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Concurrent Treatmen...
Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure ( COPE): A Pilot Study in Alcohol-dependent Women
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- Persson, Anna (författare)
- Karolinska Institutet
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- Back, Sudie E. (författare)
- Medical University of South Carolina, USA; Ralph H Johnson Vet Affairs VA Medical Centre, SC USA
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- Killeen, Therese K. (författare)
- Medical University of South Carolina, SC 29425 USA
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- Brady, Kathleen T. (författare)
- Medical University of South Carolina, SC 29425 USA; Ralph H Johnson Vet Affairs VA Medical Centre, SC USA
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- Schwandt, Melanie L. (författare)
- NIAAA, MD USA
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- Heilig, Markus (författare)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken
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- Magnusson, Åsa (författare)
- Karolinska Institutet
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(creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2017
- 2017
- Engelska.
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Ingår i: Journal of addiction medicine. - : LIPPINCOTT WILLIAMS & WILKINS. - 1932-0620 .- 1935-3227. ; 11:2, s. 119-125
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives: Posttraumatic stress disorder (PTSD) and substance use disorders are highly comorbid. Effective treatments are largely lacking. This pilot study evaluated the safety and feasibility of a novel intervention, Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE), in preparation for a randomized controlled trial. Methods: Twenty-two treatment-seeking women with current DSM-IV-TR PTSD and alcohol dependence (AD) were recruited. Participants received COPE. Safety and feasibility were evaluated, as were efficacy-related outcomes: PTSD and depression symptom severity, alcohol use, craving, and dependence severity. Results: No adverse events occurred. COPE was implemented in routine clinical practice. Among the assessed women, 95.8% were eligible to participate. Treatment attendance and completion were higher than in previous studies. Post treatment, all efficacy-related outcomes, including PTSD and depression symptom severity, alcohol use, craving, and dependence severity, were significantly reduced. Conclusions: COPE was safe and feasible to use. Concerns that trauma-focused, exposure-based therapy might promote relapse in this population appear unwarranted. Our findings provide initial evidence suggestive of COPE efficacy for comorbid PTSD and AD in women. These results provide a strong rationale for investigating the efficacy of COPE for comorbid PTSD and AD in women in a randomized controlled trial.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Beroendelära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Substance Abuse (hsv//eng)
Nyckelord
- alcohol dependence; alcohol use disorder; integrated treatment; PTSD; women
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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