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Antagonists of IGF :
Antagonists of IGF : Vitronectin Interactions Inhibit IGF-I-Induced Breast Cancer Cell Functions
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- Kashyap, Abhishek S. (författare)
- Queensland Univ Technol, Tissue Repair & Regenerat Program, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia.;Univ Basel Hosp, Dept Biomed, Canc Immunol, Basel, Switzerland.
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- Shooter, Gary K. (författare)
- Queensland Univ Technol, Tissue Repair & Regenerat Program, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia.
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- Shokoohmand, Ali (författare)
- Queensland Univ Technol, Tissue Repair & Regenerat Program, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia.
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- McGovern, Jacqui (författare)
- Queensland Univ Technol, Tissue Repair & Regenerat Program, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia.
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- Sivaramakrishnan, Manaswini (författare)
- Roche Innovat Ctr, Pharma Res & Early Dev, Basel, Switzerland.
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- Croll, Tristan I. (författare)
- Queensland Univ Technol, Tissue Repair & Regenerat Program, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia.
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- Cane, Gaelle (författare)
- Uppsala Univ, Dept Immunol Genet & Pathol, Sci Life Lab, BMC, Uppsala, Sweden.
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- Leavesley, David I. (författare)
- Queensland Univ Technol, Tissue Repair & Regenerat Program, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia.
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- Söderberg, Ola (författare)
- Uppsala universitet,Molekylära verktyg,Science for Life Laboratory, SciLifeLab
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- Upton, Zee (författare)
- Queensland Univ Technol, Tissue Repair & Regenerat Program, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia.
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- Hollier, Brett G. (författare)
- Queensland Univ Technol, Tissue Repair & Regenerat Program, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia.;Australian Prostate Canc Res Ctr Queensland, Inst Hlth & Biomed Innovat, Translat Res Inst, Brisbane, Qld, Australia.
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Queensland Univ Technol, Tissue Repair & Regenerat Program, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia;Univ Basel Hosp, Dept Biomed, Canc Immunol, Basel, Switzerland. Queensland Univ Technol, Tissue Repair & Regenerat Program, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia. (creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Molecular Cancer Therapeutics. - 1535-7163 .- 1538-8514. ; 15:7, s. 1602-1613
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- We provide proof-of-concept evidence for a new class of therapeutics that target growth factor: extracellular matrix (GF: ECM) interactions for the management of breast cancer. Insulinlike growth factor-I (IGF-I) forms multiprotein complexes with IGF-binding proteins (IGFBP) and the ECM protein vitronectin (VN), and stimulates the survival, migration and invasion of breast cancer cells. For the first time we provide physical evidence for IGFBP-3: VN interactions in breast cancer patient tissues; these interactions were predominantly localized to tumor cell clusters and in stroma surrounding tumor cells. We show that disruption of IGF-I: IGFBP: VN complexes with L27-IGF-II inhibits IGF-I: IGFBP: VN-stimulated breast cancer cell migration and proliferation in two-and three-dimensional assay systems. Peptide arrays screened to identify regions critical for the IGFBP-3/-5: VN and IGF-II: VN interactions demonstrated IGFBP-3/-5 and IGF-II binds VN through the hemopexin-2 domain, and VN binds IGFBP-3 at residues not involved in the binding of IGF-I to IGFBP-3. IGFBP-interacting VN peptides identified from these peptide arrays disrupted the IGF-I: IGFBP: VN complex, impeded the growth of primary tumor-like spheroids and, more importantly, inhibited the invasion of metastatic breast cancer cells in 3D assay systems. These studies provide first-in-field evidence for the utility of small peptides in antagonizing GF: ECM-mediated biologic functions and present data demonstrating the potential of these peptide antagonists as novel therapeutics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Kashyap, Abhishe ...
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Shooter, Gary K.
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Shokoohmand, Ali
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McGovern, Jacqui
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Sivaramakrishnan ...
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Croll, Tristan I ...
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visa fler...
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Cane, Gaelle
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Leavesley, David ...
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Söderberg, Ola
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Upton, Zee
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Hollier, Brett G ...
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