) (peak nasal inspiratory flow), and number of identified odors (Scandinavian Odor Identification Test) were determined. RESULTS: The cleft side of unilateral cleft lip and palate patients had significantly lower values for all parameters compared with controls (p < .001). No difference was found between one-stage and two-stage procedures in values for the cleft side. However, the nasal area and volume of the noncleft side were significantly larger in patients who underwent one-stage as compared with two-stage procedures (p < .05). CONCLUSION: The nasal airway of unilateral cleft lip and palate patients demonstrates a wide range of impairments that can be quantified by objective measurements. However, the measurements used did not differentiate between patients operated on with the one-stage and two-stage procedures except for values of the noncleft side.
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| 15. |
- Mani, Maria
(författare)
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Unilateral Cleft Lip and Palate : Quality of Life and Nasal Form and Function among Adults
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Unilateral cleft lip and palate (UCLP) is a craniofacial malformation with functional and aesthetical impact on the face and the upper airways. The aims of the current thesis were to evaluate Quality of life (QoL) in adults treated for UCLP (I), to objectively evaluate nasal form and function and to search for possible differences in residual nasal deformity and impairment of function between patients operated according to one-stage and two-stage palate closure (II) as well as to evaluate the relationship between professional and lay rating and patient satisfaction with nasolabial appearance (III) and to identify factors associated with lower levels of QoL and less satisfaction with nasal appearance among adults treated for UCLP (IV). Analyses of data from a homogenous population of UCLP patients treated at Uppsala University Hospital form the basis of this thesis. The mean follow-up time after primary surgery was 35 years (20-47 years) and participation rate was 79% (n=86). An age and gender matched control group of 68 people without clefts were evaluated according to the same protocol. The evaluation protocol included the Short Form 36 questionnaire (SF-36), rhinomanometry, acoustic rhinometry, odor test, peak nasal inspiratory flow test and photographies of faces. For the SF-36 data, age- and gender-matched norm data of 1385 people from the Swedish population were used. Unilateral cleft lip and palate affected QoL differently depending on gender and age of the patient. Younger patients were affected more negatively than older patients in several subscales. However, except for lower values in the Mental Health subscale, QoL was similar among UCLP patients and norm data. Objectively measured nasal function was extensively affected among adults treated for UCLP. No difference in impairment of nasal function was found between one-stage and two-stage palate closure protocols on the cleft side. Judgment of nasolabial appearance differed between professionals, lay people and patients. Large infant cleft width was associated with less satisfaction with nasal appearance and male gender was associated with lower levels of mental QoL. Correlation between high nasal breathing resistance and low levels of physical QoL was found. In conclusion, this thesis provides a platform for future research for optimal evaluation of cleft treatment outcome.
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| 16. |
- Nilsson, Hans, et al.
(författare)
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Heavy ion escape from Mars, influence from solar wind conditions and crustal magnetic fields
- 2011
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Ingår i: Icarus. - : Elsevier BV. - 0019-1035 .- 1090-2643. ; 215:2, s. 475-484
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Tidskriftsartikel (refereegranskat)abstract
- We have used more than 4 years of Mars Express ion data to estimate the escape of heavy ions (O(1)(+) O(2)(+) and CO(2)(+)) from Mars. To take the limited field of view of the instrument into account, the data has been binned into spatial bins and angular bins to create average distribution functions for different positions in the near Mars space. The net escape flux for the studied low solar activity period, between May 2007 and May 2011, is 2.0 +/- 0.2 x 10(24) s(-1). The escape has been calculated independently for four different quadrants in the Y(MSO) - Zmso plane, south, dusk, north and dawn. Escape is highest from the northern and dusk quadrants, 0.6 +/- 0.1 x 10(24) s(-1), and smallest from the south and dawn quadrants, 0.4 +/- 0.1 x 10(24) s(-1). The flux ratio of molecular (O(2)(+) and CO(2)())(+) to 0 ions is 0.9 +/- 0.1, averaged over all quadrants. The flux difference between the north and south quadrants is statistically significant, and is presumed to be due to the presence of significant crustal magnetic fields in the southern hemisphere, reducing the outflow. The difference between the dawn and dusk quadrants is likely due to the magnetic tension associated with the nominal Parker angle spiral, which should lead to higher average magnetic tension on the dusk side. The escape increases during periods of high solar wind flux and during times when co-rotating interaction regions (CIR) affect Mars. In the latter case the increase is a factor 2.4-2.9 as compared to average conditions.
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| 17. |
- Poppe, A.R., et al.
(författare)
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ARTEMIS observations of extreme diamagnetic fields in the lunar wake
- 2014
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Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 41:11, s. 3766-3773
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Tidskriftsartikel (refereegranskat)abstract
- We present two Acceleration, Reconnection, Turbulence, and Electrodynamics of the Moon's Interaction with the Sun ( ARTEMIS) observations of diamagnetic fields in the lunar wake at strengths exceeding twice the ambient magnetic field during high plasma beta conditions. The first observation was 350 km from the lunar surface while the Moon was located in the terrestrial magnetosheath with elevated particle temperatures. The second observation was in the solar wind ranging from 500 to 2000 km downstream, with a relatively low magnetic field strength of approximately 1.6 nT. In both cases, the plasma beta exceeded 10. We discuss the observations and compare the data to hybrid plasma simulations in order to validate the model under such extreme conditions and to elucidate the global structure of the lunar wake during these observations. The extreme nature of the diamagnetic field in the lunar wake provides an important end-member test case for theoretical and modeling studies of the various plasma processes operating in the lunar wake.
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| 18. |
- Reiser, Erika, et al.
(författare)
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Initial size of cleft does not correlate with size and function of nasal airway in adults with unilateral cleft lip and palate
- 2011
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Ingår i: Journal of plastic surgery and hand surgery. - 2000-656X. ; 45:3, s. 129-135
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Tidskriftsartikel (refereegranskat)abstract
- The noses of patients with clefts are often functionally inadequate. The aim of the present study was to evaluate the correlation between size of the maxillary cleft in infancy and size and function of the nasal airway in adults with unilateral cleft lip and palate (UCLP). This is a long-term follow up study including 53 patients with UCLP born between 1960 and 1987 and treated at the Cleft Lip and Palate Centre, Uppsala University Hospital, Sweden. Lip repair was performed at 3--4 months of age followed by either a one-stage or a two-stage palatal closure. The size of the cleft was measured on infant maxillary dental casts. Nasal minimum cross-sectional area (cm
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| 19. |
- Serenius, Fredrik, et al.
(författare)
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EXPRESS study shows significant regional differences in 1-year outcome of extremely preterm infants in Sweden
- 2014
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Ingår i: Acta Paediatrica. - : Wiley-Blackwell. - 0803-5253 .- 1651-2227. ; 103:1, s. 27-37
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Tidskriftsartikel (refereegranskat)abstract
- Aim: The aim of this study was to investigate differences in mortality up to 1year of age in extremely preterm infants (before 27weeks) born in seven Swedish healthcare regions.Methods: National prospective observational study of consecutively born, extremely preterm infants in Sweden 2004-2007. Mortality was compared between regions. Crude and adjusted odds ratios and 95% CI were calculated.Results: Among 844 foetuses alive at mother's admission for delivery, regional differences were identified in perinatal mortality for the total group (22-26weeks) and in the stillbirth and perinatal and 365-day mortality rates for the subgroup born at 22-24weeks. Among 707 infants born alive, regional differences were found both in mortality before 12h and in the 365-day mortality rate for the subgroup (22-24weeks) and for the total group (22-26weeks). The mortality rates were consistently lower in two healthcare regions. There were no differences in the 365-day mortality rate for infants alive at 12h or for infants born at 25weeks. Neonatal morbidity rates among survivors were not higher in regions with better survival rates. Perinatal practices varied between regions.Conclusion: Mortality rates in extremely preterm infants varied considerably between Swedish healthcare regions in the first year after birth, particularly between the most immature infants.
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| 20. |
- Serenius, Fredrik, 1939-, et al.
(författare)
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Neurodevelopmental outcome in extremely preterm infants at 2.5 years after active perinatal care in Sweden.
- 2013
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Ingår i: Journal of the American Medical Association. - : American Medical Association (AMA). - 0098-7484 .- 1538-3598. ; 309:17, s. 1810-20
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Tidskriftsartikel (refereegranskat)abstract
- Importance Active perinatal care increases survival of extremely preterm infants; however, improved survival might be associated with increased disability among survivors. Objective To determine neurodevelopmental outcome in extremely preterm children at 2.5 years (corrected age). Design, Setting, and Participants Population-based prospective cohort of consecutive extremely preterm infants born before 27 weeks of gestation in Sweden between 2004 and 2007. Of 707 live-born infants, 491 (69%) survived to 2.5 years. Survivors were assessed and compared with singleton control infants who were born at term and matched by sex, ethnicity, and municipality. Assessments ended in February 2010 and comparison estimates were adjusted for demographic differences. Main Outcomes and Measures Cognitive, language, and motor development was assessed with Bayley Scales of Infant and Toddler Development (3rd edition; Bayley-III), which are standardized to mean (SD) scores of 100 (15). Clinical examination and parental questionnaires were used for diagnosis of cerebral palsy and visual and hearing impairments. Assessments were made by week of gestational age. Results At a median age of 30.5 months (corrected), 456 of 491 (94%) extremely preterm children were evaluated (41 by chart review only). For controls, 701 had information on health status and 366 had Bayley-III assessments. Mean (SD) composite Bayley-III scores (cognition, 94 [12.3]; language, 98 [16.5]; motor, 94 [15.9]) were lower than the corresponding mean scores for controls (cognition, 104 [10.6]; P < .001; adjusted difference in mean scores, 9.2 [99% CI, 6.9-11.5]; language, 109 [12.3]; P < .001; adjusted difference in mean scores, 9.3 [99% Cl, 6.4-12.3]; and motor, 107 [13.7]; P < .001; adjusted difference in mean scores, 12.6 [99% Cl, 9.5-15.6]). Cognitive disability was moderate in 5% of the extremely preterm group vs 0.3% in controls (P < .001) and it was severe in 6.3% of the extremely preterm group vs 0.3% in controls (P < .001). Language disability was moderate in 9.4% of the extremely preterm group vs 2.5% in controls (P < .001) and severe in 6.6% of the extremely preterm group vs 0% in controls (P < .001). Other comparisons between the extremely preterm group vs controls were for cerebral palsy (7.0% vs 0.1%; P < .001), for blindness (0.9% vs 0%; P = .02), and for hearing impairment (moderate and severe, 0.9% vs 0%; P = .02, respectively). Overall, 42% (99% CI, 36%-48%) of extremely preterm children had no disability, 31% (99% CI, 25%-36%) had mild disability, 16% (99% CI, 12%-21%) had moderate disability, and 11% (99% CI, 7.2%-15%) had severe disability. Moderate or severe overall disability decreased with gestational age at birth (22 weeks, 60%; 23 weeks, 51%; 24 weeks, 34%; 25 weeks, 27%; and 26 weeks, 17%; P for trend < .001). Conclusions and Relevance Of children born extremely preterm and receiving active perinatal care, 73% had mild or no disability and neurodevelopmental outcome improved with each week of gestational age. These results are relevant for clinicians counseling families facing extremely preterm birth. JAMA. 2013;309(17):1810-1820
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| 21. |
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| 22. |
- Sävenstrand, Andreas, et al.
(författare)
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Pärlbandsprojekt : projekt som verktyg i en långsiktig utvecklingsstrategi
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Inom Socialfonden förekommer ibland projekt som upplevs som repriser – de har setts förut. Men det är inte repriser utan nytänkande som Socialfonden ska finansiera. Forskning har visat att många projekt är välskötta, genomför en rad aktiviteter och visar på goda resultat, men de ger inga långsiktiga effekter. Kombinationen av goda resultat och avsaknad av effekter kan leda projektägare in på spåret att söka ett liknande projekt igen. Men detta kommer aldrig leda till långsiktig utveckling. Effekter uppnås istället då projektägare återkommer med en idé som bygger vidare på en tidigare satsning där resultaten tagits tillvara och utvecklats. Projekten utgör en del i en långsiktig utvecklingsstrategi som pärlor på en tråd – pärlbandsprojekt. Denna rapport innehåller fyra exempel på projektägare som har bedrivit flera utvecklingssatsningar över tid och där verksamheten visar tecken på kontinuerlig progression. Vi har utgått från en analysmodell för hållbart utvecklingsarbete som inkluderar aktivt ägarskap, samverkan och ett utvecklingsinriktat lärande. Med detta som grund har vi studerat i vilken mån de fyra exemplen har haft ett lärande över tid, har ökat ambitionsnivån, utvecklat nya samverkansformer, stärkt ägarskapet och bidragit till kunskapsbärare på flera nivåer. Rapporten riktar sig främst till ESF-rådet, projektägare och andra utvecklingsansvariga. Syftet med rapporten är att tydliggöra skillnaden mellan repriser och pärlband. Om fler projektägare avser, och ges möjlighet, att använda projekt som verktyg i en långsiktig utvecklingsstrategi så följer sannolikt fler långsiktiga effekter.
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| 23. |
- Zhou, X.-Z., et al.
(författare)
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Lunar dayside current in the terrestrial lobe: ARTEMIS observations
- 2014
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Ingår i: Journal of Geophysical Research - Space Physics. - : John Wiley & Sons. - 2169-9380 .- 2169-9402. ; 119:5, s. 3381-3391
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Tidskriftsartikel (refereegranskat)abstract
- We report Acceleration, Reconnection, Turbulence and Electrodynamics of Moon's Interaction with the Sun (ARTEMIS) dual-probe observations of two events in the terrestrial magnetotail lobe, both characterized by upward moving heavy ions of lunar origin at one of the probes that is magnetically connected with the dayside lunar surface. By treating magnetic measurements at the other probe as the unperturbed lobe fields, we obtain background-subtracted magnetic perturbations (most significantly in Bz) when the first probe moved in the dawn-dusk direction across flux tubes magnetically connected to the Moon. These magnetic perturbations indicate the presence of field-aligned current above the lunar surface. By examining possible carriers of field-aligned current, we find that lunar heavy ions and accompanying electrons both contribute considerably to the current. Observations of the field-aligned current also suggest that the charging process at the dayside lunar surface and the associated lobe plasma environment, which have traditionally been viewed as a one-dimensional current balance problem, are actually more complicated. These observations give the first insights into how heavy ions affect the lunar dayside environment in terms of multispecies plasma dynamics.
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