Sökning: WFRF:(Kyrgiou M)
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Cervical microbiota...
Cervical microbiota in women with cervical intra-epithelial neoplasia, prior to and after local excisional treatment, a Norwegian cohort study
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- Wiik, Johanna (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Sykehuset Østfold,Østfold Hospital Trust,University of Gothenburg
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- Sengpiel, V. (författare)
- Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
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- Kyrgiou, M. (författare)
- Imperial College of Science, Technology and Medicine
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- Nilsson, Staffan, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för matematiska vetenskaper,Institute of Biomedicine,Department of Mathematical Sciences,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
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- Mitra, A. (författare)
- Imperial College of Science, Technology and Medicine
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- Tanbo, T. (författare)
- Oslo universitetssykehus,Oslo University Hospital
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- Jonassen, C. M. (författare)
- Sykehuset Østfold,Østfold Hospital Trust
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- Tannaes, T. M. (författare)
- Akershus University Hospital
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- Sjoborg, K. (författare)
- Sykehuset Østfold,Østfold Hospital Trust
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(creator_code:org_t)
- 2019-02-06
- 2019
- Engelska.
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Ingår i: Bmc Womens Health. - : Springer Science and Business Media LLC. - 1472-6874. ; 19
- Relaterad länk:
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https://bmcwomenshea...
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https://research.cha... (primary) (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- BackgroundLocal treatment for cervical intraepithelial neoplasia (CIN) by Loop Electrosurgical Excision Procedure (LEEP) has been correlated with reproductive morbidity, while the cervicovaginal microbiota is also known to affect the risk of preterm delivery. CIN and treatment by LEEP might change the cervical microbiota. The main aim of this study was to describe the cervical microbiota before and after LEEP and assess its associaton with cone depth and HPV persistence. Further, we aimed to compare the microbiota to references with normal cervical cytology.MethodsBetween 2005 and 2007, we prospectively identified 89 women planned for LEEP in a Norwegian hospital and recruited 100 references with a normal cervical cytology. Endocervical swabs were collected prior to treatment and at six (n=77) and 12months (n=72) post LEEP for bacterial culture and PCR, and post LEEP for DNA testing for human papillomavirus (HPV). We compared the cervical microbiota composition before and after treatment and between women planned for LEEP vs references.ResultsThere was a reduction in the number of non-Lactobacillus bacterial species six and 12months after LEEP compared to before treatment and a tendency towards a concomitant increase in Lactobacillus. No association between the detection of cervical bacteria, HPV persistence or cone depth was found.Women planned for LEEP carried significantly more Bacteroides spp., Gardnerella vaginalis, Mycoplasma hominis and Ureaplasma parvum as well as a greater number of bacterial species than the references.ConclusionsLocal excisional treatment appears to alter the cervical microbiota towards a less diverse microbiota. Women with CIN have a more diverse cervical microbiota compared to women with normal cervical cytology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Klinisk vetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Clinical Science (hsv//eng)
Nyckelord
- Vaginal microbiota
- HPV
- Human papillomavirus
- Lactobacillus
- Cervical Intraepithelial Neoplasia
- CIN
- bacterial vaginosis
- preterm birth
- pregnancy
- association
- risk
- DNA
- Public
- Environmental & Occupational Health
- Obstetrics & Gynecology
- Human papillomavirus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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