| 1. |
- Scherer, SW, et al.
(författare)
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Human chromosome 7: DNA sequence and biology
- 2003
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 300:5620, s. 767-772
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Tidskriftsartikel (refereegranskat)abstract
- DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description, additional structural features such as imprinted genes, fragile sites, and segmental duplications were integrated at the level of the DNA sequence with medical genetic data, including 440 chromosome rearrangement breakpoints associated with disease. This approach enabled the discovery of candidate genes for developmental diseases including autism.
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| 2. |
- Anthonis, Marc Henry, et al.
(författare)
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Crystalline molecular sieve layers and processes for their manufacture
- 2000
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Patent (populärvet., debatt m.m.)abstract
- A process is described for the manufacture of crystalline molecular sieve layers with good para-xylene over meta-xylene selectivity's good para-xylene permeances and selectivities. The process requires impregnation of the support prior to hydrothermal synthesis using the seeded method and may be undertaken with pre-impregnation masking. The crystalline molecular sieve layer has a selectivity (.alpha..sub.x) for para-xylene over meta-xylene of 2 or greater and a permeance (Q.sub.x) for para-xylene of 3.27.times.10.sup.-8 mole(px)/m.sup.2.s.Pa(px) or greater measured at a temperature of .gtoreq.250.degree. C. and an aromatic hydrocarbon partial pressure of .gtoreq.10.times.10.sup.3 Pa.
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| 3. |
- Lai-Kee-Him, J., et al.
(författare)
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In vitro versus in vivo cellulose microfibrils from plant primary wall synthases : Structural differences
- 2002
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Ingår i: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 277:40, s. 36931-36939
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Tidskriftsartikel (refereegranskat)abstract
- Detergent extracts of microsomal fractions from suspension cultured cells of Rubus fruticosus (blackberry) were tested for their ability to synthesize in vitro sizable quantities of cellulose from UDP-glucose. Both Brij 58 and taurocholate were effective and yielded a substantial percentage of cellulose microfibrils together with (1-->3)-beta-D-glucan (callose). The taurocholate extracts, which did not require the addition of Mg2+, were the most efficient, yielding roughly 20% of cellulose. This cellulose was characterized after callose removal by methylation analysis, electron microscopy, and electron and x-ray synchrotron diffractions; its resistance toward the acid Updegraff reagent was also evaluated. The cellulose microfibrils synthesized in vitro had the same diameter as the endogenous microfibrils isolated from primary cell walls. Both polymers diffracted as cellulose IVI, a disorganized form of cellulose I. Besides these similarities, the in vitro microfibrils had a higher perfection and crystallinity as well as a better resistance toward the Updegraff reagent. These differences can be attributed to the mode of synthesis of the in vitro microfibrils that are able to grow independently in a neighbor-free environment, as opposed to the cellulose in the parent cell walls where new microfibrils have to interweave with the already laid polymers, with the result of a number of structural defects.
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| 4. |
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| 5. |
- Chen, L., et al.
(författare)
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Process development and reliability for system-in-a-package using liquid crystal polymer substrate
- 2004
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Ingår i: Proc Electron Compon Technol Conf. ; , s. 24-28
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Konferensbidrag (refereegranskat)abstract
- In this study, embedded chip technology for system-in-a-package (SiP) application using liquid crystal polymer (LCP) substrate was developed and the reliability issue for embedded structure was evaluated. To this end two test chips with daisy chain joints were used with one copper layer. After assembly, modules were exposed to thermal cycling. The failure was investigated by SEM, and compared with finite element method (FEM) simulation results. Passive components as inductors were also fabricated on the LCP during the embedded technology. Their inductance and quality factors were simulated and discussed.
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| 6. |
- Dillier, N, et al.
(författare)
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Measurement of the electrically evoked compound action potential via a neural response telemetry system
- 2002
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Ingår i: Annals of Otology, Rhinology & Laryngology. - 0003-4894. ; 111:5, s. 407-414
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Tidskriftsartikel (refereegranskat)abstract
- The main aim of this study was to validate a new technique, neural response telemetry (NRT), for measuring the electrically evoked compound action potential in adult cochlear implant users via their Nucleus CI24M implant. Thirty-eight adults were evaluated with a variety of measurement procedures with the NRT software. Electrically evoked compound action potentials were obtained in 31 of the 38 adults (81.6%) and in 132 of the 160 electrodes (82.5%) tested. In addition to validating this technique, We also established a set of default clinical test parameters.
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| 7. |
- Kuo, Jer-Lai, et al.
(författare)
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On the use of graph invariants for efficiently generating hydrogen bond topologies and predicting physical properties of water clusters and ice
- 2001
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Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 114:6, s. 2527-2540
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Tidskriftsartikel (refereegranskat)abstract
- Water clusters and some phases of ice are characterized by many isomers with similar oxygen positions, but which differ in direction of hydrogen bonds. A relationship between physical properties, like energy or magnitude of the dipole moment, and hydrogen bond arrangements has long been conjectured. The topology of the hydrogen bond network can be summarized by oriented graphs. Since scalar physical properties like the energy are invariant to symmetry operations, graphical invariants are the proper features of the hydrogen bond network which can be used to discover the correlation with physical properties. We demonstrate how graph invariants are generated and illustrate some of their formal properties. It is shown that invariants can be used to change the enumeration of symmetry-distinct hydrogen bond topologies, nominally a task whose computational cost scales like N2, where N is the number of configurations, into an N ln N process. The utility of graph invariants is confirmed by considering two water clusters, the (H2O)6 cage and (H2O)20 dodecahedron, which, respectively, possess 27 and 30 026 symmetry-distinct hydrogen bond topologies associated with roughly the same oxygen atom arrangements. Physical properties of these clusters are successfully fit to a handful of graph invariants. Using a small number of isomers as a training set, the energy of other isomers of the (H2O)20 dodecahedron can even be estimated well enough to locate phase transitions. Some preliminary results for unit cells of ice-Ih are given to illustrate the application of our results to periodic systems.
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| 8. |
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| 9. |
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| 10. |
- Martinez, David, et al.
(författare)
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Acoustic noise prediction in a vector controlled induction machine
- 2003
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Ingår i: IEMDC'03. IEEE International Electric Machines and Drives Conference (Cat. No.03EX679). - 0780378172 ; , s. 104-110
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Konferensbidrag (refereegranskat)abstract
- The deterministic approach for the prediction of noise in electrical machines is generally based on the use of FEM/BEM models. Mechanical and electromagnetic properties included in these models, such as the damping or the BH curve, are difficult to estimate, compromising the accuracy in the noise prediction. Simulations showed that a 10% increase in the saturated part of the BH curve results in an increase of up to 3 dB in the sound power level, and that the sound power level could be reduced by up to 10 dB with a 5 times increase in the damping coefficient. The accuracy of the noise prediction was tested using a vector controlled drive with a very high PWM switching frequency. This system allowed the structure to be excited with the radial and tangential forces independently. Discrepancies between predictions and measurements of the sound power level at low frequencies have been attributed to the rotor and some stator/casing modes not being modeled, while at high frequencies, discrepancies are due to skewing of the rotor not being included in the model
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| 11. |
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| 12. |
- Ong, ML, et al.
(författare)
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Non-invasive cardiac assessment in beta-thalassaemia major
- 2002
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Ingår i: International journal of clinical practice (Esher). - 1368-5031 .- 1742-1241. ; 56:5, s. 345-348
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Tidskriftsartikel (refereegranskat)abstract
- Iron deposition in the heart occurs in beta-thalassaemia major and contributes to cardiac dysfunction. Eighteen patients with beta-thalassaemia major were assessed clinically and had non-invasive investigations. They were young (15.5 +/- 3.6 years). Two patients had clinical heart failure. Doppler echocardiography demonstrated higher transmitral peak flow velocity in early and late diastole compared with controls (e: p<0.05, a: p<0.01). Transtricuspid peak late diastolic flow velocity was higher in patients (p<0.005). Isovolumic relaxation time was shortened (p<0.001). Pulmonary venous flow velocity was higher in diastole than systole (S: 0.51 +/- 0.11 m/s, D: 0.62 +/- 0.08 m/s). Reversal of pulmonary venous flow during atrial systole was seen in eight patients. These diastolic filling abnormalities did not significantly change with blood transfusion. Left ventricular ejection fraction was normal in patients. Two patients had cardiomegaly on chest X-ray. In beta-thalassaemia with iron overload, there is a restrictive pattern of diastolic dysfunction. This is not altered by recent blood transfusion. Left ventricular function remains relatively intact.
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