| 1. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 2. |
- Ades, M., et al.
(författare)
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Global Climate : in State of the climate in 2019
- 2020
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Ingår i: Bulletin of The American Meteorological Society - (BAMS). - : American Meteorological Society. - 0003-0007 .- 1520-0477. ; 101:8, s. S17-S127
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Ades, M., et al.
(författare)
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GLOBAL CLIMATE
- 2020
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Ingår i: BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY. - 0003-0007 .- 1520-0477. ; 101:8
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Tidskriftsartikel (refereegranskat)
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| 4. |
- Hohenschurz-Schmidt, David, et al.
(författare)
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Recommendations for the development, implementation, and reporting of control interventions in efficacy and mechanistic trials of physical, psychological, and self-management therapies : the CoPPS Statement
- 2023
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Ingår i: BMJ. British Medical Journal. - : BMJ Publishing Group Ltd. - 0959-8146 .- 0959-535X. ; 381, s. e072108-
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Tidskriftsartikel (refereegranskat)abstract
- Control interventions (often called "sham," "placebo," or "attention controls") are essential for studying the efficacy or mechanism of physical, psychological, and self-management interventions in clinical trials. This article presents core recommendations for designing, conducting, and reporting control interventions to establish a quality standard in non-pharmacological intervention research. A framework of additional considerations supports researchers' decision making in this context. We also provide a reporting checklist for control interventions to enhance research transparency, usefulness, and rigour.
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| 5. |
- Mahajan, Anubha, et al.
(författare)
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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
- 2022
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 54:5, s. 560-572
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Tidskriftsartikel (refereegranskat)abstract
- We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 x 10(-9)), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background. Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.
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| 6. |
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| 7. |
- Ammenberg, Jonas, 1973-, et al.
(författare)
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Perspectives on biomethane as a transport fuel within acircular economy, energy, and environmental system
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The literature indicates that the life cycle costs of biomethane fueled light vehicles may be 15 to 20% highe rthan for similar petrol and diesel fueled vehicles, while liquid biomethane fueled heavy duty trucks may have similar life cycle costs to diesel. However, such an analysis can be two dimensional and limited in the message it conveys. On one hand the acceptance of diesel fueled trucks and buses will be limited due to the climate emergency and air pollution and after 2030 diesel may not be the competition for biomethane anymore. On the otherhand, biomethane production is part of a larger circular economy, energy, and environmental system. It is verydifficult to divorce the energy vector, biomethane, from the system through which it is produced. In essence biomethane can be considered as one of the products or services of a broad biogas system.An advantage of biogas is that it can be produced from most wet organic wastes or by-products, includingfor food waste, animal by-products, (such as manure), agricultural residues, sewage sludge, industrial biowaste (such as from slaughterhouses and food and beverage processing industries). Biogas production is an element in the environmental management of such wastes; biogas plants can also deliver digestate, which contains most ofthe nutrients in the feedstock and can be an excellent biofertilizer. In addition, it is possible to utilize the carbon dioxide removed in upgrading biogas to biomethane as a product with added value. The resource of biomethane is very significant in considering the vast amounts of organic wastes landfilled around the world each year, that instead could be used to produce biogas, biofertilizers and food grade CO2 while improving the environment through reduced fugitive methane emissions and improved water quality. Furthermore, the application of biogas systems in bio-industrial contexts (such as paper mills, food production facilities, or other types of biorefineries) has huge potential to decarbonize industry while significantly increasing the resource of biomethane. Due to the multifunctionality of biomethane solutions, broad assessment methods are needed to grasp thewide spectrum of relevant factors when comparing different technologies:• Biomethane has a competitive performance compared with fossil fuels and other biofuels on a whole lifecycle analysis and is particularly suited to long distance heavy vehicles.• Biomethane from manure, residues, waste & catch crops is estimated to have low GHG emissions ascompared to other renewable fuels.• Biomethane may contribute to reduced air pollution in comparison with diesel, petrol, and other biofuels.• Biomethane can contribute to a substantial reduction in acidification compared with fossil fuels.• Biomethane may contribute to significantly reduced noise levels in comparison with diesel heavy goodsvehicles.• Well-designed and applied biogas systems may be essential to transform conventional farming to moresustainable farming and to organic farming.• Common types of biogas solutions provide essential sociotechnical systems services as components ofsystems for waste and (waste) water management.• Biogas solutions may importantly contribute to improved energy supply/security and flexibility.Natural gas systems should be a facilitator of the introduction of biomethane for transport, but the sustainability problems associated with natural gas negatively impact the view of biomethane. This is where arguments amongst the renewable sector actors can hinder progress. Biomethane and (power to methane) can utilize the existing gas grid and accelerate progress to decarbonization of the overall energy sector beyond just electricity and also to decarbonize chemical (such as ammonia and methanol) and steel production. This should be advantageous especially when realizing that more energy is procured from the natural gas grid than the electricity gridin the EU and the US; however, suggestions that biomethane is only greenwashing the natural gas industry, and in doing so extending the lifetime of natural gas, greatly impedes this progress.This report provides exemplars of very good biomethane based transport solutions, with a high technologicalreadiness level for all elements of the chain from production to vehicles. Transport biomethane sits well in the broad circular economy, energy, and environmental system providing services across a range of sectors including reduction in fugitive methane emissions from slurries, treatment of residues, environmental protection, provision of biofertiliser, provision of food grade CO2 and a fuel readily available for long distance heavy haulage. What we do not have is time to postpone the sustainable implementation of such circular economy biomethane systems as the climate emergency will not wait for absolutely perfect zero emission solutions; should they exist.
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| 8. |
- Gräsner, Jan Thorsten, et al.
(författare)
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Epidemiologie des Kreislaufstillstands in Europa : Leitlinien des European Resuscitation Council 2021
- 2021
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Ingår i: Notfall und Rettungsmedizin. - : Springer Science and Business Media LLC. - 1434-6222 .- 1436-0578. ; 24:4, s. 346-366
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Forskningsöversikt (refereegranskat)abstract
- In this section of the European Resuscitation Council Guidelines 2021, key information on the epidemiology and outcome of in- and out-of-hospital cardiac arrest are presented. Key contributions from the European Registry of Cardiac Arrest (EuReCa) collaboration are highlighted. Recommendations are presented to enable health systems to develop registries as a platform for quality improvement and to provide support for health system planning and responses to cardiac arrest.
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| 9. |
- Gustafsson, Marcus, 1987-, et al.
(författare)
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IEA Bioenergy Task 37 – Country Reports Summaries 2019
- 2020
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This publication contains a compilation of summaries of country reports from members of IEA Bioenergy Task 37 (Energy from Biogas).Each country report summary includes information on the number of biogas plants in operation, biogas production data, how the biogas is utilised, the number of biogas upgrading plants, the number of vehicles using biomethane as fuel, the number of biomethane filling stations, details of financial support schemes in each country and some information on national biogas projects and production facilities. The publication is an annual update and is valid for information collected in 2019. Reference year for production and utilisation is as a rule 2018.
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| 10. |
- Kiguchi, Tekeyuki, et al.
(författare)
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Out-of-hospital cardiac arrest across the World : First report from the International Liaison Committee on Resuscitation (ILCOR).
- 2020
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Ingår i: Resuscitation. - : Elsevier BV. - 0300-9572 .- 1873-1570. ; 152, s. 39-49
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Since development of the Utstein style recommendations for the uniform reporting of cardiac arrest, increasing numbers of national and regional out-of-hospital cardiac arrest (OHCA) registries have been established worldwide. The International Liaison Committee on Resuscitation (ILCOR) created the Research and Registries Working Group and aimed to systematically report data collected from these registries.METHODS: We conducted two surveys of voluntarily participating national and regional registries. The first survey aimed to identify which core elements of the current Utstein style for OHCA were collected by each registry. The second survey collected descriptive summary data from each registry. We chose the data collected for the second survey based on the availability of core elements identified by the first survey.RESULTS: Seven national and four regional registries were included in the first survey and nine national and seven regional registries in the second survey. The estimated annual incidence of emergency medical services (EMS)-treated OHCA was 30.0-97.1 individuals per 100,000 population. The combined data showed the median age varied from 64 to 79 years and more than half were male in all 16 registries. The provision of bystander cardiopulmonary resuscitation (CPR) and bystander automated external defibrillator (AED) use was 19.1-79.0% in all registries and 2.0-37.4% among 11 registries, respectively. Survival to hospital discharge or 30-day survival after EMS-treated OHCA was 3.1-20.4% across all registries. Favorable neurological outcome at hospital discharge or 30 days after EMS-treated OHCA was 2.8-18.2%. Survival to hospital discharge or 30-day survival after bystander-witnessed shockable OHCA ranged from 11.7% to 47.4% and favorable neurological outcome from 9.9% to 33.3%.CONCLUSION: This report from ILCOR describes data on systems of care and outcomes following OHCA from nine national and seven regional registries across the world. We found variation in reported survival outcomes and other core elements of the current Utstein style recommendations for OHCA across nations and regions.
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| 11. |
- Lindfors, Axel, 1993-
(författare)
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In what way is it sustainable? : Developing a multi-criteria method for sustainability assessment of socio-technical systems
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Due to increasing environmental degradation, decreasing resource stocks, and growing inequality there is an urgent need for sustainable development. Many of these societal challenges are interlinked and interconnected and sustainable development represents a multi-dimensional and integrative concept to overcome them. To achieve sustainable development, system changes and the implementation of new technologies will be necessary— technologies that contribute toward solving several sustainability challenges in an integrated manner. The identification and implementation of more sustainable sociotechnical systems will require assessment methods that can encompass the meaning of sustainable development. Sustainable development is a dynamic and relative concept where what constitutes sustainability changes depending on the temporal, cultural, and technical context in which the system is introduced and on the reference used for comparison. Because of this, it is impossible to define specific technologies as universally sustainable; instead, each technology must be assessed concerning how the socio-technical systems that encompasses the technology contributes toward overcoming sustainability challenges in the context in which it is implemented. This assessment requires a method capable of encompassing the complexity, context-dependency, and value pluralism of sustainable development. In addition, the assessment method should contribute to the implementation of the most sustainable alternative to accelerate the societal transformation to sustainable development. Based on this, the thesis aimed to develop a method for sustainability assessment that could encompass the complexity, context-dependency, and value pluralism of sustainable development and which includes features that explicitly aim to facilitate the implementation of the most sustainable alternative(s). The method developed in the thesis is based on participatory multicriteria assessment. It differs from other participatory multi-criteria assessments in several ways because of its theoretical basis in soft system thinking and value pluralism. These theories have several implications for the assessment method. Some examples include: that quantitative relations between sustainability challenges in different moral value domains cannot be constructed, that there is no rigorous or dependable way to find the most sustainable alternative, and that multiple alternatives can be viewed as the most sustainable alternative because this is dependent on the values and norms of the decisionmakers. The sustainability assessment method developed in the thesis is a sixstep iterative method. The method is flexible and need not be strictly adhered to; instead, it should be adapted to the decision context it is used within. It provides decision-makers with a systematic overview of knowledge on how different relevant alternatives contribute to, or counteract, overcoming various sustainability challenges. This enables informed and rational decision-making concerning what alternatives are perceived as the most sustainable and, therefore, should be implemented. This implementation process is one that the assessment method contributes toward by, for example, including criteria for assessing feasibility in the assessment framework and recommending what type of actors to involve in the assessment process. The method builds on the idea that the purpose of sustainability assessments can never be to state if a system is sustainable or not; rather, the purpose is to state in what way a system is sustainable or not.
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| 12. |
- Pan, Feng, et al.
(författare)
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On the importance of np-pairs in the isovector pairing model
- 2020
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Ingår i: Europhysics letters. - : IOP Publishing. - 0295-5075 .- 1286-4854. ; 132:3
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Tidskriftsartikel (refereegranskat)abstract
- It is shown that the isovector np-pair number operator can be realized in the O(5) quasi-spin basis. The computation of the isovector np-pair number is demonstrated for even-even and odd-odd ds-shell nuclei described by the charge-independent mean field plus isovector pairing model restricted within the O(5) seniority-zero subspace, thereby binding energies and low-lying excited states of these ds-shell nuclei are fit, along with estimates for the isovector neutron-proton pairing contributions. For reasonable neutron-proton pairing strengths the isovector np-pairing energy contribution to the total binding energy in odd-odd N = Z nuclei is systematically larger than that in the even-even nuclei. In sum, the results suggest that the isovector np-pairing mode is favored in odd-odd N = Z nuclei; and additionally, a decrease in the double binding-energy difference for odd-odd nuclei is primarily due to the symmetry and Wigner energy contributions to the binding energy.
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| 13. |
- Perkins, Gavin D., et al.
(författare)
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Brain injury after cardiac arrest
- 2021
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Ingår i: The Lancet. - 0140-6736. ; 398:10307, s. 1269-1278
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Forskningsöversikt (refereegranskat)abstract
- As more people are surviving cardiac arrest, focus needs to shift towards improving neurological outcomes and quality of life in survivors. Brain injury after resuscitation, a common sequela following cardiac arrest, ranges in severity from mild impairment to devastating brain injury and brainstem death. Effective strategies to minimise brain injury after resuscitation include early intervention with cardiopulmonary resuscitation and defibrillation, restoration of normal physiology, and targeted temperature management. It is important to identify people who might have a poor outcome, to enable informed choices about continuation or withdrawal of life-sustaining treatments. Multimodal prediction guidelines seek to avoid premature withdrawal in those who might survive with a good neurological outcome, or prolonging treatment that might result in survival with severe disability. Approximately one in three admitted to intensive care will survive, many of whom will need intensive, tailored rehabilitation after discharge to have the best outcomes.
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| 14. |
- Solis, Jerry Luis, et al.
(författare)
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Ethanol Production from Schinus molle Essential Oil Extraction Residues
- 2020
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Ingår i: Waste and Biomass Valorization. - : Springer Nature. - 1877-2641 .- 1877-265X. ; 11:8, s. 4053-4065
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Tidskriftsartikel (refereegranskat)abstract
- Abstract: The present study determines the best conditions for the fermentation of Schinus molle drupes by the combination of different types of hydrolysis with the search for an adequate yeast strain. Schinus molle seed residues from an essential oil extraction plant (EOEP) have a high potential for ethanol production. Native yeast strains were isolated from the residues and were used to ferment the lignocellulosic residues, along with baker’s yeast (Saccharomyces cerevisiae) at 30 °C and pH 5.5 for comparison. Morphological and biochemical characterizations were carried out on the isolated yeast strains. Thermogravimetric and high-performance liquid chromatography analyses were done on the S. molle seeds (fresh and residue) to determine the ethanol production potential. The followed methodology included increasing the sugar content by hydrolysis with chemical (sulphuric acid, acetic acid, and sodium hydroxide), physical (thermal, vacuum, and ultrasound), and enzymatic treatments (amyloglucosidase and α-amylase). Once the optimum combination of yeast-hydrolysis was determined, a comparison of the greenhouse gas emissions between the original and proposed processes was done. The fermentation of the residues might replace methane from uncontrolled decomposition and reduce the solid residues in 50%/day, hence the EOEP global warming potential is reduced by 47%. The yearly income was estimated to increase by USD 2592.50 from 6302.6 L of ethanol produced from the residues.
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| 15. |
- Stael, Simon, et al.
(författare)
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Structure-function study of a Ca2+-independent metacaspase involved in lateral root emergence
- 2023
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences (PNAS). - 0027-8424 .- 1091-6490. ; 120
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Tidskriftsartikel (refereegranskat)abstract
- Metacaspases are part of an evolutionarily broad family of multifunctional cysteine proteases, involved in disease and normal development. As the structure-function relationship of metacaspases remains poorly understood, we solved the X-ray crystal structure of an Arabidopsis thaliana type II metacaspase (AtMCA-IIf) belonging to a particular subgroup not requiring calcium ions for activation. To study metacaspase activity in plants, we developed an in vitro chemical screen to identify small molecule metacaspase inhibitors and found several hits with a minimal thioxodihydropyrimidine-dione structure, of which some are specific AtMCA-IIf inhibitors. We provide mechanistic insight into the basis of inhibition by the TDP-containing compounds through molecular docking onto the AtMCA-IIf crystal structure. Finally, a TDP-containing compound (TDP6) effectively hampered lateral root emergence in vivo, probably through inhibition of metacaspases specifically expressed in the endodermal cells overlying developing lateral root primordia. In the future, the small compound inhibitors and crystal structure of AtMCA-IIf can be used to study metacaspases in other species, such as important human pathogens, including those causing neglected diseases.
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| 16. |
- Tapia-Ruiz, Nuria, et al.
(författare)
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2021 roadmap for sodium-ion batteries
- 2021
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Ingår i: Journal of Physics. - : Institute of Physics Publishing (IOPP). - 2515-7655. ; 3:3
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Tidskriftsartikel (refereegranskat)abstract
- Increasing concerns regarding the sustainability of lithium sources, due to their limited availability and consequent expected price increase, have raised awareness of the importance of developing alternative energy-storage candidates that can sustain the ever-growing energy demand. Furthermore, limitations on the availability of the transition metals used in the manufacturing of cathode materials, together with questionable mining practices, are driving development towards more sustainable elements. Given the uniformly high abundance and cost-effectiveness of sodium, as well as its very suitable redox potential (close to that of lithium), sodium-ion battery technology offers tremendous potential to be a counterpart to lithium-ion batteries (LIBs) in different application scenarios, such as stationary energy storage and low-cost vehicles. This potential is reflected by the major investments that are being made by industry in a wide variety of markets and in diverse material combinations. Despite the associated advantages of being a drop-in replacement for LIBs, there are remarkable differences in the physicochemical properties between sodium and lithium that give rise to different behaviours, for example, different coordination preferences in compounds, desolvation energies, or solubility of the solid-electrolyte interphase inorganic salt components. This demands a more detailed study of the underlying physical and chemical processes occurring in sodium-ion batteries and allows great scope for groundbreaking advances in the field, from lab-scale to scale-up. This roadmap provides an extensive review by experts in academia and industry of the current state of the art in 2021 and the different research directions and strategies currently underway to improve the performance of sodium-ion batteries. The aim is to provide an opinion with respect to the current challenges and opportunities, from the fundamental properties to the practical applications of this technology.
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| 17. |
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| 19. |
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| 20. |
- Varma, Niraj, et al.
(författare)
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Контроль аритмий с помощью технологий мобильного здравоохранения: цифровые медицинские технологии для специалистов по сердечному ритму. Консенсус экспертов 2021
- 2021
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Ingår i: Russian Journal of Cardiology. - : Silicea - Poligraf, LLC. - 1560-4071 .- 2618-7620. ; 26:S1
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Tidskriftsartikel (refereegranskat)abstract
- This collaborative statement from the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm Association/Asia Pacific Heart Rhythm Society describes the current status of mobile health (“mHealth”) technologies in arrhythmia management. The range of digital medical tools and heart rhythm disorders that they may be applied to and clinical decisions that may be enabled are discussed. The facilitation of comorbidity and lifestyle management (increasingly recognized to play a role in heart rhythm disorders) and patient self-management are novel aspects of mHealth. The promises of predictive analytics but also operational challenges in embedding mHealth into routine clinical care are explored.
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| 21. |
- Voss, Michael G., et al.
(författare)
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Time to Peak Glucose and Peak C-Peptide During the Progression to Type 1 Diabetes in the Diabetes Prevention Trial and TrialNet Cohorts
- 2021
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Ingår i: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 44:10, s. 2329-2336
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To assess the progression of type 1 diabetes using time to peak glucose or C-peptide during oral glucose tolerance tests (OGTTs) in autoantibody-positive relatives of people with type 1 diabetes. RESEARCH DESIGN AND METHODS: We examined 2-h OGTTs of participants in the Diabetes Prevention Trial Type 1 (DPT-1) and TrialNet Pathway to Prevention (PTP) studies. We included 706 DPT-1 participants (mean ± SD age, 13.84 ± 9.53 years; BMI Z-score, 0.33 ± 1.07; 56.1% male) and 3,720 PTP participants (age, 16.01 ± 12.33 years; BMI Z-score, 0.66 ± 1.3; 49.7% male). Log-rank testing and Cox regression analyses with adjustments (age, sex, race, BMI Z-score, HOMA-insulin resistance, and peak glucose/C-peptide levels, respectively) were performed. RESULTS: In each of DPT-1 and PTP, higher 5-year diabetes progression risk was seen in those with time to peak glucose >30 min and time to peak C-peptide >60 min (P < 0.001 for all groups), before and after adjustments. In models examining strength of association with diabetes development, associations were greater for time to peak C-peptide versus peak C-peptide value (DPT-1: χ2 = 25.76 vs. χ2 = 8.62; PTP: χ2 = 149.19 vs. χ2 = 79.98; all P < 0.001). Changes in the percentage of individuals with delayed glucose and/or C-peptide peaks were noted over time. CONCLUSIONS: In two independent at-risk populations, we show that those with delayed OGTT peak times for glucose or C-peptide are at higher risk of diabetes development within 5 years, independent of peak levels. Moreover, time to peak C-peptide appears more predictive than the peak level, suggesting its potential use as a specific biomarker for diabetes progression.
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