| 1. |
- Villa, Luisa L., et al.
(författare)
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Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18
- 2006
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Ingår i: Vaccine. - : Elsevier BV. - 1873-2518 .- 0264-410X. ; 24:27-28, s. 5571-5583
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Tidskriftsartikel (refereegranskat)abstract
- Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenicity in baseline HPV 6/11/16 or 18-naive and previously infected subjects. All three formulations were highly immunogenic. At Month 2 (postdose 1), among women with vaccine-type antibodies at baseline, vaccine-induced anti-HPV responses were similar to 12- to 26-fold higher than those observed in baseline-naive women, suggesting an anamnestic response. Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported. (c) 2006 Elsevier Ltd. All rights reserved.
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| 2. |
- Krockenberger, Y., et al.
(författare)
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Sr2CrOsO6 : End point of a spin-polarized metal-insulator transition by 5d band filling
- 2007
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 75:2, s. 020404-
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Tidskriftsartikel (refereegranskat)abstract
- In the search for new spintronic materials with high spin polarization at room temperature, we have synthesized an osmium-based double perovskite with a Curie temperature of 725 K. Our combined experimental results confirm the existence of a sizable induced magnetic moment at the Os site, supported by band-structure calculations, in agreement with a proposed kinetic-energy-driven mechanism of ferrimagnetism in these compounds. The intriguing property of Sr2 CrOs O6 is that it is at the end point of a metal-insulator transition due to 5d band filling and at the same time ferrimagnetism and high-spin polarization are preserved.
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| 3. |
- Raval, Aparna, et al.
(författare)
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Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia
- 2007
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Ingår i: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 129:5, s. 879-890
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Tidskriftsartikel (refereegranskat)abstract
- The heritability of B cell chronic lymphocytic leukemia (CLL) is relatively high; however, no predisposing mutation has been convincingly identified. We show that loss or reduced expression of death-associated protein kinase 1 (DAPK1) underlies cases of heritable predisposition to CLL and the majority of sporadic CLL. Epigenetic silencing of DAPK1 by promoter methylation occurs in almost all sporadic CLL cases. Furthermore, we defined a disease haplotype, which segregates with the CLL phenotype in a large family. DAPK1 expression of the CLL allele is downregulated by 75% in germline cells due to increased HOXB7 binding. In the blood cells from affected family members, promoter methylation results in additional loss of DAPK1 expression. Thus, reduced expression of DAPK1 can result from germline predisposition, as well as epigenetic or somatic events causing or contributing to the CLL phenotype.
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| 4. |
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| 5. |
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| 6. |
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| 7. |
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| 8. |
- Bouskova, Alzbeta, et al.
(författare)
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The effect of operational temperature on dewatering characteristics of digested sludge
- 2006
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Ingår i: Journal of Residuals Science and Technology. - 1544-8053. ; 3:1, s. 43-49
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Tidskriftsartikel (refereegranskat)abstract
- Dewatering properties and sludge structure of anaerobically digested sludge were studied in relation to an increasing operational temperature. Sludge samples were taken from 5 pilot-scale CSTR reactors treating municipal sewage sludge with working volume of 20 L and operating at 33, 35, 37, 39 and 55 degrees C, respectively. The main parameters of interest were capillary suction time (CST), concentration of extracellular polymeric substances (EPS), charge density of the extracted EPS, filterability (dry solids content after vacuum filtration), compactibility (dry solids content after pressing) and concentration of fine particles in the liquid phase (turbidity). Sludge from the reactor working at 55 degrees C (thermophilic) contained the most fine particles in the liquid phase, which remarkably deteriorated filterability of the sample, however when subjected to an external pressure, the sludge reached the highest dry matter content of the sludge cake. Sludge originating from the reactor working at 37 degrees C reached the best filtration properties.
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| 9. |
- Dinnebier, R., et al.
(författare)
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Crystal structures of the trifluoromethyl sulfonates M(SO3CF3)(2) (M = Mg, Ca, Ba, Zn, Cu) from synchrotron X-ray powder diffraction data
- 2006
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Ingår i: Acta Crystallographica Section B. - 0108-7681 .- 1600-5740. ; 62, s. 467-473
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Tidskriftsartikel (refereegranskat)abstract
- The crystal structures of divalent metal salts of trifluoromethyl sulfonic acid ('trifluoromethyl sulfonates') M( SO3CF3)(2) (M = Mg, Ca, Ba, Zn, Cu) were determined from high-resolution X-ray powder diffraction data. Magnesium, calcium and zinc trifluoromethyl sulfonate crystallize in the rhombohedral space group R (3) over bar . Barium trifluoromethyl sulfonate crystallizes in the monoclinic space group I2= a(C2/c) and copper trifluoromethyl sulfonate crystallizes in the triclinic group P (1) over bar. Within the crystal structures the trifluoromethyl sulfonate anions are arranged in double layers with the apolar CF3 groups pointing towards each other. The cations are located next to the SO3 groups. The symmetry relations between the different crystal structures have been analysed.
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| 10. |
- Hallor, Karolin H, et al.
(författare)
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Genomic profiling of chondrosarcoma: chromosomal patterns in central and peripheral tumors.
- 2009
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Ingår i: Clinical Cancer Research. - 1078-0432. ; 15:8, s. 2685-2694
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Histologic grade is currently the best predictor of clinical course in chondrosarcoma patients. Grading suffers, however, from extensive interobserver variability and new objective markers are needed. Hence, we have investigated DNA copy numbers in chondrosarcomas with the purpose of identifying markers useful for prognosis and subclassification. EXPERIMENTAL DESIGN: The overall pattern of genomic imbalances was assessed in a series of 67 chondrosarcomas using array comparative genomic hybridization. Statistical analyses were applied to evaluate the significance of alterations detected in subgroups based on clinical data, morphology, grade, tumor size, and karyotypic features. Also, the global gene expression profiles were obtained in a subset of the tumors. RESULTS: Genomic imbalances, in most tumors affecting large regions of the genome, were found in 90% of the cases. Several apparently distinctive aberrations affecting conventional central and peripheral tumors, respectively, were identified. Although rare, recurrent amplifications were found at 8q24.21-q24.22 and 11q22.1-q22.3, and homozygous deletions of loci previously implicated in chondrosarcoma development affected the CDKN2A, EXT1, and EXT2 genes. The chromosomal imbalances in two distinct groups of predominantly near-haploid and near-triploid tumors, respectively, support the notion that polyploidization of an initially hyperhaploid/hypodiploid cell population is a common mechanism of chondrosarcoma progression. Increasing patient age as well as tumor grade were associated with adverse outcome, but no copy number imbalance affected metastasis development or tumor-associated death. CONCLUSION: Despite similarities in the overall genomic patterns, the present findings suggest that some regions are specifically altered in conventional central and peripheral tumors, respectively.
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| 11. |
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| 12. |
- Hildebrandt, Lars, et al.
(författare)
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Crystal structure and ionic conductivity of cesium trifluoromethyl sulfonate, CSSO3CF3
- 2005
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Ingår i: Zeitschrift für Anorganische und Allgemeines Chemie. - : Wiley. - 0044-2313 .- 1521-3749. ; 631:9, s. 1660-1666
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Tidskriftsartikel (refereegranskat)abstract
- The crystal structures of the room and the high temperature modifications of cesium trifluoromethyl sulfonate were solved from high resolution X-ray powder diffraction data. At room temperature, alpha-CsSO3CF3 crystallizes in the monoclinic space group P2(1) with lattice parameters a = 9.7406(2) angstrom, b = 6.1640(1) angstrom, c = 5.4798(1) angstrom, and beta = 104.998(1)degrees; Z = 2. At temperatures above T = 380 K, a second order phase transformation towards a disordered C-centered orthorhombic phase in space group Cmcm occurs with lattice parameters at T = 492 K of a = 5.5074(3) angstrom, b = 19.4346(14) angstrom, and c = 6.2978(4) angstrom; Z = 4. Within the crystal structures, the triflate anions are arranged in double layers with the apolar CF3-groups pointing towards each other. The cesium ions are located between the SO3-groups. CsSO3CF3 shows a specific ion conductivity ranging from sigma = 1.06 center dot 10(-8) Scm(-1) at T = 393 K to sigma = 5.18 center dot 10(-4) Scm(-1) at T = 519 K.
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| 13. |
- Hildebrandt, Lars, et al.
(författare)
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Crystal structure and ionic conductivity of three polymorphic phases of rubidium trifluoromethyl sulfonate, RbSO3CF3
- 2006
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Ingår i: Inorganic Chemistry. - : American Chemical Society (ACS). - 0020-1669 .- 1520-510X. ; 45:8, s. 3217-3223
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Tidskriftsartikel (refereegranskat)abstract
- The crystal structures of three polymorphic phases of rubidium trifluoromethyl sulfonate (RbSO3CF3, rubidium 'triflate') were solved from X-ray powder diffraction data. At room temperature, rubidium triflate crystallizes in the monoclinic space group Cm with lattice parameters of a = 19.9611(5) angstrom, b = 23.49113(7) angstrom, c = 5.1514(2) angstrom, beta = 102.758(2)degrees; Z = 16. At T = 321 K, a first-order phase transition occurs toward a monoclinic phase in space group P2(1) with lattice parameters at T = 344 K of a = 10,3434(5) angstrom, b = 5.8283(3) angstrom, c = 5.1982(3) angstrom, beta = 104.278(6)degrees; Z = 2). At T = 461 K, another phase transition, this time of second order, occurs toward an orthorhombic phase in space group Cmcm with lattice parameters at T = 510 K of a = 5.3069(2) angstrom, b = 20.2423(10) angstrom, c = 5.9479(2) angstrom; Z = 4. As a common feature within all three crystal structures of rubidium triflate, the triflate anions are arranged in double layers with the lipophilic CF3 groups facing each other. The rubidium ions are located between the SO3 groups. The general packing is similar to the packing in cesium triflate. Rubidium triflate can be classified as a solid electrolyte with a specific ionic conductivity of sigma = 9.89 x 10(-9) S/cm at T = 384 K and sigma = 3.84 x 10(-6) S/cm at T = 481 K.
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| 14. |
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| 15. |
- Jansen, Anna M, et al.
(författare)
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PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system.
- 2009
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Ingår i: The Journal of comparative neurology. - : Wiley. - 1096-9861 .- 0021-9967. ; 517:3, s. 313-32
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Tidskriftsartikel (refereegranskat)abstract
- The protein interacting with C kinase 1 (PICK1) protein was first identified as a novel binding partner for protein kinase C. PICK1 contains a membrane-binding BAR domain and a PDZ domain interacting with many synaptic proteins, including the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor subunit GluR2 and the dopamine transporter. PICK1 is strongly implicated in GluR2 trafficking and synaptic plasticity. In mammals, PICK1 has been characterized extensively in cell culture studies. To study PICK1 in an intact system, we characterized PICK1 expression immunohistochemically in the adult and larval Drosophila central nervous system. PICK1 was found in cell bodies in the subesophageal ganglion, the antennal lobe, the protocerebrum, and the neuroendocrine center pars intercerebralis. The cell types that express PICK1 were identified using GAL4 enhancer trap lines. The PICK1-expressing cells form a subpopulation of neurons. PICK1 immunoreactivity was neither detected in glutamatergic nor in dopaminergic neurons. Also, we observed PICK1 expression in only a few GABAergic neurons, located in the antennal lobe. In contrast, we detected robust PICK1 immunolabeling of peptidergic neurons in the neuroendocrine system, which express the transcription factor DIMM and the amidating enzyme peptidylglycine-alpha-hydroxylating monooxygenase (PHM). The PICK1-positive cells include neurosecretory cells that produce the insulin-like peptide dILP2. PICK1 expression in insulin-producing cells also occurs in mammals, as it was also observed in a rat insulinoma cell line derived from pancreatic beta-cells. At the subcellular level, PICK1 was found in the perinuclear zone but surprisingly not in synaptic domains. We conclude that PICK1 may serve an important role in the neuroendocrine system both in insects and vertebrates.
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| 16. |
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| 17. |
- Jansen, K, et al.
(författare)
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Polynomial time approximation schemes for max-bisection on planar and geometric graphs
- 2005
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Ingår i: SIAM Journal on Computing. - 0097-5397. ; 35:1, s. 110-119
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The max-bisection and min-bisection problems are to find a partition of the vertices of a graph into two equal size subsets that, respectively, maximizes or minimizes the number of edges with endpoints in both subsets. We design the first polynomial time approximation scheme for the max-bisection problem on arbitrary planar graphs solving a long-standing open problem. The method of solution involves designing exact polynomial time algorithms for computing optimal partitions of bounded treewidth graphs, in particular max- and min-bisection, which could be of independent interest. Using a similar method we design also the first polynomial time approximation scheme for max-bisection on unit disk graphs ( which could also be easily extended to other geometrically defined graphs).
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| 18. |
- Jenab, Mazda, et al.
(författare)
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Vitamin D receptor and Calcium sensing receptor Polymorphisms and the risk of Colorectal Cancer in European populations
- 2009
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 18, s. 2485-2491
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Tidskriftsartikel (refereegranskat)abstract
- Increased levels of vitamin D and calcium may play a protective role in colorectal cancer (CRC) risk. It has been suggested that these effects may be mediated by genetic variants of the vitamin D receptor (VDR) and the calcium sensing receptor (CASR). However, current epidemiologic evidence from European populations for a role of these genes in CRC risk is scarce. In addition, it is not clear whether these genes may modulate CRC risk independently or by interaction with blood vitamin D concentration and level of dietary calcium intake. A case-control study was conducted nested within the European Prospective Investigation into Cancer and Nutrition. CRC cases (1,248) were identified and matched to 1,248 control subjects. Genotyping for the VDR (BsmI: rs1544410; Fok1: rs2228570) and CASR (rs1801725) genes was done by Taqman, and serum vitamin D (25OHD) concentrations were measured. Conditional logistic regression was used to estimate the incidence rate ratio (RR). Compared with the wild-type bb, the BB genotype of the VDR BsmI polymorphism was associated with a reduced risk of CRC [RR, 0.76; 95% confidence interval (CI), 0.59-0.98). The association was observed for colon cancer (RR, 0.69; 95% CI, 0.45-0.95) but not rectal cancer (RR, 0.97; 95% CI, 0.62-1.49). The Fok1 and CASR genotypes were not associated with CRC risk in this study. No interactions were noted for any of the polymorphisms with serum 25OHD concentration or level of dietary calcium. These results confirm a role for the BsmI polymorphism of the VDR gene in CRC risk, independent of serum 25OHD concentration and dietary calcium intake. (Cancer Epidemiol Biomarkers Prev 2009;18(9):2485-91).
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| 19. |
- Lang, Niklaus P., et al.
(författare)
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Implant surfaces and design (Working Group 4)
- 2009
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Ingår i: Clinical Oral Implants Research. - 0905-7161 .- 1600-0501. ; 20 Suppl 4, s. 228-231
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: The remit of this working group (4) was to update existing knowledge on the effects of implant surface topography, composition and design on bone integration and re-osseointegration. MATERIAL AND METHODS: Based on five narrative reviews that were performed following a defined search strategy, clinical implications as well as suggestions for further research have been formulated. RESULTS: The results and conclusions of the review processes in the following papers together with the group consensus, clinical implications and directions for future research are presented: 1. Effects of titanium surface topography on bone integration. 2. Effects of implant surface coatings and composition on bone integration (two reviews). 3. Effects of different implant surfaces and designs on marginal bone level alterations. 4. Re-osseointegration onto previously contaminated implant surfaces.
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| 20. |
- Lang, Niklaus P., et al.
(författare)
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Implant surfaces and design (Working Group 4)
- 2009
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Ingår i: Clinical Oral Implants Research. - : Blackwell Munksgaard. - 0905-7161 .- 1600-0501. ; 20 Suppl 4, s. 228-231
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: The remit of this working group (4) was to update existing knowledge on the effects of implant surface topography, composition and design on bone integration and re-osseointegration. MATERIAL AND METHODS: Based on five narrative reviews that were performed following a defined search strategy, clinical implications as well as suggestions for further research have been formulated. RESULTS: The results and conclusions of the review processes in the following papers together with the group consensus, clinical implications and directions for future research are presented: 1. Effects of titanium surface topography on bone integration. 2. Effects of implant surface coatings and composition on bone integration (two reviews). 3. Effects of different implant surfaces and designs on marginal bone level alterations. 4. Re-osseointegration onto previously contaminated implant surfaces.
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| 21. |
- Luijsterburg, MS, et al.
(författare)
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Heterochromatin protein 1 is recruited to various types of DNA damage
- 2009
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Ingår i: The Journal of cell biology. - : Rockefeller University Press. - 1540-8140 .- 0021-9525. ; 185:4, s. 577-586
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Tidskriftsartikel (refereegranskat)abstract
- Heterochromatin protein 1 (HP1) family members are chromatin-associated proteins involved in transcription, replication, and chromatin organization. We show that HP1 isoforms HP1-α, HP1-β, and HP1-γ are recruited to ultraviolet (UV)-induced DNA damage and double-strand breaks (DSBs) in human cells. This response to DNA damage requires the chromo shadow domain of HP1 and is independent of H3K9 trimethylation and proteins that detect UV damage and DSBs. Loss of HP1 results in high sensitivity to UV light and ionizing radiation in the nematode Caenorhabditis elegans, indicating that HP1 proteins are essential components of DNA damage response (DDR) systems. Analysis of single and double HP1 mutants in nematodes suggests that HP1 homologues have both unique and overlapping functions in the DDR. Our results show that HP1 proteins are important for DNA repair and may function to reorganize chromatin in response to damage.
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| 22. |
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| 23. |
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| 24. |
- Persson, N, et al.
(författare)
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Biologisk denitrifikation av dricksvatten - Biological denitrification of drinking water
- 2006
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Ingår i: Vatten: tidskrift för vattenvård /Journal of Water Management and research. - 0042-2886. ; 62:4, s. 323-333
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- A pilot-plant study, made to clarify whether biological denitrification is a possible and suitable method for nitrate reduction of drinking water in Sweden is presented. The concentration of nitrate-nitrogen in un-treated water was 10–15 mg/l. The reactor was a 1.2 m aluminium tube with a inner diameter of 0.19 m. 0.75 m was filled with Filtralite®, expanded clay, through which the nitrate-contaminated water was forced to flow upwards with a velocity of 0.5 m/h. The system was run with artificial nitrate-polluted potable water from the three pumps during a week. The nitrate was then added to the water by using a solution of sodium nitrate. As carbon-source, sodium acetate was used. The Hydraulic Retention Time (HRT) of the system was 5.9 h, of which approximately 2.6 hours were within the bacterial support material. The C:N ratio was found to be below 1.5 and the system was very stable. Since the process will not work as long as oxygen is present, oxygen was degassed, but the importance of trace oxygen amounts could not be decided, since it wasn’t possible to decrease the oxygen to really low concentrations in the water prior inlet to the reactor. It was concluded that it is possible to use biological denitrification for drinking water. Post-treatment in an aerated reactor will be needed to ensure that no carbon or nitrite-nitrogen comes into the potable water.
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| 25. |
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| 26. |
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| 27. |
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| 28. |
- van Wuellen, Leo, et al.
(författare)
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NMR studies of cation transport in the crystalline ion conductors MCF3SO3 (M = Li, Na) and Li7TaO6
- 2006
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Ingår i: Solid State Ionics. - : Elsevier BV. - 0167-2738 .- 1872-7689. ; 177:19-25, s. 1665-1672
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Tidskriftsartikel (refereegranskat)abstract
- In this contribution we present studies on the mechanism of ion transport in crystalline solid electrolytes employing a range of different solid state nuclear magnetic resonance (NMR) experiments. The first part is devoted to the elucidation of a possible correlation of cation transport and anion reorientation in the dynamically disordered rotor phases of alkali trifluoromethane sulfonates MCF3SO3 (M = Li, Na) employing Li-7, C-13, O-17 and Na-23 NMR line shape analysis, whereas the second part focuses on the tracking of cation diffusion pathways in the hexaoxometalate Li7TaO6 utilizing Li-6 1D and 2D exchange MAS NMR approaches.
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| 29. |
- van Wullen, L., et al.
(författare)
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Cation mobility and anion reorientation in lithium trifluoromethane sulfonate, LiCF3SO3
- 2005
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Ingår i: Solid State Ionics. - : Elsevier BV. - 0167-2738 .- 1872-7689. ; 176:15-16, s. 1449-1456
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Tidskriftsartikel (refereegranskat)abstract
- We present a detailed study of the dynamic processes present in the lithium ionic conductor lithium trifluoromethane sulfonate, LiCF3SO3. Using Li-7-, O-17- and F-19 solid state NMR line shape analysis and T-1-NMR, the anionic (CF3- and SO3-reorientation) and cationic dynamics (Li motion) could be studied separately. Whereas the CF3- and SO3 reorientations are active at ambient temperatures and not correlated to the cation motion, the NMR data indicate a strong correlation between the Li motion and the reorientation of the complete triflate anion.
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| 30. |
- Villa, LL, et al.
(författare)
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Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial
- 2005
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Ingår i: The Lancet Oncology. - 1474-5488 .- 1470-2045. ; 6:5, s. 271-278
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Tidskriftsartikel (refereegranskat)abstract
- Background A randomised double-blind placebo-controlled phase II study was done to assess the efficacy of a prophylactic quadrivalent vaccine targeting the human papillomavirus (HPV) types associated with 70% of cervical cancers (types 16 and 18) and with 90% of genital warts (types 6 and 11). Methods 277 young women (mean age 20.2 years [SD 1.7]) were randomly assigned to quadrivalent HPV (20 μ g type 6, 40 μ g type 11, 40 μ g type 16, and 20 μ g type 18) L1 virus-like-particle (VLP) vaccine and 275 (mean age 20.0 years [1.7]) to one of two placebo preparations at day 1, month 2, and month 6. For 36 months, participants underwent regular gynaecological examinations, cervicovaginal sampling for HPV DNA, testing for serum antibodies to HPV, and Pap testing. The primary endpoint was the combined incidence of infection with HPV 6, 11, 16, or 18, or cervical or external genital disease (ie, persistent HPV infection, HPV detection at the last recorded visit, cervical intraepithelial neoplasia, cervical cancer, or external genital lesions caused by the HPV types in the vaccine). Main analyses were done per protocol. Findings Combined incidence of persistent infection or disease with HPV 6, 11, 16, or 18 fell by 90% (95% CI 71-97, p< 0.0001) in those assigned vaccine compared with those assigned placebo. Interpretation A vaccine targeting HPV types 6, 11, 16, 18 could substantially reduce the acquisition of infection and clinical disease caused by common HPV types.
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