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Absence of ECG task...
Absence of ECG task force criteria does not rule out structural changes in genotype positive ARVC patients
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- Stokke, Mathis K (författare)
- Institute of Clinical Medicine, University of Oslo, Norway,Norwegian Radium Hospital
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- Castrini, Anna I. (författare)
- Oslo University Hospital, Norway,Norwegian Radium Hospital
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- Åström Aneq, Meriam, 1964- (författare)
- Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Fysiologiska kliniken US
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- Jensen, Henrik Kjærulf (författare)
- Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark,Aarhus University Hospital
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- Madsen, Trine (författare)
- Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Denmark
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- Hansen, Jim (författare)
- Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
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- Bundgaard, Henning (författare)
- University of Copenhagen, Denmark; Unit for Inherited Cardiac Diseases, The Heart Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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- Gilljam, Thomas (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Platonov, Pyotr G. (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University and Arrhythmia Clinic, Skåne University Hospital, Lund, Sweden.
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- Svendsen, Jesper Hastrup (författare)
- Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
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- Edvardsen, Thor (författare)
- Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway,Norwegian Radium Hospital
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- Haugaa, Kristina H (författare)
- Oslo University Hospital, Rikshospitalet, Norway; University of Oslo, Oslo, Norway,Norwegian Radium Hospital
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Kjaerlulf Jensen, Henrik (författare)
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- Engelska.
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Ingår i: International Journal of Cardiology. - : Elsevier. - 0167-5273 .- 1874-1754. ; 317, s. 152-158
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Abstract
Ämnesord
Stäng
- AIMS: In Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), electrophysiological pathology has been claimed to precede morphological and functional pathology. Accordingly, an ECG without ARVC markers should be rare in ARVC patients with pathology identified by cardiac imaging. We quantified the prevalence of ARVC patients with evidence of structural disease, yet without ECG Task Force Criteria (TFC).METHODS AND RESULTS: We included 182 probands and family members with ARVC-associated mutations (40 ± 17 years, 50% women, 73% PKP2 mutations) from the Nordic ARVC Registry in a cross-sectional analysis. For echocardiography and cardiac MR (CMR), we differentiated between "abnormalities" and TFC. "Abnormalities" were defined as RV functional or structural measures outside TFC reference values, without combinations required to fulfill TFC. ECG TFC were used as defined, as these are not composite parameters. We found that only 4% of patients with ARVC fulfilled echocardiographic TFC without any ECG TFC. However, importantly, 38% of patients had imaging abnormalities without any ECG TFC. These results were supported by CMR data from a subset of 51 patients: 16% fulfilled CMR TFC without fulfilling ECG TFC, while 24% had CMR abnormalities without any ECG TFC. In a multivariate analysis, echocardiographic TFC were associated with arrhythmic events.CONCLUSION: More than one third of ARVC genotype positive patients had subtle imaging abnormalities without fulfilling ECG TFC. Although most patients will have both imaging and ECG abnormalities, structural abnormalities in ARVC genotype positive patients cannot be ruled out by the absence of ECG TFC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Arrhythmogenic right ventricular cardiomyopathy
- Cardiac magnetic resonance imaging
- Diagnostics
- ECG
- Echocardiography
- Pathophysiology
- Arrhythmogenic Right Ventricular Cardiomyopathy
- Cardiac magnetic resonance imaging
- Diagnostics
- ECG
- Echocardiography
- Pathophysiology
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Stokke, Mathis K
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Castrini, Anna I ...
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Åström Aneq, Mer ...
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Jensen, Henrik K ...
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Madsen, Trine
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Hansen, Jim
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Bundgaard, Henni ...
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Gilljam, Thomas
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Platonov, Pyotr ...
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Svendsen, Jesper ...
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Edvardsen, Thor
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Haugaa, Kristina ...
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Kjaerlulf Jensen ...
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