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- Bergqvist, David, et al.
(författare)
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Secondary aortoenteric fistula : changes from 1973 to 1993
- 1996
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Ingår i: European Journal of Vascular and Endovascular Surgery. - 1078-5884 .- 1532-2165. ; 11:4, s. 425-428
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To investigate a series of patients with secondary aortoenteric fistulas and compare it with a previous series (1985-93 vs. 1973-84). DESIGN: Retrospective study of medical records. SETTING: Sixteen vascular surgical centers in Sweden. PATIENTS: Twenty-seven patients were identified making an overall incidence of 0.5% of all aortoiliac operations. Among aneurysm patients the incidence was significantly lower than in the previous series. One patient record could not be identified. Fourteen primary operations were for aortic aneurysm, 12 for occlusive disease and one was an aortorenal vein bypass. RESULTS: Symptoms of the fistula occurred after a median interval of 90 months which is significantly later than the previous series (32 months; p<0.05). The commonest presentation was bleeding followed by septis. The median diagnostic delay was 10.5 days, which was significantly shorter than in the previous series. Most fistulas involved the duodenum (88%). One patient died before surgery. The postoperative mortality was 28%, significantly lower than in the previous series (58%) (p<0.05). At the end of follow up (median 43 months) significantly more patients were alive than in the previous series (42% vs 18%) (p<0.05). CONCLUSION: Over a 21 year period there seems to have been a decrease in the frequency of secondary aortoenteric fistulas after aneurysm surgery, a longer interval before they occur, a shorter diagnostic delay, and a better survival.
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- Andersen, S, et al.
(författare)
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Extracellular phospholipase A2 expression in sarcoidosis
- 1996
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Ingår i: Sarcoidosis Vasculitis and Diffuse Lung Diseases. - 1124-0490. ; 13:1, s. 70-73
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Tidskriftsartikel (refereegranskat)abstract
- This study was conducted in order to focus upon the Ca2- dependent secretory non-pancreatic phospholipase A2 (npPLA2) enzyme and its possible role in the pathophysiology of sarcoidosis. Serum samples were taken from 24 patients with sarcoidosis to determine the levels of npPLA2. Moreover, in another group of patients with active chest x-ray stage II and III sarcoidosis, bronchoscopy with bronchoalveolar lavage (BAL) and transbronchial lung biopsies (TBL) were taken. Highly significant increase of npPLA2 in serum was found in patients compared to controls (p < 0.001). Furthermore, those patients with stable and inactive disease and those who were under treatment with corticosteroids, tended to have lower values than those with active disease and those who were untreated. An intense accumulation of npPLA2 was found in smooth muscle tissue in lung biopsy specimens, in close connection with fibroblast accumulation and deposition of collagen. These cells also stained positive for alpha-smooth muscle actin (alpha-SMA). In addition, when using the technique of in situ hybridization, expression of npPLA2-mRNA was found in the fibroblast layer surrounding the epitheloid cell granulomas. These fibroblasts did not stain positive for alpha-SMA. Our data suggest that npPLA2 is actively involved, and has an important role, in the pathophysiology of sarcoidosis.
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- Hansen, G, et al.
(författare)
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Retningslinjer for utredning og behandling av kronisk obstruktiv lungesykdom
- 1995
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Ingår i: Tidsskrift for Den Norske Lægeforening. - 0029-2001. ; 115:6, s. 710-713
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Tidskriftsartikel (refereegranskat)abstract
- A group of chest physicians, general practitioners, clinical pharmacologist and pharmacists appointed by the Institute of Pharmacotherapy, University of Oslo has evaluated the present knowledge about treatment of chronic obstructive lung disease. The group discusses today's medical treatment of this rather numerous group of patients. It is stated that, to a high degree, the treatment of these patients lacks proper documentation, and that treatment needs to be tested out on an individual basis. The group proposes a flow chart for this purpose.
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- Hansson, Kenny, 1972-, et al.
(författare)
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Surface plasmon resonance (SPR) analysis of coagulation in whole blood with application in prothrombin time assay
- 1999
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Ingår i: Biosensors & bioelectronics. - 0956-5663 .- 1873-4235. ; 14:8-9, s. 671-682
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Tidskriftsartikel (refereegranskat)abstract
- It is previously shown that surface plasmon resonance (SPR) can be used to study blood plasma coagulation. This work explores the use of this technique for the analysis of tissue factor induced coagulation, i.e. prothrombin time (PT) analysis, of whole blood and plasma. The reference method was nephelometry. The prothrombin time analysis by SPR was performed by mixing two volumes of blood/plasma, one volume of thromboplastin, and one volume of CaCl2 solution directly on a sensor surface. The measurements show good agreement between nephelometry and SPR plasma analysis and also between SPR plasma and whole blood analysis. The effect of anticoagulant treatment on the clotting times was significant both quantitatively and qualitatively. The impact on the SPR signal of different physiological events in the coagulation process is discussed, and tentative interpretations of the sensorgram features are given. The major advantage of the SPR method compared to nephelometry is the possibility to perform analysis on whole blood instead of plasma. In conclusion, SPR is a promising method for whole blood coagulation analysis.
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- Koblischka, M. R., et al.
(författare)
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Magneto-optic imaging of flux penetration into an artificially granular high-Tc superconductor
- 1999
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Ingår i: Advances in Superconductivity XI. Proceedings of the 11th International Symposium on Superconductivity (ISS'98). - 4431702563 ; 2, s. 693-696
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- A YBa2Cu3O7- (YBCO) thin film is patterned into a hexagonal close packed lattice of disks which are touching each other at the circumferences in order to enable the flow of an intergranular current. Such a sample was suggested by Koblischka et al. [Appl. Phys. Lett 70, 514 (1997)] as a model for a layered granular structure like in a Bi2Sr2Ca2Cu3O10- tape. Magnetization measurements reveal an anomalous position of the low field peak (central peak) similar to the tapes. Magneto-optic imaging is employed to visualize the local field distributions
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- Koblishka, M. R., et al.
(författare)
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Flux penetration into an artificially granular high-Tc superconductor
- 1999
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Ingår i: Physical Review B. - 2469-9969 .- 2469-9950. ; 59, s. 12114-20
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Tidskriftsartikel (refereegranskat)abstract
- A YBa2Cu3O7- thin film is patterned into a hexagonal close-packed lattice of disks (2r=50 m) which are touching each other at the circumferences in order to enable the flow of an intergranular current. Such a sample was suggested by Koblischka et al. [Appl. Phys. Lett. 70, 514 (1997)] as a model for a layered granular structure like in a (Pb,Bi)2Sr2Ca2Cu3O10+ (Bi-2223) tape. The magnetization measurements reveal an anomalous position of the low-field peak (central peak) similar to Bi-2223 tapes. Magneto-optic imaging is employed to visualize the local-field distributions. At low magnification, the flux patterns in the intergranular area between the disks are observed. The observations at high magnification reveal the flux penetration and pinning within the disks. It is shown that such samples may serve as model samples for granular high-Tc superconductors
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- Truedsson, Lennart, et al.
(författare)
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Sharing of MHC haplotypes among patients with systemic lupus erythematosus from unrelated Caucasian multicase families: disease association with the extended haplotype [HLA-B8, SC01, DR17]
- 1995
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Ingår i: Journal of Rheumatology. - 0315-162X. ; 22:10, s. 1852-1861
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease often clustered in families. We investigated the association between MHC haplotypes and SLE in multicase Caucasian families. METHODS: Ten consecutive families with 2 or more patients with SLE, in total 27 patients among 66 individuals, were studied. MHC haplotypes were determined by typing for HLA-A, B, C, DR, and DQ by serological and DNA methods. Complotypes were determined by protein typing and C4 gene polymorphism by DNA analysis. RESULTS: Fifty-four independent MHC haplotypes were found. Ten of the 31 haplotypes in the patients with SLE were examples of the extended haplotype [HLA-B8,SC01,DR17]. Six of these were found in 2 or more patients with SLE within the same family. All the 14 SLE sib-pairs in the families shared at least one haplotype and in 9 of the sib-pairs the shared haplotype was [HLA-B8,SCO1,DR17]. Three SLE associated haplotypes were [HLA-B7,SC31,DR15]. Four of the 27 patients with SLE were C4A deficient. Two C2 deficient siblings were homozygous for the haplotype [HLA-B18,S042,DR15]. CONCLUSION: We demonstrate that a very limited number of MHC haplotypes are associated with familial SLE. The haplotype [HLA-B8,SCO1,DR17] was closely related with the disease. There was no evidence suggesting familial SLE constitutes a disease subset. Determination of MHC haplotypes in multicase families is of value for assessment of disease susceptibility.
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| 15. |
- Vikinge, Trine P., et al.
(författare)
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Blood plasma coagulation studied by surface plasmon resonance
- 1999
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Ingår i: BIOMEDICAL SENSORS, FIBERS, AND OPTICAL DELIVERY SYSTEMS, PROCEEDINGS. - : SPIE - International Society for Optical Engineering. ; , s. 107-114
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Konferensbidrag (refereegranskat)abstract
- A surface plasmon resonance (SPR) apparatus was used to investigate blood plasma coagulation in real-time as a function of thromboplastin and heparin concentrations. The physical reason for the SPR signal observed is discussed and 3 different models are proposed. The response curves were analyzed by multivariable curve fitting followed by feature extraction. Interesting parameters of the sigmoid curves were lag time, slope and maximum response. When thromboplastin concentrations were increased, the lag-time decreased and the slope of the curve increased. A prolonged clotting time was mostly followed by increased maximum response, with exception for samples with no or very little thromboplastin added. High heparin concentrations changed the clotting kinetics, as seen from the lag-time vs. slope relation. Atomic force microscopy (AFM) pictures of sensor surfaces dried after completed clotting, revealed differences in fibrin network structures as a function of thromboplastin concentration, and fiber thickness increased with lower thromboplastin concentration. The results correlate well with present common methods.
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