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- Thorgeirsson, Thorgeir E, et al.
(författare)
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A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
- 2008
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 452:7187, s. 9-638
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Tidskriftsartikel (refereegranskat)abstract
- Smoking is a leading cause of preventable death, causing about 5 million premature deaths worldwide each year(1,2). Evidence for genetic influence on smoking behaviour and nicotine dependence (ND)(3-8) has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important to public health(9,10). Smoking is the major risk factor for lung cancer (LC)(11-14) and is one of the main risk factors for peripheral arterial disease (PAD)(15-17). Here we identify a common variant in the nicotinic acetylcholine receptor gene cluster on chromosome 15q24 with an effect on smoking quantity, ND and the risk of two smoking- related diseases in populations of European descent. The variant has an effect on the number of cigarettes smoked per day in our sample of smokers. The same variant was associated with ND in a previous genomewide association study that used low- quantity smokers as controls(18,19), and with a similar approach we observe a highly significant association with ND. A comparison of cases of LC and PAD with population controls each showed that the variant confers risk of LC and PAD. The findings provide a case study of a gene - environment interaction(20), highlighting the role of nicotine addiction in the pathology of other serious diseases.
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- Golubev, Pavel, et al.
(författare)
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Pion Emission in H-2,C-12,Al-27(gamma,pi+) Reactions at Threshold
- 2008
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Ingår i: Nuclear Physics, Section A. - : Elsevier BV. - 0375-9474 .- 1873-1554. ; 806:1-4, s. 216-229
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Tidskriftsartikel (refereegranskat)abstract
- The very first data from MAX-lab in Lund, Sweden on pion photoproduction at threshold energies are presented. The decrease of the total π+ yield in γ+12C, 27Al reactions below 200 MeV as well as the dσ/dΩ cross-section data essentially follow the predictions of an intranuclear-cascade model with an attractive potential for the pion–nucleus interaction. However, View the MathML source, cross-section data at 176 MeV show deviations which call for refinements of the model and possibly also for the inclusion of coherent pion-production mechanisms.
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- Divine, D. V., et al.
(författare)
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Deuterium excess record from a small Arctic ice cap
- 2008
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 113:D19, s. D19104-
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we present a deuterium excess (d) record from an ice core drilled on a small ice cap in Svalbard in 1997. The core site is located at Lomonosovfonna at 1255 m asl, and the analyzed time series spans the period 1400-1990 A. D. The record shows pronounced multidecadal to centennial-scale variations coherent with sea surface temperature changes registered in the subtropical to southern middle-latitude North Atlantic during the instrumental period. We interpret the negative trend in the deuterium excess during the 1400s and 1500s as an indication of cooling in the North Atlantic associated with the onset of the Little Ice Age. Consistently positive anomalies of d after 1900, peaking at about 1950, correspond with well-documented contemporary warming. Yet the maximum values of deuterium excess during 1900-1990 are not as high as in the early part of the record (pre-1550). This suggests that the sea surface temperatures during this earlier period of time in the North Atlantic to the south of approximately 45 degrees N were at least comparable with those registered in the 20th century before the end of the 1980s. We examine the potential for a cold bias to exist in the deuterium excess record due to increased evaporation from the local colder sources of moisture having isotopically cold signature. It is argued that despite a recent oceanic warming, the contribution from this local moisture to the Lomonosovfonna precipitation budget is still insufficient to interfere with the isotopic signal from the primary moisture region in the midlatitude North Atlantic.
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- Feldman, G., et al.
(författare)
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Compton scattering from deuterium and the polarizabilities of the neutron
- 2008
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Ingår i: Few-Body Systems. - : Springer Science and Business Media LLC. - 0177-7963 .- 1432-5411. ; 44:1-4, s. 325-328
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Konferensbidrag (refereegranskat)abstract
- A new program of Compton scattering on deuterium is under way at the tagged-photon facility at MAX-Lab in Lund, Sweden. We will measure differential cross sections between 60A degrees and 150A degrees over the photon energy range 60-115 MeV in 5 MeV steps, with the ultimate goal of obtaining new precision information on the electric and magnetic polarizabilities of the neutron.
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- Isaksson, Alf J., et al.
(författare)
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Reglering over trådlös länk
- 2008
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Ingår i: Reglermöte 2008. - Luleå : Luleå tekniska universitet.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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