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| 3. |
- Harrington, Robert A., et al.
(författare)
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The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA.CER) trial : study design and rationale
- 2009
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Ingår i: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 158:3, s. 327-334
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Tidskriftsartikel (refereegranskat)abstract
- Background The protease-activated receptor 1 (PAR-1), the main platelet receptor for thrombin, represents a novel target for treatment of arterial thrombosis, and SCH 530348 is an orally active, selective, competitive PAR-1 antagonist. We designed TRA.CER to evaluate the efficacy and safety of SCH 530348 compared with placebo in addition to standard of care in patients with non-ST-segment elevation (NSTE) acute coronary syndromes (ACS) and high-risk features. Trial design TRA.CER is a prospective, randomized, double-blind, multicenter, phase III trial with an original estimated sample size of 10,000 subjects. Our primary objective is to demonstrate that SCH 530348 in addition to standard of care will reduce the incidence of the composite of cardiovascular death, myocardial infarction (MI), stroke, recurrent ischemia with rehospitalization, and urgent coronary revascularization compared with standard of care alone. Our key secondary objective is to determine whether SCH 530348 will reduce the composite of cardiovascular death, MI, or stroke compared with standard of care alone. Secondary objectives related to safety are the composite of moderate and severe GUSTO bleeding and clinically significant TIMI bleeding. The trial will continue until a predetermined minimum number of centrally adjudicated primary and key secondary end point events have occurred and all subjects have participated in the study for at least I year. The TRA.CER trial is part of the large phase III SCH 530348 development program that includes a concomitant evaluation in secondary prevention. Conclusion TRA.CER will define efficacy and safety of the novel platelet PAR-1 inhibitor SCH 530348 in the treatment of high-risk patients with NSTE ACS in the setting of current treatment strategies.
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| 4. |
- Madic, C., et al.
(författare)
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Futuristic back-end of the nuclear fuel cycle with the partitioning of minor actinides
- 2007
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Ingår i: Journal of Alloys and Compounds. - 0925-8388. ; 444, s. 23-27
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Tidskriftsartikel (refereegranskat)abstract
- For future back-end of the nuclear fuel cycle, the partitioning of minor actinides: Np, Am and Cm, followed by their transmutation will minimize importantly the radiotoxicity of nuclear glass waste. In this paper, the research done in France and in Europe will be presented: (i) partitioning of Np by modified PUREX process, (ii) partitioning of Am and Cm by the DIAMEX and SANEX hydrometallurgical processes. (c) 2007 Published by Elsevier B.V.
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| 5. |
- Horvath, Rita, et al.
(författare)
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Molecular basis of infantile reversible cytochrome c oxidase deficiency myopathy.
- 2009
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Ingår i: Brain : a journal of neurology. - : Oxford University Press (OUP). - 1460-2156. ; 132:Pt 11, s. 3165-74
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Tidskriftsartikel (refereegranskat)abstract
- Childhood-onset mitochondrial encephalomyopathies are usually severe, relentlessly progressive conditions that have a fatal outcome. However, a puzzling infantile disorder, long known as 'benign cytochrome c oxidase deficiency myopathy' is an exception because it shows spontaneous recovery if infants survive the first months of life. Current investigations cannot distinguish those with a good prognosis from those with terminal disease, making it very difficult to decide when to continue intensive supportive care. Here we define the principal molecular basis of the disorder by identifying a maternally inherited, homoplasmic m.14674T>C mt-tRNA(Glu) mutation in 17 patients from 12 families. Our results provide functional evidence for the pathogenicity of the mutation and show that tissue-specific mechanisms downstream of tRNA(Glu) may explain the spontaneous recovery. This study provides the rationale for a simple genetic test to identify infants with mitochondrial myopathy and good prognosis.
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| 6. |
- Hudson, D.S., et al.
(författare)
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Hospitalizations for immersion-related injuries in Alaska 1991-2000
- 2006
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Ingår i: Safety Science. - : Elsevier BV. - 0925-7535 .- 1879-1042. ; 44:6, s. 479-489
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Tidskriftsartikel (refereegranskat)abstract
- Objective: This study analyzed factors associated with injuries to hospitalized victims of nonfatal immersion-related events in Alaska from 1991 through 2000. Data: Alaska Trauma Registry (ATR) records of victims of nonfatal immersion events requiring hospitalization were examined to identify factors associated with injury outcomes. Subjects were divided into two groups: the "immersion only" (IO) group had no additional injuries associated with their immersion-related events, while subjects in the "associated injury" (AI) group incurred additional trauma during injury events. Results: There were 176 ATR records of nonfatal immersion events. In 87 (49.5%) cases, hospitalizations were due to the effects of immersion only (IO group). In 89 (50.5%) cases, hospitalizations were due not only to the effects of immersion, but also due to additional injuries occurring immediately before or while immersion took place (AI group). The final logistic regression model revealed statistically significant relationships between age greater than 12 years, female gender, white ethnicity, and operation of water transport vehicles, and increased risk for associated injury outcomes (p < 0.05). Discussion: This study is the first of its kind to analyze factors associated with the most severe nonfatal immersion-related injuries in Alaska, and identifies target populations for future safety campaigns. © 2005 Elsevier Ltd. All rights reserved.
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| 7. |
- Hudson, John A., et al.
(författare)
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Characterising and modelling the excavation damaged zone in crystalline rock in the context of radioactive waste disposal
- 2009
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Ingår i: Environmental Geology. - : Springer Science and Business Media LLC. - 0943-0105 .- 1432-0495. ; 57:6, s. 1275-1297
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes current knowledge about the nature of and potential for thermo-hydro-mechanical-chemical modelling of the excavation damaged zone (EDZ) around the excavations for an underground radioactive waste repository. In the first part of the paper, the disturbances associated with excavation are explained, together with reviews of Workshops that have been held on the subject. In the second part of the paper, the results of a DECOVALEX [DEmonstration of COupled models and their VALidation against EXperiment: research funded by an international consortium of radioactive waste regulators and implementers (http://www.decovalex.com)] research programme on modelling the EDZ are presented. Four research teams used four different models to simulate the complete stress-strain curve for Avro granite from the Swedish A"spo Hard Rock Laboratory. Subsequent research extended the work to computer simulation of the evolution of the repository using a 'wall-block model' and a 'near-field model'. This included assessing the evolution of stress, failure and permeability and time-dependent effects during repository evolution. As discussed, all the computer models are well suited to sensitivity studies for evaluating the influence of their respective supporting parameters on the complete stress-strain curve for rock and for modelling the EDZ.
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| 8. |
- Birney, Ewan, et al.
(författare)
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Prepublication data sharing
- 2009
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 461:7261, s. 168-170
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Tidskriftsartikel (refereegranskat)abstract
- Rapid release of prepublication data has served the field of genomics well. Attendees at a workshop in Toronto recommend extending the practice to other biological data sets.
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| 9. |
- Bäckström, Ann, 1976-
(författare)
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Rock damage caused by underground excavation and meteorite impacts
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The intent of this thesis is to contribute to the understanding of the origin of fractures in rock. The man-made fracturing from engineering activities in crystalline rock as well as the fracturing induced by the natural process of meteorite impacts is studied by means of various characterization methods. In contrast to engineering induced rock fracturing, where the goal usually is to minimize rock damage, meteorite impacts cause abundant fracturing in the surrounding bedrock. In a rock mass the interactions of fractures on the microscopic scale (mm-cm scale) influence fractures on the mesoscopic scale (dm-m scale) as well as the interaction of the mesocopic fractures influencing fractures on the macroscopic scale (m-km scale). Thus, among several methods used on different scales, two characterization tools have been developed further. This investigation ranges from the investigation of micro-fracturing in ultra-brittle rock on laboratory scale to the remote sensing of fractures in large scale structures, such as meteorite impacts. On the microscopic scale, the role of fractures pre-existing to the laboratory testing is observed to affect the development of new fractures. On the mesoscopic scale, the evaluation of the geometric information from 3D-laser scanning has been further developed for the characterisation of fractures from tunnelling and to evaluate the efficiency of the tunnel blasting technique in crystalline rock. By combining information on: i) the overbreak and underbreak; ii) the orientation and visibility of blasting drillholes and; iii) the natural and blasting fractures in three dimensions; a analysis of the rock mass can be made. This analysis of the rock mass is much deeper than usually obtained in rock engineering for site characterization in relation to the blasting technique can be obtained based on the new data acquisition. Finally, the estimation of fracturing in and around two meteorite impact structures has been used to reach a deeper understanding of the relation between fracture, their water content and the electric properties of the rock mass. A correlation between electric resistivity and fracture frequency in highly fractured crystalline rock has been developed and applied to potential impact crater structures. The results presented in this thesis enables more accurate modelling of rock fractures, both supporting rock engineering design and interpretation of meteorite impact phenomena.
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| 10. |
- Clayton, R.E, et al.
(författare)
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Fe isotope fractionation during the precipitation of ferrihydrite and transformation of ferrihydrite to goethite
- 2005
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Ingår i: Mineralogical magazine. - : Mineralogical Society. - 0026-461X .- 1471-8022. ; 69:5, s. 667-676
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Tidskriftsartikel (refereegranskat)abstract
- Ferrihydrite and goethite are amongst the most important substrates for the sorption of contaminants in soil and other environmental media. Isotopic studies of the transition elements, particularly those that exhibit more than one oxidation state and show pH- and/or redox-sensitive behaviour at low temperatures, have been shown to be potentially useful present-day and past proxies for redox (or palaeoredox) conditions. We have made preliminary investigations of Fe isotope fractionation that take place during the formation of FeIII (oxy)hydroxides (FeIIIox) from an aqueous FeIII(NO3)3 solution (FeIIIaq) under laboratory conditions. We have attempted to keep the chemical system simple by excluding 'vital effects' and major changes in redox through the maintenance of abiotic conditions and use of FeIIIaq. Isotopic measurements (56Fe/54Fe, 57Fe/54Fe) of the FeIII(NO3)3 stock solution, the original ferrihydrite and the mixed ferrihydrite/goethite-supernatant FeIIIaq 'pairs' were carried out using a double focusing multicollector inductively coupled plasma mass spectrometer. The results reveal an apparent systematic variation indicating larger ΔFeIIIaq-FeIIIox with decrease in the ferrihydrite:goethite ratio, which reflects the time allowed for isotopic exchange. These values range from virtually zero (0.03‰) after 24 h to 0.30‰ after 70 h. In each FeIIIox-FeIIIaq 'pair' the lighter Fe isotope is partitioned into the FeIIIox, leaving the FeIIIaq isotopically heavier. The observed fractionation reflects isotopic exchange of Fe between the FeIIIox and FeIIIaq upon at least a two step transition of ferrihydrite to goethite.
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| 13. |
- Hudson, John A., et al.
(författare)
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Guidance on numerical modelling of thermo-hydro-mechanical coupled processes for performance assessment of radioactive waste repositories
- 2005
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Ingår i: International Journal of Rock Mechanics And Mining Sciences. - : Elsevier BV. - 1365-1609 .- 1873-4545. ; 42:5-6, s. 850-870
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Tidskriftsartikel (refereegranskat)abstract
- This paper provides advice on how to incorporate thermo-hydro-mechanical (THM) coupled processes into performance and safety assessments and design studies for radioactive waste disposal in geological formations. The advice is based on work conducted for the EU research project BENCHPAR: "Benchmark Tests and Guidance on Coupled Processes for Performance Assessment of Nuclear Waste Repositories". In Section 1, there is an explanation of why numerical analyses incorporating THM mechanisms are required for radioactive waste studies and background material on the subject is provided. Then, the THM processes and their interactions are explained in Section 2. Three case examples of THM numerical analysis are presented in Section 3 to illustrate the type of work that can be conducted to study the near-field, upscaling, and the far-field. The importance and priority of the THM couplings are summarized in Section 4. Recommended soft and hard auditing procedures are presented in Section 5. We place special emphasis on the fact that the most important step in numerical modelling is not executing the calculations per se, but the earlier conceptualization of the problem regarding the dominant processes, the material properties and parameters, the engineering perturbations, and their mathematical presentations. The associated modelling component of addressing the uncertainties and estimating their influence on the results is also important. Thus, the specific models and codes should be studied first to evaluate the harmony between the nature of the problem and the nature of the codes. The tactical use of particular numerical techniques will then be based on a sound strategic foundation. An associated listing of bullet point recommendations and issues for future directions for this THM subject area is given in Section 6.
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| 14. |
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| 15. |
- Simon, M., et al.
(författare)
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Elastic peak of K shell excited HCl molecule : Comparison HCl-DCl - Experiment and theory
- 2007
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Ingår i: Journal of Electron Spectroscopy and Related Phenomena. - : Elsevier BV. - 0368-2048 .- 1873-2526. ; 155:1-3, s. 91-94
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Tidskriftsartikel (refereegranskat)abstract
- Fermosecond dynamics has been recently observed by resonant X-ray Raman scattering (RXRS) after excitation along the dissociative Cl 1s -> 6 sigma* resonance of gas phase HCl. In this paper, we show a method to take into account and correct for self-absorption of the elastic peak, in order to allow for quantitative comparison with theory. We have performed measurements on the DCl molecule exhibiting ultrafast nuclear motion. A comparison between HCl and DCl is presented.
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| 16. |
- Simon, M., et al.
(författare)
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Femtosecond nuclear motion of HCl probed by resonant x-ray Raman scattering in the Cl 1s region
- 2006
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Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 73:2, s. 020706(R)-
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Tidskriftsartikel (refereegranskat)abstract
- Femtosecond dynamics are observed by resonant x-ray Raman scattering (RXS) after excitation along the dissociative Cl 1s -> 6 sigma(*) resonance of gas-phase HCl. The short core-hole lifetime results in a complete breakdown of the common nondispersive behavior of soft-x-ray transitions between parallel potentials. We evidence a general phenomenon of RXS in the hard-x-ray region: a complete quenching of vibrational broadening. This opens up a unique opportunity for superhigh resolution x-ray spectroscopy beyond vibrational and lifetime limitations.
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