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- Chen, W., et al.
(författare)
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A generic FMU interface for modelica
- 2011
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Ingår i: Proceedings of the 4th International Workshop on Equation-Based Object-Oriented Modeling Languages and Tools, EOOLT 2011. ; , s. 19-24
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Konferensbidrag (refereegranskat)abstract
- This paper discusses technical issues and implementation of a generic interface to import a Functional Mock-up Unit (FMU) into Modelica simulators, specifically the Open- Modelica environment. Whereas other approaches for importing the FMUs rely on functionality specific to the simulator environment, this approach tries to provide a generic Modelica interface for embedding an FMU to be imported into a Modelica model. In this way any FMU conforming to the Functional Mock-up Interface (FMI) for Model Exchange v1.0 Specification for model exchange from MODELISAR can be imported into any Modelica simulator. When importing an FMU into a model, the resulting Modelica model can be used just like any pure Modelica models. Hence, a better reusability and interoperability for both sides, namely the external models provided via FMI and the Modelica environment, are achieved.
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- Wang, Hui, et al.
(författare)
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A coding IRAK2 variant compromises TLR signaling and is associated with colorectal cancer survival.
- 2014
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Ingår i: Journal of Biological Chemistry. - 1083-351X. ; 289:33, s. 23123-23131
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Tidskriftsartikel (refereegranskat)abstract
- Within innate immune signaling pathways, Interleukin-1 receptor (IL-1R&)-associated kinases (IRAKs) fulfill key roles downstream of multiple Toll-like receptors (TLR) and the IL-1R. Whereas human IRAK4-deficiency was shown to lead to severe immunodeficiency in response to pyogenic bacterial infection during childhood, little is known about the role of human IRAK2. We here identified a non-synonymous IRAK2 variant, rs35060588 (coding R214G), as hypofunctional in terms of NF-κB signaling and TLR-mediated cytokine induction. This was due to reduced ubiquitination of TRAF6, a key step in signal transduction. IRAK2 rs35060588 occurs in 3-9% of individuals in different ethnic groups and our studies uncovered a significant genetic association of rs35060588 with colorectal cancer survival. This for the first time firmly implicates human IRAK2 in human disease and highlights the R214G IRAK2 variant as a potential novel and broadly applicable biomarker for disease or as a therapeutic intervention point.
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