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- Fountoulakis, K.N., et al.
(författare)
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Modeling psychological function in patients with schizophrenia with the PANSS : An international multi-center study
- 2021
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Ingår i: CNS Spectrums. - : Cambridge University Press. - 1092-8529 .- 2165-6509. ; 26:3, s. 290-298
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Tidskriftsartikel (refereegranskat)abstract
- Background.The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model.Methods.Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed.Results.The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage.Conclusions.The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct “cores” of schizophrenia, the “Positive” and the “Negative,” while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition.
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- Colucci, A., et al.
(författare)
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MLComp : A Methodology for Machine Learning-based Performance Estimation and Adaptive Selection of Pareto-Optimal Compiler Optimization Sequences
- 2021
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Ingår i: Proceedings -Design, Automation and Test in Europe, DATE. - : Institute of Electrical and Electronics Engineers Inc.. - 9783981926354 ; , s. 108-113
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Konferensbidrag (refereegranskat)abstract
- Embedded systems have proliferated in various consumer and industrial applications with the evolution of Cyber-Physical Systems and the Internet of Things. These systems are subjected to stringent constraints so that embedded software must be optimized for multiple objectives simultaneously, namely reduced energy consumption, execution time, and code size. Compilers offer optimization phases to improve these metrics. However, proper selection and ordering of them depends on multiple factors and typically requires expert knowledge. State-of-the-art optimizers facilitate different platforms and applications case by case, and they are limited by optimizing one metric at a time, as well as requiring a time-consuming adaptation for different targets through dynamic profiling. To address these problems, we propose the novel MLComp methodology, in which optimization phases are sequenced by a Reinforcement Learning-based policy. Training of the policy is supported by Machine Learning-based analytical models for quick performance estimation, thereby drastically reducing the time spent for dynamic profiling. In our framework, different Machine Learning models are automatically tested to choose the best-fitting one. The trained Performance Estimator model is leveraged to efficiently devise Reinforcement Learning-based multi-objective policies for creating quasi-optimal phase sequences. Compared to state-of-the-art estimation models, our Performance Estimator model achieves lower relative error (< 2%) with up to 50 × faster training time over multiple platforms and application domains. Our Phase Selection Policy improves execution time and energy consumption of a given code by up to 12% and 6%, respectively. The Performance Estimator and the Phase Selection Policy can be trained efficiently for any target platform and application domain. © 2021 EDAA.
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- Elekes, Z., et al.
(författare)
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Shape coexistence in 66Se
- 2023
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Ingår i: Physics Letters B. - : Elsevier. - 0370-2693 .- 1873-2445. ; 844
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Tidskriftsartikel (refereegranskat)abstract
- The nuclear structure of 66Se, nucleus beyond the N=Z line on the proton-rich side of the valley of stability, was investigated by the neutron knock-out reaction 67Se(12C,X)66Se using a 12C target. The analysis of the singles spectrum of the γ-rays emitted during the de-excitation of the populated low-lying excited states revealed two previously detected (927(4) keV, 1460(32) keV) and three new (744(6) keV, 1210(17) keV, 1661(23) keV) transitions. The 744-keV, the 1210-keV, and the 1460-keV transitions were found to be in coincidence with the one at 927 keV. The spectrum coincident with the 927-keV transition showed a further possible transition at 299(35) keV, which was obscured by significant atomic background in the singles spectrum. This transition might correspond to a peak previously reported at 273(5) keV that could not be assigned to 66Se unambiguously. Based on a comparison of the experimental data to theoretical calculations, four new excited states are proposed which suggest that 66Se exhibits shape coexistence.
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- Jin, Han, et al.
(författare)
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Genome-scale metabolic network of human carotid plaque reveals the pivotal role of glutamine/glutamate metabolism in macrophage modulating plaque inflammation and vulnerability
- 2024
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Ingår i: Cardiovascular Diabetology. - : Springer Nature. - 1475-2840. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Metabolism is increasingly recognized as a key regulator of the function and phenotype of the primary cellular constituents of the atherosclerotic vascular wall, including endothelial cells, smooth muscle cells, and inflammatory cells. However, a comprehensive analysis of metabolic changes associated with the transition of plaque from a stable to a hemorrhaged phenotype is lacking. Methods: In this study, we integrated two large mRNA expression and protein abundance datasets (BIKE, n = 126; MaasHPS, n = 43) from human atherosclerotic carotid artery plaque to reconstruct a genome-scale metabolic network (GEM). Next, the GEM findings were linked to metabolomics data from MaasHPS, providing a comprehensive overview of metabolic changes in human plaque. Results: Our study identified significant changes in lipid, cholesterol, and inositol metabolism, along with altered lysosomal lytic activity and increased inflammatory activity, in unstable plaques with intraplaque hemorrhage (IPH+) compared to non-hemorrhaged (IPH−) plaques. Moreover, topological analysis of this network model revealed that the conversion of glutamine to glutamate and their flux between the cytoplasm and mitochondria were notably compromised in hemorrhaged plaques, with a significant reduction in overall glutamate levels in IPH+ plaques. Additionally, reduced glutamate availability was associated with an increased presence of macrophages and a pro-inflammatory phenotype in IPH+ plaques, suggesting an inflammation-prone microenvironment. Conclusions: This study is the first to establish a robust and comprehensive GEM for atherosclerotic plaque, providing a valuable resource for understanding plaque metabolism. The utility of this GEM was illustrated by its ability to reliably predict dysregulation in the cholesterol hydroxylation, inositol metabolism, and the glutamine/glutamate pathway in rupture-prone hemorrhaged plaques, a finding that may pave the way to new diagnostic or therapeutic measures.
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- Klionsky, DJ, et al.
(författare)
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Autophagy in major human diseases
- 2021
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Ingår i: The EMBO journal. - : EMBO. - 1460-2075 .- 0261-4189. ; 40:19, s. e108863-
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Tidskriftsartikel (refereegranskat)
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| 10. |
- Juhasz, M. M., et al.
(författare)
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First spectroscopic study of( 51)Ar by the (p,2p) reaction
- 2021
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Ingår i: Physics Letters B. - : ELSEVIER. - 0370-2693 .- 1873-2445. ; 814
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Tidskriftsartikel (refereegranskat)abstract
- The nuclear structure of Ar-51, an uncharted territory so far, was studied by the (p,2p) reaction using gamma-ray spectroscopy for the bound states and the invariant mass method for the unbound states. Two peaks were detected in the gamma-ray spectrum and six peaks were observed in the Ar-50+n relative energy spectrum. Comparing the results to our shell-model calculations, two bound and six unbound states were established. Three of the unbound states could only be placed tentatively due to the low number of counts in the relative energy spectrum of events associated with the decay through the first excited state of Ar-50. The low cross sections populating the two bound states of Ar-51 could be interpreted as a clear signature for the presence of significant subshell closures at neutron numbers 32 and 34 in argon isotopes. It was also revealed that due to the two valence holes, unbound collective states coexist with individual-particle states in Ar-51.
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| 11. |
- Juhasz, M. M., et al.
(författare)
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First spectroscopic study of V-63 at the N=40 island of inversion
- 2021
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Ingår i: Physical Review C. - : AMER PHYSICAL SOC. - 2469-9985 .- 2469-9993. ; 103:6
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Tidskriftsartikel (refereegranskat)abstract
- The low-lying level structure of V-63 was studied for the first time by the inelastic proton scattering and the proton knock-out reaction in inverse kinematics. The comparison of the newly observed gamma-ray transitions at 696(8) keV and 889(16) keV with our shell-model calculations using the Lenzi-Nowacki-Poves-Sieja interaction established two excited states proposed to be the first 11/2(-) and 9/2(-) levels. The (p, p') excitation cross sections were analyzed by the coupled channel formalism assuming pure quadrupole as well as quadrupole+hexadecapole deformations. This resulted in large deformation parameters placing V-63 in the island of inversion located below Ni-68.
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