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Expression profilin...
Expression profiling reveals metabolic and structural components of extraocular muscles
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- Fischer, M Dominik (författare)
- University of Pennsylvania School of Medicine
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- Gorospe, J Rafael (författare)
- George Washington University, Washington
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- Felder, Edward (författare)
- University of Pennsylvania School of Medicine, Philadelphia
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- Bogdanovich, Sasha (författare)
- University of Pennsylvania School of Medicine
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- Pedrosa-Domellöf, Fatima (författare)
- Umeå universitet,Anatomi
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- Ahima, Rexford S (författare)
- University of Pennsylvania School of Medicine, Philadelphia
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- Rubinstein, Neal A (författare)
- University of Pennsylvania School of Medicine, Philadelphia
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- Hoffman, Eric P (författare)
- George Washington University, Washington
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- Khurana, Tejvir S (författare)
- University of Pennsylvania School of Medicine
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(creator_code:org_t)
- American Physiological Society, 2002
- 2002
- Engelska.
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Ingår i: Physiological Genomics. - : American Physiological Society. - 1094-8341 .- 1531-2267. ; 9:2, s. 71-84
- Relaterad länk:
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http://physiolgenomi...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The extraocular muscles (EOM) are anatomically and physiologically distinct from other skeletal muscles. EOM are preferentially affected in mitochondrial myopathies, but spared in Duchenne's muscular dystrophy. The anatomical and pathophysiological properties of EOM have been attributed to their unique molecular makeup: an allotype. We used expression profiling to define molecular features of the EOM allotype. We found 346 differentially expressed genes in rat EOM compared with tibialis anterior, based on a twofold difference cutoff. Genes required for efficient, fatigue-resistant, oxidative metabolism were increased in EOM, whereas genes for glycogen metabolism were decreased. EOM also showed increased expression of genes related to structural components of EOM such as vessels, nerves, mitochondria, and neuromuscular junctions. Additionally, genes related to specialized functional roles of EOM such as the embryonic and EOM-specific myosin heavy chains and genes for muscle growth, development, and/or regeneration were increased. The EOM expression profile was validated using biochemical, structural, and molecular methods. Characterization of the EOM expression profile begins to define gene transcription patterns associated with the unique anatomical, metabolic, and pathophysiological properties of EOM.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- extraocular muscle
- allotype
- expression profile
- transcriptome
- energy metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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