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- Eckhardt, CL, et al.
(författare)
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Factor VIII gene (F8) mutation and risk of inhibitor development in nonsevere hemophilia A
- 2013
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 122:11, s. 1954-1962
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Tidskriftsartikel (refereegranskat)abstract
- The inhibitor incidence in nonsevere hemophilia A patients with certain F8 mutations approaches the inhibitor incidence in severe patients. These findings are highly relevant for clinical practice, as they facilitate identification of high-risk patients based on F8 genotype.
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- Isomaa, B., et al.
(författare)
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A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study
- 2010
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 1432-0428 .- 0012-186X. ; 53:8, s. 1709-1713
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Tidskriftsartikel (refereegranskat)abstract
- We studied the impact of a family history of type 2 diabetes on physical fitness, lifestyle factors and diabetes-related metabolic factors. The Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study is a population-based study in Western Finland, which includes a random sample of 5,208 individuals aged 18 to 75 years identified through the national Finnish Population Registry. Physical activity, dietary habits and family history of type 2 diabetes were assessed by questionnaires and physical fitness by a validated 2 km walking test. Insulin secretion and action were assessed based upon OGTT measurements of insulin and glucose. A family history of type 2 diabetes was associated with a 2.4-fold risk of diabetes and lower physical fitness (maximal aerobic capacity 29.2 +/- 7.2 vs 32.1 +/- 7.0, p = 0.01) despite having similar reported physical activity to that of individuals with no family history. The same individuals also had reduced insulin secretion adjusted for insulin resistance, i.e. disposition index (p < 0.001) despite having higher BMI (27.4 +/- 4.6 vs 26.0 +/- 4.3 kg/m(2), p < 0.001). Individuals with a family history of type 2 diabetes are characterised by lower physical fitness, which cannot solely be explained by lower physical activity. They also have an impaired capacity of beta cells to compensate for an increase in insulin resistance imposed by an increase in BMI. These defects should be important targets for interventions aiming at preventing type 2 diabetes in individuals with inherited susceptibility to the disease.
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- Nilsson, H., et al.
(författare)
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Ion distributions in the vicinity of Mars : Signatures of heating and acceleration processes
- 2012
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Ingår i: Earth Planets and Space. - : Springer Science and Business Media LLC. - 1343-8832 .- 1880-5981. ; 64:2, s. 135-148
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Tidskriftsartikel (refereegranskat)abstract
- More than three years of data from the ASPERA-3 instrument on-board Mars Express has been used to compile average distribution functions of ions in and around the Mars induced magnetosphere. We present samples of average distribution functions, as well as average flux patterns based on the average distribution functions, all suitable for detailed comparison with models of the near-Mars space environment. The average heavy ion distributions close to the planet form thermal populations with a temperature of 3 to 10 eV. The distribution functions in the tail consist of two populations, one cold which is an extension of the low altitude population, and one accelerated population of ionospheric origin ions. All significant fluxes of heavy ions in the tail are tailward. The heavy ions in the magnetosheath form a plume with the flow aligned with the bow shock, and a more radial flow direction than the solar wind origin flow. Summarizing the escape processes, ionospheric ions are heated close to the planet, presumably through wave-particle interaction. These heated populations are accelerated in the tailward direction in a restricted region. Another significant escape path is through the magnetosheath. A part of the ionospheric population is likely accelerated in the radial direction, out into the magnetosheath, although pick up of an oxygen exosphere may also be a viable source for this escape. Increased energy input from the solar wind during CIR events appear to mainly increase the number flux of escaping particles, the average energy of the escaping particles is not strongly affected. Heavy ions on the dayside may precipitate and cause sputtering of the atmosphere, though fluxes are likely lower than 0.4 x 10(23) s(-1).
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