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- Koblischka, M. R., et al.
(författare)
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Magneto-optic imaging of flux penetration into an artificially granular high-Tc superconductor
- 1999
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Ingår i: Advances in Superconductivity XI. Proceedings of the 11th International Symposium on Superconductivity (ISS'98). - 4431702563 ; 2, s. 693-696
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- A YBa2Cu3O7- (YBCO) thin film is patterned into a hexagonal close packed lattice of disks which are touching each other at the circumferences in order to enable the flow of an intergranular current. Such a sample was suggested by Koblischka et al. [Appl. Phys. Lett 70, 514 (1997)] as a model for a layered granular structure like in a Bi2Sr2Ca2Cu3O10- tape. Magnetization measurements reveal an anomalous position of the low field peak (central peak) similar to the tapes. Magneto-optic imaging is employed to visualize the local field distributions
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- Koblishka, M. R., et al.
(författare)
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Flux penetration into an artificially granular high-Tc superconductor
- 1999
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Ingår i: Physical Review B. - 2469-9969 .- 2469-9950. ; 59, s. 12114-20
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Tidskriftsartikel (refereegranskat)abstract
- A YBa2Cu3O7- thin film is patterned into a hexagonal close-packed lattice of disks (2r=50 m) which are touching each other at the circumferences in order to enable the flow of an intergranular current. Such a sample was suggested by Koblischka et al. [Appl. Phys. Lett. 70, 514 (1997)] as a model for a layered granular structure like in a (Pb,Bi)2Sr2Ca2Cu3O10+ (Bi-2223) tape. The magnetization measurements reveal an anomalous position of the low-field peak (central peak) similar to Bi-2223 tapes. Magneto-optic imaging is employed to visualize the local-field distributions. At low magnification, the flux patterns in the intergranular area between the disks are observed. The observations at high magnification reveal the flux penetration and pinning within the disks. It is shown that such samples may serve as model samples for granular high-Tc superconductors
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- Andersen, S, et al.
(författare)
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Extracellular phospholipase A2 expression in sarcoidosis
- 1996
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Ingår i: Sarcoidosis Vasculitis and Diffuse Lung Diseases. - 1124-0490. ; 13:1, s. 70-73
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Tidskriftsartikel (refereegranskat)abstract
- This study was conducted in order to focus upon the Ca2- dependent secretory non-pancreatic phospholipase A2 (npPLA2) enzyme and its possible role in the pathophysiology of sarcoidosis. Serum samples were taken from 24 patients with sarcoidosis to determine the levels of npPLA2. Moreover, in another group of patients with active chest x-ray stage II and III sarcoidosis, bronchoscopy with bronchoalveolar lavage (BAL) and transbronchial lung biopsies (TBL) were taken. Highly significant increase of npPLA2 in serum was found in patients compared to controls (p < 0.001). Furthermore, those patients with stable and inactive disease and those who were under treatment with corticosteroids, tended to have lower values than those with active disease and those who were untreated. An intense accumulation of npPLA2 was found in smooth muscle tissue in lung biopsy specimens, in close connection with fibroblast accumulation and deposition of collagen. These cells also stained positive for alpha-smooth muscle actin (alpha-SMA). In addition, when using the technique of in situ hybridization, expression of npPLA2-mRNA was found in the fibroblast layer surrounding the epitheloid cell granulomas. These fibroblasts did not stain positive for alpha-SMA. Our data suggest that npPLA2 is actively involved, and has an important role, in the pathophysiology of sarcoidosis.
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- Bergqvist, David, et al.
(författare)
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Secondary aortoenteric fistula : changes from 1973 to 1993
- 1996
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Ingår i: European Journal of Vascular and Endovascular Surgery. - 1078-5884 .- 1532-2165. ; 11:4, s. 425-428
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To investigate a series of patients with secondary aortoenteric fistulas and compare it with a previous series (1985-93 vs. 1973-84). DESIGN: Retrospective study of medical records. SETTING: Sixteen vascular surgical centers in Sweden. PATIENTS: Twenty-seven patients were identified making an overall incidence of 0.5% of all aortoiliac operations. Among aneurysm patients the incidence was significantly lower than in the previous series. One patient record could not be identified. Fourteen primary operations were for aortic aneurysm, 12 for occlusive disease and one was an aortorenal vein bypass. RESULTS: Symptoms of the fistula occurred after a median interval of 90 months which is significantly later than the previous series (32 months; p<0.05). The commonest presentation was bleeding followed by septis. The median diagnostic delay was 10.5 days, which was significantly shorter than in the previous series. Most fistulas involved the duodenum (88%). One patient died before surgery. The postoperative mortality was 28%, significantly lower than in the previous series (58%) (p<0.05). At the end of follow up (median 43 months) significantly more patients were alive than in the previous series (42% vs 18%) (p<0.05). CONCLUSION: Over a 21 year period there seems to have been a decrease in the frequency of secondary aortoenteric fistulas after aneurysm surgery, a longer interval before they occur, a shorter diagnostic delay, and a better survival.
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- Bogstedt, AK, et al.
(författare)
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Passive immunity against diarrhoea
- 1996
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Ingår i: Acta paediatrica (Oslo, Norway : 1992). - : Wiley. - 0803-5253 .- 1651-2227. ; 85:2, s. 125-128
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Tidskriftsartikel (refereegranskat)
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- Broberger, C, et al.
(författare)
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The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
- 1998
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 95:25, s. 15043-15048
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Tidskriftsartikel (refereegranskat)abstract
- Neuropeptide Y (NPY) and the endogenous melanocortin receptor antagonist, agouti gene-related protein (AGRP), coexist in the arcuate nucleus, and both exert orexigenic effects. The present study aimed primarily at determining the brain distribution of AGRP. AGRP mRNA-expressing cells were limited to the arcuate nucleus, representing a major subpopulation (95%) of the NPY neurons, which also was confirmed with immunohistochemistry. AGRP-immunoreactive (-ir) terminals all contained NPY and were observed in many brain regions extending from the rostral telencephalon to the pons, including the parabrachial nucleus. NPY-positive, AGRP-negative terminals were observed in many areas. AGRP-ir terminals were reduced dramatically in all brain regions of mice treated neonatally with monosodium glutamate as well as of mice homozygous for the anorexia mutation. Terminals immunoreactive for the melanocortin peptide α-melanocyte-stimulating hormone formed a population separate from, but parallel to, the AGRP-ir terminals. Our results show that arcuate NPY neurons, identified by the presence of AGRP, project more extensively in the brain than previously known and indicate that the feeding regulatory actions of NPY may extend beyond the hypothalamus.
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- Hansen, G, et al.
(författare)
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Retningslinjer for utredning og behandling av kronisk obstruktiv lungesykdom
- 1995
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Ingår i: Tidsskrift for Den Norske Lægeforening. - 0029-2001. ; 115:6, s. 710-713
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Tidskriftsartikel (refereegranskat)abstract
- A group of chest physicians, general practitioners, clinical pharmacologist and pharmacists appointed by the Institute of Pharmacotherapy, University of Oslo has evaluated the present knowledge about treatment of chronic obstructive lung disease. The group discusses today's medical treatment of this rather numerous group of patients. It is stated that, to a high degree, the treatment of these patients lacks proper documentation, and that treatment needs to be tested out on an individual basis. The group proposes a flow chart for this purpose.
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- Hansson, Kenny, 1972-, et al.
(författare)
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Surface plasmon resonance (SPR) analysis of coagulation in whole blood with application in prothrombin time assay
- 1999
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Ingår i: Biosensors & bioelectronics. - 0956-5663 .- 1873-4235. ; 14:8-9, s. 671-682
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Tidskriftsartikel (refereegranskat)abstract
- It is previously shown that surface plasmon resonance (SPR) can be used to study blood plasma coagulation. This work explores the use of this technique for the analysis of tissue factor induced coagulation, i.e. prothrombin time (PT) analysis, of whole blood and plasma. The reference method was nephelometry. The prothrombin time analysis by SPR was performed by mixing two volumes of blood/plasma, one volume of thromboplastin, and one volume of CaCl2 solution directly on a sensor surface. The measurements show good agreement between nephelometry and SPR plasma analysis and also between SPR plasma and whole blood analysis. The effect of anticoagulant treatment on the clotting times was significant both quantitatively and qualitatively. The impact on the SPR signal of different physiological events in the coagulation process is discussed, and tentative interpretations of the sensorgram features are given. The major advantage of the SPR method compared to nephelometry is the possibility to perform analysis on whole blood instead of plasma. In conclusion, SPR is a promising method for whole blood coagulation analysis.
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- Johansen, K., et al.
(författare)
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Incidence of estimates of the disease burden of rotavirus in Sweden
- 1999
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Ingår i: Acta Paediatrica. Supplement. - : Wiley. - 0803-5326 .- 0803-5253 .- 1651-2227. ; 88:426, s. 20-23
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Tidskriftsartikel (refereegranskat)abstract
- Laboratory and hospitalization data from two children's hospitals with large primary catchment areas and national laboratory and hospitalization data for children under 4 y of age with acute diarrhoea were compiled to estimate the number of hospitalizations and the cost burden associated with rotavirus diarrhoea in Sweden. According to our estimates 1500-1700 rotavirus-associated hospitalizations occur annually in Sweden in children under 4 y of age (3.7 hospitalizations/1000 children/y). This number represents 2.3% of admissions for all diagnoses in children of this age group. The cost of these hospitalizations is 13.5-15 million Swedish crowns (US$1.8-2 million). Serotyping by PCR for two years revealed that serotype 1 (G1) was the most common (49% and 58%, respectively) identified. Serotypes 2-4 were identified in the following proportions G2 (23% and 5%), G3 (21% and 0%) and G4 (7% and 16%). The national laboratory report data for 1993-96 show that as much as 7-13% of rotavirus infections occur in elderly people.
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