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1.
  • Medlock, Jolyon M, et al. (författare)
  • Driving forces for changes in geographical distribution of Ixodes ricinus ticks in Europe
  • 2013
  • Ingår i: Parasites & Vectors. - : Springer Science and Business Media LLC. - 1756-3305. ; 6:1
  • Forskningsöversikt (refereegranskat)abstract
    • Many factors are involved in determining the latitudinal and altitudinal spread of the important tick vector Ixodes ricinus (Acari: Ixodidae) in Europe, as well as in changes in the distribution within its prior endemic zones. This paper builds on published literature and unpublished expert opinion from the VBORNET network with the aim of reviewing the evidence for these changes in Europe and discusses the many climatic, ecological, landscape and anthropogenic drivers. These can be divided into those directly related to climatic change, contributing to an expansion in the tick’s geographic range at extremes of altitude in central Europe, and at extremes of latitude in Scandinavia; those related to changes in the distribution of tick hosts, particularly roe deer and other cervids; other ecological changes such as habitat connectivity and changes in land management; and finally, anthropogenically induced changes. These factors are strongly interlinked and often not well quantified. Although a change in climate plays an important role in certain geographic regions, for much of Europe it is non-climatic factors that are becoming increasingly important. How we manage habitats on a landscape scale, and the changes in the distribution and abundance of tick hosts are important considerations during our assessment and management of the public health risks associated with ticks and tick-borne disease issues in 21st century Europe. Better understanding and mapping of the spread of I. ricinus (and changes in its abundance) is, however, essential to assess the risk of the spread of infections transmitted by this vector species. Enhanced tick surveillance with harmonized approaches for comparison of data enabling the follow-up of trends at EU level will improve the messages on risk related to tick-borne diseases to policy makers, other stake holders and to the general public.
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  • Aidas, Kestutis, et al. (författare)
  • The Dalton quantum chemistry program system
  • 2014
  • Ingår i: WIREs Computational Molecular Science. - : Wiley. - 1759-0876 .- 1759-0884. ; 4:3, s. 269-284
  • Tidskriftsartikel (refereegranskat)abstract
    • Dalton is a powerful general-purpose program system for the study of molecular electronic structure at the Hartree-Fock, Kohn-Sham, multiconfigurational self-consistent-field, MOller-Plesset, configuration-interaction, and coupled-cluster levels of theory. Apart from the total energy, a wide variety of molecular properties may be calculated using these electronic-structure models. Molecular gradients and Hessians are available for geometry optimizations, molecular dynamics, and vibrational studies, whereas magnetic resonance and optical activity can be studied in a gauge-origin-invariant manner. Frequency-dependent molecular properties can be calculated using linear, quadratic, and cubic response theory. A large number of singlet and triplet perturbation operators are available for the study of one-, two-, and three-photon processes. Environmental effects may be included using various dielectric-medium and quantum-mechanics/molecular-mechanics models. Large molecules may be studied using linear-scaling and massively parallel algorithms. Dalton is distributed at no cost from for a number of UNIX platforms.
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  • Andersson, Jonas, et al. (författare)
  • Markers of fibrinolysis as predictors for maintenance of sinus rhythm after electrical cardioversion
  • 2011
  • Ingår i: Thrombosis Research. - : Elsevier BV. - 0049-3848 .- 1879-2472. ; 127:3, s. 189-192
  • Tidskriftsartikel (refereegranskat)abstract
    • No fibrinolytic component alone was found to be a predictor of recurrence of atrial fibrillation. In multivariate models lower PAI-1 mass was associated with sinus rhythm even after adjusting for CRP, markers of the metabolic syndrome and treatment with atorvastatin. Our findings suggest a patophysiological link between AF and PAI-1 mass but the relation to inflammation remains unclear.
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  • Gejl, K. D., et al. (författare)
  • Muscle glycogen content modifies SR Ca2+ release rate in elite endurance athletes
  • 2014
  • Ingår i: Medicine & Science in Sports & Exercise. - 0195-9131 .- 1530-0315. ; 46:3, s. 496-505
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: The aim of the present study was to investigate the influence of muscle glycogen content on sarcoplasmic reticulum (SR) function and peak power output (Wpeak) in elite endurance athletes. Methods: Fourteen highly trained male triathletes (V̇O2max = 66.5 ± 1.3 mL O2·kg·min), performed 4 h of glycogen-depleting cycling exercise (HRmean = 73% ± 1% of maximum). During the first 4 h of recovery, athletes received either water (H2O) or carbohydrate (CHO), separating alterations in muscle glycogen content from acute changes affecting SR function and performance. Thereafter, all subjects received CHO-enriched food for the remaining 20-h recovery period. Results: Immediately after exercise, muscle glycogen content and SR Ca release rate was reduced to 32% ± 4% (225 ± 28 mmol·kg dw) and 86% ± 2% of initial levels, respectively (P < 0.01). Glycogen markedly recovered after 4 h of recovery with CHO (61% ± 2% of preexercise) and SR Ca release rate returned to preexercise level. However, in the absence of CHO during the first 4 h of recovery, glycogen and SR Ca release rate remained depressed, with the normalization of both parameters at the end of the 24 h of recovery after receiving a CHO-enriched diet. Linear regression demonstrated a significant correlation between SR Ca release rate and muscle glycogen content (P < 0.01, r = 0.30). The 4 h of cycling exercise reduced Wpeak by 5.5%-8.9% at different cadences (P < 0.05), and Wpeak was normalized after 4 h of recovery with CHO, whereas Wpeak remained depressed (P < 0.05) after water provision. Wpeak was fully recovered after 24 h in both the H2O and the CHO group. Conclusion: In conclusion, the present results suggest that low muscle glycogen depresses muscle SR Ca release rate, which may contribute to fatigue and delayed recovery of Wpeak 4 h postexercise. © 2014 by the American College of Sports Medicine.
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  • Hébert-Losier, Kim, et al. (författare)
  • Jumping and hopping in elite and amateur orienteering athletes and correlations to sprinting and running
  • 2014
  • Ingår i: International Journal of Sports Physiology and Performance. - : Human Kinetics. - 1555-0265 .- 1555-0273. ; 9:6, s. 993-999
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE:Jumping and hopping are used to measure lower-body muscle power, stiffness, and stretch-shortening-cycle utilization in sports, with several studies reporting correlations between such measures and sprinting and/or running abilities in athletes. Neither jumping and hopping nor correlations with sprinting and/or running have been examined in orienteering athletes.METHODS:The authors investigated squat jump (SJ), countermovement jump (CMJ), standing long jump (SLJ), and hopping performed by 8 elite and 8 amateur male foot-orienteering athletes (29 ± 7 y, 183 ± 5 cm, 73 ± 7 kg) and possible correlations to road, path, and forest running and sprinting performance, as well as running economy, velocity at anaerobic threshold, and peak oxygen uptake (VO(2peak)) from treadmill assessments.RESULTS:During SJs and CMJs, elites demonstrated superior relative peak forces, times to peak force, and prestretch augmentation, albeit lower SJ heights and peak powers. Between-groups differences were unclear for CMJ heights, hopping stiffness, and most SLJ parameters. Large pairwise correlations were observed between relative peak and time to peak forces and sprinting velocities; time to peak forces and running velocities; and prestretch augmentation and forest-running velocities. Prestretch augmentation and time to peak forces were moderately correlated to VO(2peak). Correlations between running economy and jumping or hopping were small or trivial.CONCLUSIONS:Overall, the elites exhibited superior stretch-shortening-cycle utilization and rapid generation of high relative maximal forces, especially vertically. These functional measures were more closely related to sprinting and/or running abilities, indicating benefits of lower-body training in orienteering.
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6.
  • Hébert-Losier, Kim, et al. (författare)
  • The influence of surface on the running velocities of elite and amateur orienteer athletes
  • 2014
  • Ingår i: Scandinavian Journal of Medicine & Science in Sports. - : Wiley. - 0905-7188 .- 1600-0838. ; 24:6
  • Tidskriftsartikel (refereegranskat)abstract
    • We compared the reduction in running velocities from road to off-road terrain in eight elite and eight amateur male orienteer athletes to investigate whether this factor differentiates elite from amateur athletes. On two separate days, each subject ran three 2-km time trials and three 20-m sprints all-out on a road, on a path, and in a forest. On a third day, the running economy and maximal aerobic power of individuals were assessed on a treadmill. The elite orienteer ran faster than the amateur on all three surfaces and at both distances, in line with their better running economy and aerobic power. In the forest, the elites ran at a slightly higher percentage of their 2-km (approximate to 3%) and 20-m (approximate to 4%) road velocities. Although these differences did not exhibit traditional statistical significance, magnitude-based inferences suggested likely meaningful differences, particularly during 20-m sprinting. Of course, cognitive, mental, and physical attributes other than the ability to run on different surfaces are required for excellence in orienteering (e.g., a high aerobic power). However, we suggest that athlete-specific assessment of running performance on various surfaces and distances might assist in tailoring training and identifying individual strengths and/or weaknesses in an orienteer.
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7.
  • Höglund, Niklas, et al. (författare)
  • The predictive value of C-reactive protein on recurrence of atrial fibrillation after cardioversion with or without treatment with atorvastatin
  • 2013
  • Ingår i: International Journal of Cardiology. - : Elsevier. - 0167-5273 .- 1874-1754. ; 167:5, s. 2088-2091
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: The aim of this study was to investigate whether high-sensitivity C-reactive protein (hsCRP) levels prior to cardioversion (CV) predict recurrence of atrial fibrillation (AF) in patients randomized to treatment with either atorvastatin or placebo 30 and 180 days after CV. Methods: This was a prespecified substudy of 128 patients with persistent AF randomized to treatment with atorvastatin 80 mg/day or placebo, initiated 14 days before CV, and continued 30 days after CV. HsCRP levels were measured at randomization, at the time of CV, and 2 days and 30 days after CV. Results: In univariate analysis of those who were in sinus rhythm 2 h after CV, hsCRP did not significantly (odds ratio [OR] 1.11, 95% confidence interval [CI] 0.99-1.25) predict recurrence of AF at 30 days. However, after adjusting for treatment with atorvastatin, hsCRP predicted the recurrence of AF (OR 1.14, 95% CI 1.01-1.27). In a multivariate logistic regression analysis with gender, age, body mass index (BMI), smoking, cholesterol, and treatment with atorvastatin as covariates, the association was still significant (OR 1.14, 95% CI 1.01-1.29). Six months after CV, hsCRP at randomization predicted recurrence of AF in both univariate analysis (OR 1.30, 95% CI 1.06-1.60) and in multivariate logistic regression analysis (OR 1.33, 95% CI 1.06-1.67). Conclusion: HsCRP was associated with AF recurrence one and six months after successful CV of persistent AF. However, the association at one month was significant only after adjusting for atorvastatin treatment.
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  • Jensen, Kurt, et al. (författare)
  • Changes in physical performance parameters during and after moderate altitude training in elite cross country skiers
  • 2013
  • Ingår i: Proceedings for the 6<sup>th</sup> International Congress on Science and Skiing. - 9783200034174 ; , s. 115-
  • Konferensbidrag (refereegranskat)abstract
    • INTRODUCTION: The Olympic cross country skiing competitions in 2014 will be held in Sochi, Russia at an altitude of approximately 1500m. Although moderate, this altitude is known to reduce performance in highly trained endurance athletes. It is also known that individuals react differently during altitude exposure. The purpose of this study was to evaluate performance changes during and after three weeks of training in moderate altitude in elite skiers.METHOD: Four male and three female skiers were tested on a roller skiing treadmill using the classic technique  at sea level (NORM1), after 3 and 20 days at 1500m altitude (ALT1 and ALT2), and 10 days after altitude at sea level (NORM2). The test protocol was a standardized progressive submaximal session of 4 min exercise with 1 min rest between each stage, followed by a 6-10 min progressive “all out” exercise with an increase in first speed and then grade every minute. Oxygen uptake (VO2) was measured continuously during submaximal and maximal exercise. Blood lactate concentrations were measured during the 1 min rest between submax stages and 2 min after the max test. Power at each submax and max stage were calculated from roller ski friction and body weight against gravity [1]. Each stage power was further used for calculations of power at VO2max, (WVO2max), work efficiency at submaximal loads (GE) and for the estimation of O2 cost at maximal work load (used to calculate accumulated O2 deficit (MOD)) [2].RESULTS: At NORM1, the skiers’ body mass was 71.9±10.7kg and VO2max 214±12ml/min/kg0.73. The GE varied between 17.9-19.5% during the 3-5 submaximal loads, with no difference between conditions (P>0.05). Also, blood lactate accumulation after submaximal exercise loads showed no difference between conditions (P<0.05). At ALT1, the VO2max and the WVO2max decreased 8.9% and 9.1%, respectively (P<0.05), however there were no differences between ALT1 and ALT2 or from NORM1 and NORM2 (P>0.05). In contrast, the average power output (322±87W) during the “all out” test increased 3.4±2.7% 10 days after the altitude training (P<0.05). Average MOD varied between 57-79 mlO2·kg-1 over the training period, but with no change between conditions (P>0.05). The coefficient of variation (CV%) for the changes in MOD between NORM1 and 2 was 40%.DISCUSSION: This study demonstrated that performance (VO2max, WVO2max) deteriorates by 8-9% in a group of elite skiers training at a moderate altitude corresponding to 1500m. No increase in any of the physiological parameters related to performance included in the study was seen after moderate altitude training, except for the maximal power which increased 3.4%. The response after moderate altitude training seems to be related more to anaerobic than aerobic factors. However, this was not confirmed by the MOD in this group of highly trained skiers. The large CV for change in MOD reflects the individual responses to this training.CONCLUSION: Small changes of 2-3% in performance in highly trained in elite skiers after moderate altitude training seems not to be related to any single parameter. One should not ignore individual differences in adaptation. REFERENCES1.         Ainegren, M. et al Engineering of Sport 7, Vol 2, 2008: p. 393-400.2.         Medbo, J.I.et al J.Appl.Physiol., 1988. 64: p. 50-60.
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14.
  • Jensen, Kurt Villads, 1957- (författare)
  • A Cistercian Sermon Collection from Løgum
  • 2014
  • Ingår i: Monastic Culture. - Odense : University Press of Southern Denmark. - 9788776747749 ; , s. 81-100
  • Bokkapitel (refereegranskat)
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15.
  • Jensen, Kurt Villads, 1957- (författare)
  • A Cruzada nas Fronteiras do Mundo : Portugal e Dinamarca desde cerca do ano 1000 até cerca de 1250
  • 2014
  • Bok (refereegranskat)abstract
    • Portugal e a Dinamarca são os dois estados nação mais antigos da Europa. Tiveram, na Idade Média, uma evolução histórica semelhante.A Cruzada nas Fronteiras do Mundo é o primeiro livro que mostra como Portugal e a Dinamarca se tornaram reinos importantes no contexto do movimento comum das Cruzadas. Havia, na Idade Média, uma muito maior comunicação entre os países da Europa do que até hoje julgámos ter existido. Foi possível coordenar grandes expedições militares a milhares de quilómetros de distância. Não é, por isso, de estranhar que as casas reais portuguesa e dinamarquesa se tivesse munido através do casamento, em 1214, do rei dinamarquês Valdemar II, o Vitorioso, com Berengária, filha de D. Sancho I de Portugal.Este livro é a primeira tentativa de, de maneira sistemática, comparar Portugal e a Dinamarca, da Idade Média, baseado em 25 anos de pesquisa em fontes medievais escritas em latim, dinamarquês antigo, português arcaico e muitas outras línguas
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  • Jensen, Kurt Villads, 1957- (författare)
  • Introduction
  • 2014
  • Ingår i: Monastic culture: The Long Thirteenth Century. - Odense : University Press of Southern Denmark. - 9788776747749 ; , s. 7-11
  • Bokkapitel (refereegranskat)
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  • Jensen, Kurt Villads, 1957- (författare)
  • Sicilien, riget i midten
  • 2014
  • Ingår i: Sfinx. - 0105-7618. ; 37:2, s. 57-62
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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26.
  • Jensen, Kurt Villads, 1957- (författare)
  • What did Saxo not write?
  • 2014
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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  • Monastic culture: the long thirteenth century : essays in honour of Brian Patrick McGuire
  • 2014
  • Samlingsverk (redaktörskap) (refereegranskat)abstract
    • Monasteries were important cultural centers in the Middle Ages. In monasteries, classical authors were copied and studied, new music and new sermons were composed, and new standards from abroad were introduced and spread throughout an ever larger Europe. Monks and nuns created European networks, connecting them to individuals with whom they shared particular interests in theology and learning, but they also had a keen eye for the importance of cultivating connections to local magnates and kings. In the long 13th century, new orders like the mendicants emerged, and monastic life as a whole flourished. Sustained experimentation, the adaptation of new intellectual inspirations, and the adjustment of organizational structures were major characteristics of this life. There was a balance between contemplating the transcendent and securing the material foundation that allowed the individual monk or nun to disappear into the Divine. Monastic communities were powerful centers for innovation that decisively influenced secular life and shaped European history. The contributions in this festschrift are offered in honor of Professor Brian Patrick McGuire, a recognized authority on the Cistercians, and in acknowledgment of his significant contribution to the study of European monastic culture.
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29.
  • Orlando, Ludovic, et al. (författare)
  • Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse
  • 2013
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 499:7456, s. 74-
  • Tidskriftsartikel (refereegranskat)abstract
    • The rich fossil record of equids has made them a model for evolutionary processes(1). Here we present a 1.12-times coverage draft genome from a horse bone recovered from permafrost dated to approximately 560-780 thousand years before present (kyr BP)(2,3). Our data represent the oldest full genome sequence determined so far by almost an order of magnitude. For comparison, we sequenced the genome of a Late Pleistocene horse (43 kyr BP), and modern genomes of five domestic horse breeds (Equus ferus caballus), a Przewalski's horse (E. f. prze-walskii) and a donkey (E. asinus). Our analyses suggest that the Equus lineage giving rise to all contemporary horses, zebras and donkeys originated 4.0-4.5 million years before present (Myr BP), twice the conventionally accepted time to the most recent common ancestor of the genus Equus(4,5). We also find that horse population size fluctuated multiple times over the past 2 Myr, particularly during periods of severe climatic changes. We estimate that the Przewalski's and domestic horse populations diverged 38-72 kyr BP, and find no evidence of recent admixture between the domestic horse breeds and the Przewalski's horse investigated. This supports the contention that Przewalski's horses represent the last surviving wild horse population(6). We find similar levels of genetic variation among Przewalski's and domestic populations, indicating that the former are genetically viable and worthy of conservation efforts. We also find evidence for continuous selection on the immune system and olfaction throughout horse evolution. Finally, we identify 29 genomic regions among horse breeds that deviate from neutrality and show low levels of genetic variation compared to the Przewalski's horse. Such regions could correspond to loci selected early during domestication.
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30.
  • Qi, Qibin, et al. (författare)
  • FTO genetic variants, dietary intake and body mass index : insights from 177 330 individuals
  • 2014
  • Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:25, s. 6961-6972
  • Tidskriftsartikel (refereegranskat)abstract
    • FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.
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  • Wormser, David, et al. (författare)
  • Adult height and the risk of cause-specific death and vascular morbidity in 1 million people : individual participant meta-analysis
  • 2012
  • Ingår i: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 41:5, s. 1419-1433
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundThe extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.MethodsWe calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.ResultsFor people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.ConclusionAdult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.
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  • Öjendal, Joakim, 1962, et al. (författare)
  • Politics and Development of the Mekong River Basin - Transboundary dilemmas and participatory ambitions
  • 2012
  • Ingår i: Politics and Development in a Transboundary Watershed – The Case of the Lower Mekong Region. - London : Springer. - 9789400704756 ; , s. 37-59
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • The chapter takes a two-pronged approach. Firstly it reviews the fundamentals of the Mekong Basin system, providing a broad overview of the natural system and its basic water regime and from there defines the key developmental and governance challenges. Secondly, it performs a historical odyssey in order to assess which previous attempts have been made to regulate the system, and what we have learnt from them. At its core we find three contemporary tools developed to accommodate a sharpening regional politics with urgent development imperatives, all emanating from the MRC. These are the Water Utilization Project (WUP), the IWRM Strategic Framework, and the Basin Development Plan (BDP). They are scrutinized before we conclude that the MRC-agreement, as well as these three tools, have delivered valuable input to basin governance. Simultaneously we are pointing out that they have not provided the final solution for how to deal with the accelerating urge for exploitation of the system’s natural resources
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