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1.	Bärnarp, Tora, et al. (författare) Skönhet hållbarhet funktion 2023 Rapport (övrigt vetenskapligt/konstnärligt)abstract Denna publikation redovisar studenternas enskilda arbeten. Materialet har tillkommit inom ramen för läsårets tema ”Skönhet, hållbarhet och funktion”, men varje studie utgår ifrån studenternas egna val av ämne.
2.	Fricke, Katrin, et al. (författare) Impact of Left Ventricular Morphology on Adverse Outcomes Following Stage 1 Palliation for Hypoplastic Left Heart Syndrome: 20 Years of National Data From Sweden 2022 Ingår i: Journal of the American Heart Association. - : John Wiley & Sons. - 2047-9980. ; 11:7 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: Hypoplastic left heart syndrome is associated with significant morbidity and mortality. We aimed to assess the influence of left ventricular morphology and choice of shunt on adverse outcome in patients with hypoplastic left heart syndrome and stage 1 palliation. METHODS AND RESULTS: This was a retrospective analysis of patients with hypoplastic left heart syndrome with stage 1 palliation between 1999 and 2018 in Sweden. Patients (n=167) were grouped based on the anatomic subtypes aortic-mitral atresia, aortic atresia-mitral stenosis (AA-MS), and aortic-mitral stenosis. The left ventricular phenotypes including globular left ventricle (Glob-LV), miniaturized and slit-like left ventricle (LV), and the incidence of major adverse events (MAEs) including mortality were assessed. The overall mortality and MAEs were 31% and 41%, respectively. AA-MS (35%) was associated with both mortality (all other subtypes versus AA-MS: interstage-I: hazard ratio [HR], 2.7; P=0.006; overall: HR, 2.2; P=0.005) and MAEs (HR, 2.4; P=0.0009). Glob-LV (57%), noticed in all patients with AA-MS, 61% of patients with aortic stenosis-mitral stenosis, and 19% of patients with aortic atresia-mitral atresia, was associated with both mortality (all other left ventricular phenotypes versus Glob-LV: interstage-I: HR, 4.5; P=0.004; overall: HR, 3.4; P=0.0007) and MAEs (HR, 2.7; P=0.0007). There was no difference in mortality and MAEs between patients with AA-MS and without AA-MS with Glob-LV (P>0.15). Patients with AA-MS (35%) or Glob-LV (38%) palliated with a Blalock-Taussig shunt had higher overall mortality compared with those palliated with Sano shunts, irrespective of the stage 1 palliation year (AA-MS: HR, 2.6; P=0.04; Glob-LV: HR, 2.1; P=0.03). CONCLUSIONS: Glob-LV and AA-MS are independent morphological risk factors for adverse short-and long-term outcome, especially if a Blalock-Taussig shunt is used as part of stage 1 palliation. These findings are important for the clinical management of patients with hypoplastic left heart syndrome.
3.	Krupanek, Janusz, et al. (författare) Sectoral Guidance for Chemicals Management in the Surface treatment of metals and plastics Industry : HAZBREF-project Activity 4.1 report 2021 Rapport (övrigt vetenskapligt/konstnärligt)abstract BackgroundThe main instrument on EU level to control industrial releases is the Industrial Emissions Directive (IED), particularly through the publication of BAT reference documents (BREFs) and related BAT Conclusions, which is the reference for setting the permit conditions throughout EU for IED installations. However, the BREFs published so far do not contain adequate information on specific hazardous chemicals used and released from industry which makes the control difficult for the industry and the permitting and supervising authorities.One of the case sectors in the HAZBREF project is the surface treatment of metals and plastics (STM). This sector was chosen due to the use of chemicals, potential emissions, the wide range of products as well as technological processes and the upcoming STM BREF review. The other HAZBREF case sectors are textile industry and chemical industry which are addressed in separate reports.The lack of knowledge on the use and flow of specific hazardous chemicals in the industrial processes makes chemical control and reduction measures difficult. The problem is that often neither plant operators nor authorities know which substances are relevant to be treated and which handling measures are needed. Surface treatment of metals and plastics is covered by the STM BREF document, published in 2006. According to the last work programme of the EIPPCB the review of the EU STM BREF is planned to start in 2021.Purpose of the documentThis sectoral guidance contains information on uses of hazardous chemicals, the best practices in chemical management and recommendations on enhancing the permitting process in the STM sector. This document sums up the findings from HAZBREF project and is based on industrial case studies, interviews with authorities and expert judgment. The aim is to describe good practices in chemical management to be utilized by STM installations as well as environmental and chemical authorities. These include technical, organisational and management aspects and concrete tools supporting chemical management.The report addresses the STM sector as a whole in Europe, although the main part of the findings is generated from HAZBREF case installation and other experiences in the Baltic Sea Region. The document provides also general descriptions of BAT proposals related to management of hazardous chemicals and substances. These findings of the guidance will feed into in the forthcoming revision of the STM BREF. They are also to be used for HELCOM recommendations on how to reduce the discharge of hazardous substances into the Baltic Sea.Moreover, the document provides an overview of applicable legal requirements, procedures and other obligations of installation operators regarding use of chemicals and releases of hazardous substances. This includes guidance for tools to identify and assess relevant hazardous substances used and released from the STM installations.Main findings and proposalsImprovement of chemical management systemA Chemical Management System provides a systematic way of managing chemicals through the whole process on the site. Most of the companies have implemented quality management standards such as ISO 9000, ISO 14000, EMAS and integrated EHS programs which also address certain aspects of chemical management. The quality of chemical management systems in the companies differs depending on the scale of operation, ownership and awareness. Integration of good practices of chemical management within already implemented management systems strengthens the ability to reduce environmental risks. HAZBREF project strongly recommends the establishment and regular use of a chemical management system at IED installations.Development of a chemical inventoryThe establishment and maintenance of a chemical inventory is an importantprerequisite for effective and responsible chemicals management in the STMsector. All chemicals and raw materials along with information on their propertiesused in all processes and activities at the site should be listed in a database. Such adatabase is a key part of chemical management allowing for systematic riskassessment, management of chemicals flows and their storage. The information in the chemical list/database must be searchable and should be updated regularly. Most of the information needed is available in the safety datasheets (SDS). If some information is missing from the SDS, the supplier should be asked to provide this. Good routines to handle new and updated SDSs are crucial to have an up to date and reliable chemical database. These routines should involve on-site handling and updates as well as communication with suppliers on how SDSs are delivered. Well-managed chemical inventories can significantly simplify the environmental permit application process both for the operators and the permitting authorities.Better use of Chemical Management Tools and training of stafNumerous references and tools are available to support STM companies and competent authorities in implementing the good chemical management required in the IED. HAZBREF recommends that operators use proper tools for risk assessment and evaluation of the efficiency of chemical management.Use and improvement of risk assessment tools such as extended SDS and material flow analysis should be promoted among installation operators in this respect. The HAZBREF project has developed a comprehensive tool that helps the operators to identify the site-specific hazardous substances that should be considered in strategic and operational decisions.Awareness raising and training of staff in the use of chemical management tools and systems is crucial for implementation of good chemical management practices at the installations.SubstitutionA regular check aiming at identifying potentially new available and safer alternatives to the hazardous chemicals used is an important measure to minimise chemical risks at the installation. A successful substitution work can be performed in four stages: - Identification of hazardous substances - Screening for possible alternatives - Evaluation and choice of alternatives and Development of new alternatives.Substitution can be aimed for any hazardous chemical used at installation level where it is needed in order to protect environment or human health. However, regrettable substitution (i.e. move to use new chemical that is equally or more hazardous than the substituted chemical or results in cross-media effects) must be avoided.Assessment and improvement of SDSEfficient chemicals management requires high quality of the Safety Data Sheets (SDS). The SDS should sufficiently describe the chemical properties and include information about exposure (including use and emissions), eco-toxicology and proper storage and handling. A SDS must also contain information on whether the chemical product contains substances on the SVHC list, priority substances under the Water Framework Directive WFD and the POPs convention. In case a chemical supplier fails to provide a SDS of sufficient quality, it is the duty of both the operator and the competent authority to demand the missing information. This is already required by law in some countries, e.g. Germany. It is also important that the operators know how to extract and consolidate the relevant information from the SDS to their permit applications and verify the quality of different information sources.The development of an extended SDS including exposure scenarios and improved data on environmental effects would facilitate better risk assessment of individual chemicals used in specific processes. This would lead to more efficient monitoring and help focusing on substances of concern. Improved SDSs for raw materials with information on impurities or additives would facilitate more complete chemical inventories.Continuous improvement of BAT implementation The implementation of BAT needs to be continuously monitored and improved at the installation considering site specific technological, economical and environmental aspects. The findings from Polish HAZBREF case studies is that fulfilment of BAT requirements can be challenging if all improvements need to be done in a short time period. For example, closed-loop systems are considered necessary additional process-integrated techniques that it is important to implementstep by step in the installations.Circular economyThe STM sector is a significant user of non-renewable resources (metals), and recycling of recovered metal containing materials such as metal substrates orelectrolytes back to the process is good practice. Such recovery processes are widely used for basic metals, such as zinc, copper and nickel, which are used as valuable secondary raw materials SRM. High costs of recovery processes and high energy consumption as well as the variety of chemicals and metals used in STM processes often hinders recycling. In cases where recycling is not feasible, pretreatment of contaminated waste water on site and subsequent off-site treatment of generated metal containing sludges is standard practice.Permitting processBeside best practices in chemical management, the project also elaborated recommendations on enhancing the permitting process in the STM sector. It can be concluded that the existing general structure and content of the permit application procedures are as such sufficient to deal with hazardous substances and chemicals. Nevertheless, in practice the permit process could be improved with more communication between the applicant and the permitting authority during the application phase. More co-operation between chemical, environmental and occupational health authorities is suggested to achieve a smooth information flow and reduce double work regarding requirements under different legislations concerning chemicals and hazardous substances. In some countries, for example in Finland, the supervising practices in different parts of a given country need harmonising s
4.	Moberg, Christina, et al. (författare) De unga gör helt rätt när de stämmer staten 2022 Ingår i: Aftonbladet. - 1103-9000. Tidskriftsartikel (populärvet., debatt m.m.)abstract 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
5.	Pascual, Didac, et al. (författare) The missing pieces for better future predictions in subarctic ecosystems: A Torneträsk case study 2021 Ingår i: Ambio. - : Springer. - 0044-7447 .- 1654-7209. ; 50:2, s. 375-392 Forskningsöversikt (refereegranskat)abstract Arctic and subarctic ecosystems are experiencing substantial changes in hydrology, vegetation, permafrost conditions, and carbon cycling, in response to climatic change and other anthropogenic drivers, and these changes are likely to continue over this century. The total magnitude of these changes results from multiple interactions among these drivers. Field measurements can address the overall responses to different changing drivers, but are less capable of quantifying the interactions among them. Currently, a comprehensive assessment of the drivers of ecosystem changes, and the magnitude of their direct and indirect impacts on subarctic ecosystems, is missing. The Torneträsk area, in the Swedish subarctic, has an unrivalled history of environmental observation over 100 years, and is one of the most studied sites in the Arctic. In this study, we summarize and rank the drivers of ecosystem change in the Torneträsk area, and propose research priorities identified, by expert assessment, to improve predictions of ecosystem changes. The research priorities identified include understanding impacts on ecosystems brought on by altered frequency and intensity of winter warming events, evapotranspiration rates, rainfall, duration of snow cover and lake-ice, changed soil moisture, and droughts. This case study can help us understand the ongoing ecosystem changes occurring in the Torneträsk area, and contribute to improve predictions of future ecosystem changes at a larger scale. This understanding will provide the basis for the future mitigation and adaptation plans needed in a changing climate.
6.	Abreu, Ilka, et al. (författare) A metabolite roadmap of the wood-forming tissue in Populus tremula 2020 Ingår i: New Phytologist. - : John Wiley & Sons. - 0028-646X .- 1469-8137. ; 228:5, s. 1559-1572 Tidskriftsartikel (refereegranskat)abstract Wood, or secondary xylem, is the product of xylogenesis, a developmental process that begins with the proliferation of cambial derivatives and ends with mature xylem fibers and vessels with lignified secondary cell walls. Fully mature xylem has undergone a series of cellular processes, including cell division, cell expansion, secondary wall formation, lignification and programmed cell death. A complex network of interactions between transcriptional regulators and signal transduction pathways controls wood formation. However, the role of metabolites during this developmental process has not been comprehensively characterized. To evaluate the role of metabolites during wood formation, we performed a high spatial resolution metabolomics study of the wood-forming zone of Populus tremula, including laser dissected aspen ray and fiber cells. We show that metabolites show specific patterns within the wood-forming zone, following the differentiation process from cell division to cell death. The data from profiled laser dissected aspen ray and fiber cells suggests that these two cell types host distinctly different metabolic processes. Furthermore, by integrating previously published transcriptomic and proteomic profiles generated from the same trees, we provide an integrative picture of molecular processes, for example, deamination of phenylalanine during lignification is of critical importance for nitrogen metabolism during wood formation.
7.	Abugabbara, Marwan, et al. (författare) How to develop fifth-generation district heating and cooling in Sweden? : Application review and best practices proposed by middle agents 2023 Ingår i: Energy Reports. - : Elsevier Ltd. - 2352-4847. ; 9, s. 4971-4983 Tidskriftsartikel (refereegranskat)abstract Sweden has an ambitious plan to fully decarbonise district heating by 2030 and to contribute with negative emissions of greenhouse gases in 2050. The vagaries of the energy market associated with climate, political, and social changes entail cross-sectoral integration that can fulfill these national targets. Fifth-generation district heating and cooling (5GDHC) is a relatively new concept of district energy systems that features a simultaneous supply of heating and cooling using power-to-heat technologies. This paper presents best practices for developing 5GDHC systems in Sweden to reach a consensus view on these systems among all stakeholders. A mixed-method combining best practice and roadmapping workshops has been used to disseminate mixed knowledge and experience from middle agents representing industry professionals and practitioners. Four successful implementations of 5GDHC systems are demonstrated and the important learned lessons are shared. The best practices are outlined for system planning, system modeling and simulation, prevailing business models for energy communities, and system monitoring. A roadmap from the middle agents’ point of view is composed and can be utilised to establish industry standards and common regulatory frameworks. © 2023 The Author(s)
8.	Ahonen, Pasi, et al. (författare) Writing resistance together 2020 Ingår i: Gender, Work and Organization. - : John Wiley & Sons. - 0968-6673 .- 1468-0432. ; 27:4, s. 447-470 Tidskriftsartikel (refereegranskat)abstract This piece of writing is a joint initiative by the participants in the Gender, Work and Organization writing workshop organized in Helsinki, Finland, in June 2019. This is a particular form of writing differently. We engage in collective writing and embody what it means to write resistance to established academic practices and conventions together. This is a form of emancipatory initiative where we care for each other as writers and as human beings. There are many author voices and we aim to keep the text open and dialogical. As such, this piece of writing is about suppressed thoughts and feelings that our collective picket line allows us to express. In order to maintain the open-ended nature of the text, and perhaps also to retain some 'dirtiness' that is essential to writing, the article has not been language checked throughout by a native speaker of English.
9.	Al-Amin, Rasel A., Researcher, 1983-, et al. (författare) Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ 2022 Ingår i: Nucleic Acids Research. - : Oxford University Press. - 0305-1048 .- 1362-4962. ; 50:22, s. e129-e129 Tidskriftsartikel (refereegranskat)abstract Drugs are designed to bind their target proteins in physiologically relevant tissues and organs to modulate biological functions and elicit desirable clinical outcomes. Information about target engagement at cellular and subcellular resolution is therefore critical for guiding compound optimization in drug discovery, and for probing resistance mechanisms to targeted therapies in clinical samples. We describe a target engagement-mediated amplification (TEMA) technology, where oligonucleotide-conjugated drugs are used to visualize and measure target engagement in situ, amplified via rolling-circle replication of circularized oligonucleotide probes. We illustrate the TEMA technique using dasatinib and gefitinib, two kinase inhibitors with distinct selectivity profiles. In vitro binding by the dasatinib probe to arrays of displayed proteins accurately reproduced known selectivity profiles, while their differential binding to fixed adherent cells agreed with expectations from expression profiles of the cells. We also introduce a proximity ligation variant of TEMA to selectively investigate binding to specific target proteins of interest. This form of the assay serves to improve resolution of binding to on- and off-target proteins. In conclusion, TEMA has the potential to aid in drug development and clinical routine by conferring valuable insights in drug–target interactions at spatial resolution in protein arrays, cells and in tissues.
10.	Alm, Fredrik, 1983-, et al. (creator_code:cre_t) Örebro University’s Nobel Day Festivities : Book of abstracts, 2023 2023. - 1 Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)
11.	Ara, Mostarin, et al. (författare) Pre-commercial thinning in Norway spruce-birch mixed stands can provide abundant forage for ungulates without losing volume production 2022 Ingår i: Forest Ecology and Management. - : Elsevier BV. - 0378-1127 .- 1872-7042. ; 520 Tidskriftsartikel (refereegranskat)abstract Mixed stands of Norway spruce and birch have the potential to simultaneously produce timber and provide large ungulates with a significant amount of forage during the regeneration phase. While the growth and yield of such mixtures are well studied, little is known about potential trade-offs between timber and forage production and which management techniques are suitable for meeting both goals. In this study, four different pre-commercial thinning (PCT) strategies were used to study the trade-offs between production and available forage for free-ranging ungulates in a Norway spruce-birch mixture. The four PCT strategies were: 1) retaining 2000 birch stems ha(-1) with 2000 Norway spruce ha(-1), 2) removing all birches within a 0.75 m radius around Norway spruce stems, 3) removing all birches and other broadleaves, and 4) no PCT (control). Growth of Norway spruce was higher in the 2000 birch ha(-1) and full removal treatments compared to the untreated control, but these two treatments did not differ from one another in volume production of Norway spruce. We found a negative effect of PCT on forage availability but no effect on ungulate browsing. Therefore, PCT strategies that provide both sufficient birch forage and maximize volume production of Norway spruce can be implemented.
12.	Balkenius, Christian, et al. (författare) The Missing Link Between Memory and Reinforcement Learning 2020 Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 11 Tidskriftsartikel (refereegranskat)abstract Reinforcement learning systems usually assume that a value function is defined over all states (or state-action pairs) that can immediately give the value of a particular state or action. These values are used by a selection mechanism to decide which action to take. In contrast, when humans and animals make decisions, they collect evidence for different alternatives over time and take action only when sufficient evidence has been accumulated. We have previously developed a model of memory processing that includes semantic, episodic and working memory in a comprehensive architecture. Here, we describe how this memory mechanism can support decision making when the alternatives cannot be evaluated based on immediate sensory information alone. Instead we first imagine, and then evaluate a possible future that will result from choosing one of the alternatives. Here we present an extended model that can be used as a model for decision making that depends on accumulating evidence over time, whether that information comes from the sequential attention to different sensory properties or from internal simulation of the consequences of making a particular choice. We show how the new model explains both simple immediate choices, choices that depend on multiple sensory factors and complicated selections between alternatives that require forward looking simulations based on episodic and semantic memory structures. In this framework, vicarious trial and error is explained as an internal simulation that accumulates evidence for a particular choice. We argue that a system like this forms the “missing link” between more traditional ideas of semantic and episodic memory, and the associative nature of reinforcement learning.
13.	Bark, Glenn, et al. (författare) Politikerna struntar i klimatforskningen : 420 forskare: Regeringens politik är katastrofal – nu måste fler svenskar kräva en omställning 2023 Ingår i: Aftonbladet Debatt. - 1103-9000. Tidskriftsartikel (populärvet., debatt m.m.)abstract DEBATE. We researchers have long demanded that the government take climate research seriously and speed up the transition to a sustainable society.Instead, the government is pursuing a policy that deliberately increases emissions. Now more citizens need to raise their voices and show that we demand a knowledge-based climate transition, and it is urgent.
14.	Bay, Annika, et al. (författare) Enablers and barriers for being physically active : experiences from adults with congenital heart disease 2021 Ingår i: European Journal of Cardiovascular Nursing. - : Sage Publications. - 1474-5151 .- 1873-1953. ; 20:3, s. 276-284 Tidskriftsartikel (refereegranskat)abstract Background: In general, adults with congenital heart disease have reduced exercise capacity and many do not reach the recommended level of physical activity. A physically active lifestyle is essential to maintain health and to counteract acquired cardiovascular disease, therefore enablers and barriers for being physically active are important to identify.Aim: To describe what adults with complex congenital heart diseases consider as physical activity, and what they experience as enablers and barriers for being physically active. Methods: A qualitative study using semi-structured interviews in which 14 adults with complex congenital heart disease (seven women) participated. The interviews were analysed using qualitative content analysis.Results: The analysis revealed four categories considered enablers and barriers - encouragement, energy level, approach and environment. The following is exemplified by the category encouragement as an enabler: if one had experienced support and encouragement to be physically active as a child, they were more positive to be physically active as an adult. In contrast, as a barrier, if the child lacked support and encouragement from others, they had never had the opportunity to learn to be physically active.Conclusion: It is important for adults with congenital heart disease to have the opportunity to identify barriers and enablers for being physically active. They need knowledge about their own exercise capacity and need to feel safe that physical activity is not harmful. This knowledge can be used by healthcare professionals to promote, support and eliminate misconceptions about physical activity. Barriers can potentially be transformed into enablers through increased knowledge about attitudes and prerequisites. © The European Society of Cardiology 2020.
15.	Bay, Annika, 1970-, et al. (författare) Symptoms during pregnancy in primiparous women with congenital heart disease. 2024 Ingår i: Scandinavian Cardiovascular Journal. - : Taylor & Francis. - 1401-7431 .- 1651-2006. ; 58:1 Tidskriftsartikel (refereegranskat)abstract Background: As more women with congenital heart disease (CHD) are reaching childbearing age, it becomes more common for their symptoms to be evaluated during pregnancy. However, pregnancy-related symptoms are similar to those caused by heart disease. This study investigated the prevalence of factors associated with symptoms during pregnancy in women with CHD.Methods: The national birth register was searched for primiparous women with CHD who were registered in the national quality register for patients with CHD.Results: Symptoms during the third trimester were reported in 104 of 465 evaluated women. The most common symptom was palpitations followed by dyspnea. Factors associated with symptoms were tested in a univariable model; higher NYHA classification (>1) (OR 11.3, 95%CI 5.5-23.2), low physical activity (≤3 h/week) (OR 2.1 95%CI 1.3-3.6) and educational level ≤ 12 years (OR 1.9 95%CI 1.2-3.0) were associated with having symptoms. In multivariable analysis, low physical activity level (OR 2.4 95%CI 1.2-5.0) and higher NYHA class (OR 11.3 95%CI 5.0-25.6) remained associated with symptoms during pregnancy. There were no cases with new onset of impaired systemic ventricular function during pregnancy.Conclusion: Symptoms during pregnancy are common in women with CHD but are often already present before pregnancy. Because ordinary symptoms during pregnancy often overlap with symptoms of heart disease, it is important to know if symptoms were present before pregnancy and if they became worse during pregnancy. These results should be included in pre-pregnancy counselling and considered in the monitoring during pregnancy.
16.	Bing, Zhao, 1990, et al. (författare) Unconventional Charge–Spin Conversion in Weyl-Semimetal WTe2 2020 Ingår i: Advanced Materials. - : Wiley. - 0935-9648 .- 1521-4095. ; 32:38 Tidskriftsartikel (refereegranskat)abstract An outstanding feature of topological quantum materials is their novel spin topology in the electronic band structures with an expected large charge-to-spin conversion efficiency. Here, a charge-current-induced spin polarization in the type-II Weyl semimetal candidate WTe2 and efficient spin injection and detection in a graphene channel up to room temperature are reported. Contrary to the conventional spin Hall and Rashba–Edelstein effects, the measurements indicate an unconventional charge-to-spin conversion in WTe2, which is primarily forbidden by the crystal symmetry of the system. Such a large spin polarization can be possible in WTe2 due to a reduced crystal symmetry combined with its large spin Berry curvature, spin–orbit interaction with a novel spin-texture of the Fermi states. A robust and practical method is demonstrated for electrical creation and detection of such a spin polarization using both charge-to-spin conversion and its inverse phenomenon and utilized it for efficient spin injection and detection in the graphene channel up to room temperature. These findings open opportunities for utilizing topological Weyl materials as nonmagnetic spin sources in all-electrical van der Waals spintronic circuits and for low-power and high-performance nonvolatile spintronic technologies.
17.	Bjursell, Cecilia, 1970-, et al. (författare) Higher education as learning organizations – An empirical study of education managers perception of their work situation 2022 Ingår i: NFF 2022 Conference Papers. Konferensbidrag (refereegranskat)abstract The paper presents a study of Swedish academic leaders’ perception of their work situation. The aim was to explore the conditions which can enable creativity and learning in higher education institutions. The KEYS survey was sent to a sample of 64 university managers from social sciences, humanities and technical departments at Swedish universities. The response rate was 39 % (n25). The result indicates that education managers perceive a lack of feedback from upper management, but at the same time, they claim to have a high level of trust from upper management.
18.	Carbone, Dina, et al. (författare) Design and performance of a dedicated coherent X-ray scanning diffraction instrument at beamline NanoMAX of MAX IV 2022 Ingår i: Journal of Synchrotron Radiation. - 1600-5775. ; 29, s. 876-887 Tidskriftsartikel (refereegranskat)abstract The diffraction endstation of the NanoMAX beamline is designed to provide high-flux coherent X-ray nano-beams for experiments requiring many degrees of freedom for sample and detector. The endstation is equipped with high-efficiency Kirkpatrick-Baez mirror focusing optics and a two-circle goniometer supporting a positioning and scanning device, designed to carry a compact sample environment. A robot is used as a detector arm. The endstation, in continued development, has been in user operation since summer 2017.
19.	Carlsson, Annika, et al. (författare) Flytande väte som ett logistiskt bränsle – En förstudie 2022 Rapport (övrigt vetenskapligt/konstnärligt)abstract Energibolagen gör stora investeringar för att tillhandahålla infrastruktur för produktion, distribution och tankning av vätgas. Det är därför viktigt att hitta de mest effektiva och genomförbara scenarierna för väte i samhället. Detta innebär att välja mellan värdekedjor för flytande väte (LH2) eller komprimerad vätgas (CGH2) i stegen från produktion till lagring ombord på fordon inom transportsegment, till exempel tunga lastbilar. Under projektet övervägdes också det ännu oetablerade konceptet med kryo-komprimerad vätgas (CcH2). Projektet syftade till att identifiera de kritiska utmaningarna och nuvarande begränsningar som påverkar den utbredda användningen av väte som bränsle för transporttillämpningar. Det har fokuserat på att öka kunskapen om teknologier som kan göra LH2- eller CGH2-infrastruktur och fordonsanvändning effektivare och säkrare, genom att bedöma den aktuella teknikens nivå såväl som mognad samt potential för ny teknik. I detta ingick också ett segment fokuserat på säkerhetsrisker kring alternativen längs de senare delarna av värdekedjan. Projektet som helhet genomfördes som en litteraturstudie. För teknologimognaden i olika delar av värdekedjan har projektet sammanfattat resultaten i ett kategoriseringssystem på mycket hög nivå, se tabell nedan. Definitionerna är huvudsakligen kvalitativa i följande kategorier: • Etablerad (används i större skala, ~TRL 9-10) • Beprövat koncept (demonstranter eller snart det här stadiet, ~TRL 7-8) • Initial design (inga offentliga demonstratorer tillgängliga, ~TRL 3-6) • Osäker tillämplighet (tillämpligheten fastställdes inte i detta arbete) • Ej tillämpbart (Kan inte användas för detta tillstånd av väte) Tabellen ovan ger också en översikt över de segment som ingår i rapporten. I kombination med den tekniska utvärderingen gjordes också en kvalitativ kostnadsanalys av de olika fastillstånden för väte. Här indikeras att även om LH2 har en högre kostnad i den inledande delen av värdekedjan, har den lägre kostnader i slutsegmenten. Därför är det möjligt att slutpriset för användaren blir liknande för både LH2 och CGH2. Hela kostnaden kan jämföras först när LH2 tankstationer och fordon byggs offentligt och kostnadsinformation är tillgänglig. Detsamma gäller för CcH2. Under förstudien för säkerhet, föreskrifter och standarder kom följande slutsats: Ur ett säkerhetsperspektiv finns det inga oöverstigliga barriärer med avseende på användningen av LH2 ombord på tunga vägfordon på medellång sikt, men det finns flera utmaningar att övervinna, inte minst på kort sikt. Inom EU finns regler som tillåter typgodkännande av tunga vägfordon med LH2 lagringssystem. Dessa är dock baserade på arbete som utfördes för 15 - 20 år sedan och är allmänt erkända som i behov av att uppdateras och valideras på samma sätt som CGH2 vägfordonsreglerna har varit. Det finns även en brist på uppdaterade industristandarder för LH2-lagringssystem för vägfordon. En särskild lucka är avsaknaden av en uppdaterad standard som kan refereras till i föreskrifter för munstycket i tanköppningens geometri. För LH2-påfyllningsstationer som helhet finns det dessutom inga lämpliga, uppdaterade internationella standarder, så det finns en risk att enskilda länder ställer sina egna krav. Sammantaget drog projektet slutsatsen att det inte finns några oöverkomliga hinder för implementeringen av LH2. Det är en genomförbar värdekedja ur både teknologiska-, kostnads- och säkerhetsperspektiv. Den kan också i framtiden bli jämförbar med den mer beprövade värdekedjan CGH2, men vissa initiala hinder och investeringar måste övervinnas.
20.	Crescitelli, Rossella, 1985, et al. (författare) Subpopulations of extracellular vesicles from human metastatic melanoma tissue identified by quantitative proteomics after optimized isolation 2020 Ingår i: Journal of Extracellular Vesicles. - : Wiley. - 2001-3078. ; 9:1 Tidskriftsartikel (refereegranskat)abstract The majority of extracellular vesicle (EV) studies conducted to date have been performed on cell lines with little knowledge on how well these represent the characteristics of EVs in vivo. The aim of this study was to establish a method to isolate and categorize subpopulations of EVs isolated directly from tumour tissue. First we established an isolation protocol for subpopulations of EVs from metastatic melanoma tissue, which included enzymatic treatment (collagenase D and DNase). Small and large EVs were isolated with differential ultracentrifugation, and these were further separated into high and low-density (HD and LD) fractions. All EV subpopulations were then analysed in depth using electron microscopy, Bioanalyzer (R), nanoparticle tracking analysis, and quantitative mass spectrometry analysis. Subpopulations of EVs with distinct size, morphology, and RNA and protein cargo could be isolated from the metastatic melanoma tissue. LD EVs showed an RNA profile with the presence of 18S and 28S ribosomal subunits. In contrast, HD EVs had RNA profiles with small or no peaks for ribosomal RNA subunits. Quantitative proteomics showed that several proteins such as flotillin-1 were enriched in both large and small LD EVs, while ADAM10 were exclusively enriched in small LD EVs. In contrast, mitofilin was enriched only in the large EVs. We conclude that enzymatic treatments improve EV isolation from dense fibrotic tissue without any apparent effect on molecular or morphological characteristics. By providing a detailed categorization of several subpopulations of EVs isolated directly from tumour tissues, we might better understand the function of EVs in tumour biology and their possible use in biomarker discovery.
21.	Cromsigt, Joris, et al. (författare) Adaptiv sam- och flerartsförvaltning av klövvilt 2023 Rapport (övrigt vetenskapligt/konstnärligt)
22.	Cruz-Rojas, A., et al. (författare) Prevalence and incidence of Carotid-Fetal-Posterior syndrome 2023 Ingår i: Cerebrovascular Diseases. - : S. Karger AG. - 1015-9770 .- 1421-9786. ; 52:6, s. 643-650 Tidskriftsartikel (refereegranskat)abstract Introduction: Carotid-Fetal-Posterior (CFP) syndrome is a posterior cerebral artery (PCA) territory ischemic stroke/TIA caused by symptomatic >= 50% carotid stenosis or occlusion via fetal posterior communicating artery. We aimed to assess the incidence of CFP syndrome and prevalence of CFP syndrome among symptomatic >= 50% carotid stenosis or occlusion as these are unknown. Methods: We reassessed consecutive CTAs from 4042 persons, and included locally admitted patients with >= 50% carotid stenosis or occlusion. These were assessed for symptoms and signs of possible posterior circulation stroke/TIA (suspicion of CFP syndrome). Among these, those with unilateral PCA territory stroke/TIA, ipsilateral stenosis and fetal/fetal type PCA were considered CFP syndrome. Results: We included 208 locally admitted patients with >= 50% carotid stenosis or occlusion, 33 (16%) patients had suspicion of CFP syndrome, of which 3 (9%) had CFP syndrome. The prevalence of CFP syndrome was 2.9% of symptomatic >= 50% carotid stenosis or occlusion; incidence was 4.23 per 1 000 000 person-years. Also, we found a lower prevalence of CFP-syndrome (0.9%, p=0.047) among referred patients with symptomatic >= 50% carotid stenosis or occlusion than among locally admitted patients with symptomatic >= 50% carotid stenosis or occlusion. Discussion/Conclusion: CFP syndrome has a low incidence and low prevalence among symptomatic carotid stenosis cases. Given lower prevalence of CFP syndrome among referred cases than local, CFP-syndrome seems susceptible to underdiagnosis. On the other hand, few cases with suspicion of CFP syndrome had CFP syndrome, why CFP syndrome also seems susceptible to overdiagnosis if detailed assessment is not employed.
23.	Cruz-Rojas, Agneta, et al. (författare) Prevalence and incidence of Carotid-Fetal-Posterior syndrome 2023 Ingår i: Cerebrovascular Diseases. - : S. Karger. - 1015-9770 .- 1421-9786. ; 52:6, s. 643-650 Tidskriftsartikel (refereegranskat)abstract Introduction: Carotid-Fetal-Posterior (CFP) syndrome is a posterior cerebral artery (PCA) territory ischemic stroke/TIA caused by symptomatic >= 50% carotid stenosis or occlusion via fetal posterior communicating artery. We aimed to assess the incidence of CFP syndrome and prevalence of CFP syndrome among symptomatic >= 50% carotid stenosis or occlusion as these are unknown.Methods: We reassessed consecutive CTAs from 4042 persons, and included locally admitted patients with >= 50% carotid stenosis or occlusion. These were assessed for symptoms and signs of possible posterior circulation stroke/TIA (suspicion of CFP syndrome). Among these, those with unilateral PCA territory stroke/TIA, ipsilateral stenosis and fetal/fetal type PCA were considered CFP syndrome.Results: We included 208 locally admitted patients with >= 50% carotid stenosis or occlusion, 33 (16%) patients had suspicion of CFP syndrome, of which 3 (9%) had CFP syndrome. The prevalence of CFP syndrome was 2.9% of symptomatic >= 50% carotid stenosis or occlusion; incidence was 4.23 per 1 000 000 person-years. Also, we found a lower prevalence of CFP-syndrome (0.9%, p=0.047) among referred patients with symptomatic >= 50% carotid stenosis or occlusion than among locally admitted patients with symptomatic >= 50% carotid stenosis or occlusion.Discussion/Conclusion: CFP syndrome has a low incidence and low prevalence among symptomatic carotid stenosis cases. Given lower prevalence of CFP syndrome among referred cases than local, CFP-syndrome seems susceptible to underdiagnosis. On the other hand, few cases with suspicion of CFP syndrome had CFP syndrome, why CFP syndrome also seems susceptible to overdiagnosis if detailed assessment is not employed.
24.	De Ridder, Reglindis, Associate Professor, et al. (författare) How the PJ Masks become “PJ Heroes” : A contrastive corpus study of gender portrayal in dubbed children’s animation 2024 Ingår i: Journal of Audiovisual Translation. - 2617-9148. ; 7:1 Tidskriftsartikel (refereegranskat)abstract In this study of dubbing for children, a quantitative and qualitative corpus analysis of a popular TV series were conducted. The parallel corpus consists of twelve episodes of the animated series PJ Masks, and its corresponding Dutch (Pyjamahelden [Pyjamas heroes]) and Swedish (Pyjamashjältarna [Pyjamas heroes]) audiovisual translations. The focus of the analyses is the portrayal of the main characters. In the light of ongoing criticism of children’s animation, regarding a lack of diversity and gender stereotyping, this translation analysis studies potential changes in gender representation with a particular interest in the female main character. First, the character portrayal in all language versions was systematically analysed based on the characters’ utterances . Subsequently, a closer qualitative analysis revealed some interesting translation shifts, particularly, in the Dutch target text. These were contrasted against the Swedish translation to check if this results in subtle or less subtle changes in the depiction of the heroes vis-à-vis the source text. Needless to say, such translation shifts in audiovisual translation for children and their effect on the representation of children in this multimodal glocal product is highly relevant amidst ongoing criticism of gender and diversity issues in children’s television.
25.	Devarakonda, Sravani, et al. (författare) Low-grade intestinal inflammation two decades after pelvic radiotherapy. 2023 Ingår i: EBioMedicine. - 2352-3964. ; 94 Tidskriftsartikel (refereegranskat)abstract Radiotherapy is effective in the treatment of cancer but also causes damage to non-cancerous tissue. Pelvic radiotherapy may produce chronic and debilitating bowel symptoms, yet the underlying pathophysiology is still undefined. Most notably, although pelvic radiotherapy causes an acute intestinal inflammation there is no consensus on whether the late-phase pathophysiology contains an inflammatory component or not. To address this knowledge gap, we examined the potential presence of a chronic inflammation in mucosal biopsies from irradiated pelvic cancer survivors.We biopsied 24 cancer survivors two to 20 years after pelvic radiotherapy, and four non-irradiated controls. Using tandem mass tag (TMT) mass spectrometry and mRNA sequencing (mRNA-seq), we charted proteomic and transcriptomic profiles of the mucosal tissue previously exposed to a high or a low/no dose of radiation. Changes in the immune cell populations were determined with flow cytometry. The integrity of the protective mucus layers were determined by permeability analysis and 16S rRNA bacterial detection.942 proteins were differentially expressed in mucosa previously exposed to a high radiation dose compared to a low radiation dose. The data suggested a chronic low-grade inflammation with neutrophil activity, which was confirmed by mRNA-seq and flow cytometry and further supported by findings of a weakened mucus barrier with bacterial infiltration.Our results challenge the idea that pelvic radiotherapy causes an acute intestinal inflammation that either heals or turns fibrotic without progression to chronic inflammation. This provides a rationale for exploring novel strategies to mitigate chronic bowel symptoms in pelvic cancer survivors.This study was supported by the King Gustav V Jubilee Clinic Cancer Foundation (CB), The Adlerbertska Research Foundation (CB), The Swedish Cancer Society (GS), The Swedish State under the ALF agreement (GS and CB), Mary von Sydow's foundation (MA and VP).
26.	Diamanti, Riccardo, et al. (författare) Comparative structural analysis provides new insights into the function of R2-like ligand-binding oxidase 2022 Ingår i: FEBS Letters. - : John Wiley & Sons. - 0014-5793 .- 1873-3468. ; 596:12, s. 1600-1610 Tidskriftsartikel (refereegranskat)abstract R2-like ligand-binding oxidase (R2lox) is a ferritin-like protein that harbours a heterodinuclear manganese–iron active site. Although R2lox function is yet to be established, the enzyme binds a fatty acid ligand coordinating the metal centre and catalyses the formation of a tyrosine–valine ether cross-link in the protein scaffold upon O2 activation. Here, we characterized the ligands copurified with R2lox by mass spectrometry-based metabolomics. Moreover, we present the crystal structures of two new homologs of R2lox, from Saccharopolyspora erythraea and Sulfolobus acidocaldarius, at 1.38 Å and 2.26 Å resolution, respectively, providing the highest resolution structure for R2lox, as well as new insights into putative mechanisms regulating the function of the enzyme.
27.	Dimou, Niki, et al. (författare) Cigarette Smoking and Endometrial Cancer Risk : observational and Mendelian Randomization Analyses 2022 Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 31:9, s. 1839-1848 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses.METHODS: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In two-sample MR analyses, genetic variants robustly associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined.RESULTS: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91-1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer.CONCLUSIONS: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. IMPACT: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk.
28.	Ekblom Bak, Elin, 1981-, et al. (författare) Accelerometer derived physical activity patterns in 27.890 middle‐aged adults : The SCAPIS cohort study 2022 Ingår i: Scandinavian Journal of Medicine and Science in Sports. - : John Wiley & Sons. - 0905-7188 .- 1600-0838. ; 32:5, s. 866-880 Tidskriftsartikel (refereegranskat)abstract The present study aims to describe accelerometer-assessed physical activity (PA) patterns and fulfillment of PA recommendations in a large sample of middle-aged men and women, and to study differences between subgroups of socio-demographic, socio-economic, and lifestyle-related variables. A total of 27 890 (92.5% of total participants, 52% women, aged 50–64 years) middle-aged men and women with at least four days of valid hip-worn accelerometer data (Actigraph GT3X+, wGT3X+ and wGT3X-BT) from the Swedish CArdioPulmonary bioImage Study, SCAPIS, were included. In total, 54.5% of daily wear time was spent sedentary, 39.1% in low, 5.4% in moderate, and only 0.1% in vigorous PA. Male sex, higher education, low financial strain, born in Sweden, and sedentary/light working situation were related to higher sedentary time, but also higher levels of vigorous PA. High BMI and having multiple chronic diseases associated strongly with higher sedentary time and less time in all three PA intensities. All-year physically active commuters had an overall more active PA pattern. The proportion fulfilling current PA recommendations varied substantially (1.4% to 92.2%) depending on data handling procedures and definition used. Twenty-eight percent was defined as having an “at-risk” behavior, which included both high sedentary time and low vigorous PA. In this large population-based sample, a majority of time was spent sedentary and only a fraction in vigorous PA, with clinically important variations between subgroups. This study provides important reference material and emphasizes the importance of a comprehensive assessment of all aspects of the individual PA pattern in future research and clinical practice.
29.	Eliasson, Inger, 1966-, et al. (författare) The disengagement process among young athletes when withdrawing from sport : A new research approach 2021 Ingår i: International Review for the Sociology of Sport. - : Sage Publications. - 1012-6902 .- 1461-7218. ; 56:4, s. 537-557 Tidskriftsartikel (refereegranskat)abstract The reasons young athletes drop out of sport have eluded scientists and sport organizations for many decades. Despite a large body of research on the subject, unanswered questions remain. This article reports on a new research approach that analyses sport withdrawal as a process. The study draws on Ebaugh’s sociological theory of disengagement and is based on data from semi-structured interviews with 12 girls aged 12 to 17 and 12 of their parents. By studying withdrawal from sport as a process, we found that the reasons comprise a combination of several salient interplaying factors related to changes. Organizational changes in sport and changes in the young athletes’ overall lives, together with changes in normative cultural and individual expectations associated with the young athlete role, are decisive for these girls to withdraw from sport. Furthermore, the disengagement process may be fairly long and emotional for young athletes, and less reversible the further into the process they progress.
30.	Engström, Annika, 1964-, et al. (författare) Artificial intelligence and work transformations : integrating sensemaking and workplace learning perspectives 2024 Ingår i: Information Technology and People. - : Emerald Group Publishing Limited. - 0959-3845 .- 1758-5813. Tidskriftsartikel (refereegranskat)abstract PurposeThe purpose of this study is to explore the process of initial sensemaking that organizational members activate when they reflect on AI adoption in their work settings, and how the perceived features of AI technologies trigger sensemaking processes which in turn have the potential to influence workplace learning modes and trajectories.Design/methodology/approachWe adopted an explorative qualitative and interactive approach to capture free fantasies and imaginative ideas of AI among people within the industry. We adopt a conceptual perspective that combines theories on initial sensemaking and workplace learning as a theoretical lens to analyze data collected during 23 focus groups held at four large Swedish manufacturing companies. The data were analyzed using the Gioia method.FindingsTwo aggregated dimensions were defined and led to the development of an integrated conceptualization of the initial sensemaking of AI technology adoption. Specifically, sensemaking triggered by abstract features of AI technology mainly pointed to an exploitative learning path. Sensemaking triggered by concrete features of the technology mainly pointed to explorative paths, where socio-technical processes appear to be crucial in the process of AI adoption.Originality/valueThis is one of the first studies that attempts to explore and conceptualize how organizations make sense of prospective workplace learning in the context of AI adoption.
31.	Engström, Annika, 1964-, et al. (författare) How AI Transformation triggers new perspectives in organizational learning 2022 Konferensbidrag (refereegranskat)
32.	Engström, Annika, 1964-, et al. (författare) Knowledge creation in projects : an interactive research approach for deeper business insight 2023 Ingår i: International Journal of Managing Projects in Business. - : Emerald Group Publishing Limited. - 1753-8378 .- 1753-8386. ; 16:1, s. 22-44 Tidskriftsartikel (refereegranskat)abstract Purpose The purpose of this paper is to shed light on different types of knowledge created and how this links to the project design, process, and content. Design/methodology/approach In this paper the authors investigate participants' experiences from a three-year interactive research project, designed to trigger reflection among the participants. They apply a knowledge creation perspective on experiences expressed by participants as a result of different research project activities. Findings The study resulted in five categories of insights with potential for sustainable influence on the participating organizations: an understanding of concepts and theories; an understanding of the impacts of collaborative, reflective work processes; an understanding of the meaning of one's own organizational context; an understanding of the importance of increased organizational self-awareness; and an understanding of the potential for human interaction and communication. Practical implications The author's findings suggest that it is possible to design a project to promote more profound and sustainable effects on a business beyond the explicit purpose of the project. They advise practitioners to make room for iterative reflection; be mindful to create a trustful and open environment in the team; challenge results with opposing views and theories; and make room for sharing experiences and giving feedback. Originality/value This study contributes to unraveling key practices which can nurture conditions for knowledge creation in interactive research projects and business projects alike.
33.	Engström, Annika, 1964-, et al. (författare) Understanding Organizational Tensions During Artificial Intelligence Transformation 2022 Konferensbidrag (refereegranskat)
34.	Engström, Annika, 1964-, et al. (författare) Understanding Organizational Tensions During Artificial Intelligence Transformation 2022 Ingår i: Proceedings of The Annual Meeting of The Academy of Management, 2022, Vol. 2022, No. 1. - : Academy of Management. ; , s. 12745- Konferensbidrag (refereegranskat)abstract AI has the potential to be a disruptive technology causing paradigm shifts in industries and greatly impacting both operational and strategic decision making. Adopting AI technologies requires proactively engaging both the technical and social system of the organization as processes, workflows, as well as individual employees, are influenced. This paper explores potential tensions between the social and technical systems in the early change process of AI transformation to understand the nature and degree of AI transformation. We do this by analyzing in-depth inquiry from 23 focus groups involving 112 white-collar industrial employees in large multinational industrial firms using a change management perspective. Our study revealed nine categories of tensions divided into tensions between the current and future state and tensions between humans and machines. This stresses the need to adopt a socio-technical perspective in the attempt to understand organizations approaching AI and provides practical implications for organizations considering adopting AI technologies.
35.	Fristedt, Sofi, 1969-, et al. (författare) Registered nurses and undergraduate nursing students' attitudes to performing end-of-life care 2021 Ingår i: Nurse Education Today. - : Elsevier BV. - 0260-6917 .- 1532-2793. ; 98 Tidskriftsartikel (refereegranskat)abstract Registered Nurses (RNs) are in the immediate position to provide End-of-life (EOL) care and counselling for patients and families in various settings. However, EOL-care often creates feelings of uncertainty and inadequacy linked to inexperience, lack of education, and attitude. To identify and describe factors associated with RNs' attitudes towards EOL-care, and to identify whether and how these attitudes differ from undergraduate nursing students' (UNSs) attitudes, a descriptive and comparative, quantitative study was performed. The FATCOD-instrument, focusing on attitude towards EOL-care, was used and the results analysed with descriptive and nonparametric statistics. In total, 287 RNs in 14 different specialist programmes, and 124 UNSs participated. A statistically significant difference (p = 0.032) was found in attitude towards EOL-care based on clinical experience. RNs in “Acute Care” and “Paediatric & Psychiatry Care” specialist programmes had a less positive attitude towards EOL-care (compared to RNs in other specialist programmes), while RNs attending the Palliative Care programme had the most positive attitudes. RNs and UNSs' scores differed statistically significantly in 17 out of 30 FATCOD variables. Finally, the results imply that there is a need for greater emphasis on further continuing education within EOL care for RNs working in all types of clinical specialities to encourage RNs talking about death and to enhance attitudes towards EOL care. © 2021 Elsevier Ltd
36.	Green, Alanna C., et al. (författare) Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells 2023 Ingår i: Nature Metabolism. - : Springer Nature. - 2522-5812. ; 5:4, s. 642-659 Tidskriftsartikel (refereegranskat)abstract Cancer cells fuel their increased need for nucleotide supply by upregulating one-carbon (1C) metabolism, including the enzymes methylenetetrahydrofolate dehydrogenase–cyclohydrolase 1 and 2 (MTHFD1 and MTHFD2). TH9619 is a potent inhibitor of dehydrogenase and cyclohydrolase activities in both MTHFD1 and MTHFD2, and selectively kills cancer cells. Here, we reveal that, in cells, TH9619 targets nuclear MTHFD2 but does not inhibit mitochondrial MTHFD2. Hence, overflow of formate from mitochondria continues in the presence of TH9619. TH9619 inhibits the activity of MTHFD1 occurring downstream of mitochondrial formate release, leading to the accumulation of 10-formyl-tetrahydrofolate, which we term a ‘folate trap’. This results in thymidylate depletion and death of MTHFD2-expressing cancer cells. This previously uncharacterized folate trapping mechanism is exacerbated by physiological hypoxanthine levels that block the de novo purine synthesis pathway, and additionally prevent 10-formyl-tetrahydrofolate consumption for purine synthesis. The folate trapping mechanism described here for TH9619 differs from other MTHFD1/2 inhibitors and antifolates. Thus, our findings uncover an approach to attack cancer and reveal a regulatory mechanism in 1C metabolism.
37.	Gustavsson, Larisa, et al. (författare) Resistance to Neonectria ditissima in apple : insights from metabolomics and lipidomics analyses 2023 Ingår i: Xxxi international horticultural congress (ihc2022). - : International Society for Horticultural Science. - 9789462613614 ; , s. 329-335, s. 329-336 Konferensbidrag (refereegranskat)abstract European canker, caused by the necrotrophic fungus Neonectria ditissima, is the most serious disease in apple production in Sweden. The disease is favored by a relatively cool and rainy climate. The canker damages have a significant economic impact due to reduced bearing surface and increased orchard management costs. The possibilities for chemical and biological control are very limited. Therefore, directed breeding for new resistant cultivars is urgently needed. Knowledge of inheritance of canker resistance and understanding of molecular mechanisms involved in resistant and susceptible responses to fungal attacks would facilitate breeding. In this study, we evaluated the tempo-spatial differences in plant-pathogen interactions in a set of partially resistant and susceptible cultivars by conducting metabolomic and lipidomic analyses. The major trends in metabolomics and lipidomic profiles were common among cultivars, irrespective of the degree of susceptibility. Several metabolites and lipids varied with time point and cultivar under N. ditissima infection. Putative key metabolites such as suberic acid and jasmonic acid were upregulated in all cultivars upon infection. Additionally, several lipids exhibited changes 30 to 45 days post-inoculation. Thus, the approach used seems to have resulted in a rich data set to be further analyzed in light of ongoing QTL-mapping efforts.
38.	Hamberg Levedahl, Kerstin, et al. (författare) How persons with systemic mastocytosis describe the time between symptom onset and receiving diagnosis 2022 Ingår i: Primary Health Care Research and Development. - : Cambridge University Press. - 1463-4236 .- 1477-1128. ; 23 Tidskriftsartikel (refereegranskat)abstract Aim: The aim of the study was to explore how persons with systemic mastocytosis (SM) described the time between the onset of symptoms and signs and getting the diagnosis.Background: SM is a rare disease caused by the accumulation of clonal mast cells with abnormal function. The symptoms and signs of the disease are varied, often diffuse and affect individuals differently. Due to this complexity, a multi-disciplinary diagnostic approach is required, in which general practitioners play an important part in identifying and referring patients relevant for such investigations.Methods: Sixteen persons with SM were interviewed about their experiences of the time before the diagnosis was received. Systematic text condensation was used in the analysis process.Findings: The time between symptom and signs onset and diagnosis was perceived as difficult. SM often had a complex and unpredictable effect on a person’s daily life, long before diagnosis. In the analysis, three themes were found. Having symptoms and signs with an unknown cause included the participants’ descriptions of numerous symptoms and signs, often years before diagnosis. These could be severe and result in worries for both participants and their next-of-kin. Dealing with the symptoms and signs encompassed the different ways in which the participants coped with the symptoms and signs, and sought relief. Being a patient without a diagnosis underlined the lack of information and knowledge within healthcare, often resulting in a delayed or incorrect diagnosis. The study highlighted the importance of a person-centred approach and the need to increase knowledge of the disease within primary care, to shorten this stressful and vulnerable time.
39.	Holstad, Ylva, et al. (författare) Breastfeeding in primiparous women with congenital heart disease : a register study 2024 Ingår i: International Breastfeeding Journal. - : BMJ Publishing Group Ltd. - 1746-4358. ; 19:1 Tidskriftsartikel (refereegranskat)abstract BackgroundThe number of pregnant women with congenital heart disease (CHD) is rising, and the disease poses increased risks of cardiovascular and obstetric complications during pregnancy, potentially impacting breastfeeding success. This study aimed to investigate breastfeeding in primiparous women with CHD compared to primiparous women without CHD, and to examine potential hindering factors for breastfeeding in women with CHD.MethodsThe data were gathered between 2014 and 2019 and obtained by merging the Swedish Congenital Heart Disease Register (SWEDCON) with the Swedish Pregnancy Register. Primiparous women ≥ 18 years of age with CHD (n = 578) were matched by age and municipality to 3049 women without CHD, giving birth after 22 gestational weeks. Multivariable logistic regression analysis was used to identify factors associated with non-breastfeeding in women with CHD.ResultsFewer women with CHD breastfed than women without CHD two days (94% vs. 97%, p = 0.001) and four weeks after birth (84% vs. 89%, p = 0.006). When all women were analysed, having CHD was associated with non-breastfeeding at both two days and four weeks after birth. For women with CHD, body mass index (BMI) ≥ 30 (OR 3.1; 95% CI 1.4, 7.3), preterm birth (OR 6.4; 95% CI 2.1, 19.0), self-reported history of psychiatric illness (OR 2.4; 95% CI 1.2, 5.1), small for gestational age (OR 4.2; 95% CI 1.4, 12.2), and New York Heart Association Stages of Heart Failure class II − III (OR 6.0; 95% CI 1.4, 26.7) were associated with non-breastfeeding two days after birth. Four weeks after birth, factors associated with non-breastfeeding were BMI ≥ 30 (OR 4.3; 95% CI 2.1, 9.0), self-reported history of psychiatric illness (OR 2.2; 95% CI 1.2, 4.2), and preterm birth (OR 8.9; 95% CI 2.8, 27.9).ConclusionsThe study shows that most women with CHD breastfeed, however, at a slightly lower proportion compared to women without CHD. In addition, factors related to the heart disease were not associated with non-breastfeeding four weeks after birth. Since preterm birth, BMI ≥ 30, and psychiatric illness are associated with non-breastfeeding, healthcare professionals should provide greater support to women with CHD having these conditions.
40.	Holstad, Ylva, et al. (författare) Self-rated health in primiparous women with congenital heart disease before, during and after pregnancy : a register study 2023 Ingår i: Scandinavian Cardiovascular Journal. - : Taylor & Francis. - 1401-7431 .- 1651-2006. ; 58:1 Tidskriftsartikel (refereegranskat)abstract Background: Poor maternal self-rated health in healthy women is associated with adverse neonatal outcomes, but knowledge about self-rated health in pregnant women with congenital heart disease (CHD) is sparse. This study, therefore, investigated self-rated health before, during, and after pregnancy in women with CHD and factors associated with poor self-rated health.Methods: The Swedish national registers for CHD and pregnancy were merged and searched for primiparous women with data on self-rated health; 600 primiparous women with CHD and 3062 women in matched controls. Analysis was performed using descriptive statistics, chi-square test and logistic regression.Results: Women with CHD equally often rated their health as poor as the controls before (15.5% vs. 15.8%, p = .88), during (29.8% vs. 26.8% p = .13), and after pregnancy (18.8% vs. 17.6% p = .46). None of the factors related to heart disease were associated with poor self-rated health. Instead, factors associated with poor self-rated health during pregnancy in women with CHD were ≤12 years of education (OR 1.7, 95%CI 1.2–2.4) and self-reported history of psychiatric illness (OR 12.6, 95%CI 1.4–3.4). After pregnancy, solely self-reported history of psychiatric illness (OR 5.2, 95%CI 1.1–3.0) was associated with poor self-rated health.Conclusion: Women with CHD reported poor self-rated health comparable to controls before, during, and after pregnancy, and factors related to heart disease were not associated with poor self-rated health. Knowledge about self-rated health may guide professionals in reproductive counselling for women with CHD. Further research is required on how pregnancy affects self-rated health for the group in a long-term perspective.
41.	Hubert, Madlen, et al. (författare) Lipid accumulation controls the balance between surface connection and scission of caveolae. 2020 Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 9 Tidskriftsartikel (refereegranskat)abstract Caveolae are bulb-shaped invaginations of the plasma membrane (PM) that undergo scission and fusion at the cell surface and are enriched in specific lipids. However, the influence of lipid composition on caveolae surface stability is not well described or understood. Accordingly, we inserted specific lipids into the cell PM via membrane fusion and studied their acute effects on caveolae dynamics. We demonstrate that sphingomyelin stabilizes caveolae to the cell surface, whereas cholesterol and glycosphingolipids drive caveolae scission from the PM. Although all three lipids accumulated specifically in caveolae, cholesterol and sphingomyelin were actively sequestered, whereas glycosphingolipids diffused freely. The ATPase EHD2 restricts lipid diffusion and counteracts lipid-induced scission. We propose that specific lipid accumulation in caveolae generates an intrinsically unstable domain prone to scission if not restrained by EHD2 at the caveolae neck. This work provides a mechanistic link between caveolae and their ability to sense the PM lipid composition.
42.	Jaitner, Annika, et al. (författare) Smoking during pregnancy and its effect on placental weight: a Mendelian randomization study. 2024 Ingår i: BMC pregnancy and childbirth. - 1471-2393. ; 24:1 Tidskriftsartikel (refereegranskat)abstract The causal relationship between maternal smoking in pregnancy and reduced offspring birth weight is well established and is likely due to impaired placental function. However, observational studies have given conflicting results on the association between smoking and placental weight. We aimed to estimate the causal effect of newly pregnant mothers quitting smoking on their placental weight at the time of delivery.We used one-sample Mendelian randomization, drawing data from the Avon Longitudinal Study of Parents and Children (ALSPAC) (N=690 to 804) and the Norwegian Mother, Father and Child Cohort Study (MoBa) (N=4267 to 4606). The sample size depends on the smoking definition used for different analyses. The analysis was performed in pre-pregnancy smokers only, due to the specific role of the single-nucleotide polymorphism (SNP) rs1051730 (CHRNA5 - CHRNA3 - CHRNB4) in affecting smoking cessation but not initiation.Fixed effect meta-analysis showed a 182g [95%CI: 29,335] higher placental weight for pre-pregnancy smoking mothers who continued smoking at the beginning of pregnancy, compared with those who stopped smoking. Using the number of cigarettes smoked per day in the first trimester as the exposure, the causal effect on placental weight was 11g [95%CI: 1,21] per cigarette per day. Similarly, smoking at the end of pregnancy was causally associated with higher placental weight. Using the residuals of birth weight regressed on placental weight as the outcome, we showed evidence of lower offspring birth weight relative to the placental weight, both for continuing smoking at the start of pregnancy as well as continuing smoking throughout pregnancy (change in z-score birth weight adjusted for z-score placental weight: -0.8 [95%CI: -1.6,-0.1]).Our results suggest that continued smoking during pregnancy causes higher placental weights.
43.	Johansson, Annika, 1967- (författare) Digital examination i språkfärdighet 2022 Rapport (övrigt vetenskapligt/konstnärligt)abstract Projektets mål är att utveckla former för digital examination i språkfärdighet som äger rum på distans. Examination i språkfärdighet har tidigare skett vid Institutionen för slaviska och baltiska språk, finska, nederländska och tyska främst i form av salstentamen men sedan våren 2020 har det blivit tydligt att en utveckling av digital examination när den sker på distans krävs. Det finns två anledningar till detta. För det första och mest givna att vi i samband med corona-pandemin på kort tid blev tvungna att ställa om till online-undervisning med som konsekvens digital examination eller online-examination. Digital examination i språkfärdighet på distans är en utmaning eftersom den handlar om att testa nivån på inlärningen av ett andra eller tredje språk och inte om examination av språket som struktur, vilket sker i kurser i lingvistik. För det andra, flera av institutionens språk planerar att i framtiden erbjuda fler kurser online för att nå ut till studenter runt om i landet, eftersom ett antal av institutionens språk endast ges vid Stockholms universitet i Sverige. Att gå tillbaka till salstentamen efter pandemin för online-kurser passar mindre bra. Nämnda anledningar har skapat behov av att utveckla former för digital examination som kan motverka plagiat. I projektet utvecklas i första hand pedagogiska former för både formativ och summativ digital examination där den formativa bedömningen kopplas till studenternas självreglerande lärande.
44.	Johansson, Annika, 1967- (författare) Een verhaal over non-verbale taal in vertaling 2020 Ingår i: VakTaal: Tijdschrift van de Internationale Vereniging voor Neerlandistiek. - 0921-5867. ; 33:4, s. 16-17 Tidskriftsartikel (populärvet., debatt m.m.)
45.	Johansson, Annika, et al. (författare) Female genital mutilation (FGM) in Somaliland – why is change so slow? 2021 Ingår i: Somali Health Action Journal. - Umeå : Umeå University. - 2004-1985. ; 1:1 Tidskriftsartikel (refereegranskat)abstract Female genital mutilation (FGM) is defined as any procedure involving the alteration or excision of external female genitalia for no medical reason. Somaliland has among the highest prevalence rates of FGM globally. In this article we describe how the Civil Society Organisation (CSO) ‘Network against female genital mutilation in Somaliland’ (NAFIS) has approached the challenge to reduce the high FGM prevalence. From its start in 2006, NAFIS has developed a multifaceted program to reach the overall goal: the elimination of all forms of FGM in Somaliland.Alone among the group of CSOs in the network, NAFIS introduced in its activities medical care and counselling for women who suffer from the consequences of FGM. From 2011 and onwards, thousands of women have been relieved of their FGM-related health complications and participated in counselling sessions at project centres. Shortly after this visit they have been invited to participate in community group meetings to share their experiences with other women who also have received FGM care and counselling, and other community members.The aim of the article is to describe this model of work - combining FGM care and counselling with community dialogues. The article is basically descriptive, using the authors’ own observations and encounters with project clients and staff over eight years. We have also used findings from three Master's theses on aspects of the process, and from other small scale studies to highlight people’s understanding, experiences and opinions in a context of an on-going health intervention.A lesson learnt from NAFIS project is that it has helped to open up communicative spaces in community dialogues where experiences are shared and understanding created of the harm caused by FGM, without the habitual stigma and shame. We discuss this process in a context of behavioural change theories. A major challenge during the process has been to involve men in the project’s FGM information and counselling activities. The role of nurses/midwives, being the first to meet women with FGM complications, is also discussed and the need emphasised to strengthen capacity of this category of health workers. One type of FGM gaining in usage is the poorly defined sunna, the health risks of which are unclear.
46.	Johansson, Emil, et al. (författare) Hierarchical Clustering and Trajectory Analyses Reveal Viremia-Independent B-Cell Perturbations in HIV-2 Infection 2022 Ingår i: Cells. - : MDPI. - 2073-4409. ; 11:19 Tidskriftsartikel (refereegranskat)abstract Time to AIDS in HIV-2 infection is approximately twice as long compared to in HIV-1 infection. Despite reduced viremia, HIV-2-infected individuals display signs of chronic immune activation. In HIV-1-infected individuals, B-cell hyperactivation is driven by continuous antigen exposure. However, the contribution of viremia to B-cell perturbations in HIV-2-infected individuals remains largely unexplored. Here, we used polychromatic flow cytometry, consensus hierarchical clustering and pseudotime trajectory inference to characterize B-cells in HIV-1- or HIV-2-infected and in HIV seronegative individuals. We observed increased frequencies of clusters containing hyperactivated T-bethighCD95highCD27int and proliferating T-bet+CD95highCD27+CD71+ memory B-cells in viremic HIV-1 (p < 0.001 and p < 0.001, respectively), viremic HIV-2 (p < 0.001 and p = 0.014, respectively) and in treatment-naïve aviremic HIV-2 (p = 0.004 and p = 0.020, respectively)-infected individuals, compared to seronegative individuals. In contrast, these expansions were not observed in successfully treated HIV-1-infected individuals. Finally, pseudotime trajectory inference showed that T-bet-expressing hyperactivated and proliferating memory B-cell populations were located at the terminal end of two trajectories, in both HIV-1 and HIV-2 infections. As the treatment-naïve aviremic HIV-2-infected individuals, but not the successfully ART-treated HIV-1-infected individuals, showed B-cell perturbations, our data suggest that aviremic HIV-2-infected individuals would also benefit from antiretroviral treatment.
47.	Johansson, Elias, et al. (författare) The Issue of Optimal Timing of Carotid Revascularisation Is Both Relevant and Unresolved 2022 Ingår i: European Journal of Vascular and Endovascular Surgery. - : Elsevier. - 1078-5884 .- 1532-2165. ; 63:2, s. 181-183 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
48.	Johansson, Elias, 1984, et al. (författare) The Issue of Optimal Timing of Carotid Revascularisation Is Both Relevant and Unresolved. 2022 Ingår i: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. - : Elsevier BV. - 1532-2165 .- 1078-5884. ; 63:2, s. 181-183 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
49.	Johansson, Maria, et al. (författare) AFFILIATED COMPETENCE – A NEW MOBILITY CONCEPT TESTED AT LUND UNIVERSITY AND LULEÅ UNIVERSITY OF TECHNOLOGY 2022 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
50.	Johansson, Magnus C, 1954, et al. (författare) Echocardiographic diagnosis of heart failure with preserved ejection fraction in elderly patients with hypertension 2022 Ingår i: Scandinavian Cardiovascular Journal. - : Informa UK Limited. - 1401-7431 .- 1651-2006. ; 56:1, s. 368-377 Tidskriftsartikel (refereegranskat)abstract Objectives. The aim of this study is to evaluate the diagnostic performance of echocardiography for the diagnosis of heart failure with preserved ejection fraction (HFpEF) in the elderly and to validate the Heart Failure Association diagnostic algorithm (HFA-PEFF). Design. A case-control study was conducted in patients with hypertension with or without HFpEF who were matched for age (n = 33; 78.4 +/- 5.3 years) and sex. Participants underwent echocardiography including assessment of left atrial (LA) volume index (LAVI), early mitral filling to early diastolic mitral annulus velocity ratio (E/e '), LA reservoir strain (LASr), tissue Doppler LA contraction (a '), right ventricular isovolumic relaxation time (RVIVRT), and a 6-minute walk test (6-MWT). The filling pressure algorithm from the European association of cardiovascular imaging (EACVI) 2021 was applied. The HFA-PEFF score was also applied, using echocardiography parameters and the value of NT pro-BNP, without considering symptomatic status. Results. Echocardiographic parameters identified patients with HFpEF with an area under the curve (AUC) >0.9 for E/e ', RVIVRT, LASr, a ', and the ratio of LAVI/a '. LASr correlated with 6-MWT (r = 0.59, p = .0003). The EACVI algorithm classified all controls with normal filling pressure and 94% of patients with HFpEF with increased filling pressure. When the HFA-PEFF diagnostic algorithm was validated, a high score (>= 5 points) had 100% sensitivity for HFpEF, while 88% of controls had intermediate scores (2-4 points). Conclusion. The EACVI filling pressure algorithm, RVIVRT, LASr, and the ratio LAVI/a ' were accurate for diagnosing HFpEF in elderly patients with hypertension. The HFA-PEFF score had high sensitivity but limited ability to exclude HFpEF.

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