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Essential roles of ...
Essential roles of SHPS-1 in induction of contact hypersensitivity of skin.
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- Motegi, Sei-Ichiro (författare)
- Gunma University
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- Okazawa, Hideki (författare)
- Gunma University
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- Murata, Yoji (författare)
- Gunma University
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- Kanazawa, Yoshitake (författare)
- Gunma University
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- Saito, Yasuyuki (författare)
- Gunma University
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- Kobayashi, Hisae (författare)
- Gunma University
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- Ohnishi, Hiroshi (författare)
- Gunma University
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- Oldenborg, Per-Arne (författare)
- Umeå universitet,Histologi med cellbiologi
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- Ishikawa, Osamu (författare)
- Gunma University
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- Matozaki, Takashi (författare)
- Gunma University
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
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Ingår i: Immunology Letters. - : Elsevier BV. - 0165-2478 .- 1879-0542. ; 121:1, s. 52-60
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- SHPS-1 is a transmembrane protein that binds the protein tyrosine phosphatases SHP-1 and SHP-2 and is abundant on the surface of CD11c(+) dendritic cells (DCs). We recently showed that SHPS-1 is essential for priming by DCs of CD4(+) T cells and for development of Th17 cell-mediated experimental autoimmunity. We have now further evaluated the importance of SHPS-1 and that of its ligand CD47 in contact hypersensitivity (CHS) to 2,4-dinitro-1-fluorobenzene (DNFB). Whereas the DNFB-induced CHS response was impaired in mice that express a mutant form of SHPS-1 lacking most of the cytoplasmic region, it was unaffected in CD47-deficient mice. Moreover, treatment of wild-type mice with mAbs to SHPS-1 that either block or do not block the binding of SHPS-1 to CD47 inhibited the CHS response. A mAb to CD47 had no such effect. The 2,4-dinitro-benzenesulfonic acid-induced proliferation of, and production of IFN-gamma or IL-17 by, T cells from DNFB-sensitized wild-type mice were inhibited by either mAb to SHPS-1 but not by that to CD47. In contrast, the blocking mAbs to SHPS-1, but not that to CD47, inhibited an allogeneic mixed leukocyte reaction. Both mAbs to SHPS-1, but not that to CD47, also inhibited the lipopolysaccharide- or polyinosinic-polycytidylic acid-induced production of TNF-alpha by DCs. These results suggest that SHPS-1 is essential for development of CHS, likely as a result of its positive regulation of the priming by DCs of CD4(+) T cells. However, such regulation by SHPS-1 does not appear to require its interaction with CD47.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
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Motegi, Sei-Ichi ...
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Okazawa, Hideki
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Murata, Yoji
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Kanazawa, Yoshit ...
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Saito, Yasuyuki
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Kobayashi, Hisae
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visa fler...
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Ohnishi, Hiroshi
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Oldenborg, Per-A ...
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Ishikawa, Osamu
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Matozaki, Takash ...
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visa färre...
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