| 1. |
- Almroth, Henrik, et al.
(författare)
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Atorvastatin and persistent atrial fibrillation following cardioversion : a randomized placebo-controlled multicentre study
- 2009
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Ingår i: European Heart Journal. - Philadelphia : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 30:7, s. 827-833
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: To evaluate the effect of atorvastatin in achieving stable sinus rhythm (SR) 30 days after electrical cardioversion (CV) in patients with persistent atrial fibrillation (AF). METHODS AND RESULTS: The study included 234 patients. The patients were randomized to treatment with atorvastatin 80 mg daily (n = 118) or placebo (n = 116) in a prospective, double-blinded fashion. Treatment was initiated 14 days before CV and was continued 30 days after CV. The two groups were well-balanced with respect to baseline characteristics. Mean age was 65 +/- 10 years, 76% of the patients were male and 4% had ischaemic heart disease. Study medication was well-tolerated in all patients but one. Before primary endpoint 12 patients were excluded. In the atorvastatin group 99 patients (89%) converted to SR at electrical CV compared with 95 (86%) in the placebo group (P = 0.42). An intention-to-treat analysis with the available data, by randomization group, showed that 57 (51%) in the atorvastatin group and 47 (42%) in the placebo group were in SR 30 days after CV (OR 1.44, 95%CI 0.85-2.44, P = 0.18). CONCLUSION: Atorvastatin was not statistically superior to placebo with regards to maintaining SR 30 days after CV in patients with persistent AF.
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| 2. |
- Boeing, Heiner, et al.
(författare)
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Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract: the prospective EPIC-study
- 2006
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Ingår i: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 1573-7225 .- 0957-5243. ; 17:7, s. 957-969
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Tidskriftsartikel (refereegranskat)abstract
- Epidemiologic studies suggest that a high intake of fruits and vegetables is associated with decreased risk of cancers of the upper aero-digestive tract. We studied data from 345,904 subjects of the prospective European Investigation into Cancer and Nutrition (EPIC) recruited in seven European countries, who had completed a dietary questionnaire in 1992-1998. During 2,182,560 person years of observation 352 histologically verified incident squamous cell cancer (SCC) cases (255 males; 97 females) of the oral cavity, pharynx, larynx, and esophagus were identified. Linear and restricted cubic spline Cox regressions were fitted on variables of intake of fruits and vegetables and adjusted for potential confounders. We observed a significant inverse association with combined total fruits and vegetables intake (estimated relative risk (RR) = 0.91; 95% confidence interval (95% CI) 0.83-1.00 per 80 g/d of consumption), and nearly significant inverse associations in separate analyses with total fruits and total vegetables intake (RR: 0.97 (95% CI: 0.92-1.02) and RR = 0.89 (95% CI: 0.78-1.02) per 40 g/d of consumption). Overall, vegetable subgroups were not related to risk with the exception of intake of root vegetables in men. Restricted cubic spline regression did not improve the linear model fits except for total fruits and vegetables and total fruits with a significant decrease in risk at low intake levels (< 120 g/d) for fruits. Dietary recommendations should consider the potential benefit of increasing fruits and vegetables consumption for reducing the risk of cancers of the upper aero-digestive tract, particularly at low intake.
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| 3. |
- Kjaer, Kurt, et al.
(författare)
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Eurasian ice-sheet interaction in northwestern Russia throughout the late Quaternary
- 2006
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Ingår i: Boreas. - : Wiley. - 1502-3885 .- 0300-9483. ; 35:3, s. 444-475
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Tidskriftsartikel (refereegranskat)abstract
- Sediment successions from the Kanin Peninsula and Chyoshskaya Bay in northwestern Russia contain information on the marginal behaviour of all major ice sheets centred in Scandinavia, the Barents Sea and the Kara Sea during the Eemian - Weichselian. Extensive luminescence dating of regional lithostratigraphical units, supported by biostratigraphical evidence, identifies four major ice advances at 100 - 90, 70 - 65, 55 - 45 and 20 - 18 kyr ago interbedded with lacustrine, glaciolacustrine and marine sediments. The widespread occurrence of marine tidal sediments deposited c. 65 - 60 kyr ago allows a stratigraphical division of the Middle Weichselian Barents Sea and Kara Sea ice sheets into two shelf-based glaciations separated by almost complete deglaciation. The first ice dispersal centre was in the Barents Sea and thereafter in the Kara Sea. It is possible to extract both flow patterns from ice marginal landforms inside the southward termination. Accordingly, it is proposed that the Markhida line and its western continuation are asynchronous and originate from two separate glaciations before and after the marine transgression. The marine sedimentation occurred during a eustatic sea-level rise of up to 20 m/1000 yr, i. e. the Mezen Transgression. We speculate that the rapid eustatic sea-level rise triggered a collapse of the Barents Sea Ice Sheet at the MIS ( Marine Isotope Stage) 4 to 3 transition. This is motivated by lack of an early marine highstand, the timing of events, and the marginal position of Arkhangelsk relative to open marine conditions.
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| 4. |
- Larsen, Eiliv, et al.
(författare)
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Early Weichselian palaeoenvironments reconstructed from a mega-scale thrust-fault complex, Kanin Peninsula, northwestern Russia
- 2006
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Ingår i: Boreas. - : Wiley. - 1502-3885 .- 0300-9483. ; 35:3, s. 476-492
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Tidskriftsartikel (refereegranskat)abstract
- A section, almost 20 km long and up to 80 m high, through alternating layers of diamict and sorted sediments is superbly exposed on the north coast of the Kanin Peninsula, northwestern Russia. The diamicts represent multiple glacial advances by the Barents Sea and the Kara Sea ice sheets during the Weichselian. The diamicts and stratigraphically older lacustrine, fluvial and shallow marine sediments have been thrust as nappes by the Barents Sea and Kara Sea ice sheets. Based on stratigraphic position, OSL dating, sea level information and pollen, it is evident that the sorted sediments were deposited in the Late Eemian-Early Weichselian. Sedimentation started in lake basins and continued in shallow marine embayments when the lakes opened to the sea. The observed transition from lacustrine to shallow marine sedimentation could represent coastal retreat during stable or rising sea level.
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