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Träfflista för sökning "WFRF:(Jawahar S.) srt2:(2021)"

Sökning: WFRF:(Jawahar S.) > (2021)

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1.
  • Ahluwalia, T. S., et al. (författare)
  • Genome-wide association study of circulating interleukin 6 levels identifies novel loci
  • 2021
  • Ingår i: Human molecular genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 30:5, s. 393-409
  • Tidskriftsartikel (refereegranskat)abstract
    • Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67428 (n(discovery)=52654 and n(replication)=14774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (P-combined=1.8x10(-11)), HLA-DRB1/DRB5 rs660895 on Chr6p21 (P-combined=1.5x10(-10)) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (P-combined=1.2x10(-122)). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.
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2.
  • Anand, R. S., et al. (författare)
  • A comprehensive review on Crossflow turbine for hydropower applications
  • 2021
  • Ingår i: Ocean Engineering. - : Elsevier BV. - 0029-8018 .- 1873-5258. ; 240
  • Forskningsöversikt (refereegranskat)abstract
    • A Crossflow turbine is a device used to generate power from hydro, which is a renewable source of energy. The salient feature of this turbine is its simplicity in construction. In the past few decades, variables such as flow diverter, air holes, bidirectional flow were introduced in the turbine design to improve its efficiency. This paper presents a comprehensive review of the performance of the cross flow turbine. The review of literature is classified into experimental and numerical studies. The present study highlights the optimum range of geometrical variables required for the efficient design of a cross flow turbine. The study also emphasizes the importance of employing the cross flow turbine in remote places where run-of-river hydro power plants are feasible, as it provides a low-cost energy solution. The outcome of the present study will help the researchers to identify the research gap based on the present status of work done and to improve the performance of the cross flow turbine further in the future.
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