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- Lönnberg, Maria, et al.
(författare)
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Patients with anaemia can shift from kidney to liver production of erythropoietin as shown by glycoform analysis
- 2013
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Ingår i: Journal of Pharmaceutical and Biomedical Analysis. - : Elsevier BV. - 0731-7085 .- 1873-264X. ; 81-82, s. 187-192
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Tidskriftsartikel (refereegranskat)abstract
- The primary production site of erythropoietin (EPO) is shifted from the liver to the kidney shortly after birth. Under conditions of lost or reduced kidney production, it is valuable to measure the production capacity of the liver. However, there is a lack of urine or serum based methods that can distinguish endogenous EPO produced in different cell types. Here is presented a method based on chromatographic interaction with the lectin wheat germ agglutinin (WGA) that can distinguish presumably liver-produced EPO, found in anaemic patients receiving epoetin and darbepoetin, from kidney-produced EPO found in healthy individuals.All the tested samples from haemodialysis patients with end-stage renal disease showed a presence of liver EPO. In some samples, the liver-produced EPO made up 90–100% of total EPO at a concentration of 8–10 ng/L in urine, which indicates that the liver has a quite high production capacity, although not adequate for the degree of anaemia.This glycoform analysis has made it possible to affirm that some anaemic patients can increase their liver-production of EPO. The use of such a method can give better insight into the regulation of non-renal endogenous EPO production, a potential source of EPO intended to replace administration of exogenous EPO.
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| 2. |
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| 3. |
- de Jong, Johnny, et al.
(författare)
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Consequences of an increased extraction of forest biofuel in Sweden : a synthesis from the biofuel research programme 2007-2011
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- EXECUTIVE SUMMARY.This report summarizes the state of knowledge with respect to possibilities for increasing the extraction of forest fuel in Sweden and the consequences of such increases on soil, water and biodiversity. It is based, above all, on research carried out within the Swedish Energy Agency’s research programme “the Bioenergy Feedstock Programme” (2007-2011), as well as on other, related projects financed by the Energy Agency. The goal of the study was to investigate and highlight1. New knowledge emerged from the Bioenergy Feedstock Programme;2. The link between research results and national environmental objectives and forestry guidelines;3. What questions remain to be answered in order to allow for a long-term and sustainable production and use of forest fuels.The result shows that there is a considerable potential for increasing forest fuel extraction without decreasing possibilities of achieving other societal, environmental and forest production objectives. The current extraction level of approximately 50 PJ can be increased to 87 PJ, at least. Branches and tops are the least problematic, while some questions remain regarding the consequences of stump extraction. Nevertheless, limited stump extraction should be possible. This increased extraction is linked to a number of conditions which must be fulfilled in order for negative effects to be avoided, i.e.:1. That the general environmental considerations in forestry are not negatively affected.2. That extracted branches, tops and stumps mainly comes from conifers.3. That compensation for loss of base cations by means of ash recycling is done where needed, using good-quality ash.4. That it is possible to limit soil damage as felling residues and stumps, when harvested, cannot be used to reinforce the strip roads (extraction of branches, tops and stumps can only be done on land with good load-bearing capacity).5. That extraction is not done near woodland key habitats and nature reserves, where an increase in the amount of deadwood exposed to sunlight is likely to be more beneficial for biodiversity than if it is left elsewhere in a managed forest landscape
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| 5. |
- Lönnberg, Lina, et al.
(författare)
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Sand pits as habitats for beetles (Coleoptera): does area affect species number and composition?
- 2012
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Ingår i: Biodiversity and Conservation. - : Springer Science and Business Media LLC. - 0960-3115 .- 1572-9710. ; 21, s. 853-874
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Tidskriftsartikel (refereegranskat)abstract
- Species living in open sandy habitats are declining in northern Europe because of habitat loss and degradation. However, mining of sand creates potential new habitats for these species in the form of sand pits. In this study we investigated the beetle fauna in sand pits in order to determine what kind of sand pits are the most valuable for conservation, in terms of sand pit area (primarily) and the proportion of sand material, vegetation cover, tree cover and edge habitats. Thirteen sand pits in Uppsala County, Sweden, ranging in size from 0.02 to 18 ha, were included in this study. A total of 2,500 individuals of beetles, belonging to 256 species, were sampled by pitfall traps. Thirty-nine of the species were classified as specialized sand-dwelling species and two were Swedish Red List species. We found that the area of sand pits affects both species number and species composition of beetles. A positive species-area relationship was found, best explained by a quadratic power function, for the habitat-specific species (i.e., sand species). Our recommendation is to prioritize sand pits with areas between 0.3 and 5 ha, with preference towards the lower end of this range, for conserving sand-dwelling beetles.
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