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Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFR alpha in Adult Brain
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- Dang, Thanh Chung (author)
- Univ Toyama, Grad Sch Med & Pharmaceut Sci, Dept Pathol, Toyama 9300194, Japan
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- Ishii, Yoko (author)
- Univ Toyama, Grad Sch Med & Pharmaceut Sci, Dept Pathol, Toyama 9300194, Japan;Univ Nagano, Fac Hlth & Human Dev, Dept Hlth Sci, Nagano 3808525, Japan
- Nguyen, Van De (author)
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- Nguyen, Quang Linh (author)
- , an De Nguyen (author)
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- (creator_code:org_t)
- CELL PRESS, 2019
- 2019
- English.
- In: Cell Reports. - : CELL PRESS. - 2211-1247. ; 27:4, s. 1073-1089
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Oligodendrocyte progenitor cells (OPCs) are widely distributed cells of ramified morphology in adult brain that express PDGFR alpha and NG2. They retain mitotic activities in adulthood and contribute to oligodendrogenesis and myelin turnover; however, the regulatory mechanisms of their cell dynamics in adult brain largely remain unknown. Here, we found that global Pdgfra inactivation in adult mice rapidly led to elimination of OPCs due to synchronous maturation toward oligodendrocytes. Surprisingly, OPC densities were robustly reconstituted by the active expansion of Nestin(+) immature cells activated in meninges and brain parenchyma, as well as a few OPCs that escaped from Pdgfra inactivation. The multipotent immature cells were induced in the meninges of Pdgfra-inactivated mice, but not of control mice. Our findings revealed powerful homeostatic control of adult OPCs, engaging dual cellular sources of adult OPC formation. These properties of the adult oligodendrocyte lineage and the alternative OPC source may be exploited in regenerative medicine.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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