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Träfflista för sökning "WFRF:(Hu Rong Gang) srt2:(2012)"

Sökning: WFRF:(Hu Rong Gang) > (2012)

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1.
  • Hu, Chun, et al. (författare)
  • Intestinal metabolite compound K of panaxoside inhibits the growth of gastric carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway
  • 2012
  • Ingår i: Journal of Cellular and Molecular Medicine (Print). - : Wiley-Blackwell. - 1582-1838 .- 1582-4934. ; 16:1, s. 96-106
  • Tidskriftsartikel (refereegranskat)abstract
    • Compound K (20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, CK), an intestinal bacterial metabolite of panaxoside, has been shown to inhibit tumour growth in a variety of tumours. However, the mechanisms involved are largely unknown. We use human gastric carcinoma cell lines BGC823, SGC7901 and human gastric carcinoma xenograft in nude mice as models to study the mechanisms of CK in gastric cancers. We found that CK significantly inhibits the viabilities of BGC823 and SGC7901 cells in dose- and time-dependent manners. CK-induced BGC823 and SGC7901 cells apoptosis and cell cycle arrest in G2 phase by up-regulation of p21 and down-regulation of cdc2 and cyclin B1. Further studies show that CK induces apoptosis in BGC823 and SGC7901 cells mainly through mitochondria-mediated internal pathway, and that CK induces the translocation of nuclear Bid to mitochondria. Finally, we found that CK effectively inhibited the tumour formation of SGC7901 cells in nude mice. Our studies show that CK can inhibit the viabilities and induce apoptosis of human gastric carcinoma cells via Bid-mediated mitochondrial pathway.
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2.
  • Ye, Chen-Qing, et al. (författare)
  • Probing the vertical profiles of potential in a thin layer of solution closed to electrode surface during localized corrosion of stainless steel
  • 2012
  • Ingår i: Corrosion Science. - : Elsevier BV. - 0010-938X .- 1879-0496. ; 61, s. 242-245
  • Tidskriftsartikel (refereegranskat)abstract
    • Based on a home-built integrated system of scanning reference electrode technique and scanning tunneling microscope (SRET/STM), a method for in situ measurement of vertical potential in the thin layer of solution closed to electrode surface during localized corrosion of stainless steel has been successfully established in this work. An obviously different vertical profile of potential over corrosion active sites and passive sites were firstly observed. The reason for this different was discussed taking into account the distribution of electric field and concentration of Fe3+/Fe2+ in a thin layer solution closed to electrode surface, due to the occurrence of localized corrosion.
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