Sökning: WFRF:(Krejsgaard Thorbjørn)
> (2021) >
Bacterial genotoxin...
Bacterial genotoxins induce T cell senescence
-
- Mathiasen, Sarah L. (författare)
- LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
-
- Gall-Mas, Laura (författare)
- LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
-
- Pateras, Ioannis S. (författare)
- Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece
-
visa fler...
-
- Theodorou, Sofia D.P. (författare)
- Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece
-
- Namini, Martin R.J. (författare)
- LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
-
- Hansen, Morten B. (författare)
- Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
-
- Martin, Océane C.B. (författare)
- Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
-
- Vadivel, Chella Krishna (författare)
- LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
-
- Ntostoglou, Konstantinos (författare)
- Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece
-
- Butter, Deborah (författare)
- Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
-
- Givskov, Michael (författare)
- Costerton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
-
- Geisler, Carsten (författare)
- LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
-
- Akbar, Arne N. (författare)
- Division of Medicine, University College London, London, United Kingdom
-
- Gorgoulis, Vassilis G. (författare)
- Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece; Biomedical Research Foundation of the Academy of Athens, Athens, Greece; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom
-
- Frisan, Teresa, 1967- (författare)
- Umeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
-
- Ødum, Niels (författare)
- LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
-
- Krejsgaard, Thorbjørn (författare)
- LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
-
visa färre...
-
(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
-
Ingår i: Cell Reports. - : Elsevier. - 2211-1247. ; 35:10
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Several types of pathogenic bacteria produce genotoxins that induce DNA damage in host cells. Accumulating evidence suggests that a central function of these genotoxins is to dysregulate the host's immune response, but the underlying mechanisms remain unclear. To address this issue, we investigated the effects of the most widely expressed bacterial genotoxin, the cytolethal distending toxin (CDT), on T cells—the key mediators of adaptive immunity. We show that CDT induces premature senescence in activated CD4 T cells in vitro and provide evidence suggesting that infection with genotoxin-producing bacteria promotes T cell senescence in vivo. Moreover, we demonstrate that genotoxin-induced senescent CD4 T cells assume a senescence-associated secretory phenotype (SASP) which, at least partly, is orchestrated by the ATM-p38 signaling axis. These findings provide insight into the immunomodulatory properties of bacterial genotoxins and uncover a putative link between bacterial infections and T cell senescence.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Nyckelord
- ATM
- bacteria
- cytolethal distending toxin
- DNA damage
- genotoxins
- inflammation
- senescence
- senescence-associated secretory phenotype
- T cells
- typhoid toxin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Mathiasen, Sarah ...
-
Gall-Mas, Laura
-
Pateras, Ioannis ...
-
Theodorou, Sofia ...
-
Namini, Martin R ...
-
Hansen, Morten B ...
-
visa fler...
-
Martin, Océane C ...
-
Vadivel, Chella ...
-
Ntostoglou, Kons ...
-
Butter, Deborah
-
Givskov, Michael
-
Geisler, Carsten
-
Akbar, Arne N.
-
Gorgoulis, Vassi ...
-
Frisan, Teresa, ...
-
Ødum, Niels
-
Krejsgaard, Thor ...
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
-
och Immunologi
- Artiklar i publikationen
-
Cell Reports
- Av lärosätet
-
Umeå universitet
-
Karolinska Institutet