SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Huhn M.) srt2:(2010-2014)"

Sökning: WFRF:(Huhn M.) > (2010-2014)

  • Resultat 1-6 av 6
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  •  
4.
  • Chen, W., et al. (författare)
  • A generic FMU interface for modelica
  • 2011
  • Ingår i: Proceedings of the 4th International Workshop on Equation-Based Object-Oriented Modeling Languages and Tools, EOOLT 2011. ; , s. 19-24
  • Konferensbidrag (refereegranskat)abstract
    • This paper discusses technical issues and implementation of a generic interface to import a Functional Mock-up Unit (FMU) into Modelica simulators, specifically the Open- Modelica environment. Whereas other approaches for importing the FMUs rely on functionality specific to the simulator environment, this approach tries to provide a generic Modelica interface for embedding an FMU to be imported into a Modelica model. In this way any FMU conforming to the Functional Mock-up Interface (FMI) for Model Exchange v1.0 Specification for model exchange from MODELISAR can be imported into any Modelica simulator. When importing an FMU into a model, the resulting Modelica model can be used just like any pure Modelica models. Hence, a better reusability and interoperability for both sides, namely the external models provided via FMI and the Modelica environment, are achieved.
  •  
5.
  •  
6.
  • Wang, Hui, et al. (författare)
  • A coding IRAK2 variant compromises TLR signaling and is associated with colorectal cancer survival.
  • 2014
  • Ingår i: Journal of Biological Chemistry. - 1083-351X. ; 289:33, s. 23123-23131
  • Tidskriftsartikel (refereegranskat)abstract
    • Within innate immune signaling pathways, Interleukin-1 receptor (IL-1R&)-associated kinases (IRAKs) fulfill key roles downstream of multiple Toll-like receptors (TLR) and the IL-1R. Whereas human IRAK4-deficiency was shown to lead to severe immunodeficiency in response to pyogenic bacterial infection during childhood, little is known about the role of human IRAK2. We here identified a non-synonymous IRAK2 variant, rs35060588 (coding R214G), as hypofunctional in terms of NF-κB signaling and TLR-mediated cytokine induction. This was due to reduced ubiquitination of TRAF6, a key step in signal transduction. IRAK2 rs35060588 occurs in 3-9% of individuals in different ethnic groups and our studies uncovered a significant genetic association of rs35060588 with colorectal cancer survival. This for the first time firmly implicates human IRAK2 in human disease and highlights the R214G IRAK2 variant as a potential novel and broadly applicable biomarker for disease or as a therapeutic intervention point.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-6 av 6

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy