| 1. |
- Aad, G., et al.
(författare)
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Readiness of the ATLAS Tile Calorimeter for LHC collisions
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:4, s. 1193-1236
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Tidskriftsartikel (refereegranskat)abstract
- The Tile hadronic calorimeter of the ATLAS detector has undergone extensive testing in the experimental hall since its installation in late 2005. The readout, control and calibration systems have been fully operational since 2007 and the detector has successfully collected data from the LHC single beams in 2008 and first collisions in 2009. This paper gives an overview of the Tile Calorimeter performance as measured using random triggers, calibration data, data from cosmic ray muons and single beam data. The detector operation status, noise characteristics and performance of the calibration systems are presented, as well as the validation of the timing and energy calibration carried out with minimum ionising cosmic ray muons data. The calibration systems' precision is well below the design value of 1%. The determination of the global energy scale was performed with an uncertainty of 4%.
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| 2. |
- Aad, G., et al.
(författare)
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Studies of the performance of the ATLAS detector using cosmic-ray muons
- 2011
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 71:3
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Tidskriftsartikel (refereegranskat)abstract
- Muons from cosmic-ray interactions in the atmosphere provide a high-statistics source of particles that can be used to study the performance and calibration of the ATLAS detector. Cosmic-ray muons can penetrate to the cavern and deposit energy in all detector subsystems. Such events have played an important role in the commissioning of the detector since the start of the installation phase in 2005 and were particularly important for understanding the detector performance in the time prior to the arrival of the first LHC beams. Global cosmic-ray runs were undertaken in both 2008 and 2009 and these data have been used through to the early phases of collision data-taking as a tool for calibration, alignment and detector monitoring. These large datasets have also been used for detector performance studies, including investigations that rely on the combined performance of different subsystems. This paper presents the results of performance studies related to combined tracking, lepton identification and the reconstruction of jets and missing transverse energy. Results are compared to expectations based on a cosmic-ray event generator and a full simulation of the detector response.
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| 3. |
- Aad, G., et al.
(författare)
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The ATLAS Inner Detector commissioning and calibration
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 787-821
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Tidskriftsartikel (refereegranskat)abstract
- The ATLAS Inner Detector is a composite tracking system consisting of silicon pixels, silicon strips and straw tubes in a 2 T magnetic field. Its installation was completed in August 2008 and the detector took part in data-taking with single LHC beams and cosmic rays. The initial detector operation, hardware commissioning and in-situ calibrations are described. Tracking performance has been measured with 7.6 million cosmic-ray events, collected using a tracking trigger and reconstructed with modular pattern-recognition and fitting software. The intrinsic hit efficiency and tracking trigger efficiencies are close to 100%. Lorentz angle measurements for both electrons and holes, specific energy-loss calibration and transition radiation turn-on measurements have been performed. Different alignment techniques have been used to reconstruct the detector geometry. After the initial alignment, a transverse impact parameter resolution of 22.1 +/- 0.9 mu m and a relative momentum resolution sigma (p) /p=(4.83 +/- 0.16)x10(-4) GeV(-1)xp (T) have been measured for high momentum tracks.
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| 4. |
- Li, Jun, et al.
(författare)
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CFD Approach for Unburned Carbon Reduction in Pulverized Coal Boilers
- 2012
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Ingår i: Energy & Fuels. - : American Chemical Society (ACS). - 0887-0624 .- 1520-5029. ; 26:2, s. 926-937
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Tidskriftsartikel (refereegranskat)abstract
- Low-NO, technologies are widely used in pulverized coal boilers, but they usually produce high levels of carbon in the fly ash. High levels of unburned carbon represent fuel loss, so the overall boiler efficiency is reduced. Additionally, the higher carbon content affects the suitability of fly ash for cement applications. The purpose of this paper is to provide a CFD approach for unburned carbon reduction by optimizing operating conditions. In this paper, three different boiler loads were simulated: 200 MW, 170 MW, and 140 MW. The air supply System was simulated previously for preparing as precise as possible boundary conditions. At last, the unburned carbon level of every burner was investigated, and the effects of residue residence time and the local fuel air momentum ratio are discussed in detail. According to the predicted results, operating conditions and the residence time of the coal particles affects the unburned carbon level in fly ash. Operating conditions play a more significant role during the combustion process, while the residence time affects char burnout only when the burner's location is low. Therefore, it is concluded that a cost-effective method could be developed for reducing the unburned carbon level in ash and correspondingly, the loss on ignition level. First, it is necessary to determine which burners are operating under poor conditions through CFD analysis. Then, the fuel air momentum ratios of those burners should be modified by changing the operating conditions, meanwhile increasing the residence time of coal particles to ensure complete combustion.
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| 5. |
- Poplawski, Andrzej B., et al.
(författare)
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Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression
- 2010
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Ingår i: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 18:5, s. 560-568
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer is a major cause of morbidity and mortality in women and its metastatic spread is the principal reason behind the fatal outcome. Metastasis-related research of breast cancer is however underdeveloped when compared with the abundant literature on primary tumors. We applied an unexplored approach comparing at high resolution the genomic profiles of primary tumors and synchronous axillary lymph node metastases from 13 patients with breast cancer. Overall, primary tumors displayed 20% higher number of aberrations than metastases. In all but two patients, we detected in total 157 statistically significant differences between primary lesions and matched metastases. We further observed differences that can be linked to metastatic disease and there was also an overlapping pattern of changes between different patients. Many of the differences described here have been previously linked to poor patient survival, suggesting that this is a viable approach toward finding biomarkers for disease progression and definition of new targets useful for development of anticancer drugs. Frequent genetic differences between primary tumors and metastases in breast cancer also question, at least to some extent, the role of primary tumors as a surrogate subject of study for the systemic disease. European Journal of Human Genetics (2010) 18, 560-568; doi:10.1038/ejhg.2009.230; published online 6 January 2010
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| 6. |
- Razzaghian, Hamid Reza, et al.
(författare)
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Post-Zygotic and Inter-Individual Structural Genetic Variation in a Presumptive Enhancer Element of the Locus between the IL10Rβ and IFNAR1 Genes
- 2013
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:9, s. e67752-
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Tidskriftsartikel (refereegranskat)abstract
- Although historically considered as junk-DNA, tandemly repeated sequence motifs can affect human phenotype. For example, variable number tandem repeats (VNTR) with embedded enhancers have been shown to regulate gene transcription. The post-zygotic variation is the presence of genetically distinct populations of cells in an individual derived from a single zygote, and this is an understudied aspect of genome biology. We report somatically variable VNTR with sequence properties of an enhancer, located upstream of IFNAR1. Initially, SNP genotyping of 63 monozygotic twin pairs and multiple tissues from 21 breast cancer patients suggested a frequent post-zygotic mosaicism. The VNTR displayed a repeated 32 bp core motif in the center of the repeat, which was flanked by similar variable motifs. A total of 14 alleles were characterized based on combinations of segments, which showed post-zygotic and inter-individual variation, with up to 6 alleles in a single subject. Somatic variation occurred in similar to 24% of cases. In this hypervariable region, we found a clustering of transcription factor binding sites with strongest sequence similarity to mouse Foxg1 transcription factor binding motif. This study describes a VNTR with sequence properties of an enhancer that displays post-zygotic and inter-individual genetic variation. This element is within a locus containing four related cytokine receptors: IFNAR2, IL10R beta, IFNAR1 and IFNGR2, and we hypothesize that it might function in transcriptional regulation of several genes in this cluster. Our findings add another level of complexity to the variation among VNTR-based enhancers. Further work may unveil the normal function of this VNTR in transcriptional control and its possible involvement in diseases connected with these receptors, such as autoimmune conditions and cancer.
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| 7. |
- Aad, G., et al.
(författare)
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- 2011
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swepub:Mat__t (refereegranskat)
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| 8. |
- Aad, G., et al.
(författare)
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- 2011
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Tidskriftsartikel (refereegranskat)
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| 9. |
- Aad, G., et al.
(författare)
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- 2012
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swepub:Mat__t (refereegranskat)
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| 10. |
- Aad, G., et al.
(författare)
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- 2012
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| 11. |
- Aad, G., et al.
(författare)
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- 2011
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| 12. |
- Aad, G., et al.
(författare)
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- 2013
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swepub:Mat__t (refereegranskat)
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| 13. |
- Aad, G., et al.
(författare)
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- 2012
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swepub:Mat__t (refereegranskat)
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| 14. |
- Aad, G., et al.
(författare)
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- 2012
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swepub:Mat__t (refereegranskat)
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| 15. |
- Aad, G., et al.
(författare)
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- 2012
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swepub:Mat__t (refereegranskat)
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| 16. |
- Aad, G., et al.
(författare)
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- 2012
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swepub:Mat__t (refereegranskat)
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| 17. |
- Aad, G., et al.
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- 2012
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swepub:Mat__t (refereegranskat)
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| 18. |
- Aad, G., et al.
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- 2012
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swepub:Mat__t (refereegranskat)
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| 19. |
- Aad, G., et al.
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- 2012
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| 20. |
- Aad, G., et al.
(författare)
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- 2011
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| 21. |
- Aad, G., et al.
(författare)
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- 2011
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| 22. |
- Aad, G., et al.
(författare)
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- 2011
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| 23. |
- Aad, G., et al.
(författare)
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- 2011
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swepub:Mat__t (refereegranskat)
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| 24. |
- Aad, G., et al.
(författare)
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- 2012
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swepub:Mat__t (refereegranskat)
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| 25. |
- Aad, G., et al.
(författare)
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- 2012
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| 26. |
- Aad, G., et al.
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- 2012
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| 27. |
- Aad, G., et al.
(författare)
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- 2013
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| 28. |
- Aad, G., et al.
(författare)
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- 2012
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| 29. |
- Aad, G., et al.
(författare)
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- 2012
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| 30. |
- Aad, G., et al.
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- 2012
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swepub:Mat__t (refereegranskat)
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| 31. |
- Aad, G., et al.
(författare)
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- 2011
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| 32. |
- Aad, G., et al.
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- 2012
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| 33. |
- Aad, G., et al.
(författare)
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- 2011
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| 34. |
- Aad, G., et al.
(författare)
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- 2011
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| 35. |
- Aad, G., et al.
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- 2012
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| 36. |
- Aad, G., et al.
(författare)
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- 2011
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| 37. |
- Aad, G., et al.
(författare)
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- 2011
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| 38. |
- Aad, G., et al.
(författare)
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- 2012
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| 39. |
- Aad, G., et al.
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- 2011
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| 40. |
- Aad, G., et al.
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- 2011
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swepub:Mat__t (refereegranskat)
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| 41. |
- Aad, G., et al.
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- 2012
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| 42. |
- Aad, G., et al.
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- 2011
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| 43. |
- Aad, G., et al.
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- 2011
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| 44. |
- Aad, G., et al.
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- 2012
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| 45. |
- Aad, G., et al.
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- 2011
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| 46. |
- Aad, G., et al.
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- 2011
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| 47. |
- Aad, G., et al.
(författare)
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- 2011
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| 48. |
- Aad, G., et al.
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- 2012
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| 49. |
- Aad, G., et al.
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- 2011
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| 50. |
- Aad, G., et al.
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- 2011
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