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| 2. |
- Abe, K., et al.
(författare)
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J-PARC Neutrino Beamline Upgrade Technical Design Report
- 2019
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Rapport (refereegranskat)abstract
- In this document, technical details of the upgrade plan of the J-PARC neutrino beamline for the extension of the T2K experiment are described. T2K has proposed to accumulate data corresponding to 2×1022 protons-on-target in the next decade, aiming at an initial observation of CP violation with 3σ or higher significance in the case of maximal CP violation. Methods to increase the neutrino beam intensity, which are necessary to achieve the proposed data increase, are described.
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| 3. |
- Narangifard, A., et al.
(författare)
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Human skin barrier formation takes place via a cubic to lamellar lipid phase transition as analyzed by cryo-electron microscopy and EM-simulation
- 2018
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Ingår i: Experimental Cell Research. - : Elsevier BV. - 0014-4827 .- 1090-2422. ; 366:2, s. 139-151
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Tidskriftsartikel (refereegranskat)abstract
- The skin's permeability barrier consists of stacked lipid sheets of splayed ceramides, cholesterol and free fatty acids, positioned intercellularly in the stratum corneum. We report here on the early stage of skin barrier formation taking place inside the tubuloreticular system in the secretory cells of the topmost viable epidermis and in the intercellular space between viable epidermis and stratum corneum. The barrier formation process was analysed in situ in its near-native state, using cryo-EM combined with molecular dynamics modeling and EM simulation. Stacks of lamellae appear towards the periphery of the tubuloreticular system and they are closely associated with granular regions. Only models based on a bicontinuous cubic phase organization proved compatible with the granular cryo-EM patterns. Only models based on a dehydrated lamellar phase organization agreed with the lamellar cryo-EM patterns. The data support that human skin barrier formation takes place via a cubic to lamellar lipid phase transition.
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| 4. |
- Reinardy, Benedict T. I., et al.
(författare)
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Repeated advance and retreat of the East Antarctic Ice Sheet on the continental shelf during the early Pliocene warm period
- 2015
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Ingår i: Palaeogeography, Palaeoclimatology, Palaeoecology. - : Elsevier BV. - 0031-0182 .- 1872-616X. ; 422, s. 65-84
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Tidskriftsartikel (refereegranskat)abstract
- Diatom analysis of a sediment core recovered at IODP Site U1358 on the continental shelf off the Adélie Coast indicated that the lower section of the core contained an assemblage dating back to the Thalassiosira innura Zone of the lower Pliocene that ranges from 4.2 to 5.12. Ma. Based on lithological descriptions at both a macro- and micro-scale of this early Pliocene part of the core, four facies were interpreted from the diamictons representing the progressive advance and retreat of the grounding line over the site. Facies 1a and 1b contain a distinct directional signal from the orientation of the a-axis of clasts with several phases of fabric development along with both brittle and ductile deformation features that are common in sediments that have been subglacially deformed. Facies 1c and 1d are finely laminated and were deposited in open marine conditions. The four facies within the depositional model provide for the first time direct evidence for ice advancing across the shelf adjacent to the Wilkes Subglacial Basin on at least four occasions separated by three periods of open marine conditions indicating retreat of grounded ice inland of the site during a warmer than present early Pliocene. The times of open marine conditions are correlated with previous findings from the neighbouring rise sites that also indicated an oscillating ice margin. This has significant implications because firstly it suggests a dynamic East Antarctic Ice Sheet (EAIS) that is probably far more sensitive to climatic and oceanic forcing even during relatively short time periods than had previously been thought. Secondly it suggests that proxies used to interpret the advance and retreat of the grounding line from the rise can be linked with direct evidence of grounding line migration from the shelf. It also has important implications for the future behaviour and sensitivity of the EAIS under present continuing warming conditions. Together with results from the rise, this paper provides a crucial ice extent target for a new ice sheet model of this region during the Pliocene.
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