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Träfflista för sökning "WFRF:(Kohlmann J.) srt2:(2005-2009)"

Sökning: WFRF:(Kohlmann J.) > (2005-2009)

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  • Peternell, Mark, 1974, et al. (författare)
  • A new approach to crystallographic orientation measurement for apatite fission track analysis: Effects of crystal morphology and implications for automation
  • 2009
  • Ingår i: Chemical Geology. - : Elsevier BV. - 0009-2541. ; 265, s. 527-539
  • Tidskriftsartikel (refereegranskat)abstract
    • Apatite fission track analysis and in particular, computer-assisted fission track recognition require the determination of crystallographic orientation, crystal morphology, cracks, fractures and inclusions. The selection of a crystal for fission track analysis has largely been based on its surface and track etching characteristics that, in conventional fission track dating, is performed by the analyst. This requires manual scanning of the entire mount for suitable grains, which is a very time-intensive process during manual fission track counting. Therefore, a computer-assisted grain characterisation system is of interest to allow for an automated pre-selection of suitable crystals. With the use of a fully automated Fabric Analyser, c-axis orientations can be measured inside an apatite crystal for each pixel with a spatial resolution of 5 μm. The results are represented in geometric quality and retardation maps consisting of the c-axis orientations for each pixel and two quality values evaluating each orientation. These maps allow the determination of the crystallography of the apatite grain as well as its outline. In addition, most of the crystal morphologies, fractures and impurities, which can influence automated fission track recognition techniques based on image analysis, are determinable using the quality maps. On the other hand, the method is not sensitive to smaller crystal cracks, high fission track densities or coating. The quantification of the crystal geometric properties by this method is a step forward to develop a fully automated fission track analysis process. © 2009 Elsevier B.V. All rights reserved.
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3.
  • Leachman, Sancy A., et al. (författare)
  • Selection criteria for genetic assessment of patients with familial melanoma
  • 2009
  • Ingår i: Journal of American Academy of Dermatology. - : Elsevier BV. - 0190-9622. ; 61:4, s. 677-684
  • Forskningsöversikt (refereegranskat)abstract
    • Approximately 5% to 10% of melanoma may be hereditary in nature, and about 2% of melanoma can be specifically attributed to pathogenic germline mutations in cyclin-dependent kinase inhibitor 2A (CDKN2A). To appropriately identify the small proportion of patients Who benefit most from referral to a genetics specialist for consideration of genetic testing for CDKN2A, We have reviewed available published studies of CDKN2A mutation analysis in cohorts with invasive, cutaneous melanoma and found variability in the rate of CDKN2A mutations based on geography, ethnicity, and the type of study and eligibility criteria used. Except in regions of high melanoma incidence, such as Australia, we found higher rates of CDKN2A positivity in individuals with 3 or more primary invasive melanomas and/or families with at least one invasive melanoma and two or more other diagnoses of invasive melanoma and/or pancreatic cancer among first- or second-degree relatives on the same side of the family. The Work summarized in this review should help identify individuals who are appropriate candidates for referral for genetic consultation and possible testing. (J Am Acad Dermatol 2009;61:677-84.)
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