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A multiple sclerosi...
A multiple sclerosis disease progression measure based on cumulative disability
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- Manouchehrinia, A. (författare)
- Karolinska Institutet
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Kingwell, E. (författare)
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Zhu, F. (författare)
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Tremlett, H. (författare)
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- Hillert, J. (författare)
- Karolinska Institutet
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- Ramanujam, Ryan (författare)
- Karolinska Institutet,KTH,Matematik (Avd.),Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm,
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Karolinska Institutet Matematik (Avd) (creator_code:org_t)
- 2021-01-25
- 2021
- Engelska.
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Ingår i: Multiple Sclerosis Journal. - : SAGE Publications Ltd. - 1352-4585 .- 1477-0970. ; 27:12, s. 1875-1883
- Relaterad länk:
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https://doi.org/10.1...
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https://journals.sag...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Existing severity measurements in multiple sclerosis (MS) are often cross-sectional, making longitudinal comparisons of disease course between individuals difficult. Objective: The objective of this study is to create a severity metric that can reliably summarize a patient’s disease course. Methods: We developed the nARMSS – normalized ARMSS (age-related MS severity score) over follow-up, using the deviation of individual ARMSS scores from the expected value and integrated over the corresponding time period. The nARMSS scales from −5 to +5; a positive value indicates a more severe disease course for a patient when compared to other patients with similar disease timings. Results: Using Swedish MS registry data, the nARMSS was tested using data at 2 and 4 years of follow-up to predict the most severe quartile during the subsequent period up to 10 years total follow-up. The metric used was area under the curve of the receiver operating characteristic (AUC-ROC). This resulted in measurements of 0.929 and 0.941. In an external Canadian validation cohort, the equivalent AUC-ROCs were 0.901 and 0.908. Conclusion: The nARMSS provides a reliable, generalizable and easily measurable metric which makes longitudinal comparison of disease course between individuals feasible.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- disability
- Multiple sclerosis
- outcome
- progression measure
- adult
- age related multiple sclerosis severity score
- Article
- cognitive function test
- cohort analysis
- controlled study
- diagnostic test accuracy study
- disease exacerbation
- disease severity
- disease severity assessment
- Expanded Disability Status Scale
- female
- follow up
- human
- major clinical study
- male
- receiver operating characteristic
- sensitivity and specificity
- Swedish citizen
- symbol digit modalities test
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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