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Severe fatigue and ...
Severe fatigue and memory impairment are associated with lower serum level of anti-SARS-CoV-2 antibodies in patients with Post-COVID symptoms
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- Molnar, Tihamer (författare)
- Department of Anaesthesiology and Intensive Care, University of Pecs, Medical School, Pecs, Hungary
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- Varnai, Reka (författare)
- Department of Primary Health Care, University of Pecs, Medical School, Pecs, Hungary
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- Schranz, Daniel (författare)
- Department of Neurology, University of Pecs, Medical School, Pecs, Hungary
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- Zavori, Laszlo (författare)
- Salisbury NHS Foundation Trust, Salisbury, United Kingdom
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- Peterfi, Zoltan (författare)
- 1st Department of Internal Medicine, Division of Infectology, University of Pecs, Medical School, Pecs, Hungary
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- Sipos, David (författare)
- 1st Department of Internal Medicine, Division of Infectology, University of Pecs, Medical School, Pecs, Hungary
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- Tőkés-Füzesi, Margit (författare)
- Department of Laboratory Medicine, University of Pecs, Medical School, Pecs, Hungary
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- Illes, Zsolt (författare)
- Department of Neurology, Odense University Hospital, University of Southern Denmark, Odense, Denmark
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- Büki, Andras, 1966- (författare)
- Department of Neurosurgery, University of Pecs, Medical School, Pecs, Hungary
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- Csecsei, Peter (författare)
- Department of Neurosurgery, University of Pecs, Medical School, Pecs, Hungary
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(creator_code:org_t)
- 2021-09-23
- 2021
- Engelska.
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Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 10:19, s. 4337-4337
- Relaterad länk:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: Post-COVID manifestation is defined as persistent symptoms or long-term complications beyond 4 weeks from disease onset. Fatigue and memory impairment are common post-COVID symptoms. We aimed to explore associations between the timeline and severity of post-COVID fatigue and anti-SARS-CoV-2 antibodies.Methods: Fatigue and memory impairment were assessed in a total of 101 post-COVID subjects using the Chalder fatigue scale (CFQ-11) and a visual analogue scale. Using the bimodal scoring system generated from CFQ-11, a score ≥4 was defined as severe fatigue. Serum anti-SARS-CoV-2 spike (anti-S-Ig) and nucleocapsid (anti-NC-Ig) antibodies were examined at two time points: 4-12 weeks after onset of symptoms, and beyond 12 weeks.Results: The serum level of anti-S-Ig was significantly higher in patients with non-severe fatigue compared to those with severe fatigue at 4-12 weeks (p = 0.006) and beyond 12 weeks (p = 0.016). The serum level of anti-NC-Ig remained high in patients with non-severe fatigue at both time points. In contrast, anti-NC-Ig decreased significantly in severe fatigue cases regardless of the elapsed time (4-12 weeks: p = 0.024; beyond 12 weeks: p = 0.005). The incidence of memory impairment was significantly correlated with lower anti-S-Ig levels (-0.359, p < 0.001).Conclusion: The systemic immune response reflected by antibodies to SARS-CoV-2 is strongly correlated with the severity of post-COVID fatigue.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- anti-SARS-CoV-2 nucleocapsid Ig
- anti-SARS-CoV-2 spike Ig
- memory impairment
- post-COVID fatigue
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Molnar, Tihamer
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Varnai, Reka
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Schranz, Daniel
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Zavori, Laszlo
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Peterfi, Zoltan
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Sipos, David
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Tőkés-Füzesi, Ma ...
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Illes, Zsolt
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Büki, Andras, 19 ...
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Csecsei, Peter
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