| 1. |
- Schael, S, et al.
(author)
-
Precision electroweak measurements on the Z resonance
- 2006
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In: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
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Research review (peer-reviewed)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
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| 2. |
- Aaron, F. D., et al.
(author)
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Multi-leptons with high transverse momentum at HERA
- 2009
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In: Journal of High Energy Physics. - : Springer Science and Business Media LLC. - 1029-8479. ; :10
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Journal article (peer-reviewed)abstract
- Events with at least two high transverse momentum leptons (electrons or muons) are studied using the H1 and ZEUS detectors at HERA with an integrated luminosity of 0.94 fb(-1). The observed numbers of events are in general agreement with the Standard Model predictions. Seven di- and tri-lepton events are observed in e(+)p collision data with a scalar sum of the lepton transverse momenta above 100 GeV while 1.94 +/- 0.17 events are expected. Such events are not observed in e(-)p collisions for which 1.19 +/- 0.12 are predicted. Total visible and differential di-electron and di-muon photoproduction cross sections are extracted in a restricted phase space dominated by photon-photon collisions.
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| 3. |
- Elsik, Christine G., et al.
(author)
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The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
- 2009
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
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Journal article (peer-reviewed)abstract
- To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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| 4. |
- Haas, Brian J., et al.
(author)
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Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans
- 2009
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 461:7262, s. 393-398
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Journal article (peer-reviewed)abstract
- Phytophthora infestans is the most destructive pathogen of potato and a model organism for the oomycetes, a distinct lineage of fungus-like eukaryotes that are related to organisms such as brown algae and diatoms. As the agent of the Irish potato famine in the mid-nineteenth century, P. infestans has had a tremendous effect on human history, resulting in famine and population displacement(1). To this day, it affects world agriculture by causing the most destructive disease of potato, the fourth largest food crop and a critical alternative to the major cereal crops for feeding the world's population(1). Current annual worldwide potato crop losses due to late blight are conservatively estimated at $6.7 billion(2). Management of this devastating pathogen is challenged by its remarkable speed of adaptation to control strategies such as genetically resistant cultivars(3,4). Here we report the sequence of the P. infestans genome, which at similar to 240 megabases (Mb) is by far the largest and most complex genome sequenced so far in the chromalveolates. Its expansion results from a proliferation of repetitive DNA accounting for similar to 74% of the genome. Comparison with two other Phytophthora genomes showed rapid turnover and extensive expansion of specific families of secreted disease effector proteins, including many genes that are induced during infection or are predicted to have activities that alter host physiology. These fast-evolving effector genes are localized to highly dynamic and expanded regions of the P. infestans genome. This probably plays a crucial part in the rapid adaptability of the pathogen to host plants and underpins its evolutionary potential.
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| 5. |
- Petri, M., et al.
(author)
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Nuclear levels in proton-unbound I-109 : Relative single-particle energies beyond the proton drip line
- 2007
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 76:5
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Journal article (peer-reviewed)abstract
- A level scheme has been constructed for the proton-unbound, T-z=3/2 nuclide I-109(53)56 following a recoil-decay-tagging experiment using the Ni-58(Fe-54, p2n gamma) reaction at a beam energy of 195 MeV. The experiment was performed using the highly efficient JUROGAM gamma-ray spectrometer in conjunction with the RITU gas-filled recoil separator and the GREAT focal-plane spectrometer. Cranking calculations are used to interpret band structures built on pi g(7/2) and pi h(11/2) states in a weakly deformed, triaxial nucleus.
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| 6. |
- Birney, Ewan, et al.
(author)
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Prepublication data sharing
- 2009
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 461:7261, s. 168-170
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Journal article (peer-reviewed)abstract
- Rapid release of prepublication data has served the field of genomics well. Attendees at a workshop in Toronto recommend extending the practice to other biological data sets.
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| 7. |
- Hurst, A. M., et al.
(author)
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Measurement of the sign of the spectroscopic quadrupole moment for the 2(1)(+) state in Se-70: No evidence for oblate shape
- 2007
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In: Physical Review Letters. - 1079-7114. ; 98:7
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Journal article (peer-reviewed)abstract
- Using a method whereby molecular and atomic ions are independently selected, an isobarically pure beam of Se-70 ions was postaccelerated to an energy of 206 MeV using REX-ISOLDE. Coulomb-excitation yields for states in the beam and target nuclei were deduced by recording deexcitation gamma rays in the highly segmented MINIBALL gamma-ray spectrometer in coincidence with scattered particles in a silicon detector. At these energies, the Coulomb-excitation yield for the first 2(+) state is expected to be strongly sensitive to the sign of the spectroscopic quadrupole moment through the nuclear reorientation effect. Experimental evidence is presented here for a prolate shape for the first 2(+) state in Se-70, reopening the question over whether there are, as reported earlier, deformed oblate shapes near to the ground state in the light selenium isotopes.
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| 8. |
- Joss, D. T., et al.
(author)
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Yrast states and band crossings in the neutron-deficient platinum isotopes Pt169-173
- 2006
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 74:1
-
Journal article (peer-reviewed)abstract
- The yrast states in the light platinum isotopes Pt169-173 have been investigated in a recoil-decay tagging experiment using the JUROGAM gamma-ray spectrometer in conjunction with the RITU gas-filled recoil separator and the GREAT tagging spectrometer. Gamma-ray transitions have been established for the first time in the odd-N isotopes, Pt-169 and Pt-173, and the yrast sequences in Pt-170 and Pt-172 have been extended. We discuss the possibility that the weakly deformed yrast structures of Pt-170, Pt-172, and Pt-173 are crossed by a deformed intruder configuration at spin similar to 8h.
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| 9. |
- Joss, D. T., et al.
(author)
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Yrast structures in the light Pt isotopes Pt169-173
- 2005
-
In: Journal of Physics G. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 31:10, s. S1715-S1718
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Journal article (peer-reviewed)abstract
- The exploitation of the recoil-decay tagging (RDT) technique has reinvigorated experimental investigations of the shape coexistence phenomenon in heavy neutron-deficient nuclei. In a recent experiment using the JUROGAM and GREAT spectrometers in conjunction with the RITU gas-filled separator, excited states have been investigated in the light platinum isotopes. In addition to extending the yrast sequences in Pt-170 and Pt-172, the first observation of excited states in the odd-N isotopes, Pt-169 and Pt-173, is reported. The bands are discussed in terms of trends in level excitation energies as a function of neutron number.
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| 10. |
- Lagergren, Karin, et al.
(author)
-
High-spin states in the proton-unbound nucleus Re-161
- 2006
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 74:2, s. 024316-
-
Journal article (peer-reviewed)abstract
- Excited states in Re-161 were populated using the Cd-106(Ni-58, p2n) reaction at a beam energy of 270 MeV, resulting in the first observation of gamma rays emitted from this nucleus. The reaction products were separated from scattered beam and fission fragments by the gas-filled recoil separator RITU, and were implanted in the double-sided silicon strip detectors of the GREAT spectrometer. Prompt gamma rays were detected by the JUROGAM Ge detector array and were assigned to Re-161 based on alpha- and proton-decay tagging of the implanted reaction products. The near-yrast high-spin level structure, which was delineated to spins around 39/2, is discussed in the context of the total Routhian surface formalism. The level scheme is interpreted in terms of the alignment of h(9/2)/f(7/2) neutrons at lower spins, followed by excitations involving the pi h(11/2) subshell at higher spins.
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| 11. |
- Richards, Stephen, et al.
(author)
-
The genome of the model beetle and pest Tribolium castaneum.
- 2008
-
In: Nature. - 1476-4687. ; 452:7190, s. 949-55
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Journal article (peer-reviewed)abstract
- Tribolium castaneum is a representative of earth’s most numerous eukaryotic order, a powerful model organism for the study of generalized insect development, and also an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved an ability to interact with a diverse chemical environment as evidenced by large expansions in odorant and gustatory receptors, as well as p450 and other detoxification enzymes. Developmental patterns in Tribolium are more representative of other arthropods than those found in Drosophila, a fact represented in gene content and function. For one, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, and some are expressed in the growth zone crucial for axial elongation in short germ development. Systemic RNAi in T. castaneum appears to use mechanisms distinct from those found in C. elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.
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| 12. |
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| 13. |
- Hadinia, Baharak, et al.
(author)
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First identification of gamma-rays in Te-106 using recoil decay tagging technique
- 2006
-
In: Frontiers in Nuclear Structure Astrophysics, and Reactions: FINUSTAR. - MELVILLE, NY : AMER INST PHYSICS. - 0735403236 - 9780735403239 ; , s. 457-459
-
Conference paper (peer-reviewed)abstract
- Gamma-ray transitions from excited states in Te-106 have been identified using the recoil decay tagging technique. The experiment which was the reaction Fe-54(Fe-54,2n)Te-106* was performed at the JYFL accelerator facility at the University of Jyvaskyla, Finland. The production cross section was estimated at 25 nb, a new limit for in-beam gamma-ray spectroscopy. A tentative level structure for the ground state band of Te-106 is proposed.
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| 14. |
- Hadinia, Baharak, et al.
(author)
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Identification of gamma rays from Au-172 and alpha decays of Au-172, Ir-168, and Re-164
- 2009
-
In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 80:6, s. 064310-
-
Journal article (peer-reviewed)abstract
- The very neutron deficient odd-odd nucleus Au-172 was studied in reactions of 342 and 348 MeV Kr-78 beams with an isotopically enriched Ru-96 target. The alpha decays previously reported for Au-172 were confirmed and the decay chain extended down to Tm-152 through the discovery of a new alpha-decaying state in Re-164 [E-alpha=5623(10) keV; t(1/2)=864(-110)(+150) ms; b(alpha)=3(1)%]. Fine structure in these alpha decays of Au-172 and Ir-168 were identified. A new alpha-decaying state was also observed and assigned as the ground state in Au-172 [E-alpha=6762(10) keV; t(1/2)=22(-5)(+6) ms]. This decay chain was also correlated down to Tm-152 through previously reported alpha decays. Prompt gamma rays from excited states in Au-172 have been identified using the recoil-decay tagging technique. The partial level scheme constructed for Au-172 indicates that it has an irregular structure. Possible configurations of the alpha-decaying states in Au-172 are discussed in terms of the systematics of nuclei in this region and total Routhian surface calculations.
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| 15. |
- Hornillos, M. B. G., et al.
(author)
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gamma-ray spectroscopy approaching the limits of existence of atomic nuclei : A study of the excited states of Pt-168 and Pt-169
- 2009
-
In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 79:6
-
Journal article (peer-reviewed)abstract
- Excited states in the N=90 and N=91 Pt nuclei have been investigated using the JUROGAM and GREAT spectrometers in conjunction with the RITU gas-filled separator. These nuclei were populated via the reactions Mo-92(Kr-78,2n) and Mo-94(Kr-78,3n) at 335 and 348 MeV, respectively. The recoil-decay tagging technique has been used to correlate prompt gamma radiation with the characteristic alpha decays of Pt-168 and Pt-169. A gamma-gamma analysis has allowed a level scheme for Pt-168 to be reported for the first time and the level scheme for Pt-169 to be extended. The excitation energies of the proposed positive-parity yrast states of Pt-168 are compared with calculations based on the interacting boson model and found to be in excellent agreement. These data show a continuation of the trend toward vibrational nuclei as the N=82 shell gap is approached. In addition, new excited states constituting two decay paths have been discovered in Pt-169. .
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| 16. |
- Jones, Owen R., et al.
(author)
-
Senescence rates are determined by ranking on the fast-slow life-history continuum
- 2008
-
In: Ecology Letters. - : Wiley. - 1461-023X .- 1461-0248. ; 11:7, s. 664-673
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Journal article (peer-reviewed)abstract
- Comparative analyses of survival senescence by using life tables have identified generalizations including the observation that mammals senesce faster than similar-sized birds. These generalizations have been challenged because of limitations of life-table approaches and the growing appreciation that senescence is more than an increasing probability of death. Without using life tables, we examine senescence rates in annual individual fitness using 20 individual-based data sets of terrestrial vertebrates with contrasting life histories and body size. We find that senescence is widespread in the wild and equally likely to occur in survival and reproduction. Additionally, mammals senesce faster than birds because they have a faster life history for a given body size. By allowing us to disentangle the effects of two major fitness components our methods allow an assessment of the robustness of the prevalent life-table approach. Focusing on one aspect of life history - survival or recruitment - can provide reliable information on overall senescence.
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| 17. |
- Scholey, C., et al.
(author)
-
In-beam and decay spectroscopy of very neutron deficient iridium nuclei
- 2005
-
In: Journal of Physics G. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 31:10, s. S1719-S1722
-
Journal article (peer-reviewed)abstract
- Iridium nuclei at and beyond the proton drip line have been studied via fusion evaporation reactions. A reaction of Mo-92(Kr-78, p2n) at a beam energy of 360 MeV and target thickness 500 mu g cm(-2) was employed to study (167,167m) Ir. A reaction of Sn-112(Ni-58, p2n) at a beam energy of 266 MeV and target thickness 500 mu g cm(-2) was used to study (169,169m) Ir. The experiments were performed at the University of Jyvaskyla utilizing the RITU separator in conjunction with the focal plane GREAT spectrometer and the JUROGAM Ge array at the target position. Excited states feeding. both the ground state and isomeric state in Ir-169, excited states feeding the ground state of Ir-167 and the ground state alpha decay of Re-165 have been observed for the first time along with excited states feeding (167)m Ir Experimental spectroscopic factors and reduced widths have been obtained for the proton and alpha decay of these nuclei.
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| 18. |
- Zaccai, Nathan R., et al.
(author)
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Crystallographic and in silico analysis of the sialoside-binding characteristics of the Siglec sialoadhesin
- 2007
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In: Journal of Molecular Biology. - : Elsevier BV. - 0022-2836 .- 1089-8638. ; 365:5, s. 1469-1479
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Journal article (peer-reviewed)abstract
- The Siglec family of receptors mediates cell-surface interactions through recognition of sialylated glycoconjugates. Previously reported structures of the N-terminal domain of the Siglec sialoadhesin (SnD1) in complex with various sialic acid analogs revealed the structural template for sialic acid binding. To characterize further the carbohydrate-binding properties, we have determined the crystal structures of SnD1 in the absence of ligand, and in complex with 2-benzyl-Neu5NPro and 2-benzyl-Neu5NAc. These structures reveal that SnD1 undergoes very few structural changes on ligand binding and detail how two novel classes of sialic acid analogs bind, one of which unexpectedly can induce Siglec dimerization. In conjunction with in silico analysis, this set of structures informs us about the design of putative ligands with enhanced binding affinities and specificities to different Siglecs, and provides data with which to test the effectiveness of different computational drug design protocols.
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| 19. |
- Garnsworthy, A. B., et al.
(author)
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Spectroscopy of Po-212 and At-213 using a He-8 radioactive beam and EXOGAM
- 2005
-
In: Journal of Physics G. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 31:10, s. S1851-S1854
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Journal article (peer-reviewed)abstract
- A beam of 28 MeV He-8 particles with an average intensity 2 x 10(5) ions s(-1), produced by the SPIRAL facility at GANIL, was used to initiate fusion-evaporation reactions in thick targets of Pb-201 and Bi-209. Excited states of Po-212 and At-213 were populated in (He-8,4n) reactions. The emitted gamma-rays were detected using the EXOGAM array composed of four Compton suppressed germanium Clover detectors in a close geometry configuration. Preliminary results show that Po-212 has been populated to high spin (I similar or equal to 14) with a significantly increased yield compared with our previous He-8 beam experiment. An apparently increased relative population of states up to 12(+) was observed compared with published results from a Pb-208(Be-9,alpha n)(212) Po reaction at 48 MeV. Evidence is presented for a previously unreported de-excitation pathway: 69 keV (13(-) -> 12(+)). States up to I-pi = (39/2(-)) have also been observed in At-213.
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| 20. |
- Murdoch, David R, et al.
(author)
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Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study.
- 2009
-
In: Archives of internal medicine. - : American Medical Association (AMA). - 1538-3679 .- 0003-9926. ; 169:5, s. 463-73
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Journal article (peer-reviewed)abstract
- BACKGROUND: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. METHODS: Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. RESULTS: The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (<30 days) with few of the classic clinical hallmarks of IE. Recent health care exposure was found in one-quarter of patients. Staphylococcus aureus was the most common pathogen (31.2%). The mitral (41.1%) and aortic (37.6%) valves were infected most commonly. The following complications were common: stroke (16.9%), embolization other than stroke (22.6%), heart failure (32.3%), and intracardiac abscess (14.4%). Surgical therapy was common (48.2%), and in-hospital mortality remained high (17.7%). Prosthetic valve involvement (odds ratio, 1.47; 95% confidence interval, 1.13-1.90), increasing age (1.30; 1.17-1.46 per 10-year interval), pulmonary edema (1.79; 1.39-2.30), S aureus infection (1.54; 1.14-2.08), coagulase-negative staphylococcal infection (1.50; 1.07-2.10), mitral valve vegetation (1.34; 1.06-1.68), and paravalvular complications (2.25; 1.64-3.09) were associated with an increased risk of in-hospital death, whereas viridans streptococcal infection (0.52; 0.33-0.81) and surgery (0.61; 0.44-0.83) were associated with a decreased risk. CONCLUSIONS: In the early 21st century, IE is more often an acute disease, characterized by a high rate of S aureus infection. Mortality remains relatively high.
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| 21. |
- Philipp, Andreas, et al.
(author)
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Long-Term Variability of Daily North Atlantic–European Pressure Patterns since 1850 Classified by Simulated Annealing Clustering
- 2007
-
In: Journal of Climate. - 1520-0442. ; 20:16, s. 4065-4095
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Journal article (peer-reviewed)abstract
- Reconstructed daily mean sea level pressure patterns of the North Atlantic–European region are classified for the period 1850 to 2003 to explore long-term changes of the atmospheric circulation and its impact on long-term temperature variability in the central European region. Commonly used k-means clustering algorithms resulted in classifications of low quality because of methodological deficiencies leading to local optima by chance for complex datasets. In contrast, a newly implemented clustering scheme combining the concepts of simulated annealing and diversified randomization (SANDRA) is able to reduce substantially the influence of chance in the cluster assignment, leading to partitions that are noticeably nearer to the global optimum and more stable. The differences between conventional cluster analysis and the SANDRA scheme are significant for subsequent analyses of single clusters—in particular, for trend analysis. Conventional indices used to determine the appropriate number of clusters failed to provide clear guidance, indicating that no distinct separation between clusters of circulation types exists in the dataset. Therefore, the number of clusters is determined by an external indicator, the so-called dominance criteria for t-mode principal component analysis. Nevertheless, the resulting partitions are stable for certain numbers of clusters and provide meaningful and reproducible clusters. The resulting types of pressure patterns reveal pronounced long-term variability and various significant trends of the time series of seasonal cluster frequency. Tentative estimations of central European temperature changes based solely on seasonal cluster frequencies can explain between 33.9% (summer) and 59.0% (winter) of temperature variance on the seasonal time scale. However, the signs of long-term changes in temperature are correctly reproduced even on multidecadal–centennial time scales. Moreover, linear warming trends are reproduced, implying from one-third up to one-half of the observed temperature increase between 1851/52 and 2003 (except for summer, but with significant trends for spring and autumn), indicating that changes in daily circulation patterns contribute to the observed overall long-term warming in the central European region.
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| 22. |
- Wood, Laura D, et al.
(author)
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The genomic landscapes of human breast and colorectal cancers.
- 2007
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 318:5853, s. 1108-1113
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Journal article (peer-reviewed)abstract
- Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene "mountains" and a much larger number of gene "hills" that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy.
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