| 1. |
|
|
| 2. |
- Langerak, A. W., et al.
(författare)
-
EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations
- 2012
-
Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 26:10, s. 2159-2171
-
Forskningsöversikt (refereegranskat)abstract
- PCR-based immunoglobulin (Ig)/T-cell receptor (TCR) clonality testing in suspected lymphoproliferations has largely been standardized and has consequently become technically feasible in a routine diagnostic setting. Standardization of the pre-analytical and post-analytical phases is now essential to prevent misinterpretation and incorrect conclusions derived from clonality data. As clonality testing is not a quantitative assay, but rather concerns recognition of molecular patterns, guidelines for reliable interpretation and reporting are mandatory. Here, the EuroClonality (BIOMED-2) consortium summarizes important pre- and post-analytical aspects of clonality testing, provides guidelines for interpretation of clonality testing results, and presents a uniform way to report the results of the Ig/TCR assays. Starting from an immunobiological concept, two levels to report Ig/TCR profiles are discerned: the technical description of individual (multiplex) PCR reactions and the overall molecular conclusion for B and T cells. Collectively, the EuroClonality (BIOMED-2) guidelines and consensus reporting system should help to improve the general performance level of clonality assessment and interpretation, which will directly impact on routine clinical management (standardized best-practice) in patients with suspected lymphoproliferations.
|
|
| 3. |
- Flohr, E. L. R., et al.
(författare)
-
THE FATE OF THE INNER NOSE : ODOR IMAGERY IN PATIENTS WITH OLFACTORY LOSS
- 2014
-
Ingår i: Neuroscience. - : Elsevier BV. - 0306-4522 .- 1873-7544. ; 268, s. 118-127
-
Tidskriftsartikel (refereegranskat)abstract
- Cerebral activations during olfactory mental imagery are fairly well investigated in healthy participants but little attention has been given to olfactory imagery in patients with olfactory loss. To explore whether olfactory loss leads to deficits in olfactory imagery, neural responses using functional magnetic resonance imaging (fMRI) and self-report measures were investigated in 16 participants with acquired olfactory loss and 19 control participants. Participants imagined both pleasant and unpleasant odors and their visual representations. Patients reported less vivid olfactory but not visual images than controls. Results from neuroimaging revealed that activation patterns differed between patients and controls. While the control group showed stronger activation in olfactory brain regions for unpleasant compared to pleasant odors, the patient group did not. Also, activation in critical areas for olfactory imagery was correlated with the duration of olfactory dysfunction, indicating that the longer the duration of dysfunction, the more the attentional resources were employed. This indicates that participants with olfactory loss have difficulties to perform olfactory imagery in the conventional way. Regular exposure to olfactory information may be necessary to maintain an olfactory imagery capacity.
|
|
| 4. |
- Meyer, H., et al.
(författare)
-
VANET mobility modeling challenged by feedback loops
- 2011
-
Ingår i: IFIP Annu. Mediterr. Ad Hoc Networking Workshop, Med-Hoc-Net. - 9781457709005 ; , s. 95-102
-
Konferensbidrag (refereegranskat)abstract
- VANET applications are often providing street traffic information to vehicles and drivers, regarding, for instance, traffic conditions and parking space availability. This information influences in turn the driving behavior in real-world settings. Mobility models used in current VANET simulations are mostly ignoring this feedback entirely. In cases the feedback is included, it is mainly based on ad-hoc approaches with lack of generality.
|
|
| 5. |
|
|
