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- Persson, U, et al.
(författare)
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The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation.
- 1998
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Ingår i: FEBS letters. - 0014-5793. ; 434:1-2, s. 83-7
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Tidskriftsartikel (refereegranskat)abstract
- Transforming growth factor-beta (TGF-beta) and bone morphogenetic proteins (BMPs) signal via distinct type I and type II receptors and Smad proteins. A nine amino acid sequence between kinase subdomains IV and V in type I receptors, termed the L45 loop, has been shown to be important in conferring signalling specificity. We examined the responses of a mutant TGF-beta type I receptor (TbetaR-I) and a mutant BMPR-IB, in which the L45 regions of these two receptors were exchanged. Swapping the four amino acid residues that are different in BMPR-IB for those in TbetaR-I, and vice versa, switched their type I receptor-restricted Smad activation and specificity in transcriptional responses. These studies identify the L45 loop regions in type I receptors as critical determinants in specifying Smad isoform activation.
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