| 1. |
- Klintman, Marie, et al.
(author)
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Changes in expression of genes representing key biologic processes after neoadjuvant chemotherapy in breast cancer, and prognostic implications in residual disease
- 2016
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In: Clinical Cancer Research. - 1078-0432. ; 22:10, s. 2405-2416
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Journal article (peer-reviewed)abstract
- Purpose: The primary aim was to derive evidence for or against the clinical importance of several biologic processes in patients treated with neoadjuvant chemotherapy (NAC) by assessing expression of selected genes with prior implications in prognosis or treatment resistance. The secondary aim was to determine the prognostic impact in residual disease of the genes' expression. Experimental Design: Expression levels of 24 genes were quantified by NanoString nCounter on formalin-fixed paraffinembedded residual tumors from 126 patients treated with NAC and 56 paired presurgical biopsies. The paired t test was used for testing changes in gene expression, and Cox regression and penalized elastic-net Cox Regression for estimating HRs. Results: After NAC, 12 genes were significantly up- and 8 downregulated. Fourteen genes were significantly associated with time to recurrence in univariable analysis in residual disease. In a multivariable model, ACACB, CD3D, MKI67, and TOP2A added prognostic value independent of clinical ER-, PgR-, and HER2- status. In ER+/HER2- patients, ACACB, PAWR, and ERBB2 predicted outcome, whereas CD3D and PAWR were prognostic in ER-/HER2- patients. By use of elastic-net analysis, a 6-gene signature (ACACB, CD3D, DECORIN, ESR1, MKI67, PLAU) was identified adding prognostic value independent of ER, PgR, and HER2. Conclusions: Most of the tested genes were significantly enriched or depleted in response to NAC. Expression levels of genes representing proliferation, stromal activation, metabolism, apoptosis, stemcellness, immunologic response, and Ras-ERK activation predicted outcome in residual disease. Themultivariable gene models identified could, if validated, be used to identify patients needing additional post-neoadjuvant treatment to improve prognosis.
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| 2. |
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| 3. |
- Dohlsten, John, 1981
(author)
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Vad möjliggör och begränsar en hållbar elitfriidrott? Aktionsforskning i elitidrottspraktiker inom Göteborgs friidrottsförbund
- 2020
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Doctoral thesis (other academic/artistic)abstract
- In athletics, there are few strategies for detecting and managing ill health and poor well-being. New innovative collaborations are needed for coaches to meet the challenge of promoting health and creating well-being among athletes while developing top performers. This research explores the conditions for coaches’ professional development to develop a more sustainable elite sport. In addition, this study problematizes the coaches’ development work towards a more sustainable elite sport in Gothenburg athletics. The thesis consists of several theoretical perspectives. The theory of practice architecture and ecologies of practice are used as overarching theories to identify, understand, and describe how coaches develop. Careership theory is used to explore professional development. The theoretical concept of sustainability, the theory of ethics of care and practical wisdom are used to explore a deeper understanding of sustainability. The thesis is based on an action research project where the data are produced from semi-structured interviews, focus group interviews, meeting recordings, observations, and logbook notes. The results show that coaches’ professional development for creating a more sustainable elite sport takes place while reflecting with other coaches about their coaching role and their lack of knowledge. The results also show that focus on holistic perspectives and long-term processes on athletes’ development enabled the athletes to develop and perform. However, there were no structures, requirements, or support for the athletes or coaches to prioritize long-term goals over short-term goals. The coaches’ meeting practice became a forum for professional development through cooperation although the coaches’ own drive to develop the practice was constrained by the fact that there was no support from the clubs for this organized professional development. Furthermore, the results also show that the coaches expressed an ambition to develop more knowledge to be able to work towards a more sustainable elite sport, but were constrained by unclear requirements as a coach and by their athletes’ focus on results.
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| 5. |
- Lee, Francis, 1974-, et al.
(author)
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Styles of Valuation : Algorithms and Agency in High-throughput Bioscience
- 2020
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In: Science, Technology and Human Values. - : SAGE Publications. - 0162-2439 .- 1552-8251. ; 45:4, s. 659-685
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Journal article (peer-reviewed)abstract
- In science and technology studies today, there is a troubling tendency to portray actors in the biosciences as "cultural dopes" and technology as having monolithic qualities with predetermined outcomes. To remedy this analytical impasse, this article introduces the concept styles of valuation to analyze how actors struggle with valuing technology in practice. Empirically, this article examines how actors in a bioscientific laboratory struggle with valuing the properties and qualities of algorithms in a high-throughput setting and identifies the copresence of several different styles. The question that the actors struggle with is what different configurations of algorithms, devices, and humans are "good bioscience," that is, what do the actors perform as a good distribution of agency between algorithms and humans? A key finding is that algorithms, robots, and humans are valued in multiple ways in the same setting. For the actors, it is not apparent which configuration of agency and devices is more authoritative nor is it obvious which skills and functions should be redistributed to the algorithms. Thus, rather than tying algorithms to one set of values, such as "speed," "precision," or "automation," this article demonstrates the broad utility of attending to the multivalence of algorithms and technology in practice.
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| 6. |
- Ngaosuvan, Leonard, Lektor, 1973-
(author)
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Granskning av utredning angående vårdnad, boende eller umgänge
- 2022
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Reports (other academic/artistic)abstract
- Granskningen presenterar nitton brister som är så allvarliga att de var och en skulle ogiltigförklara hela utredningen. Utöver detta identifieras ytterligare tio allvarliga brister som tillsammans skulle underkänna utredningen. Flera av de allvarligaste bristerna berör partiskhet och allvarligt ifrågasättande för utredningens rättssäkerhet. I synnerlirhet gäller detta hur utredningen förhåller sig till tidigare utredning som har annan struktur och utgångspunkt. Sammantaget visar granskningen att den aktuella utredningen inte bör användas som ett underlag för beslut i rättsliga instanser.
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| 9. |
- Hvit, Sara, 1970-
(author)
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Toddlers make and use of language in their world of language : Preschool as childrens language environment
- 2010
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Conference paper (pop. science, debate, etc.)abstract
- The aim of this article is to discuss how toddlers make and use language in preschool. This will be presented in three themes regarding Doing something together, make meaning of ideas and the expressive toddlerbody. The theoretical points of departure is based on Maurice Merleau Ponty´s mainwork Phenomenology of perception (1962), Gunvor Lökkens empirical toddler peer studies and Gunther Kress theories about paths to literacy. A further aim is to discuss the didactial challenges followed of the toddler turns to the digitalized world of expression. We need more expansive theories in preschool practice about toddlers ways of use and make language if it should be possible to them to create meaning together.
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| 11. |
- Kwiatkowski, Andrzej, et al.
(author)
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Enhanced visible light-activated gas sensing properties of nanoporous copper oxide thin films
- 2024
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In: Solar Energy Materials and Solar Cells. - : Elsevier. - 0927-0248 .- 1879-3398. ; 273
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Journal article (peer-reviewed)abstract
- Metal oxide gas sensors are popular chemoresistive sensors. They are used for numerous tasks, including environmental and safety monitoring. Some gas-sensing materials exhibit photo-induced properties that can be utilized for enhanced gas detection by modifying the sensor selectivity and sensitivity when illuminated by light. Here, we present the gas sensing characteristics of highly nanoporous Cu2O thin films towards both electrophilic (NO2) and nucleophilic (C2H5OH, NH3) gas molecules under ambient temperature and modulated by visible light illumination of different colors (red: 632 nm, green: 530 nm, blue: 468 nm). Cu2O films were fabricated by reactive advanced gas deposition (AGD) technology. The surface and structural analysis of the samples confirm the deposition of nanoporous thin films of mixed copper oxide phases. The gas sensing property of Cu2O exhibited expected p-type semiconductor behavior upon electrophilic and nucleophilic gas exposures. Our results show that visible light illumination provides enhanced sensor response.
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| 12. |
- Lee, Francis, et al.
(author)
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Algorithms as folding : Reframing the analytical focus
- 2019
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In: Big Data and Society. - : SAGE PUBLICATIONS INC. - 2053-9517. ; 6:2
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Journal article (peer-reviewed)abstract
- This article proposes an analytical approach to algorithms that stresses operations of folding. The aim of this approach is to broaden the common analytical focus on algorithms as biased and opaque black boxes, and to instead highlight the many relations that algorithms are interwoven with. Our proposed approach thus highlights how algorithms fold heterogeneous things: data, methods and objects with multiple ethical and political effects. We exemplify the utility of our approach by proposing three specific operations of folding-proximation, universalisation and normalisation. The article develops these three operations through four empirical vignettes, drawn from different settings that deal with algorithms in relation to AIDS, Zika and stock markets. In proposing this analytical approach, we wish to highlight the many different attachments and relations that algorithms enfold. The approach thus aims to produce accounts that highlight how algorithms dynamically combine and reconfigure different social and material heterogeneities as well as the ethical, normative and political consequences of these reconfigurations.
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| 13. |
- Lee, S., et al.
(author)
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Tritium distributions in castellated structures of Be limiter tiles from JET-ITER-like wall experiments
- 2023
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In: Nuclear Fusion. - : IOP Publishing Ltd. - 0029-5515 .- 1741-4326. ; 63:4
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Journal article (peer-reviewed)abstract
- Tritium retention in the castellated structure of beryllium limiters used in JET with the ITER-like wall (ILW) during the first (ILW1), third (ILW3) and all three (ILW1-3) campaigns were examined and evaluated. Tritium was deposited on the surfaces inside the castellation grooves together with deuterium, beryllium, oxygen, carbon and small amounts of metallic impurities such as nickel, copper and tungsten. The tritium content after the ILW1 campaign was greater than after the ILW3 campaign. This is attributed to the steadily decreasing amount of carbon impurities in JET from campaign to campaign. The majority of tritium was retained in shallow regions in the grooves, up to 2 mm from the entrance to the gap. It was comparable on all sides of the castellation, i.e. no difference has been detected between the toroidal and poloidal gaps. Secondly, the tritium retention in the gaps was similar on all specimens independent of their position in the tokamak, while the retention on the plasma-facing surfaces clearly depended on the tile position. The tritium deposition patterns in the castellation were also compared with the deuterium distribution determined in earlier studies.
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| 14. |
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| 15. |
- Feng, Zhuo, et al.
(author)
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Nurse logs: A common seedling strategy in the Permian Cathaysian flora
- 2022
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In: iScience. - Cambridge, Massachusetts : Elsevier BV. - 2589-0042. ; 25, s. 1-11
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Journal article (peer-reviewed)abstract
- Nurse logs are common in modern forests from boreal to temperate and tropical ecosystems. However, the evolution of the nurse-log strategy remains elusive because of their rare occurrence in the fossil record. We report seven coniferous nurse logs from lowermost to uppermost Permian strata of northern China that have been colonized by conifer and sphenophyllalean roots. These roots are associated with two types of arthropod coprolites and fungal remains. Our study provides the first glimpse into plant—plant facilitative relationships between late Paleozoic gymnosperms and sphenopsids. Detritivorous arthropods and fungi appear to have been crucial for the utilization of nurse logs in Permian forests. The phylogenetically distant roots demonstrate that nurse-log interaction wasa sophisticated seedling strategy in late Paleozoic humid tropical forests, and this approach may have been adopted and developed by a succession of plant groups leading to its wide representation in modern forest ecosystems.
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| 18. |
- Kanerva, Pentti, et al.
(author)
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Stochastic pattern computing
- 1999. - 1
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In: Proceedings of the 2000 Real World Computing Symposium (RWC 2000), 17-19 Jan 2000, Tokyo, Japan. ; , s. 271-276
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Conference paper (peer-reviewed)
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| 19. |
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| 20. |
- Kilu, Rufai Haruna, et al.
(author)
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Reflections on Organizational Barriers Vis-à-Vis Women Participation in Largescale Ghanaian Mines
- 2017
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In: International Journal of Business and Social Science. - 2219-1933 .- 2219-6021.
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Journal article (peer-reviewed)abstract
- Writing from gender and organizational perspectives, this article reflects consciously with nuances upon varied effort working towards resolving the long existing binary barriers in the world of work. Working towards this goal, this article raises questions as to which organizational practices, processes, and procedures function to create participatory barriers to women in Ghanaian mine jobs. Adopting a mixed method design, the paper points to the culture of male dominance, gender biases, role models and mentorship constraints, unfriendly family work policies, and the relationship among women in male-dominated settings. These outcomes, according to the study, constitute a considerable concern for organizational development, with practical implications for industry, employment, labor relation practices, and public policy in Ghana. Therefore affirmative action among others is recommended for gender deconstruction, and promotion of gender democracy, an agenda for inclusivity, and a safety valve for poverty escapes and a compact for achieving gender equality in multinational Ghanaian mines.
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| 21. |
- Lange, David, et al.
(author)
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An application of the PEER performance based earthquake engineering framework to structures in fire
- 2014
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In: Engineering structures. - : Elsevier BV. - 0141-0296 .- 1873-7323. ; 66:May, s. 100-115
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Journal article (peer-reviewed)abstract
- The Pacific Earthquake Engineering Research (PEER) Center's Performance Based Earthquake Engineering (PBEE) framework is well documented. The framework is a linear methodology which is based upon obtaining in turn output from each of the following analyses: hazard analysis; structural analysis; loss analysis, and finally decision making based on variables of interest, such as downtime or cost to repair. The strength of the framework is in its linearity, its clear flexibility and in the consideration of uncertainty at every stage of the analysis. The framework has potential applications to other forms of extreme loading; however in order for this to be achieved the 'mapping' of the framework to the analysis of structures for other loading situations must be successful.This paper illustrates one such 'mapping' of the framework for Performance Based Fire Engineering (PBFE) of structures. Using a combination of simple analytical techniques and codified methods as well as random sampling techniques to develop a range of response records, the PEER framework is followed to illustrate its application to structural fire engineering. The end result is a successful application of the earthquake framework to fire which highlights both the assumptions which are inherent in the performance based design framework as well as subjects of future research which will allow more confidence in the design of structures for fire using performance based techniques.This article describes the PEER framework applied to structural earthquake design then follows the framework from start to completion applying suitable alternative tools to perform each stage of the analysis for structures in fire.
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| 22. |
- Sammut, Claude
(author)
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Managing Context in a Conversational Agent
- 2001
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Reports (other academic/artistic)abstract
- This paper describes a conversational agent, called "ProBot", that uses a novel structure for handling context. The ProBot is implemented as a rule-based system embedded in a Prolog interpreter. The rules consist of patterns and responses, where each pattern matches a user's input sentence and the response is an output sentence. Both patterns and responses may have attached Prolog expressions that act as constraints in the patterns and can invoke some action when used in the response.
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| 23. |
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