Studies on the Interactions Between Mucin and Surfactant Aggregates Containing the Cationic Surfactant Dodecyl Betainate

• The interactions of surfactant aggregates containing the cationic, cleavable surfactant dodecyl betainate (DB) with mucin are investigated. The aggregates were either mixed micelles of DB and the nonionic surfactant PS-80 in different ratios or a dispersion of the commercial self-emulsifying drug-delivery formulation Sandimmun Neoral charged with DB. It is found that for the surfactant aggregates to show any notable interactions with mucin these must have a high positive charge density. Also presented are results from Ussing chamber experiments, which suggest that DB has a limited impact on the integrity and the barrier function of the intestinal epithelium.

Ämnesord

NATURVETENSKAP  -- Kemi -- Fysikalisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Physical Chemistry (hsv//eng)

Nyckelord

phase-behavior

ussing chamber

mixed micelles

counterion binding

in-vitro

drug-delivery systems

self-emulsifying drug-delivery system

microemulsion

diffusion

cationic amphiphile

light-scattering

mucin

gastrointestinal mucus

Bioavailability

nonionic surfactant

self-emulsifying drug-delivery system

mucin

microemulsion

Bioavailability

cationic amphiphile

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)