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Sökning: WFRF:(Jankowski Michal) > (2006-2009)

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1.
  • Benetkiewicz, Magdalena, et al. (författare)
  • Chromosome 22 array-CGH profiling of breast cancer delimited minimal common regions of genomic imbalances and revealed frequent intra-tumoral genetic heterogeneity
  • 2006
  • Ingår i: International Journal of Oncology. - 1019-6439 .- 1791-2423. ; 29:4, s. 935-945
  • Tidskriftsartikel (refereegranskat)abstract
    • Breast cancer is a common malignancy and the second most frequent cause of death among women. Our aim was to perform DNA copy number profiling of 22q in breast tumors using a methodology which is superior, as compared to the ones applied previously. We studied 83 biopsies from 63 tumors obtained from 60 female patients. A general conclusion is that multiple distinct patterns of genetic aberrations were observed, which included deletion(s) and/or gain(s), ranging in size from affecting the whole chromosome to only a few hundred kb. Overall, the analysis revealed genomic imbalances of 22q in 22% (14 out of 63) of tumors. The predominant profile (11%) was monosomy 22. The smallest identified candidate region, in the vicinity of telomere of 22q, encompasses approximately 220 kb and was involved in all but one of the tumors with aberrations on chromosome 22. This segment is dense in genes and contains 11 confirmed and one predicted gene. The availability of multiple biopsies from a single tumor provides an excellent opportunity for analysis of possible intra-tumor differences in genetic profiles. In 15 tumors we had access to two or three biopsies derived from the same lesion and these were studied independently. Four out of 15 (26.6%) tumors displayed indications of clonal intra-tumor genotypic differences, which should be viewed as a high number, considering that we studied in detail only a single human chromosome. Our results open up several avenues for continued genetic research of breast cancer.
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2.
  • Jankowski, Michal, et al. (författare)
  • Authorizing Grid Resource Access and Consumption
  • 2009
  • Ingår i: Grid and Services Evolution. - Boston, MA : Springer-Verlag. - 9780387859651 - 0387859659 ; , s. 157-168
  • Konferensbidrag (refereegranskat)abstract
    • The tasks to authorize users access to grid resources and to authorize their regulated consumption is studied and some key functionality is identified. A novel authorization infrastructure is proposed by combining the Virtual User System (VUS) for dynamically assigning local pool-accounts to grid-users and the SweGrid Accounting System (SGAS) for grid-wide usage logging and real-time enforcement of resource pre-allocations.
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