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- Cronhjort, M, et al.
(författare)
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Influence of the phosphate balance on the activity distribution of 99mTc-hydroxy-methylene diphosphonate. Experimental studies in the mouse
- 1998
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Ingår i: Acta radiologica (Stockholm, Sweden : 1987). - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 39:4, s. 427-433
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The purpose was to determine whether changes in the phosphate balance have an influence on the distribution of bone-seeking radiopharmaceuticals. Material and Methods: The biodistribution of 99mTc-HDP in mice, intravenously administered under varying conditions, was assessed by removing different organs and estimating their activity in a scintillation counter. Some experiments were also performed with 99mTc-MDP and 99mTc-DPD. Results: After 1 h and 18 h on phosphate-enriched drinking water, the mice showed a strongly increased uptake in all organs/tissues representing background activity and a decrease in the bone uptake. This pattern changed with time. After 6–8 days of phosphate load, we saw a more favourable distribution with a reduction of the background and whole-body activity. Administration of hPTH 1–34 gave rise to an activity distribution similar to that after 6–8 days on phosphate-enriched water. Changing the phosphate balance had less obvious effects on the distribution of 99mTc-MDP and 99mTc-DPD. Conclusion: The activity distribution of bone-seeking radiopharmaceuticals in the mouse is affected by the phosphate balance. The mechanism behind this finding is unknown but it may be partially mediated by PTH. It is possible that changes in the phosphate balance, induced by pharmaceuticals or by dietary changes, may affect the image quality at bone scintigraphy.
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- Cronhjort, M, et al.
(författare)
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Sympathotropic drugs and the distribution of 99mTc-hydroxymethylene diphosphonate. Experimental studies in the mouse
- 1999
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Ingår i: Acta radiologica (Stockholm, Sweden : 1987). - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 40:3, s. 309-313
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Tidskriftsartikel (refereegranskat)abstract
- Objective: the uptake of bone-seeking radiopharmaceuticals depends on the blood flow, which is influenced by the sympathetic nervous system. Our aim was to study the effect of sympathomimetic drugs on the distribution of bone-seeking agents. Material and Methods: Various sympathomimetic and β-blocking drugs were injected in mice at different times in relation to the administration of 99mTc-HDP Three hours after this, venous blood and various organs were removed and their activities were related to the administered activity. A kinetic study of the whole-body activity retention after administration of terbutaline was also made. Results: the biodistribution of 99mTc-HDP was similar after the administration of sympathomimetics and of β-antagonists. All drugs gave rise to an increased soft tissue activity and a decreased bone activity, corresponding to a lowered quality of the potential bone scan. Terbutaline gave rise to an increased excretion of 99mTc-HDP. the mechanisms behind the findings cannot be entirely explained. Conclusion: Drug interference with the sympathetic nervous system causes undesirable effects on the biodistribution of 99mTc-HDP in the mouse. Studies in humans are necessary to evaluate whether clinical treatment with sympathotropic drugs affects the bone scintigram.
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- Jacobsson, H, et al.
(författare)
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Concentration of 123I-metaiodobenzylguanidine in left and right liver lobes. Findings indicate regional differences in function in the normal liver
- 1999
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Ingår i: Acta radiologica (Stockholm, Sweden : 1987). - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 40:2, s. 224-228
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Normal radioactivity in the liver is often shown to be higher in the left lobe than in the right lobe at clinical examination by single photon emission computed tomography (SPECT) with 123I-metaiodobenzylguanidine (123I-MIBG). Our objective was to determine whether this represents a pathological condition. Material and Methods: The distribution of 123I-MIBG in the liver was retrospectively studied in clinical patients who had normal CT examinations of the liver and spleen. In the SPECT sections of 27 123I-MIBG examinations, we determined the activity ratios between the left and right lobes. The control group comprised 33 examinations with 111In-pentetreotide (OctreoScan) and 23 examinations with 99mTc-antigranulocyte antibody. Results: The mean activity ratio between left and right lobes for 123I-MIBG was 1.24, and for 111In-pentetreotide 0.87. These figures differed significantly both from each other and from 1.00. The mean ratio for 99mTc-antibody at the early examinations was 0.99, and at the late examinations 0.95. These figures differed significantly from the values for 123I-MIBG and 111In-pentetreotide. Conclusion: The increased concentration of 123I-MIBG in the left lobe of the liver compared to the right lobe is a normal finding. The reason for this cannot be explained. The difference in the way in which the left and right lobes deal with the three radiopharmaceuticals is a new finding and indicates a regional difference in liver function that has not been reported previously.
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- Jonsson, C, et al.
(författare)
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Sweat glands accumulate Tc-99m MIBI
- 1996
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Ingår i: Clinical nuclear medicine. - : Ovid Technologies (Wolters Kluwer Health). - 0363-9762. ; 21:8, s. 612-614
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Tidskriftsartikel (refereegranskat)
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- Lundqvist, Roger, et al.
(författare)
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Classification of Functional Patterns in SPECT Brain Scans Based on Partial Least Squares Analysis
- 1999
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Ingår i: Proceedings of SCIA'99. - : Pattern Recognition Society of Denmark, Lyngby. - 8788306429 ; , s. 375-381
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Konferensbidrag (refereegranskat)abstract
- The main purpose of this paper is to show the potential of the partial least squares (PLS) method for finding image descriptors which can be used for classification of clinical single photon emission computed tomography SPECT neuroimaging data. In this ar
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- Mattsson, B., et al.
(författare)
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Raman scattering investigations of PEO and PPO sulphonic acids
- 1997
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Ingår i: Solid State Ionics. - : Elsevier. - 0167-2738 .- 1872-7689. ; 97:1-4, s. 309-314
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Tidskriftsartikel (refereegranskat)abstract
- Sulphonic acid derivatives of polyethers, of interest as proton conducting materials, were investigated using Raman spectroscopy, focusing on influence of hydration on ion configuration and polymer conformation. Upon increasing hydration we observe a polarised mode building up at approximately 1040 cm-1, assigned to the symmetric stretching vibration of a completely hydrated SO3- group. The data suggest that the proton-sulphonic groups do not dissociate until the materials are considerably hydrated thus explaining the low proton conductivities found for these materials below a relative humidity of 75%.
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