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Träfflista för sökning "WFRF:(Honig A) srt2:(2010-2014)"

Sökning: WFRF:(Honig A) > (2010-2014)

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1.
  • Bras, Jose, et al. (författare)
  • Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.
  • 2014
  • Ingår i: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 23:23, s. 6139-6146
  • Tidskriftsartikel (refereegranskat)abstract
    • Clinical and neuropathological similarities between dementia with Lewy bodies (DLB), Parkinson's and Alzheimer's diseases (PD and AD, respectively) suggest that these disorders may share etiology. To test this hypothesis, we have performed an association study of 54 genomic regions, previously implicated in PD or AD, in a large cohort of DLB cases and controls. The cohort comprised 788 DLB cases and 2624 controls. To minimize the issue of potential misdiagnosis, we have also performed the analysis including only neuropathologically proven DLB cases (667 cases). The results show that the APOE is a strong genetic risk factor for DLB, confirming previous findings, and that the SNCA and SCARB2 loci are also associated after a study-wise Bonferroni correction, although these have a different association profile than the associations reported for the same loci in PD. We have previously shown that the p.N370S variant in GBA is associated with DLB, which, together with the findings at the SCARB2 locus, suggests a role for lysosomal dysfunction in this disease. These results indicate that DLB has a unique genetic risk profile when compared with the two most common neurodegenerative diseases and that the lysosome may play an important role in the etiology of this disorder. We make all these data available.
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3.
  • Honig, Benson, et al. (författare)
  • The fox in the hen house : A critical examination of plagiarism among members of the academy of management
  • 2012
  • Ingår i: Academy of Management Learning & Education. - : Academy of Management Learning & Education. - 1537-260X .- 1944-9585. ; 11:1, s. 101-123
  • Tidskriftsartikel (refereegranskat)abstract
    • Research on academic plagiarism has typically focused on students as the perpetrators of unethical behaviors, and less attention has been paid to academic researchers as likely candidates for such behaviors. We examined 279 papers presented at the International Management division of the 2009 Academy of Management conference for the purpose of studying plagiarism among academics. Results showed that 25% of our sample had some amount of plagiarism, and over 13% exhibited significant plagiarism. This exploratory study raises an alarm regarding the inadequate monitoring of norms and professional activities associated with Academy of Management members.
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4.
  • Odin, Per, et al. (författare)
  • Apomorphininjektionstherapie bei Morbus Parkinson
  • 2011
  • Ingår i: Aktuelle Neurologie. - : Georg Thieme Verlag KG. - 0302-4350 .- 1438-9428. ; 38:Suppl. 1, s. 11-16
  • Forskningsöversikt (refereegranskat)abstract
    • Apomorphine as subcutaneous injections offers a valuable and effective treatment alternative for Parkinson patients with oral medication-resistant "off' phases. Its efficacy is stable during long-term therapy, with no signs of patient tolerance. Adverse events are usually mild. The best results are obtained with relatively young, active, and cognitively intact patients. Intermittent s.c. apomorphine therapy can improve the patients' possibilities to continue to work and to live a normal social life, by offering increased freedom and self-confidence through a reliable, quick rescue from the disabling medication-resistant off phases.
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