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Träfflista för sökning "WFRF:(Kadowaki Kazuo) srt2:(2008)"

Sökning: WFRF:(Kadowaki Kazuo) > (2008)

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1.
  • Yasuda, Kazuki, et al. (författare)
  • Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
  • 2008
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:9, s. 1092-1097
  • Tidskriftsartikel (refereegranskat)abstract
    • We carried out a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The most significant association was obtained with SNPs in KCNQ1, and dense mapping within the gene revealed that rs2237892 in intron 15 showed the lowest P value (6.7 x 10(-13), odds ratio (OR) = 1.49). The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations, and meta-analysis with a total of 19,930 individuals (9,569 cases and 10,361 controls) yielded a P value of 1.7 x 10(-42) (OR = 1.40; 95% CI = 1.34-1.47) for rs2237892. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion according to the homeostasis model assessment of beta-cell function or the corrected insulin response. Our data thus implicate KCNQ1 as a diabetes susceptibility gene in groups of different ancestries.
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2.
  • Yurgens, Avgust, 1959, et al. (författare)
  • Small-number arrays of intrinsic Josephson junctions
  • 2008
  • Ingår i: Physica C: Superconductivity and its Applications. - : Elsevier BV. - 0921-4534. ; 468:7-10, s. 674-678
  • Tidskriftsartikel (refereegranskat)abstract
    • Arrays of nanometre-thick Bi2212-intrinsic Josephson junctions (IJJ's) are studied in various geometries. The samples with only a few IJJ's allow for the intrinsic-tunnelling spectroscopy with minimum of Joule heating. The reproducible low-voltage peaks of the spectra probably stem from a superconducting gap which is half the usual size. We estimate the internal temperature in the IJJ stacks and analyze the importance of the self-heating for the macroscopic-quantum-tunnel ling experiments involving IJJ's.
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