| 1. |
- Daneshjou, Roxana, et al.
(författare)
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Working toward precision medicine : Predicting phenotypes from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges
- 2017
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Ingår i: Human Mutation. - : Hindawi Limited. - 1059-7794 .- 1098-1004. ; 38:9, s. 1182-1192
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Tidskriftsartikel (refereegranskat)abstract
- Precision medicine aims to predict a patient's disease risk and best therapeutic options by using that individual's genetic sequencing data. The Critical Assessment of Genome Interpretation (CAGI) is a community experiment consisting of genotype-phenotype prediction challenges; participants build models, undergo assessment, and share key findings. For CAGI 4, three challenges involved using exome-sequencing data: Crohn's disease, bipolar disorder, and warfarin dosing. Previous CAGI challenges included prior versions of the Crohn's disease challenge. Here, we discuss the range of techniques used for phenotype prediction as well as the methods used for assessing predictive models. Additionally, we outline some of the difficulties associated with making predictions and evaluating them. The lessons learned from the exome challenges can be applied to both research and clinical efforts to improve phenotype prediction from genotype. In addition, these challenges serve as a vehicle for sharing clinical and research exome data in a secure manner with scientists who have a broad range of expertise, contributing to a collaborative effort to advance our understanding of genotype-phenotype relationships.
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| 2. |
- Jiang, Xiaolin, et al.
(författare)
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Poster : Low latency networking for industry 4.0
- 2017
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Ingår i: International Conference on Embedded Wireless Systems and Networks. - : Junction Publishing. - 9780994988614 ; , s. 212-213
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Konferensbidrag (refereegranskat)abstract
- Industry 4.0 poses a stringent delay requirement to the communication network. However, the current protocols cannot satisfy this requirement, as they are mainly designed to achieve high data rates rather than low latency. It is difficult to reduce the delay as the end-to-end delay is accumulated from every layer of the communication network, and the delay introduced by one layer may also be coupled with that from other layers. We analyze the different delay components and investigate the potential techniques that can help reduce one or multiple delay components. To support different latency requirement together with reliability and throughput requirements, the combination and the parameters of potential techniques should be designed in a coordinate way.
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| 3. |
- Jin, Rong, et al.
(författare)
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Congener-specific determination of ultratrace levels of chlorinated and brominated polycyclic aromatic hydrocarbons in atmosphere and industrial stack gas by isotopic dilution gas chromatography/high resolution mass spectrometry method
- 2017
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Ingår i: Journal of Chromatography A. - : Elsevier. - 0021-9673 .- 1873-3778. ; 1509, s. 114-122
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Tidskriftsartikel (refereegranskat)abstract
- Isotopic dilution gas chromatography combined with high resolution mass spectrometry (GC/HRMS) has overwhelming advantages with respect to the accuracy of congener-specific ultratrace analysis of complex persistent organic pollutants (POPs) in environmental matrices. However, an isotopic dilution GC/HRMS method for analysis of chlorinated and brominated polycyclic aromatic hydrocarbons (Cl-PAHs and Br-PAHs) using 13C-labelled congeners as internal standards has not been established. In this study, a method for identification and quantification of 38 congeners of Cl-PAHs and Br-PAHs in atmosphere and stack gas samples from waste incinerators was developed using the isotopic dilution GC/HRMS technique. The instrumental detection limits of the GC/HRMS method ranged from 0.2pg to 1.8pg for Cl-PAH congeners, and 0.7pg to 2.7pg for Br-PAH congeners, which were about three orders of magnitude lower than those of the GC/quadrupole MS method. This new method developed was also the first to enable determination of Cl-PAH and Br-PAH homologs comprising congeners with the same molecular skeleton and chlorine or bromine substitution numbers. Among the detected congeners, seven Cl-PAH congeners and thirteen Br-PAH congeners that were abundant in the atmosphere and stack gases released from waste incinerators were firstly detected in real samples and reported using the established isotopic dilution GC/HRMS method. The developed isotopic dilution GC/HRMS is significant and needed for better studying the environmental behavior and health risk of Cl-PAHs and Br-PAHs.
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| 4. |
- Luvisotto, M., et al.
(författare)
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Physical Layer Design of High-Performance Wireless Transmission for Critical Control Applications
- 2017
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Ingår i: IEEE Transactions on Industrial Informatics. - : IEEE Computer Society. - 1551-3203 .- 1941-0050. ; 13:6, s. 2844-2854
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Tidskriftsartikel (refereegranskat)abstract
- The next generations of industrial control systems will require high-performance wireless networks (named WirelessHP) able to provide extremely low latency, ultrahigh reliability, and high data rates. The current strategy toward the realization of industrial wireless networks relies on adopting the bottom layers of general purpose wireless standards and customizing only the upper layers. In this paper, a new bottom-up approach is proposed through the realization of a WirelessHP physical layer specifically targeted at reducing the communication latency through the minimization of packet transmission time. Theoretical analysis shows that the proposed design allows a substantial reduction in packet transmission time, down to 1 $\mu$ s, with respect to the general purpose IEEE 802.11 physical layer. The design is validated by an experimental demonstrator, which shows that reliable communications up to 20 m range can be established with the proposed physical layer.
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