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- Ernberg, M, et al.
(författare)
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Ropivacaine for dental anesthesia: a dose-finding study
- 2002
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Ingår i: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. - : Elsevier BV. - 0278-2391. ; 60:9, s. 1004-1010
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Tidskriftsartikel (refereegranskat)
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- Kopp, S, et al.
(författare)
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Blood serotonin and joint pain in seropositive versus seronegative rheumatoid arthritis
- 2002
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Ingår i: Mediators of inflammation. - : Hindawi Limited. - 0962-9351 .- 1466-1861. ; 11:4, s. 211-217
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To investigate whether blood serotonin (5-hydroxytryptamine) (5-HT) modulates musculoskeletal pain differently in seropositive and seronegative rheumatoid arthritis (RA).Methods: Patients with temporomandibular joint (TMJ) involvement of seropositive RA (33 patients) or seronegative RA (28 patients) and 26 healthy individuals were included. TMJ pain, general musculoskeletal pain, plasma and serum 5-HT, acute phase reactants and thrombocyte count were investigated.Results: The patients with seropositive RA had higher serum (median = 1130 nmol/l) and plasma (55 nmol/l) levels of 5-HT than the healthy individuals (704 nmol/l,p=0.044and 23 nmol/l,p<0.001, respectively), and higher plasma levels of 5-HT than the seronegative patients (14 nmol/l,p<0.001). There was no significant correlation between serum and plasma levels of 5-HT in any group.In the seropositive RA patients, positive correlations were found between serum levels of 5-HT and the number of painful mandibular movements (rs=0.36,n=33,p=0.042), as well as pain on maximum mouth opening (rs=0.41,n=24,p=0.047) and tenderness to digital palpation (rs=0.49,n=33, p = 0.003).In the healthy individuals, there was a negative correlation between plasma level of 5-HT and the TMJ pressure pain threshold (rs=−0.47,n=20,p=0.037).Conclusion: Peripheral serotonergic pain mechanisms seem to be activated by blood 5-HT in patients with seropositive RA, in contrast to seronegative patients.
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- Voog, U, et al.
(författare)
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Influence of serotonin on the analgesic effect of granisetron on temporomandibular joint arthritis
- 2004
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Ingår i: Mediators of inflammation. - : Hindawi Limited. - 0962-9351 .- 1466-1861. ; 13:5-6, s. 373-376
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Tidskriftsartikel (refereegranskat)abstract
- THE influence of circulating serotonin (5-HT) on the effects of intra-articular administration of granisetron on temporomandibular joint (TMJ) pain was investigated in 11 patients with chronic polyarthritides. An analgesic effect superior to placebo has been shown previously.The change in TMJ movement pain intensity was negatively correlated to circulating 5-HT; that is, the higher the 5-HT before injection, the greater the reduction of pain intensity. The resting pain intensity reduction was not related to 5-HT.In conclusion, this study indicates a stronger short-term analgesic effect on TMJ movement pain by intra-articular administration of the 5-HT3receptor antagonist granisetron in patients with high levels of circulating 5-HT.
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