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Maternal Polybromin...
Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Thyroid Hormones in Maternal and Cord Sera : The HOME Study, Cincinnati, USA
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- Vuong, Ann M. (författare)
- University of Cincinnati College of Medicine, Cincinnati, USA
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- Webster, Glenys M. (författare)
- Simon Fraser University, Vancouver, Canada
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- Romano, Megan E. (författare)
- Brown University School of Public Health, Providence, USA
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- Braun, Joseph M. (författare)
- Brown University School of Public Health, Providence, USA
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- Zoeller, R. Thomas, 1952- (författare)
- Department of Biology, University of Massachusetts, Amherst, USA
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- Hoofnagle, Andrew N. (författare)
- University of Washington, Seattle, USA
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- Sjödin, Andreas (författare)
- National Center for Environmental Health, Atlanta, USA
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- Yolton, Kimberly (författare)
- Cincinnati Children’s Hospital Medical Center, Cincinnati, USA
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- Lanphear, Bruce P. (författare)
- Simon Fraser University, Vancouver, Canada
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- Chen, Aimin (författare)
- University of Cincinnati College of Medicine, Cincinnati, USA
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(creator_code:org_t)
- National Institute of Environmental Health Science, 2015
- 2015
- Engelska.
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Ingår i: Journal of Environmental Health Perspectives. - : National Institute of Environmental Health Science. - 0091-6765 .- 1552-9924. ; 123:10, s. 1079-1085
- Relaterad länk:
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https://doi.org/10.1...
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https://ehp.niehs.ni...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Polybrominated diphenyl ethers (PBDEs) reduce blood concentrations of thyroid hormones in laboratory animals, but it is unclear whether PBDEs disrupt thyroid hormones in pregnant women or newborn infants.OBJECTIVES: We investigated the relationship between maternal PBDE levels and thyroid hormone concentrations in maternal and cord sera.METHODS: We used data from the Health Outcomes and Measures of the Environment (HOME)Study, a prospective birth cohort of 389 pregnant women in Cincinnati, Ohio, who were enrolled from 2003 through 2006 and delivered singleton infants. Maternal serum PBDE concentrations were measured at enrollment (16 ± 3 weeks of gestation). Thyroid hormone concentrations were measured in maternal serum at enrollment (n = 187) and in cord serum samples (n = 256).RESULTS: Median maternal serum concentrations of BDEs 28 and 47 were 1.0 and 19.1 ng/g lipid, respectively. A 10-fold increase in BDEs 28 and 47 concentrations was associated with a 0.85-μg/dL [95% confidence interval (CI): 0.05, 1.64] and 0.82-μg/dL (95% CI: 0.12, 1.51) increase in maternal total thyroxine concentrations (TT4), respectively. Both congeners were also positively associated with maternal free thyroxine (FT4). We also observed positive associations between BDE-47 and maternal total and free triiodothyronine (TT3 and FT3). A 10-fold increase in BDE-28 was associated with elevated FT3 concentrations (β = 0.14 pg/mL; 95% CI: 0.02, 0.26). In contrast, maternal PBDE levels were not associated with thyroid hormone concentrations in cord serum.CONCLUSIONS: These findings suggest that maternal PBDE exposure, particularly BDEs 28 and 47, are associated with maternal concentrations of T4 and T3 during pregnancy.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
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- Enviromental Science
- Miljövetenskap
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Vuong, Ann M.
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Webster, Glenys ...
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Romano, Megan E.
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Braun, Joseph M.
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Zoeller, R. Thom ...
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Hoofnagle, Andre ...
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visa fler...
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Sjödin, Andreas
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Yolton, Kimberly
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Lanphear, Bruce ...
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Chen, Aimin
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