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Sökning: WFRF:(Krejsgaard Thorbjørn) > (2021) > Bacterial genotoxin...

Bacterial genotoxins induce T cell senescence

Mathiasen, Sarah L. (författare)
LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
Gall-Mas, Laura (författare)
LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
Pateras, Ioannis S. (författare)
Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece
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Theodorou, Sofia D.P. (författare)
Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece
Namini, Martin R.J. (författare)
LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
Hansen, Morten B. (författare)
Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Martin, Océane C.B. (författare)
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
Vadivel, Chella Krishna (författare)
LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
Ntostoglou, Konstantinos (författare)
Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece
Butter, Deborah (författare)
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
Givskov, Michael (författare)
Costerton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
Geisler, Carsten (författare)
LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
Akbar, Arne N. (författare)
Division of Medicine, University College London, London, United Kingdom
Gorgoulis, Vassilis G. (författare)
Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece; Biomedical Research Foundation of the Academy of Athens, Athens, Greece; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom
Frisan, Teresa, 1967- (författare)
Umeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
Ødum, Niels (författare)
LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
Krejsgaard, Thorbjørn (författare)
LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
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 (creator_code:org_t)
Elsevier, 2021
2021
Engelska.
Ingår i: Cell Reports. - : Elsevier. - 2211-1247. ; 35:10
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://doi.org/10.1...
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Several types of pathogenic bacteria produce genotoxins that induce DNA damage in host cells. Accumulating evidence suggests that a central function of these genotoxins is to dysregulate the host's immune response, but the underlying mechanisms remain unclear. To address this issue, we investigated the effects of the most widely expressed bacterial genotoxin, the cytolethal distending toxin (CDT), on T cells—the key mediators of adaptive immunity. We show that CDT induces premature senescence in activated CD4 T cells in vitro and provide evidence suggesting that infection with genotoxin-producing bacteria promotes T cell senescence in vivo. Moreover, we demonstrate that genotoxin-induced senescent CD4 T cells assume a senescence-associated secretory phenotype (SASP) which, at least partly, is orchestrated by the ATM-p38 signaling axis. These findings provide insight into the immunomodulatory properties of bacterial genotoxins and uncover a putative link between bacterial infections and T cell senescence.

Ämnesord

NATURVETENSKAP  -- Biologi -- Immunologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Immunology (hsv//eng)

Nyckelord

ATM
bacteria
cytolethal distending toxin
DNA damage
genotoxins
inflammation
senescence
senescence-associated secretory phenotype
T cells
typhoid toxin

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ref (ämneskategori)
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