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Sökning: WFRF:(Khamis M) > (2002-2004)

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2.
  • Wilkie, F. L., et al. (författare)
  • Cognitive functioning in younger and older HIV-1 - Infected adults
  • 2003
  • Ingår i: Journal of Acquired Immune Deficiency Syndromes. - : Wolters Kluwer. - 1525-4135 .- 1944-7884. ; 33, s. S93-S105
  • Tidskriftsartikel (refereegranskat)abstract
    • In young adults, a major neurologic complication of HIV-1 infection is cognitive motor impairment. Epidemiologic findings suggest that increasing age is a significant risk factor for HIV-1-associated dementia as the AIDS-defining illness. Findings from the few studies that have directly measured cognition in younger and older HIV-1-infected adults, however, have been mixed, in pan, because of small sample sizes and other methodologic differences between studies. The authors present preliminary findings on cognitive functioning in symptomatic HIV-1-infected younger (aged 20-39 years) and older (aged 50 years or older) adults. Independent of age, HIV-1 infection was accompanied by learning and memory retrieval deficits, which were significantly associated with high plasma viral loads in the young adults. Relative to the younger and older HIV-1-negative (HIV-1-) groups, only the younger HIV-1-positive (HIV-1(+))group had significantly longer reaction times (RTs). Within the older HIV-1(+) group, however, longer simple and choice RTs were significantly correlated with higher viral loads and lower CD4 cell counts. Although HIV-1 infection affects cognition independent of age, longitudinal studies involving large numbers of older individuals are needed to determine whether there are age differences in the prevalence, nature, and severity of HIV-1-associated cognitive dysfunction.
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3.
  • Goodkin, K., et al. (författare)
  • "Putting a face" on HIV infection/AIDS in older adults : A psychosocial context
  • 2003
  • Ingår i: Journal of Acquired Immune Deficiency Syndromes. - : Lippincott Williams & Wilkins. - 1525-4135 .- 1944-7884. ; 33, s. S171-S184
  • Forskningsöversikt (refereegranskat)abstract
    • Older HIV-1-seropositive individuals largely have not been investigated with respect to their psychosocial characteristics. In this article, the authors review research reported to date regarding the psychosocial context of this growing subgroup of HIV-1-infected individuals. Specifically, the authors consider the characteristics of mood state, life stressor burden, social support network, and coping strategies that individuals older than 50 years are more likely to adopt in adjusting to HIV-1 infection. The authors also separately consider issues of caregiving burden. Data supporting a theoretically based stressor-support-coping model are presented and related to targeting psychotherapeutic interventions for this age group.
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